What Does Methylfolate Do For Your Body?
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- čas přidán 11. 06. 2024
- What does methylfolate do for your body what's the big deal anyway? Why do people take it why are people concerned about it?
If you're wondering this maybe because you've come across the fact that you have an MTHFR gene alteration or single nucleotide polymorphism and basically some people have alteration in their ability to make the enzyme MTHFR and that leads them to not be able to create methyl foley so if that's you this video is probably gonna be helpful for you and deciding just why
if you're kind of new to this why you would want to take it and what it's actually doing for your body now there can be side effects from taking this so be sure to check out my video on methylfolate side effects because that
can happen does happen not always but depends on your dose and lots of other things.
We treat a lot of people with genetic alterations such as MTHFR and other
single nucleotide polymorphisms also known as snips so in this video we're
going to discuss the uses of methylfolate and kind of discuss what it actually does for your body.
What the heck does methylfolate do for the body anyways why is it
important? So mainly I think about it as having three distinct
functions and some of them have overlap too. The first being SAMe production which we'll go into a little more detail later. It helps with the conversion of homocysteine into SAME. It also helps with the recycling or reusing of biopterin which is needed for production of neurotransmitters. Lastly it also has a separate function to help with DNA base pairs their formation and supporting DNA repair.
So SAMe is one of the main donors of the methyl groups too many methyl transferase enzymes. If you don't know enzymes are basically proteins that help our body or assist our body in performing different reactions. So as a analogy you have some plastic here and then you get cups on the other end. Well in between the machine is what takes that that plastic and turns it into the cups. So the machine is like the enzyme.
Methyltransferases actually help transfer the methyl group to other molecules so it's very biologically active substance. the methyl group is basically ch3. A carbon molecule and three hydrogen's and then it's bound on to whatever molecule it might be like SAMe.
For instance, that SAMe with the help of the methyl transferase enzymes donate that methyl group to other things. In the process of doing that it may help your body produce creatine for instance. Creatine is very important for energy production and recycling quickly recycling or energy when you are at the anaerobic threshold. Like when you are running for a long time, doing a single rep max on the bench press or squat. Creatine kicks in and produces energy very quickly and that's important for brain function and of course muscle function. It's happening all over our bodies all the time we just don't know about it so if you don't have enough methylfolate you know have enough SAMe and you won't be able to make sufficient amount of creatine and could lead to fatigue and things like that.
Cell membrane production so it helps with the production of phospholipids so all of our cells are made up of basically a fatty outer surface a 3 dimensional kind of ball. You can think of it like a marble and it's basically thousands of these little circles that make up the cell membrane and that's a phospholipid. SAMe helps with phosphatidylethanolamine methyltransferase and it's the cofactor for that methyl transferase enzyme. So if you don't have enough methylfolate you're not going be able to produce your cell membranes efficiently which could you know affect your ability to recover from injured tissue. some kind of injury or tissue damage slows phospholipids are part of the reason that would slow kind of recovery
There's also DNA methyltransferases that help with the DNA repair and things like that. So methyfolate is involved with that and there's many other different methyl transferases that are not as well known but use SAME. It can also help with the recycling of biopterin but mainly at least from the research that I've done it's methylfolate itself and a different enzyme that basically helps with the recycling of biopterin.
So if you don't have enough methylfolate you're perhaps not gonna be recycling your by opt-in which then that's an important molecule it's a cofactor for the enzymes that help produce our neurotransmitters like dopamine epinephrine norepinephrine. You can't just take biopterin your body produces it and you have to recycle it. So recycling it's pretty important and methylfolate is important for this.
Lastly you have DNA. DNA is produced from base pairs. - Věda a technologie
Check out my books that goes into details:
"MTHFR Gene Therapy Demystified" amzn.to/3uAWLoR
High B12 Levels and More
"Don't B12 Deficient" amzn.to/35TQBWt
Courses
discover-holistic-health-academy.thinkific.com
Worst part about methylfolate is that people and advisers dont know anything about it, they just wrote that mthfr is needed for synthesis of methylfolate and they are teaching everyone that if you have mthfr then you need to suplement this nutrient. I really encourage to look at study that showed that 3mg of riboflavin lowered homocysteine by 40% in people with mthfr and this is really key nutrient for those people not methylfolate. Methlfolate is methylated god knows how many times everyday and dose that you get from suplement will be transformed into thf in like 1-2 hours after taking and then it isnt different than folic acid that is demonized. In the end i want to write that b2 is key nutrient because it speeds up mthfr and if you got polimorfism then your enzyme need more b2 and even more facinating is fact that such low dose as 3mg will be enough. If you dont notice any improvement in blood homocysteine or your mood then mthfr isnt your problem and you need to dig more into your biochemistry.
Hi thanks for sharing. I agree riboflavin is very important. It seems for some more and others less. It makes sense that it would or could lower homocysteine but clinically I do not see it work that way (even at much much larger doses than what you noted). Thanks again for your comments and contribution.
Thank you for helping me understand some of my journey :)
Happy to help!
Hi Dr, i have Cystinuria and suffer from fatigue and poor sleep. A recent blood test showed high B12 and very high folate. My doctor wasn't concerned and implied i was supplementing, which I am not. Given that Cystinuria ìs a defect in the reuptake of the COLA amino acids from Methionine, do you think it's possible my folate pathway is also impaired leading to high unrecycled folate levels please?
Thanks! Like it!
Hi! Thanks for that great video! I am just wondering, if Methylfolate acts as a mild monoamine releaser of Serotonin, Dopamine & Norepinephrine?
Hi Umhlanga, methylfolate definitely increases neurotransmitter production.
I guess I am quite randomly asking but do anyone know a good site to watch new tv shows online?
