Methyl Folate Deficiency and Depression
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- čas přidán 1. 06. 2024
- Methylfolate Deficiency, depression, MTHFR gene, biochemistry, SAM, SAMe, synthesis pathway, homocysteine, Vitamin B12, Riboflavin, vitamin B2, vitamin b6, Methyltetrahydrofolate Reductase Deficiency, David A. Johnson, S-anenosylmethionine, homocystinuria, serotonin, DOPA, Melatonin, Pathways, tetrahydrobiopterin, dihydroPteridine reductase, BH4, enzyme deficiency, vitamins, methotrexate, science, amino acid, metabolism, cobalamin, Pyridoxine, 7 15 2019
- Věda a technologie
I'm honestly laughing at this point....just diagnosed with autism in 2020 - which comes with the comorbidities of MCAS and EDS, which along with everything else in 2020 and my life prior got me the diagnosis of PTSD, so....now: I'm ASD, MCAS, EDS, PTSD & MTHFR....at least the last one has the decency to sound like a cuss word. Seriously, prayers for anyone and everyone who might be reading this - life does always get better, I refuse to quit and pray you do too. Winston Churchill said it so well I've been quoting him all year: When you're going through hell, KEEP GOING. ❤️
Sorry you are dealing with all of this !!!!! But also thank you for the giggle, I also call it that name too 🤣
Winston Churchill also said 'never, never give up'.
I liked your quip on the cuss word. Very humorous.
This needs to be spoken up much more! tests need to be available for cheaper! heard that some bipolar type 2 are now in remission after taking methyl B vitamins!!!
wow, congratulations!
@@AxelSituation there's a TED talk about it if I'm not going wrong. Not too sure, but seen a lady suffering from type 2 and she's now in full remission after years.
Not sure if you guys gives a damn but if you're stoned like me during the covid times you can stream pretty much all the latest movies on InstaFlixxer. Have been watching with my girlfriend for the last couple of months xD
@Callen Tyler yup, I have been watching on instaflixxer for months myself :D
There's many women from my research that are Bipolar Disorder symptoms free and off pharmaceutical meds on the third or fourth months of starting natural Progesterone cream ( some up to 120 mg daily) plus Methylfolate 5 or 10 000 mcg a day. There's also significant research on the use of Methylfolate, Vit B6&B2, and Methylcobalamin for Schizophrenia with good results
Thank you so much David. All I know is I started taking mega B vit complex a year ago and I almost instantly started "Feeling" better about myself, my mood improved. Having been a heavy drinker most of my earlier life, I started taking extra B3 Niacin, and that improved things even more. I,m also pretty much vegetarian, I eat meat once every month or so , so I started taking extra B12 at another time from my early morning Multi B, and again my mood and self confidence has improved even more. I am 60 years old and have only recently discovered I have been ADD with a touch of Autism all my life ................... Now on all the extra B Vits, I have never felt more balanced , healthy and confident in my life ( despite being in the middle of the world in meltdown july 2020) ....................... I will watch this video again to learn more about the Methylfolate information ..................... But I had to share the word about the B vits .............................................................. We do not need more meds, we need more vitamins, especially mega doses of C and all the B s .............................. thank you and sorry for the ramble.
Thank you for the encouragement. As an educator and scientist I value knowledge and feel an obligation to share. Glad to know you are well and healthy.
I think you'll find ADD Autism are symptoms of low B12.
I was taking SSRI’s and they kept increasing and changing my medicine, nothing really worked. My doctor suggested testing my DNA to see if something was going on. They got the results in and told me my body basically doesn’t breakdown folate like it should and suggested a supplement of methylfolate. Literally the first day I noticed a tremendous difference and after a week I was beyond amazed.
Thank you for your comment and glad you are better.
Do you have time to chat sometime?
@@bradleybaker7227
I'm currently out of the USA. Email me or comment after June 21. I'm not an MD and do not give medical advice, only science.
@@DavidJohnsonPhD I'm ordering 50 mg's of b-2, b-6 along with l-methylfolate and b-12 cobalamin. I have been dealing with 7 different psychiatric disorders my entire life and I have a strong suspicion that I have the mthfr gene mutation. I will never take meds and I'm definitely not keen on the idea of doing TMS therapy as well. Hope you can help me because I'm getting really tired and I really want my life back so I can attend Stanford University and major in biochemistry or neuroscience. Have a blessed day when you receive this message.
@@DavidJohnsonPhD Hope your safe and well.
I have my MSc thesis underway, which is centered around MTHFR gene methylation status in infertile male patients. Your video is really helpful and I'd love if you had the sources written in the description, just for the ease of copy pasting.
