VITAMIN B12 dosing strategies - 3 examples (and what I recommend)
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- čas přidán 2. 06. 2019
- Why is there such a range of doses in B12 supplements? Why do they often provide tens of thousands of percent of the RDA? Is this safe? Why is it so hard to find more conservatively dosed supplements? How much should you take?
And do you really need to take thousands of micrograms of the vitamin to get enough?
It is important to remember that the pros of ensuring a good B12 status far outweigh the potential negatives associated with how we must dose it to achieve this status. That being said, there may now be value in using a little more finesse in our dosing strategy and determining a dose that will provide enough B12 without ingesting thousands of micrograms unnecessarily.
Today we'll be exploring the relevant aspects of B12 absorption and how you can use them as a starting point to work out a conservative dosing strategy that still has a high probability of achieving adequacy, including three examples of regimens to make this topic a little easier to understand.
Please note that the strategies discussed in this video apply to healthy people with no known absorption issues. High-dose B12 supplements exist for a reason and are very effective for acquiring and maintaining a good status in some people with B12 problems, which are very common. In this case, the benefits of high-dose B12 supplementation far outweigh any potential drawbacks and you should persist with the regimen prescribed by your healthcare provider.
PREVIOUS B12 VIDEO:
• VITAMIN B12 explained ...
OTHER NUTRIENTS I'VE COVERED SO FAR IN THIS SERIES:
OMEGA-3: • Omega-3 & EFAs explain...
CHOLINE: • CHOLINE: Should VEGANS...
VITAMIN K2: • VITAMIN K2 - why I tak...
IODINE: • IODINE: Should VEGANS ...
ZINC: • ZINC: Should VEGANS be...
#B12 #Vegan #WFPB
References: 6:20
The information provided on this CZcams channel is not intended to replace professional medical advice, diagnosis or treatment. The content presented is for informational purposes only. Always seek professional medical advice before starting any new health care regimen, treatment, exercise program or diet and never disregard professional medical advice or delay in seeking it because of something you saw on this CZcams channel. Always seek the advice of your doctor with any questions you may have regarding a medical condition. - Věda a technologie
Hope this video helped clear up some of the confusion about B12 dosing! Let me know if there was something that wasn't clear or anything you'd like me to address in the next B12 video!
REFERENCES:
Qiang Y, Li Q, Xin Y, Fang X, Tian Y, Ma J, Wang J, Wang Q, Zhang R, Wang J, Wang F. Intake of Dietary One-Carbon Metabolism-Related B Vitamins and the Risk of Esophageal Cancer: A Dose-Response Meta-Analysis. Nutrients. 2018;10(7).
Brasky TM, White E, Chen CL. Long-Term, Supplemental, One-Carbon Metabolism-Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort. J Clin Oncol. 2017;35(30):3440-3448.
EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Scientific opinion on dietary reference values for cobalamin (vitamin B12). EFSA Journal 2015;13:4150.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998.
Hello Dr. Harrington, sorry for bothering you but I am concerned about something that you have talked about before and it will be very helpful to know your opinion. I have been taking supplement with 500ug B12 cyanocobalamin every day for a month and ten days in supplement tablets form and I haven't talk with a doctor. Is there something that I can be concerned for and also is this much endangering me in some way of catching cancer or other disease? Please when you can reply me back because I am really concerned. Thank you for your time.
I have vitamin b12 deficiency a lil bit. Which supplements should i take? Im 19 years old
my 82 year old mother has been taking 1000 mcg of vitamin b-12 a day, 7 days a week for awhile now, her old doctor prescribed this because she thought my mother had early dementia.. her new doctor suggests my mother does NOT have early dementia, just normal age appropriate memory (her catscan suggested only appropriate for her age brain) and stated my mother could cut back to 1000 mcg 5 days a week or even just 3 days a week, monday, wednesday, friday? what to do and what to believe?
Hello Dr. Harrington i have a question.
Is it safe If i take 1000mcg of vit. B12 per day?
Iam in my late 50's.
What if you are an elderly vegan? How much?
Exactly what I was looking for. Thank you.
Good stuff, glad it was helpful! :D
So glad that I found this video. Clear and informative. Good information to know.
Thanks for the great info that no one else takes the time to explain !!
Amazing info, as always! Love you approach, man! ;)
Thanks! :D I try to bring a different way of looking at stuff than what's out there already. :)
@@DrDesHarrington This is exactly what I say to people, when I reccomend them your awesome channel.
''...my buddy dr. Des from Dublin talks about things not usually mentioned by vegan doctors...''
@@mikeskylark1594 Haha thanks, I'd like exactly that to be one of my niches! I always found myself reading up on aspects of nutrition not covered by plant-based doctors for myself, so why not make videos on what I find! :D
@@DrDesHarrington You are next level, hands down. So bright - like Leo Venus and Ferdinand Beck! ;)
To prevent a b12 deficiency from occurring, you need to get 50-100 µg per day via supplements or 1000 µg twice a week via supplements.
Thank you.
First :D this series about B12 is very interesting my friend! I always thought they were not enough detailed information on b12 on youtube and you really bring something here! I take b12 daily but don't really watch exactly how much i take. I will change that!
do you think it's good to mix both types of b12? like one day cobalamin and the other day methylcobalamin?
Thanks, man! :D Yeah I thought there was a bit of a paucity of info out there too so I decided to look into it myself, glad you're getting some value out of it. :)
That would be a viable approach as long as you're getting some cyano in. I'll be going into more detail on methyl and cyano in the next video, so watch out for that!
Very interesting indeed!
Greetings from🇹🇩 Belgium
Thanks a lot man, glad you got something out of it! :D
Many thanks for this well informed video, and others too - excellent all around! Quick question: can you comment on the other forms of B-12, i.e., "adenosylcobalamin" & "hydroxocobalamin"? (as represented in Swanson Ultra brand "Activated B-12 Complex", for instance, among others...).
Hi Keith, I'll be returning to all nutrients I have covered in this series before I finish it out and will give my specific supplement recommendations, along with posology. :)
methylcobalamine is the easily absorbed one.
I personally use a mix approach, I take a weekly 1000mcg cyanocobalamin supplement and I regularly consume fortified food (like a daily spoon of nooch).
