Genetics and Mental Health: The MTHFR Gene
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- čas přidán 1. 06. 2024
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🎥 This video was edited by:
Rahul Kanchi / rahulkanchi24
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References:
Djokic, G., Korcok, D., Djordjevic, V., Agic, A., Rankovic, A., & Djukic, D. (2017). The effects of S-adenosyl-L-methionine-vitamin B complex on mild and moderate depressive symptoms. Hippokratia, 21(3), 140-143.
Marcin, A. (2022). What is the MTHFR gene? Retrieved from www.healthline.com/health/mth...
Stengler M. (2021). The Role of Folate and MTHFR Polymorphisms in the Treatment of Depression. Alternative therapies in health and medicine, 27(2), 53-57.
Wan, L., Li, Y., Zhang, Z., Sun, Z., He, Y., & Li, R. (2018). Methylenetetrahydrofolate reductase and psychiatric diseases. Translational psychiatry, 8(1), 242. doi.org/10.1038/s41398-018-02...
Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.
Y'all MTHFRs!
😂😂😂 Yep, I am one.... 😅
I have the mthfr mutations. This is the best video I've seen. I learned so much thank you.
You're welcome 😊
This is honestly amazing! I got the Genesight testing and wanted more information. This was insanely helpful, you rock!! 😁🤘 It answers soooo many questions and struggles I’ve had my entire life. Also it’s interesting that I was bound to have some sort of anxiety with my 25% absorption! Makes me wonder how many of us need to be on meds or if we just need supplements 🤔 Crazy that a medicine prescribing doctor for anxiety helped me figure this out and not a physical doctor that I had been complaining about joint pain and other stuff for years!!! The physical doctors only dismissed my pains and could care less. Thank God for some angels on earth that actually care about people.
My sister got a copy from our mom and her dad, she was diagnosed as schizophrenic. I wonder if this was actually the problem
😢
Can you tell me what made you choose genesight vs others?
@@te7931 She needs to go gluten free and see if that improves her symptoms. A certain percentage of schizophrenia diagnoses are actually caused by celiac disease. She should look into that.
Some great videos to watch peter Osborne just put on CZcams with details for this type of symptoms he is a doctor who tells you the science behind everything but easy to understand
TMG Beatine changed my life!!!
The good news is epigenetics, what we have control over;I.e; proper diet including green leafy vegetables ( high in folate), daily exercise and sleep influences 80% of our gene expression.
Yes!! That's why a healthy lifestyle is so important and foundational to our overall health.
Except MTFR makes it harder to convert leafy green folate into the correct meat based folate.
@@ArrosticiniVoreagreed, beef liver is the way… eating leaves ain’t gonna do jack
It’s also a lovely sentiment to tell people to get better sleep. It’s kind of like telling an anxious person to calm down. We’d love to sleep better.
Dr Julia didn't say it like that at all tho - read it again@@carolangeli1025
Thank you so much. I’ve seen dozens of healthcare professionals who just brush my MTFR homozygous mutations off and say it’s no big deal.
How do I find a provider that is knowledgeable with the MTHFR gene defect and all the things you mention on the video? I am currently seeing a Wholistic Dr. for my daughter who has the homozygous C677T mutation and has anxiety and depression. What questions should I be asking to know if he is knowledgeable enough to guide us down this road. He has been great so far, but everything we have done has not helped my daughter which tells me we are not getting to the root of the problem. And I have to agree with other comments, in that this is the BEST video about this issue I have found. I often feel overwhelmed. Thank yo soooo much!
Amazing Video, thank you! I have this gene. Both of my brothers had Schizophrenia and one of my sons has it the other has something but we are estranged so not sure he is homeless. I see a functional medicine doctor who has been helping me hack this gene and I’ve made progress, thank you for all this info. My heart is broken for my family however many will benefit from all the insight you talk about. Thank you!
I just commented on another comment about celiac disease being one cause of schizophrenia. For those people once they stop eating gluten their schizophrenia resolves. It's something worth looking into.
You explained and important and very complex topic beautifully ❤
Very useful. Ive got this variation so helpful to see this.
Very informative! Thank you for this breakdown!
You're welcome! Glad it was helpful!
amazing job!
Thank you!
Thank you for this fantastic Info
You're welcome, and thanks for watching! 😊
Very insightful, I love your meditation videos as well. Do you have any videos on trileptal .?