For me, a simple explanation of a complex process. Having just found out I have an MTHFR polymorphism, this is very helpful and I'll share with family. Thank you
keep in mind, above all, this is functional deficiency in riboflavin, vitamin. Taking a multivitamin with say 10 mg riboflavin will go a long way to make the enzym running again smoothly. Chris Masterjohn has released a podcast on this with Alex Leaf
helpful presentation. thank you.
From one East Tennesseean to another, thank you for this wonderful presentation. It was a blessing to watch and learn.
Thank you for the encouragement and blessings to you.
If I am considering methylfolate as a supplementation for: depression, bipolar, dementia, digestion problems, and neuropathy. I take two meds for the depression and bipolar. Am on a regime of B vitamins, pro and pre biotics, chlorella and spirulina, along with mangosteen, collagen, and broccoli in powder form. A vegetarian for the most part. And according to the comments I would be doing myself a favor.
Now I just need to find a good source.
This is brilliant information and as a lay person I understood the value of methylfolate.
It's unfortunate you don't have tens of thousands of followers, this is something at least that many people would benefit from.
Thanks.
Thank for your kind words. Hope you feel better soon. Internal medicine physicians are the best at diagnosing metabolic problems. God bless.
@@DavidJohnsonPhD Wow, Dr. Johnson, I honestly didn't expect a reply. If I may. Where's a good source for the methylfolate? Thanks.
Sorry I don’t recommend stuff. You can Google search, etc.
You need to add B12. Get an Active B12 test. NOT a serum test.
Excellent summary!
Thank you for the kind comment.
That's was enlightening. Thank you.
I have MTHFR compound heterozygous. When I checked two years ago, my homocysteine was too low, 3.3. I understand too low is not a good thing, but don’t find good info about it, can you enlighten me, please?
So, 3 years ago, my psychiatrist had my DNA tested.
I have the MTHFR mutation. He has me taking L-Methyl Folate. It sure seems to have helped my depression!
But what else can it do for me?
It can't actually 'fix' it, can it? I mean, am I normal again? ( LOL )
Is my really crappy health, like malnutrition, anemia, eating disorder, ADHD, Pre-ventricular tachycardia and my IQ going to get all better?
I am 57, and feel like most of my life is over. I have not finished school, only to the 9th grade, and have never kept a job.
And they have all been cleaning and food service work. Pretty simple stuff. But I have always been 'let go' because 'It's just not working out'
I have contantly been late, or not showing up. I'm just, 'WRONG, BROKEN'. Am I disabled????
I have been basically floating along in life because I've been 'a mutant' and can't do much of anything that brings me an income. I've lived off others all my life. It sucks.
Trying desperately to get SS disability. Do you think I have a chance for that?
I have to say, I'm quite surprised after finding out I have this mutation, that both my kids were born ok. I did have pre eclampsia with my first child when I was 18 years old.
Anyway, sorry for the long rant.
I'm interested in your thoughts, if you have the time.
Thanks for your video.👍
Any updates???
@@NakEdits Well, @Riley, Social Security is a joke. I had to see some people to make determinations, one guy, on a weekend, was supose to be a muskuloskeletal exam. All he did was check my main movements. And of course nothing really hurt that day.
And supposedly some sort of GI checking, which he did nothing for.
Then on my denial papers, they list a doctor I haven't even seen yet! No wonder it's so hard to be accepted. Unless you have OBVIOUS disabilities, it takes a lot of energy and determination. Which I don't have a lot of. I have an advocate helping me, and a company called The Human Arc. They are some awesome people! I haven't given up, yet. I will continue to fight for this.
It sure does take a toll on my happy happy joy joy frame of mind! LOL!
I thank you for your interest!👍🥰
@@jubi400 best of luck!
@@NakEdits Thank you so much!😊
This was very interesting and I enjoyed it very much (I'm heterozygous for MTHFR). Thank you!! (P.S. I would suggest you do your own research on vaccines. Reading the manufacturer's inserts is a good place to start.)
Thank you for your comments. Nothing is totally safe and drug inserts must mention possible adverse effects, but a few adverse effects far out weigh the sickness and deaths that would occur if we did not have vaccines. See www.vaccines.gov/ Vaccines also protect those who are too ill to get vaccinated via "herd immunity".
Love at 6:38 how L-Methylfolate stabilizes or possibly substitutes for BH4
Just found out a few days ago I’m TT. Explains so many things about me. This information should be everywhere. We need to get folic acid out of all the food and the prenatal vitamins. Especially women need to know about this way before they start making babies.