But another great way of including B12 in your daily routine is fortified toothpaste: doi: 10.1007/s40520-019-01125-6
Yep, I've had a brief look at B12 toothpaste and it does work! Can be of great use to someone that often forgets to take supplements! It's just going to be a more expensive option overall, but it might be worth it for some people.
Nooch is a very handy source, I use at least a small amount with most things I cook, I love it. :) That seems like a sensible B12 regimen, do you get your levels tested to make sure you're getting enough? Make sure you take the supplement 4-6 hours apart from any B12 fortified foods!
@@DrDesHarrington Yes, the toothpastes are indeed more expansive than regular toothpaste but so are low doses supplements compare to high doses one.
Yes my blood work are all good, it might have sound sensible but when I say a daily spoon well it's the minimum as I add nooch to a lot of my meals I don't really pay attention to how often it is but it's at least one meal a day in average. I indeed take my weekly supplement apart from fortified food or even from algae as I've read the analogues can interfere with the absorption.
@@Suna32 Algae can interfere with the absorption of b12? Which means , I should not take algae spirulina never?
@@glodusmuspell9069 no, you should only avoid to eat them around the hours you take your supplement.
@@Suna32 thanks
Thank you for sharing this information but i have one suggestion, when we say daily requirement for b12 is 2.4 mcg that means it is not actually 2.4 it is 1.2 actually and we assume 50% efficiency thats why daily requirement is 2.4 but when we calculate total amount absorbed that means we need not to divide it by 2 hence actually we need 1.2 mcg, if this is the absorbed amount.
Hello, yes that is a good point, I think nutrient reference intakes will always be expressed in intakes like this rather than physiological requirements since that is the number that is more relevant to most people and will take out one more step in the calculation!
Great Video Doc.
Does taking B12 empty stomach/after food effect the rate of absorption through passive & specific diffusion in any manner?
And what should be ideal Weekly/Daily dose for maintenance of other Vitamins B like Folic Acid B9, Niacin B3, as they are generally given and packed along in the B12 supplements, which are also required daily as are not expected to be stored in liver?
Hello! B12 absorption isn't as dependent on prandial state as other nutrients - whenever you will remember to take it is the best time! Unfortunately I haven't looked much into these issues for other B vitamins since they're not nutrients of concern on a WFPB diet. My preference would be to find a supplement that is just B12 and without these other B vitamins unless you have a specific reason for taking them, too. I am a supplement minimalist - I prefer the targeted approach rather than just taking multivitamin supplements, which have conflicting benefit at best as per the science!
You need to take folate, not folic .
Thank you for this video. Firstly, I have the brand Nature Provides which was recommended to me via a GP because my MCV levels were out of whack. Cyno B12 wasn't working it would seem on it's own. Cynoc at 50 mcg a day which seems very low. So I started taking Nature Provides daily at 3000mcg for 6 weeks and my B12 levels shot back up into the middle of the reference range.
But my question is this. I have been taking the sublingual B12 which is methyl and adeno by Nature Povides" is 3000 mcg. So is this too much a day? I did make the dropper reduced to 1000 mcg (just by judging it by eye I might add) and taking that every x days but is that too much too. My teenage kids taking 1000 mcg roughly x2 a week but that's with me judging the Nature Provides drops by eye.
We also take fortified foods in milks and nutritional yeast. But that's it for fortified.
Can you help?
What should I do. I am confused.
The specific B12 absorption mechanisms are vulnerable to failure for many reasons, so in your case you might need the megadose to take advantage of passive absorption. If you need that to maintain an adequate functional level then just do that - the health complications of B12 deficiency far outweigh the increased cancer risk associated with megadosing.
If you dose several times per day, would these ingredients not have any effect on your health? (this is from the b12 supp of 100 mcg you've shown) - microcrystalline cellulose, dicalcium phosphate, vegetable cellulose, vegetable stearic acid, silica, vegetable magnesium stearate.
I certainly wouldn't take that particular supplement multiple times a day, once is definitely enough. There are no B12 supplements intended for multiple daily dosage that I know of. It's okay to take less frequently than the intended use, but I'd always be cautious about taking anything more frequently.
The only realistic way of doing the multiple daily dosing approach at the moment is with fortified foods! Despite the inconvenience, I'm actually more in favour of this approach now than before, hopefully as more people go vegan more and more foods will be fortified making this strategy easier. :)
What study refers to increased cancer risk due to excessive B12 intake? I saw one on WebMD that really isn't convincing. It found that people over-supplementing with folate and B12 got lung cancer, but all those patients had smoked in their lives. So I gather nothing from that.
I'm really wondering if my body is more efficient on the day to day if I ingest B12 daily as opposed to once a week. I would think that if I take it once a week, the B12 I ingest on day 1 runs out by the end of day 2 (cause it's water soluble) and then I have to draw on my liver stores. Then it's a question of whether having to draw on the liver stores will eventually deplete the liver stores, or if there's enough restocking happening because of the copious amounts of B12 I'm ingesting on day 1 (assuming 2000 mcg). Please help
Yes, these are the questions I ask all the time and unfortunately you will never find totally crystal-clear answers. Nutrition can be very frustrating to study!
I'm guessing you are over in the UK and maybe there is different versions of B12 product available there. It looks like the one you have a photo of might be Solgar brand by the packaging, but you don't show the label so I can't tell for sure. When I do a search for 100mcg cyanocobalamin, I get just one hit on Amazon from a brand called "Major" which I've never heard of before and has zero ratings. So I'm just wondering where others in the US have been able to find a reputable product of this kind?
Yep that's Solgar, they have some good products. Unfortunately this is the problem, B12 dosed this low is very hard to find. As we learn more about the potential negatives of high-dose B12 and they are confirmed a market force for lower doses will emerge, but we're stuck in this situation for now. I'll be researching some specific products for my next B12 video which will be on the different forms of B12, so stick around for that one! :)
Thank you for the information
I have a question I was recently diagnosed with b12 deficiency my has been given me shots once a month and said I should take 1000mg a day ...so my question is how long does it take for the deficiency to go away 😕??