Not yet! But I will consider a video about it.
Very valuable information. Thank you!
thanks that was extremely informative! I had no idea about the b complex... I take NAC as well as b6 methyl and b9 methyl iv got compound heterozygous so YAY! Iv been diagnosed ADHD and Autistic (lv 2 High functioning) time to get me some SAM e!
Hello, I would appreciate if you make a video on the connection in between MTHFR mutation and Iga nephropaty. Thank you in advance!
Can you make a video about the COMT gene?
Thank you so much. My whole family has the mutation. This explains so much. Thank you
Thank you!
Yes, I had terrible depression until I addressed the issues that go with this. Taking thyroid hormone took away my depression.
I'd love to see you do a video on ComT if you haven't already.
Thank you! This video idea is on my list!
Very helpful!
Glad it was helpful! Thanks for watching :)
Excellent overview. Have gene links to ADD been found?
I have the MTHFR gene AND the Apoe2 gene. Can you do a video on Apoe2? EVERYONE talks about Apoe4.
I am a compound homozygous and have prostate cancer. It is my understanding that cancer is addicted to methionine so having a mutation in the mthfr gene is a good thing and one should not treat it because untreated your body can’t convert methionine or something like that. Do you know anything about this? It’s so complicated and difficult to know what to do. Treat the mutation or not?
The l methyfolate caused me bad stomach problems. I had to stop it. What can I do?
HI - how do you know whether you have a good or bad version of the C1677 and A1298c please? I have all the results but it's confusing - thank you for a very interesting video
If you had a DNA test it should say which variant you have and whether or not it is heterozygous or homozygous for that variant. If you can't understand the report, ask your doctor to review it with you.
@@LevelheadedMind thank you
You mentioned telling us about testing and some other things in "the description below"... I have no idea what that means as I see nothing on the CZcams screen. Please direct me on how to find that information. Thank you! I loved how detailed your presentation is with visual copy following your talk and what these genes can affect. I had a functional doctor that tested me for these snips, but didn't tell me what it would affect and treated me only with B12 and folate sans the B complex. Everyone should know, the B complex addition made all the difference in the world! I recommend an excellent, whole food multivitamin to get a well rounded vitamin and mineral addition to the general diet. While greens have great nutrition in them, it's terrible difficult for the human body to break down the cellulose. I like juicing.
What are the specific snips that also also affect mental health that you listed as generic snips... COMT, MAOA, etc.? Is there somewhere that specificity listed?
Can you speak on how antibiotics can ruin your gut and therefore brain health especially if you have certain genetic snips? ...Cause inflammation, cause Cfids and Fibromyalgia and how to correct the damage from floxing please?
Link in the description is where??? Still can't find it and I've searched several times.
My aunt who has done much extensive research on the jeans in our family has recently told me that we have this in our family, and from all of the considered symptoms, you can definitely tell in most of the family members.
I am now 30 and starting to experience quite a few things much more than before and although this video was extremely informative, it’s so hard for me to take in all this information and truly understand what is the best way to move forward .
Very healthy, exercise regularly, and I’m currently dealing with a lot of chronic inflammation, depression, and more.
I am still optimistic, thank you for this information
Are you taking B vitamins?
Are you taking methyl foliate?
I don’t take the vitamins consistently, because I noticed they make me hot or really hungry and I end up over eating. I do know the benefits and I’ve tried, but haven’t found ones that have worked the best.
As for the methyl folate, I purchased it in the last month or so and started taking it for about two weeks. Do you normally notice a difference pretty soon after starting?
@@Day1Million I think I do feel better on methyl foliate quite soon after starting. I take drops.
@Day1Million if you have a significant reduction in folate and the homozygous MTHFR then yes, most people notice a difference within a couple of weeks. Others a couple of months. If you're having reactions to the vitamins they may be synthetic or you may need to help your liver clear out toxins.
Hi
Please make video about Coxsackie B virus , and is there supplements that I can take .
Thank you .
My husband has Compound heterozygous for the MTHFR gene mutation and an alcoholic. I believe alcohol deletes folate in the body and can lead to mental health issues. For my husband, I believe it is bi polar disorder.