So you don’t want synthetic folate but you’re OK with injecting aluminum salts. Can you explain the pharmacokinetics of injecting aluminum and Polysorbate 80?
@@KB-sf6nt I don’t need to explain that to you. Vaccines save lives. So yes I will inject myself if it means I won’t get sick and I will inject my children so they won’t get a potentially fatal illness and die. Science proves vaccines work and there is currently no other alternative to the injections. In the case of folic acid there is an alternative methylated form to keep us from having babies born with neural tube defects, so in my case, with a double variant of C677T then I’m gonna go with the methylfolate. If there weren’t an alternative, and I were pregnant, I would still take the folic acid because science proves it greatly reduces the chance of neural tube defects. Nothing in life is without consequence. You look at the science and do the best you can. But anti-vaxxers don’t seem to be able to grasp that concept.
@@KB-sf6nt And...methylated folate is still a synthetic vitamin. But I choose to take it over folic acid due to my genetics. So I am advocating for both synthetic vitamins and vaccines :)
If I take methylcobalamin B12 supplement will it mask the MTHFR deficiency? Since the methylated B12 can convert Homocystein back to Methionine, is that correct? And the MMA test will show normal results. Given there is no IF nor parietal cell antibody. B12 serum level is high. However, MCV is 99, RBC is lower border 12.
Is Deplin the only form of L-Folate that crosses the blood brain barrier? It’s so expensive. There are a couple that have the 15mg listed and approved by the FDA so I’m wondering if there is another less expensive one other than Deplin that works just as well? Thank you so much.
Not being a physician I cannot offer medical advice. Here is a link to more info on Deplin www.drugs.com/drug-interactions/l-methylfolate,deplin.html
L Methyl Folate (5-MTHF) is sold without a prescription, but ask your MD physician.
Look up MethylPro it’s L-Methyl-Folate at the same dose as Deplin. 15mg x 90 for $75 direct from their site or $99 on Amazon. So a 3 months supply is less than a one months supply of Deplin. The only reason Deplin is so expensive is because it’s being sold as a medical food requiring a prescription. However because it’s still a vitamin there’s nothing preventing it from being sold as a normal vitamin. Like there’s over the counter supplements that contain branded Deplin, just at a super low dose relative to the normal dose.
There’s a bunch of reviews on the site and from Amazon talking about people switching from Deplin.
Hope this helps you or anyone else looking.
Can we have downregulated Methionine adenosyltransferase (s adenosyl methionine synthetase).
How can we treat it.
I had all the symptoms of undermethylation when I started researching about it. To support methylation, I took methylfolate methionine and SAMe. After taking these for few months. Now I have liver problems.
I think I have high methionine and low SAMe state because my MAT1A gene does not work how it should.
I am just 27. I had tons of unintentional weight loss due to this.
Please suggest someone something.
I had both kinds of measles when I was nine years old. While it was not fun, it was not that bad. I have tested severely allergic to polysorbate 60 and 80 and am also sensitive to polyethylene glycol (many reactions including complement activated anaphylaxis to the Moderna shot within 45 minutes. I do not detox chemicals due to my MTHFR status, COMT status and I am not sure what else as I am still saving for more gene testing. I reacted to each and every flu shot I ever had (4) and doctors are not trained to recognize the pattern even when it is pointed out to them. Vaccines poison me and steal what little health I have left. My insurance and Medicare pay for the things that hurt me, but will not pay for an environmentally trained naturopath who understands how to help me. Those of us who have the PS and PEG issues are not as rare as the world has been lead to believe....they just want us to go away, be quiet, not tell the truth.
Thank you Dr. Johnson for this helpful video. I have the TT MTHFR mutation and am trying to figure out what to take. You say to take B2, B6, and B12. How about folate/folic acid?
Methyl-folate is not very costly. Methyl-folate gets around the defect and with B12 converts Homocysteine to methionine. Methionine is needed to make S-adenosyl-methionine.
@@DrJQuillen Thank you. Can you say if the reason I have too much homocysteine (14.7 umol/L) is because I make too much of it or because I am not converting it to other things as efficiently. In someone with a "normal" MTHFR gene, do they make less homocysteine or recycle it more efficiently?
I ask because this video from Dr. Brad says that lowering homocysteine and boosting methionine does not reduce CVD and the reason might be that higher methionine is also bad for the heart.
His video (starting from 10 minute mark)
czcams.com/video/Ker58CPjDJs/video.html
Also, I can easily find folic acid here (in Hungary), but I do not see methyl-folate. Can I use folic acid instead?