Hello! Unfortunately there's no way of answering that question with any real accuracy, but certainly I'd say your doctor would be re-checking your level no sooner than after 2 or 3 injections, by which time I'd say it is highly likely your B12 level will be well back into the normal range. Even better would be if you could get a test that reflects B12 _functional status_ and not just serum level - holoTC or MMA - but unfortunately these tests are not widely available! I hope you get it sorted, let me know how you get on!
My B12 complex contains 350 μg of adenosylcobalamin and methylcobalamin. How often would you recommend taking it?
Hello Olga, that dose would be fine every second day or so. Have you had your levels checked?
Nice video. I have fairly low B12 levels despite supplementing with B12 (cobalamin through various, well-known brands) diligently. I assume I must have absorption issues. I have FUT2 gene, but I'd guess there must be more to it(I've tested for autoimmune disorders, but I didn't have any). I would like to increase my B12 levels as I understand it might improve my leukopenia. My leukopenia on the other hand is probably responsible for not clearing my HPV infection despite having it for over 2 years at this point.
2 questions.
1. If there are absorption issues which type is more likely to not be working correctly - the specific or passive absorption?
2. How long do I have to wait to be able to absorb another 1.5-2ug through specific absorption?
You probably already know but through videos I've watched, your stomach needs to be acidic.
try zinc gluconate to clear up infections, and vit d. if u still have low levels of b12 after using cobalamine, use methylcobalamine, and high doses of it. thats what i did, and i finally got enough into my system at 30,000 mcg per day in 3 divided doses.
1. It is the specific absorption that fails; passive is always there for us. What dose of cobalamin are you using?
2. Roughly the time between meals - a few hours is plenty.
I never really did the math and I just take 500mcg every few days. But I did wonder if I should even bother because everything I cook has either fortified milk or nutritional yeast. I've been getting between 275% and 375% b12 daily just from fortified food every meal. I always wondered if this was sufficient without supplementation
Yes I have found myself in the same boat of late; there seems to be so much B12 fortification of vegan staples that it seems impossible not to get enough through diet alone these days! I think your strategy sounds more than sufficient, but remember you can always get your level tested if you want absolute peace of mind. :)
Any reason not to divide a large dose pill such as 2000ig into water and use a dropper/syringe for lower dosing?
Exposing veggies to the elements (air, water, heat) tends to break down their vitamin content. It might expose the B12 in a similar way if you dissolve it from the hardened form. This is a good question I wanna know the answer.
Hello doc, after how many days or months should we stop b12 supplement to get accurate b12 result?
You've touched on one of the reasons here why the standard B12 test isn't very good - it only shows the amount in the serum, not functional status. Do you have access to the HoloTC or MMA test? If not, most of the artefact in the standard test from oral intake of high-dose supplements should be gone after 2 weeks.
Great video. For those who still have a stock of methylc, how much is the dosage on daily and weekly routine
Thank you! :D All of these dosing strategies will be fine for methylcobalamin, too!
In other videos, people complain when the narrator talks too slow or doesn't get into the matter immediately. You can never please people lol.
Thank you, it's hard to find the right balance for sure! I upload subtitles for every video and try to speak as clearly as I can, but I don't want to bore people by talking too slowly or have the videos become excessively long either!
@@DrDesHarrington Props on providing subtitles! So very thoughtful of you. People usually tend to increase the video speed, likewise, they can just decrease the speed then. And yeah you can never please folks haha. You do you Doc!
@@_aiborie Thanks for the support! :D Yes, it's a handy feature for sure!
I am very anemic ( just had a blood transfusion) and I need to take B12 along with my iron pills. So I was prescribed to take 2 tablets of 500 MCG a day. Which form is best to take though? Liquid under the tongue or tablets?
From experience ... If you take the tablet ( I take 1x1000 mcg B12 ) daily, be sure to take it with your first mouthful of food at breakfast, this seems to fast track it to the small intestine where it is absorbed. If you take it after breakfast it could remain in the stomach too long and be destroyed by your stomach acids and will give you no benefit at all.
I think whatever form you decide on, they only way to know for sure if it's working is serial serum levels. How did you get on with it since? Did your haemoglobin come up?
@@harrycurrie9664 a lot of people can't absorb b12 due to intrinsic factor problems
Thank you for uploading this video! How much B12 should I take if I’m on 20mg/day omeprazole and am worried about the medicine leading to a deficiency?
Stomach acid is required to break down animal products and isolate b12; not sure if it matters if you take a b12 supplement. Depends on your diet, etc. Ask your physician
Thanks for stopping by! :D Yes, Shaun is right, this is one of the medications that interacts with B12 absorption. He is also correct in saying that this situation would ideally require medical oversight to optimise regimen and implement serial testing. Hope this helps, and good luck with your health goals!
Great video! How big dosage do you recommend for daily sublingual dosing?
Thanks very much! :D I hadn't come across much in my reading to suggest that sublingual dosing is any different than for oral, so the intermediate 100 mcg daily dose would still apply. I will be giving an update on vitamin B12 at some stage though and one of the things I will be investigating is the difference between various routes of administration, including sublingual!
@@DrDesHarrington I understand! I heard that the bioavailability is higher because of alot of the b12 gets lost oraly, like you talked about. Doing it sublingual it goes right in to the bloodstream, making it more effective. I could be wrong
i didnt get any results until i started taking 30,000 mcg/day in divided doses of methylcobalamine b12.
In my country Cyanocobalamin is not available. My b12 test shows the level less than 159pg/mL. What should be my dosage (of Methylcobalamin) and for what duration?
Hello Nikhil, you are looking at repletion here rather than maintenance, so the concerns outlined in this video fade into insignificance until you can get your level back into a healthy range. Assuming you do not have any issues with absorption that have lead to this low level, you should take a daily oral dose of around 1 mg for a few months and check your level again. Once you're back in the healthy range you can go with one of the maintenance strategies outlined in this video.
What I do is blend a 100 mcg pill in a smoothie and take a few sips every 6 hours. Do you think this a reliable method? How long will the B12 last if the pill is mixed in food?
You could theoretically use only one 100 mcg pill per week with this if you blend it with a food that you can separate in 21 portions (3 x 7 days) getting 4.76 mcg each time.
If it is cyanocobalamin is would probably last a long time since this in one of the forms that is used to fortify food, it would vary depending on the excipients though and the only way you would know for sure for a particular product is to contact the manufacturer.