I love the breakdown the best I have seen so far. I was hoping you were gonna mention what to do if your MTFHR and you can’t handle the L5 methyl supplements. Felt horrible on them. I have heard that can happen but What to do then. That’s the spot I’m in with no answers what to do from here. Please help anyone 🙏
I think you refer to b-vitamins in their reduced -5 form..?
Pentagonal structured and pre-methylated.
Awesome info!!! A1298C from both parents
Please list tests I can ask my Dr. to order ( labs ) needed I.E. you spoke on Homocysteine… to assure my levels are or can be optimal when dealing with MTHFR ( Heterozygous ) and my mental health
Blesssings for this video ❤
Hi my granddaughter we think she has Autism we had her tested for autism on Monday we still haven't really got an answer but they think so.should i get her tested.
It wouldn't be a bad idea to test for MTHFR as well as dietary deficiencies and food allergies. Oftentimes cleaning up the diet can do a lot. No food additives, stay away from red food coloring/dyes, eat organic and anti-inflammatory foods first before confirming this diagnosis.
This is so interesting, I just found I have reduced folic acid conversion and I realized its kind of the same as My Lactose Intolerance. They both started in middle school and they both are related to breaking down compounds :P
You need FOLATE, not folic acid
Really you need a Methyl B complex
I did a genetics test and my mthfr gene is bad from one parent. Ive had anxiety and sleeping issues for a decade. Explains it. Ive started taking methylated b vitamins recently so hopefully it helps. I dont have any depression though which is good. Im also taking vitamin d and k because i was low on those.
Do you think fixing this issue could help recovery from Benzodiazepines?
BTW I would like to be tested but I dont know where or how to start, please help. TY
Have it, both genes. Does that mean it limits the efficacy of other supplements or medications
It means you need bioavailable forms of folate as I mentioned in the video.
I have a homozygous c677t mutation byt my homocystein levels is normal. Should i supplement anyway?
I'm a homozygous 677 tt carrier.
I have a normal to high COMT activity.
I have a altered DRD2 function.
I've had depression, anxiety, sleep problems all of my life. Medications stopped working 15 years ago. Whenever I take vitamin b12 I get crazy energy. ( I usually have low energy levels ). My b12 levels are always on the border of being low. I've just figured out what's going on with me and why I'm having all of these life altering issues that hurt my life. I'm gonna start taking methylfolate, methyl b12, p5p and SAM-e. Hopefully I see changes. Great video.
Thanks for watching and glad it was informative. Always make sure to check with your doctor before taking supplements.
Hey Bro where had you get your test done?
@@videshwarbissessar5234 clarityX
TRY TMG
@@charlesfuchs yea I tried tmg. I'm insanely sensitive to everything that impacts the methylation in my body. My body cannot tolerate methylfolate. Methyl b12, folinic acid is too stimulating. My body is extremely sensitive to everything because it's been depleted for all of my life. My homocysteine was last at 60. Low folate levels as well.
I've taken 15mg of l-methylfolate with 2000iu d3 for years and it for sure helps my antidepressants work better but I've never heard anything about taking b-complex with it lol, do you have any brand suggestions? I also was wondering if you could please make a video on Vraylar and maybe even compare it to Seroquel and which is less likely to cause TD and EPS symptoms... THANK YOU!!!!
Great video idea, thank you! As for the b-complex I like Pure Encapsulations, Thorne make bioactive b complex. Pure Encapsulations even has a methyl assist formula specifically for those with MTHFR.
U can watch dr.eric bercs videos and nervous doct videos
‘SmartyPants’ multivitamin have methylated bvitamins and fish oil, iodine, etc and vit d3. I also add magnesium glycinate and a small bit of vit D3 at night.
Methyl-pro is a brand selling methyl folate supplements WITH necessary co factors included.
Hey,Thanks for your guidance teachings. If there’s a way can you help extend such testing services to Canada. I’m unaware of any such services available here.
DNA Labs Lifestyle test will have MTHFR and other genes for methylation that you can order from Canada. dnalabs.ca/
@@LevelheadedMind Thank You I will look into it for sure if needed. I’ve had seizures and been led down the epilepsy road but now see through a lot more than the word epileptic. My neck has chiari most likely I’ve dealt with hydrocephalus I assume (large ventricles) over a period of time ignored after MRI at Toronto neuology I assume knowing my ventricles looked like a devils horns…. Only happens when a brain is in hydrocephalus or related such scenarios. Is saddening to see they don’t help but put on a show and pretend to. Getting to the basis of the issue is common sense and necessary but in Canada it feels far from such. Who let Canada fall apart I’m not sure but unless you’re a millionaire I wouldn’t move here. These tests better be humane (affordable).