I found this which seems to do exactly what I want:
bio.bolt.hu/termek/virde-folsav-aktiv-tabletta-30db/
Folic acid 400 µg
Vitamin B2 4 mg
Vitamin B6 4 mg
Vitamin B12 2 µg
(plus I will take a 100ug B12 pill as well)
Thank you!
(btw, I'm from the US & attended high school & university in Georgia... I'm a ramblin' wreck)
You don’t want to take folic acid if you are MTHFR because you’re going to have a harder time processing it into methylfolate. Your body basically wouldn’t be able to use the extra folic acid, depending on how much your variant affects your folate processing. Especially if you have C766T you probably need the methylfolate. If you have 2 Ts, then you will definitely want it.
@@alicerose8057 Thanks for the reply. Well, I'm in Hungary. I found a tablet that includes it all: riboflavin, b2, b5, b12 folic acid... I'm going to give that a try & see if it will work. I had this article that said the folic acid & others will work fine & you don't need large doses. www.spandidos-publications.com/mmr/8/2/609 I'll take what it says and then measure my homocysteine again.
Matthew you May be just fine. Your variant makes a difference. I am homozygous for the more serious one, so my needs may be higher. I also had some issues during pregnancy that lead me to believe I was very much deficient in folate despite eating well and taking prenatal vitamins with folic acid. My children also have some issues that may be attributed to deficiency, so the methylfolate is what I’m using now. I haven’t been using it long and I don’t have elevated homocysteine, but from what I can tell it’s the better choice than folic acid. There’s some evidence the folic acid could actually pose a problem.
I feel that this is why I have been depressed and have had fertility issues including ectopic. I also feel that this is why my father is developing dementia. I have not been tested for the gene deficiency yet. But I know high homocysteine is a risk factor for Alzheimer's. I have also had low iron regularly even when I'm not on my cycle.
Would SAM e and a B complex help anxiety?
Does methyl b vitamins cause anxiety as i suffer from anxiety and thought of trying methyl b vitamin complex for anxiety and depression.
What happened
Can you comment on this subject related to people having worse symptoms from covid when they have folate deficiency or general malnutrition or if epigenomics impact viral response?
Unfortunately, I do not know if there are any issues related to folate deficiencies in covid patients. Wear a mask and ask your physician.
in my opion, there are relationship
because researches saying if your methionine levels in the blood decreased, your immune system fails to protect you from viruses
when your methionine levels go down
of course when re-methylation issues occurs like increasing homocystein due to folate deficiency(mtfhr issue).
wearing mask is stupid while the underlying problem is unfixed
@@DrJQuillen
pubmed.ncbi.nlm.nih.gov/18373034/
research says;
"Dietary supplementation with SAM in the absence of folate restored acetylcholine levels and cognitive performance to respective levels observed in the presence of folate. "
this means if you deficiency of folate, you cant nethier produce sam-e, acethylcholine
have you ever checked out what diabete research says
they say in diabetes, acethylcholinerase enzyme activity is increased which causes acethylcholine deficiency.
diabets also suffer with active folate deficiency like alzheimers who suffer acethylcholine deficiency,
because when your homocystein is increased or relatively increased you can't re-methylate the toxic homocystein to methionine and your choline/acethylcholine/sam levels go down
its known that sam-e has insulin-like effects
proper methylation is only solution on these diseases
I have the genes that cause issues with folate methylation, so I bought Jarrow Formulas, Methyl B-12 & Methyl Folate, and took it on an empty stomach after waking up from an 8 hour sleep. Within 30 minutes of taking it I went back to bed and slept another 4 hours, and for those 4 hours I was OUT, probably the deepest sleep I've had in years. I don't know why it would cause that to happen but it did.
Are you feeling better? It might have been a slight shock to your body
@@ericrohrabaugh5644 It was a one off, I have continued to take the supplement on an empty stomach after waking up and have not had that sleepiness effect again. So it seems it may have just been some initial shock. Odd though.
@@charlieparkeris ok what happened for depression?
I have been suffering from extreme fatigue the last few months. I got a blood test and my Doctor told me last week that I am deficient in Folate. I purchased Methylfolate with no knowledge that I have the MTHFR gene. Does that matter? In other words: is supplementing Methylfolate superior than supplementing Folate or Folic Acid for everyone that is deficient?
Those that has the mutation cannot convert Folic acid and if taking Folic acid there's more harm than not taking it. Methylfolate is the active form of vit B9 and its the one that should be taken. Hope this helps
@@aneliadraganova3504
@@jamesheseltine8283 ❤️
Dear doctor: how can someone one out of California get the blood test done for mthfr gene as well as homocysteine from your office?