Yes, that could certainly be a viable strategy for getting enough provided your specific absorption is working normally. I would definitely combine it with the occasional blood test though to make sure you're getting enough!
Just remember you are assuming you have lab grade titration dilution of powdered B12 supplement and it’s distribution in the solution is even.
Mega b12 2000mg and 1000mg we’re giving me bad acne breakouts. Now trialing 100mg daily. But splitting the pill into 2x 50mg twice deadly has crossed my mind. Breakfast would be my best adherence dinner might be more of hit and miss. But at 50mg x2 daily it might not be too bad.
Starting in June, along with a daily iron pill, I’ve been taking 2000mcg/day. But, I think I should go to Quest, to get a B12 check, to see where I’m at. I’d come to realize that taking Metformin, for diabetes, for many years, blocks the absorption of B12, allowing the myelin coating over nerves to possibly be destroyed.
Yes, metformin is a well-known headwind for B12 absorption, good spot. You should still be able to overcome this headwind quite easily with supplementation, however. Did you get your status checked in the end?
@@DrDesHarrington I did, back in October and will be getting it checked again shortly. Turns out that either I was not B12 deficient or I over-supplemented. I was taking Blood Builder and B12 supplements. Now, I just take the Blood Builder, as I do know I am iron and even more so, ferritin deficient. So, I’ll see where I am, in another few days.
@@privateprivate8366 Nice one, you're well and truly on top of things! 👌
@@DrDesHarrington trying.🙂
So to be clear...I should not take 1000 mcg per day. I recently went to a plant-based eating style. But 2000 once per week is okay? Thanks Doc!!
Hi Robert, yes 2000 mcg once a week would be fine: 20 through passive diffusion plus 1.5 through active absorption (conservative numbers) would result in 21.5 mcg absorbed per week, or over 3 per day, exceeding the recommended intake. 2000 per week would only expose you to 2000 per week; as opposed to 1000 per day which would expose you to 7000 per week!
can you talk about 1000mcg sublingual tab . why we cannot take it more than 2 months .
and how you get the stored dose
Who told u that it should not be taken for more than 2 months ?
I've not heard of oral or sublingual B12 being taken only every 2 months! Did you get clarification on this since?
That's not true. U can take as much as u need it
Hi, i took 2500 mcg b12 .Now i found that daly take should be 2.4 mcg.Should i worry? Why they said that we need one tablet from 1000-2500 mcg per dey when this is too much? Thanks
You could take a supplement dosed in that range less frequently, or try and find one with a lower dose to take daily. The reason they recommend those high doses is because they are likely to provide enough for everyone, even those with absorption issues.
I have few questions sir
My grandmother is almost 80 years old, what amount of vitamin B12 is suitable for her , ??
I am 25yr old, can I take 1500mcg vitamin b12 tablet in alternate day ?
Hi! At that age the justification for megadosing increases, as well as the importance of determining status to see if there's a need for injections. In your case, if you have a 1500 mcg supplement then taking that weekly should be plenty!
I have an interesting question. What if I have a 1000mcg sublingual cyano tab and cut it into 4 pieces and take 1/4 a day?
Just remember you can't automatically do that with any tablet, but yes that will be fine with B12 supplements and I think it would be a good idea. Plus, you will get 4 times as long out of your supplement!
@@DrDesHarrington Excellent. Thanks for your help 👍
And if the person iss anemic with pale skin how much mcg do i have to take
It depends, there are many things that are much more common causes of anaemia than B12 deficiency. Why do you think it is related to B12? Did you have your levels tested?
Thank you for this video. Can i take 250 mcg a day ? It it safe ?
Thanks for stopping by! 250 mcg cyanocobalamin daily is an excellent strategy, yes!
What's optimal the dosage if you take a combination of methyl and adenosylcobolamin?
These doses apply to these other forms, too! Well done on taking both, methylcobalamin is probably not enough on its own.
Today I bought 10mcg cyanocobalamin but I'm wondering if anything will even get absorbed in such a small dose.
you need 1000mcg to absorb 10mcg into bloodstream
10 mg would fit into the multiple daily dosing strategy as outlined in this video. In some ways, this is the best way - if you can remember to take your supplement multiple times a day!
@@DrDesHarrington It seems taking only 2 tablets containing 10mcg cyanocobalamin will also do the trick i.e. 1.5+1.5= 3 mcg daily through specific mechanism.
tell me Dr. Des Harrington which company you recomended is the best and natural ingreadieance company made vitamine b12,,please tell me..
Jarrow
Hello, I am planning on returning to all these nutrients before the end of the series and discuss my recommendations for specific brands!
I have a B12 supplement dosed at 450 µg per tablet. Am I right in assuming that it would be a viable dosing strategy to take it three out of seven days a week, e.g. Tue, Thu, Sat?
If it's cyanocobalamin that would provide adequacy according to these criteria, yes!
@@DrDesHarrington yes it's indeed cyanocobalamin. Thank you for helping me make an informed decision
@@alinayossimouse No problem, glad I could help!
hey, my vit b12 levels are 243pg/ml, I found a company which is giving 1mcg methylcobalamin, so shall I take it 3 times a day or go with 1000mcg weekly dose?
Hello Maulik, 243 pg/mL is in the normal range, so the maintenance strategies outlined in this video would suit - you don't need any rapid repletion interventions at that level. Good job on finding a 1 mcg supplement, however I wouldn't rely on methylcobalamin alone as outlined in this video:
czcams.com/video/XhbhWUyJv3s/video.html
With that in mind, I would go with the 1000 mcg supplement, but if you want to take it weekly you'd have to take 2000 mcg every week to ensure adequacy, or just take 1000 mcg twice a week. Hope this helps!
I take 500mcg every other day because mine was the same as yours 243 and I had really bad symptoms
04:04 Oh alright this answered my question on the previous video. So 6 μg is fine with the
Yes, if you take these low dose supplements multiple times per day and have no issues with absorption they are perfectly fine, and this might even be the best way of getting your B12!
@@DrDesHarrington Thank you for answering Dr.!
Looking at taking a lower dose B12 mainly because ugh dose B12 gives me bad acne flare ups.
Will try the 100mcg tablets daily and see how it goes.
Can it give on top of the head? Like on scalp?