@@LevelheadedMind I just noticed it’s more expensive than another option I can privately purchase…. It’s not normal to make money off a persons ills it’s inhumane and should be acknowledged by law. I’m so tired of the mighty dollar being the main goal of such. A stimulation of medical care through simulations of the medicine industry is all health care really is. Pill you up numerous times before addressing physics they all just love ignoring the truth and persuading g you on to a pill.. they would t want you knowing of a mutation before they deem you diseased.
are these genes only damaged or can they also be missing?
Explain how we can detox folic acid from our bodies, please
Where can we get tested ?
Plz tell me about olanzapine
Age 25 male
I was on olanzapine 5mg for 7 months as i stopped now because i saw it causes diabetes plz tell me how common is this?i did my random blood sugar test it came normal
I have a video on Olanzapine here czcams.com/video/rcOnH6HXnEM/video.htmlsi=iCZzAoEpwIL7YW3Z it does have high risk for causing metabolic syndrome or diabetes, you just need to make sure to check your labs regularly, at least every 6 months to see if it is effecting you this way.
Methylated 12 & folate & methyle b1
Hmmm oddly enough when doctors ask about family history there is not much of anything and In my mind I say “mental illness” 😢 mood stabilizers didn’t work for me but b complex, fixing low hemoglobin and low vitamin d has helped. I didn’t know about this until recently but wow. 😮
diet and action will fix it
Didn't know it was in the family until my daughter was tested after 2 miscarriages. I understood it has to come from both parents . I didn't know there were 3 types .
How do I get tested
Go to a doctor/family physician
So I have the homozygous C677T. What I’m curious about is how to interpret blood work given that My B12 and Folate blood levels are typically right in the middle of the lab range. Is this mutation suggesting that my body may not doing correct things with the folate that is reflected in these lab values, or that I would be looking for a either too high or too low lab value?
I have this too homozygous c677T. My labs look ok too but I did have high homocysteine… id start by getting that checked. I cant say but if you do take supplements be careful with methyl folate or methlated b12. I was very sensitive to them and in fact alot of people cant tolerate it especially at 10mg or whatever she said. I did great with reg b12 and reg folate supplement
It is true that some people do not tolerate the methylated folate in high doses. However, if you have the homozygous MTHFR and it is expressing itself, then when you take folic acid you can only absorb 25% of it, so this means you may require higher amounts. Plus folic acid can also block the ability to absorb folate. So in this case you would need to start methyl folate very low in micrograms first. Methylated B12 is more activating and that is what most people cannot tolerate so instead try adenosylcobalamin and/or hydroxycobalamin instead.
Optimal range for B12 is above 500, folate is 15- 27 and you want homocysteine 5-7. If these are all optimal then your gene is not expressing itself. Remember that just because you have the gene does not mean that it will be turned on. This blog explains optimal levels well www.optimaldx.com/research-blog/b12-deficiency-part-3 and www.optimaldx.com/research-blog/vitamin-biomarkers-serum-folate
@@LevelheadedMind my son is homozygous for C667T. He had cannabis induced psychosis and still recovering. How do I know if the gene has been turned on?
great explanation
Folic gets sorted when very 1st incident of injustice and blame gets handled in scritzophenia
There is some data that it seems a lot of Schizophrenia patients are celiacs. It would be interesting to do a study and people with genes predisposed to schizophrenia, if they were never introduced to gluten if the disease would not be turned on with Epigenetics
This immune and neuro
Can you explain does smoking cigarettes effect mental health and does it cause you to have a mental break down? Thanks again 😂
Easy Fix TMG BETAINE
C677T is a polymorphism, not a genotype. Please correct which genotype TT or CC is associated with reduced enzyme activity. MTHFR enzyme activity in homozygous TT subjects is 50-60% lower at 37 °C and 65% lower at 46 °C compared with wild CC controls
That all depends on which research study you are using. Check the references section to review all the research used to make this video.
Do not agree. In genetics, obligatory terms have been used. In another way, we can not understand each other. If someone made mistakes that's not an excuse to multiply. @@LevelheadedMind
Nothing but a bunch of MTHFR'S on this page