Sorry, but I am not a physician (only a biochemist) so I can not do clinical work. Ask your primary care physician. I discovered that my MTHR gene was about 50% of normal when I had my 23andMe test and other genetic testing services should provide similar information. You may want to ask them or others about their test results. I'm not sure how often HomoCys is tested for ckinically, but a good internal medicine physician should be able to get that test for you.
@@DrJQuillen 👌 ok , thanks for your reply!
Husband and 1 daughter have mutation. Suffer from extreme anxiety and bought a of depression. Daughter takes Prozac but not working. What is a good starting dose of MTHF?
hopefully, someone will reply. I am in the same boat.
This not medical advice, only information. There are several vitamin products that combine B12 and methyl folate. I have not read of B12 being toxic. Folate of more than 5000 mcg/day can mask pernicious anemia, which is most often due to the inability to utilize B12. Some people have a defect in their intrinsic factor produced by stomach parietal cells and can not bind B12 from the diet. Proton pump antacids reduce intrinsic factor production because they also turn off acid production by parietal cells. B12 deficiency is thought to be a major cause of peripheral neuropathy in the aged, probably because of decreased intrinsic factor production. B12 injections are sometimes used. Always talk with your physician before taking supplements.
There is several study of 5mtfh being used at 7.5mg and 15mg in conjunction with antidepressants. Those doses are extremely high however. A dose that high can be obtained with a prescription if your pharmacy carries it, you would need to call and ask. Not all pharmacies do.
You can buy the supplement (I use jarrow or life extension brands) however most OTC doses are 400mcg to 1000mcg, so in order to reach the above does of 7.5/15 mg you would need to figure out the dosage 🙏🏻 and as always, talk with your physician before starting any new supplements 🙏🏻🌈
I dont have information about any mutations in me or my family. But I do have history of depression and schizophrenia on both sides.
I take this tablet daily: Vitagreat (Indian brand) with the following composition:
Mecobalamin 1500mcg
L methylfolate Calcium 1mg
Pyridoxal 5 phosphate 0.5mg
I was diagnosed with a long standing B12 deficiency so I also take an additional dose of B12 1500mcg subligually.
I would suggest you start with a small dose. These are water soluble vitamins that are washed away in the urine if in excess. So I wouldnt worry so much about overdosing.
@@DrJQuillen i have an overload of B12 yet i have mild peripheral neuropathy
I have it the best treatment for it is Metagenics - ceralin forte
Please slow down...need time to process.
I read that you loose too many methylgroups when you take too much niacin. Is it possible that you cant produce those hormones you when low in methyl groups?
Very interesting! I take Niacin for my cholesterol. LOTS of it! And I do have this mutation. Thanks for posting this!
@@jubi400 how much you take?
@@Chris-ol9tc 750 mgs each night with my simvastatin.
Is that a lot??
@@jubi400 yes thats a lot
Methyl folate worked well for two days then it caused irritation and anxiety
I preloaded for about a week with methyl B-12
The stuff is not for me.
Hi, I have mthfr mutations and have had depression for many years. I started methyl folate 1mg plus Thorne methyl b complex. It worked so well for about 2 weeks with my depression being lifted. It was really quite miraculous. Then it stopped working sadly. What do you suggest? I read that it can help at first, but then stops.
Sorry, but I'm not sure why it stopped working for you, but suggest you see a psychiatrist who might prescribe an antidepressant and provide counciling.
Im so sorry it stopped any updates
Maybe look into Walsh Protocol
Ok continue maybe it works like this then you will be happy?
How is it stop working? Is depression comeback or what ؟
I discovered today with gene test results that I have this , and I don’t process my folic acid. If anyone has any info I’d appreciate it.
it increases your risk of miscarriage, if youre pregnant one day take methylfolate (not folic acid, even if prescribed) to cancel this
czcams.com/video/L76PaoGaPx0/video.html
Tell it to me like I’m a 5 year old.
Immunizations tho? MTHFR folks can't metabolize the juice. That's why they have issues. I got narcolepsy from one of the shots. Oh dear.
You were onto something there until you started pushing immunizations... Which are FULL of heavy metals... which those of us with the MTHFR genetic mutations have a hard time detoxing the heavy metals from.
🙄
Thank you for saying that piece at the end regarding vaccines. For some reason a lot of people in the MTHFR community are saying we shouldn’t have vaccines. This is absolutely ridiculous to say and it’s also dangerous.