@@salmanalltheway yes mate I get them in the scalp I also found coffee causes me flare ups, drop B12 dose and stop drinking coffee it is much much better. A single latte (soy) gives me a flare up.
Francis Hemeter i have also noticed coffee thing. I got anxeity issues since march, and that time also i was drinking alot of coffee. Almost everyday..
then last month i got a bit better.. with less symptoms .. i started going out and drinking coffee, noticed again i had a relapse bad one...
i get these painful head pimples, i was wonderinf why im having them
salman all the way b12 if I take like 1000mg tablets at 100mg daily (pr 50mg if I BBC split that tablet) I don’t, coffee gives me the head pimples thry are I glanced and painful too. Chocolate also does it not as bad, even dark or just coco powder. Green test due to caffeine also causes thrn. Only other thing I’d oily meals.
Francis Hemeter damn, living in this world is no more easy 😹
Hi, very nice video! in my area I only find up to 1000μg of B12, does that mean I have to take it twice per week? isn't that even better than the rest of the options?
I don't know. I'm going to buy 1000 mcg b12 too
take as much as u like there are no known ill effects of b12
Take it daily ...what your body doesn"t need will be passed in your urine. Take it with you first mouthful of food at breakfast.
You can split it in two parts
Twice per week would be plenty for 1000 mcg if the goal is maintenance, yes!
Boots in the U.K. do a 10mcg b12 supplement
Excellent! That's market forces at work, I guess!
I am taking b12 complex sublingual vitamin of 1200mcg. Is this better weekly i been taking it daily and is that ok to take? With d3 vitamin of 2000iu but i was recommended by bloodwork of 5 years with 5000iu. Always been having dizziness and lightheaded symptoms and anxiety panic attacks.
Oh no, I would get those symptoms fully investigated since they are non-specific and not immediately related to either of these two nutrients! Hope you feel better! As far as dose, I am more in favour of lower doses of B12 daily rather than high doses weekly for maintenance, but 1200 mcg daily might be appropriate in your case given level, background, other investigations, etc., or if repletion is the goal. For vitamin D, I've just started a new series on it that might be of interest to you! :D
@@DrDesHarrington i am taking a supplement to replace tons of vitamins i have that i have a few and it's called ka'chava and but still noticed i still feel the same.
@@gamercat7004 Yes, it sounds like there might be a little more going on there than nutrient deficiencies. I would definitely consider getting the symptoms checked out.
If I'm taking b12 with.include folic ....since 2 months...now switch on ... simple b12? Sir
Yes, you can get plenty of folate from whole plant foods, so once your folate deficiency has been corrected (presumably that's why you were supplementing it) you will be fine to continue with just B12!
@@DrDesHarrington thank you sir
What do you think about 500 mcg per week? Is it effective ?
Start with you B12 blood test readings .. if they are low ... and you are eating a normal meat and dairy diet then you may have Pernicious anemia ( your "Intrinsic factor" is not working )
This would give you a weekly intake of only around 2 mcg, I think you would be wiser to take 500 mcg every second day at least!
This vitamin changed my life. My energy is back like I never had. I take 5000 mg, sublingual.
Great! What brand do you take? Can you maybe send some brand names or links?
5000 mcg or 5000 mg??
How often do you take the 5000 mcg?
He specifically said if you aren't deficient don't take high doses.
Sublingual vs typical pill.
Time release pill vs typical pill.
B12 alone or with food
B12 alone or with other supplements.
B12 supplementation guided by symptomatic response.
I have left some of these topics incomplete in my discussion of B12, along with recommendations for specific supplements. Didn't want to make the videos too long and boring! But fear not, I will be returning to each nutrient I have looked at in this series to cover all these topics in good time! :D
@@DrDesHarrington could always consider links fir individual research for topics in the particular video.
Dr. John Campbell has a great format in that respect.
Videos can be long...but highlights are covered in the first 5 minutes or so...then detail and explanation for rest of video...then links to sources in description.
Brilliant!
@@think2023 I'm familiar with Dr. Campbell, he has a winning formula for sure! It's a really good format!
please answer my question
when i stand up quickly my leg nerve tighen and i faint or when i do excessive exercise what causes it
..he can’t answer that. You have to go see a doctor. People can not diagnose you over the internet.
Yes, you will definitely need a full medical evaluation for those symptoms!
tablet contain1500 mcg dose of vitamin b12 OD perday what is scientific reasons as compared to the tds dose of 500mcg tablets three times aday
please tell OD dose of 1500mcg tablets better than TDS dose of 500mcg tablets better for patients
I'm still confused,is 2500mcg per day alot ?
Hello, there would be no additional benefit in splitting up 1500 mcg into TDS dosing. The benefit of dosing multiple times per day is that you could use a much smaller overall dose - like 1 mcg TDS. You could take 1500 mcg as infrequently as every week and still absorb enough to maintain adequacy. Please bear in mind though that the considerations would be different if you are trying to address deficiency. Hope this helps!
I take 1 500mcg b12 daily.is that ok?veggie capsules.
That should be sufficient especially given the preponderance of supplemented foods available these days!
Thanks for the clarification. If you one were to dose either 2 or 3 times per day, what would be your recommendation in terms of the potency of the do for each of those (2x and 3x per day)? Would there even be an available supplement in those amounts are is 100mcg the only real option even given the desire and ability to dose multiple times per day?
It would only need to be a tiny dose, in the order of 1 mcg. As you say though, B12-only supplements with this dose don't exist! B12 is sometimes dosed in this range in multivitamin supplements, but they're not usually taken multiple times per day, either. Actually, the study I referenced linking high-dose B12 with cancer did not find that effect with B12 from multivitamin supplements.
The only real way of doing multiple daily doses of B12 is with fortified foods - they usually contain around 1 mcg of B12 per serving. This is why I'm actually leaning more towards this strategy now, despite the inconvenience. Hopefully as more people go vegan, more (and healthier) foods will be fortified with B12 and all of this won't be as much of an issue! :)
@@DrDesHarrington I use unfortified nutritional yeast because I don't want other B vitamins besides B12, and I believe they are generally fortified with a B complex? What about just cutting the 100mcg pill in half and taking ~50cg in the morning and ~50mcg in the evening? Any advantage to doing that vs. just the single 100mcg dose once per day? Thanks again!