Yes. I do know a good site.@@westonturner3987
Hi Doctor, interesting video, I have a brother who has been diagnosed with ALS. He has high B12, and has factor 5 Leiden. Is it a good idea to to have his MTHFR tested? What other blood work or tests would you recommend? Trying to reverse or stop the progression. Thank you in advance.
Hi gaile716. Yes on MTHFR but I would recommend working with a functional medicine doctor that has some experience with neurological issues.
Hello Doctor, what b12 blood test would you recommend instead of the standard . Thank you
Dr if you have 1 alteration from the mtfhr gene but also you have hemochromatosis from another defective gene as well. Can you still take methyfolate? I suffer from fibromyalgia, neuropathy, all kind of digestive issues, anxiety and depression. I was told to take this supplement but I'm afraid for my iron levels. Thank you for your video.
Hi Paulo, it is really hard to say as it is going to depend on a few variables. I will say that just having hemochromatosis does not mean you can't take methylfolate. One would have to look at your whole system to know, though.
My ferratin was 4100. Now 2300 after 3 monthly blood draws
When I take vit b12 supplements they build up and my blood tests start showing extremely high (over 1000) vb12 levels. All my family have anemia, Is this indication of gene mutation dyou think?
Yes both (high b12 and anemia) could be. Anemia if you have large red blood cells. You might want to check out my new book on B12 as I go into a lot of detail on this topic. amzn.to/3jVGvZf
how much neuro methylation cream do you apply, and how often?
what a surge of energy expected every time, and/or what else can be expected?
what symptoms are we to have, or what are we to be suffering from, to know we need this cream?
Hi Gino, sorry I am not familiar with this product.
Can methylfolate and/or methylcobalamin cause anxiety even if a person has mthfr and comt variants? If so, how do u circumvent this and still lower homocysteine and c-reactive protein?
Yes it is possible but less likely. It is dose dependent. Best approach is to start low and go slow or find a doctor that can help you navigate it. U can also check out my course on MTHFR
You could take Folinic Acid (not the same as folic acid) which is bioavailable & can be used by the cells straight away, it doesn't have the anxiety inducing effects that some people with other polymorphisms experience.
I have Mthfr test done and A1298c detected
Risk Factor hyperhomocysteinemia particularly when serim folate. I don’t know what do with this issue. Can someone please help me with this? If I should take supplements?
TMG Trimethylglycine. Take it easy though as it can affect your mood if do to much. Get homocysteine blood test every year.
I took SAM e and I had a terrible reaction. Horrific. Could I have the same problem with methyl folate?
Yes
Hey. Why does taking methylcobalamin alone makes me comfused?
check out my video on the different forms of B12
OK so I was watching/listening to bearKy and must not have been listening because I thought methyl folate was beneficial for everyone since we all need folate, and there is no natural folate in the world anymore since 1993 or whatever he said so if we start taking him before we know whether or not we have“the Jean” do we have to worry about negative side effects?
I don't understand the question but many people without MTHFR can take methylfolate and do fine they just don't need as much.
I have ameia in which hemoglobin is low while RBC is complete...and have sinus congestion... So want to take folate can l?
Swati, thank you for your question. I cannot tell you if methylfolate would be appropriate for you with the limited information provided. Some types of anemia will respond really well to methylfolate but not all will.
I have adhd and like to yell n make funny noises n laugh n have hyperactive attacks. I take this supplement n I am doing better. Now I just make dumb faces in the mirror 🪞 for fun.
Hahaha . Same here. My ADHD gives me a golden retriever personality 😂
Please make a video on autism and food help in recovery from autism
Please tell me more abt the gene!
Lots of videos on MTHFR check those out
High triglycerides cholesterol?
thank you
Your welcome
I have been diagnosed with BPD and depression and anxiety...would this be beneficial for me to take for mental health? Many thanks 👍
Jesus is the best cure xx
@@myrtleesther8855oftentimes these bpd folks do fine around their boss, and other "authority" figures in their lives....meaning they're behavior can be modified if they so choose. You're correct if they had a real relationship with JC they would most likely be conducting themselves differently. My dad was "bipolar"....idk if she's referring to that, or borderline personality disorder, but in my opinion same same when it comes to behavior
Hi Doctor , does this help with autism patients?
It can yes
CAN SOMEONE TELL ME ABOUT L--METHYLFOLATE I A SIMPLE WAY WHAT DOES TO YOUR BODY OR THE BRAIN?
Hi Doc. I have Type 2 diabetes, I am wondering if methylfolate may help my body's cells respond to or process insulin more effectively, thus helping to reverse insulin resistance? Thank you!
Not likely no
Fasting
Can I take methl folate 400mcg without knowing if I have mthfr or not? I have ADHD. Studies suggest many people with ADHD have mthfr. Also, it helps with anxiety.
Many people do and I don't see an issues unless you are at higher doses (above 2 mg).
Does it help with chemo induced peripheral neuropathy ??
Don’t think so
What about methylated steroids and the liver?
I'm not sure what your question is.
@@swintegrative I can’t seem to find out how a methylated anabolic steroid (oral steroid) “bypasses” the liver breakdown. What exactly happens at the cellular level when one takes “methyl-testosterone” for example and why does it cause a rise in liver enzymes?
Hello doctor, please is methyl folate good for a man who does not have sperm cells? !!! !!! What is the appropriate dose of 800 or 400? !!
U will have to talk to a doctor and see if it is appropriate for you. I am not giving individual advice. In some cases it can help increase or improve spermatozoa.
Safe for those with ckd ??
Depends how bad but not typically
Making your DNA out of synthetic chemicals made in a lab.. There's got to be a better way?
1 gram is 1000 milli not micro gram 🙏😊😊
Yep thanks