@@dvdmon Remember B12 doesn't naturally occur in nutritional yeast either, so if it's not fortified with the usual stuff make sure it does have B12 added. Yep in most cases it's okay to divide B12 pills, 50 mcg twice a day would be better than 100 once a day!
@@DrDesHarrington I guess I'm uncomfortable with fortified foods mainly because of the lack of control of how much of a given vitamin may be in a serving. I know you specified a small 1-2mcg value for B12 foritification in nutrtitional yeast, but I've heard other people note that the actual amount per serving varies and isn't guaranteed in the same way that a pill is, and even pills aren't guaranteed as at least here in the US they are not regulated in the same way that pharmaceuticals are. So I'd rather take at least some of the randomness out of the equation and avoid fortified foods where I might not be getting enough or I might be getting way more than I should, I just have no idea.
I know, it's not a perfect situation at all. As consumers become more informed on these issues, over time market forces will drive changes in both supplement and food industries and all this stuff will become easier. For now, we must just do the best we can!
I take b12 under tongue but it doesn't work do they have it in pill form please let me know
How do you know it doesn't work?
My B12 levels are 54 and 26 female what is your recommended dosage?
If you are facing any known symptoms due to the deficiency ! First Recover yourself with a good supplement which contains both b12 and folate. Then get your tests done , if found within safe levels continue with Vitamin B complex taking full dose every 3 months.
Not sure what units this is, but either way it's very low. I would definitely favour a rapid repletion strategy here with injections rather than depending on oral supplements alone. How did you get on since?
Never heard of high amounts of Vitamin B12 causing cancer. Is this for the cyanocobalamin or methycobalamine
Yes, it's a relatively recent discovery and as of yet only an association, certainly "causing" would be a very strong word based on the current science - but it's something to bear in mind and keep an eye on!
@@DrDesHarrington Thank you. Is it associated with both forms of B12
@@SuperEddie0228 We're not sure yet!
I took 100micro grams per day for years, plus fortified foods, and I ended up severely B12 deficient.
Just had to have B12 shots.
Not everyone absorbs at the same level.
In addition to the shots I'm temporarily taking 1000micrograms per day for 12 weeks until my next blood test. If all is nearing normal I will continue with at least 300per day to see how that maintains.
It was quite a shock to see how low my level was.
Yes this certainly can still happen, that's why I make sure in these videos to emphasise the importance of getting your status checked every once in a while even with a regimen that is likely to provide adequacy - which is exactly what you have done. B12 injections will replenish your levels very quickly, sounds like you're on the right path now, well done!
Why supplement if not deficient and 1 tsp of nutrition yeast a day meets daily recommendations?
If you can meet the requirements through diet alone that's all the better! It's become much easier to meet the requirements through diet alone the last few years and this is the strategy I most often use. 👍
A little confusing when the 1000mcg and 5000mcg recommended dose on the bottle is daily? (Solgar) why would they recommend this? To make it cheaper could you purchase the higher doses and cut the pills down?
Hello Robert, yes megadosing B12 like this has become standard practice since it was thought there was no negative to doing so (and a lot of positives in the case of quite common absorption issues), but as I describe in these B12 videos this thinking might be about to change. Either way, I think it is sensible, not too inconvenient and very low-risk to try and devise a supplementation strategy that fits your lifestyle that also exposes you to the least amount of B12 as possible.
Most B12 supplements would be fine for dividing into smaller doses, yes - the main reasons why you should not do this are if the preparation is extended-release, must bypass the stomach or requires more intensive preservation than usual, none of which is required by B12.
@@DrDesHarrington Thank you for your reply, upon looking into Solgars entire B vitamin rage, I was wondering what your thoughts on the B complex are? It contains the 100 mcg of the cyanocobalamin as you recommended but contains the other B 1, 2, 3, 5 & 6 etc, among other things. Do you think this would be beneficial to get the whole range of vitamin B? or would you still considered it overdosing with the additional B vitamins in it? thanks
@@RobertSmith-rs1cz I don't think supplementation should be handled with broad brush strokes like this. A WFPB diet can be a great source of all B vitamins except B12, and you should always aim to get your nutrition through whole plant foods. If you have plugged your regular diet into Cronometer, found a nutrient you consistently don't get enough of, and cannot make the appropriate dietary changes to support enough intake, then you can consider supplementation. But for most people, whole plant foods should be your go-to source for nutrients!
@@DrDesHarrington Interesting and makes sense. Thank you
How to take Jarrows 2500 mcg .
I was taking it daily continuously for one and a half month ...my level was 193...I got a burst of energy and my depression(I take cipralex 10 ) also became better ...but then I started getting severe backache...I discontinued for 2 months .,My new levels are 500..now I take twice in a week ...am I doing it right ...I need energy...I am a vegetarian ,,no meat,,fish or eggs ,,,and a hypothyroid patient ...
Dr.Des Harrington ,,,,please advise ...🙏
Great stuff, sounds like you've got the diet on point, and well done on reversing your low B12 level! You could even push 2500 mcg out to weekly if you like now that you are B12 replete, especially if you're getting your levels tested. :)
How many mcg does a breasfeeding woman should take then? Also how many mcg if you are deficiency of vitamin b12?
Both depend on your own individual blood work. If you are deficient you definitely need to be under the supervision of a healthcare professional!
Is 500 mcg too much?
the medicine i take show b12 rda as 1 mcg but when i search online the rda is 2.4 mcg
the medicine name is zincowide it is a multivitamin please reply
Actually rda is 1.2mcg as far as i know but assuming 50% absorption rda is set as 2.4 mcg but if we can calculate how much we absorb then we need not to worry about efficiency in simple words need not to divide by 2 . Take for example if you absorb 1.2 mcg then it is sufficient for a day in my knowledge.
That might be enough if you include other sources of B12 with other meals away from the supplement, such as nutritional yeast or fortified foods. Have you had your levels tested?
@@DrDesHarrington now i am fine it was 1 year ago i use to faint when i stand up quickly i started eating meat and it was all fine
NOT taking high doses isn't particularly safe either, if you're deficient. I had all kinds of horrible problems until I started taking the high doses. My vision was all messed up and I was heavily depressed among other things. Gotta watch out for the additives and fillers in those supplements too, the companies producing them are not on our side either, as far as I can tell. My solgar supplement contains Mannitol, which seems to be make me feel rather dizzy. Why the hell is it in there? Other supplements don't have it. Trying to find the right one is a bit of a minefield. Also tried the Best naturals one, but appears to be less effective. Gonna try Jarrow for a bit and see how it goes.
Absolutely, once the goal is repletion rather than maintenance the considerations are completely different. The consequences of under-treating deficiency are far greater than the comparatively small incremental risk in going from a low dose to a high dose. Yes you really have to watch them excipients, Solgar are usually pretty good but if mannitol doesn't agree with you you'll have to look elsewhere. How did you get on with Jarrow?
@@jbeauty4150 at the time I suspected it was the Mannitol in the supplement, though yeah B12 deficiency can affect all kinds of things. I strongly recommend you search 'Sally Pachalok B12', as she knows the medical details of it more deeply than I. I've seen multiple doctors about my B12 issue an none of them had a damned clue and chose to patronize and gaslight me instead of help, so now I handle it myself. given a choice between potential brain and nerve damage (significant evidence of this in other members of my own family), or taking matters into my own hands, is there even really a choice? Again, there are no recorded damaging side effects in medical literature releated with b12 overdose - it's a cheap, readily available and non-toxic vitamin, much in the same way Vitamin C is. I've so far experienced only positive benefits from the B12.
@@jbeauty4150 my mood is all over the place when my levels are low, I get where you're coming from. I also get confused and clumsy and start dropping things, having little accidents, bumping into things etc. Thankfully, I've learned to recognize these signs and supplement immediately when I see them.
Regards my protocol, I'm currently taking Solgar Methylcobalamin 1000mg sublingual, B6 100mg, Folate 1000mcg and Igennus Super B-Complex to make sure I'm getting all of the co-factors. I'm also self-injecting weekly Hydroxycobalamin which I've been lucky enough to source from a supplier here in the UK (they clearly get theirs from Spain as it's a Spanish bottle). I tried injectable Cyanocobalamin from a pharmacy in Germany for a while, injecting into belly fat though never managed to achieve the same effect I got from the Hydroxycobalamin I received as part of the NHS protocol 3 years ago. Apparently the Cyano form is not as good as the body doesn't get access to it right away, and also we pee out a lot of it and it doesn't get used.
Obviously self-injection is something you don't want to half-ass but again I haven't really been given much of a choice. I am super careful and have read multiple medical documents explaining how to do it. I'm also fortunate in that I'm fluent in Spanish and can watch numerous videos in that language on CZcams of Doctors explaining how to do it safely. In combining the weekly hydroxy injections with the Solgar supplements, I'm starting to see my vision clearing up again. This seems to be corroborated by Sally (Pachalok's) B12's experience as she injects and takes the sublingual in between.
@@jbeauty4150 I should also mention I follow a Gluten-Free diet (intolerence can be a cause of multiple deficiencies), use 2 tiny scoops per day of Doctor's Best MSM powder to reduce Homocysteine levels (raised homocysteine can be a marker of B12 deficiency) and have found pure Epsom salt baths to be a lifesaver when my stress and other symptoms get really bad (Magnesium is best absorbed through the skin, is needed for 100s of processes in the body and reduces inflammation).
@@jbeauty4150 yeah, I went to a local clinic for the injections at first. £45 a shot, vs 50p if I do them myself. Unfortunately the clinics in UK are all trying to take advantage of the lack of availability and think its ok to charge sky high prices. Regards dosage, aside from the B12 I’m aiming for what’s called a clinically effective dose, in the best, cleanest, most easily absorbable form. I selected the supplements above because they use the most easily absorbable forms of each vitamin for the body, and they aren’t full of extra unnecessary filler ingredients and allergens (yikes!) and the dose is big enough to make a difference (most multivitamins are a waste of money as they don’t cover all three points).
Some people can treat the deficiency sublingually; it depends on why they’re deficient to begin with. It could be genetic (MTHFR), malabsorption due to a digestive issue (gluten intolerence, coeliac disease etc) or something else. I’ve found it takes some experimentation to find what works best. In my case, I’m assuming malabsorption and possibly MTHFR but it’s impossible to be 100% sure and my docs won’t even carry out the correct tests, even though I offered to pay and found a clinic to process it. So I go with this: if it works, it works. The end result is the most important thing.
I wouldn’t worry about side effects. There will be some, because your body has to repair the damage done due to the deficiency. I get tingly nerves, tingly brain, sometimes I feel tired and occasionally confused, so be prepared to rest after a dose if needed. Look up ‘cerebral atrophy b12’ and ‘demyelination b12’ on google/google images and you’ll start to understand that the side effects following b12 therapy are a sign things are getting better. You know deficiency also causes some kind of optic nerve atrophy preventing the eyes from communicating effectively with the brain. I’ve experienced sore eyes this past week as a result of taking a higher dose but my vision has improved every day, so I know it’s working.
I guess 1000 mcg of B12 twice a week can be a good idea too
That would work, yeah!
Hello Sir What about 1000 mcg twice a week on different days ?
Hello! Yes, that would be in between the daily and weekly dosing strategies as outlined in this video and will easily support the maintenance of adequacy in most people!
@@DrDesHarrington Thanks a lot for your reply, that helps !!!
I have been feeling really foggy headed dizzy and off no energy at all and I had a test done a while back and the doctor said to start taking a vitamin b12 because it was low and I just started taking it seriously because the symptoms have gotten worse. so the pharmacist recommended I start taking the vitamin b12 1000 mcg to help my symptoms to go away but he said once a day is that too much or how do I take this I have took one of them already just a while ago my first dose and I’m not sure how I should take it I take medications as well so I’m scared to take anything but I believe this may help do u have any suggestions on how much to actually take a day with meds I take ? And I have the 1000 mcg tablets as I mentioned thanks again for the advise..
He said 2000 weekly is better than a 1000 a day so I believe he thinks 1000 a day is the worst of all. However in your case I would your body needs it more than anything else. I personally take my 1000s every 3 days so it's about 2000 weekly and I feel great. Just giving my opinion much love
Hello i see you wrote your comment 3 months ago, can you help me? I also got strong symptoms and started taking oral 1000mcg b12 once day like 2 days ago. It seems the symtoms are getting a little better, but im worried it will take too long for me to get back to normality. Right now i cant study effectively, i stoped learning the language i was learning and i miss it very much. How long did it take you to things get back to normal again?
You can take that twice a week, then slowly once a week, then once per 15 days after few months, I took it daily and now got insomnia, anxiety. Why they write on products to take daily, I don't get that!! Its too much.
@@LeandroAlmeida108 didn't you get insomnia after taking that daily?? I got insomnia, headache after taking daily for 5 days.
@@explore_with_sagan9596 No i didnt, i think everyone reacts to it differently. My mother cant absorve b12 at all, she has to take injection so maybe i also have difficulties with its digestion. I have been taking it daily for more then 1 month, but i reduced from 1000mcg to 500 mcg a day
When I take 5000 micrograms a day, it it better to take them divided over the day? I have once you can put under your tongue, I can thake them with me to Uni and work and put one under my tongue every 3 hours no problem, one of the nuggets have 1000 micrograms.
No, there would be no added benefit to splitting up a dose of 5000 mcg over the course of the day. What you could do is take 5000 mcg every 2 weeks, which should still provide well in excess of the daily recommended intake and expose you to much less B12 overall!
Why are we using cyanocobalamin?
Your recommendations see suspect given that you are recommending the version of B12 which breaks down into cyanide when there are 2 other forms which do not do this.
The amount of cyanide in these supplements is physiologically insignificant. Check out my other B12 videos for more on why I recommend cyanocobalamin!
How much daily dose of vitamin b 12?
If anemic then how i take b 12 if i have not supplement and how much food taken?
Thanks 🙏 from Pakistan 🇵🇰
Hello! How much to take can depend on your own background. I'm thinking if you have anaemia and the top differential is that it is due to B12 deficiency, you're in a category that's way beyond the scope of this video - your daily doses and even formulations (i.e. injection vs. oral) will be completely different than someone just trying to _maintain_ a healthy level with no manifestations of deficiency. Has a doctor been involved given that you're thinking B12 deficiency anaemia? In that case, I would go with whatever they have prescribed because you will need rapid repletion. Hope this helps!
@@DrDesHarrington
Thanks 🙏
Being a genuine 'Golden Oldie' (81 years young) l just wondered if you were on speed as your instructions are delivered far too fast for me!!!
Hahaaaa !, I’m 51 and I thought exactly the same . But I have to admit that I’m Belgian and french speaking ;)
Haha not speed, just lots of coffee! For sure talking too fast is a recurring problem for me ha, I will try to slow down from now on! :)
You can adjust playback speed. .75 is good on this one
Why would anyone recommend Cyanocobalamin instead of the more natural form methylcobalamin???
Can we just split a 1000mcg tablet to 500mcg per week?
Hmm 500 mcg might not quite be enough, if you want to do weekly I would stick with the 1000 mcg.
How about 5= 9 mg vit b12 inj tu treat nerve damage ../polyneuropathi
B12 injections are in the realm of treating already-existing health problems, as you say. I cannot advise on treatment here on CZcams obviously so I stick with just advice on _maintaining_ health, but yes if nerve damage has occurred and B12 deficiency has been definitively determined to be the cause with all other possibilities ruled out, regular high-dose injections would be a very appropriate treatment and all other considerations about the link with cancer or anything else vanish into insignificance. Always follow your own doctor's advice - they have access to your records and investigations and everything else! Let me know how the injections go anyway and if they help with the symptoms, I wish you all the best with it!
Drink milk, eat egg, bacon, meat, liver. Stop with gluten
Always double drop
Ha but only if taking once a week!
Use only methylcobalamin which is best absorbed when placed under the tongue. Cyanocobalamin is a synthetic form and is not recommended as it is toxic.
I have given my strong rationale for why that is not the case in this video:
czcams.com/video/XhbhWUyJv3s/video.html
Im not sure if i am deficent. I have symptoms that I am , How much should one take?
If you think you're deficient the first and most important thing to do is to get assessed clinically. If you turn out to be deficient to the point that you have symptoms you will require rapid replenishment with injections. What symptoms are you having?
@@DrDesHarrington @DrDesHarrington thanks for your response.
tiredness (fatigue)
lack of energy (lethargy)
hearing sounds coming from inside the body, rather than from an outside source (tinnitus)
I brought b12 today 1000mcg, will that help? I noticed when i take vitamin D suppléments my symptoms subside. Strange? Thanks again
@@Jamie.abdurahman It might help if that's the cause, but don't go trying to treat this on your own! Those symptoms are very non-specific and need a proper investigation.
@@DrDesHarringtonive done an mri scan for the brain and that came back normal not sure which other tests to take?
Please please please reply can a 20 year old boy take 500mcg daily 😢
They sure can! They could also probably get away with less though unless there's a specific reason for this dose.
Is 800mcg per day ok?
Depends on your goals, this would be very appropriate for repletion of low-normal levels, for maintenance you could take it less than daily or reduce the daily dose as well if you have access to lower doses!
2000mg daily i take last 4 years..
What amount of B12 should a vegetarian and chronically ill person should take
Depends on many factors. The most fool-proof way to ensure adequacy outside of clinical interventions is megadosing!
Dave Asprey recommends to take up to 5000 micrograms daily, do you agree? Also he recommends to take 800 micgrograms of folat (5-mthf quatrofolic), otherwise taking b12 withouth folat longterm causes braindamage, do u agree?
What the hell dude. Did you watch the video? It answers your questions. By the way, Asprey is a quack.
@@Crepitom Dei Muada is a quack so sauhirte
Why do you think that cyanocobalamin is the best?
@Korn_Piros I saw many videos here that say cyanocobalamin is connected to cyancali, it is not the poison of course, but it has a bad "structure". I am so confused. Here in Germany they only use methycobalomin or adensocobalomin. Thanks you
Hi Galliano, check out this video to allay your concerns over the cyanide in cyanocobalamin:
czcams.com/video/XhbhWUyJv3s/video.html
Why do you talk so fast,
You can just slow it down imo
Trying to get the balance right between not talking too fast and not wanting to bore people! If it helps, I always include subtitles with my videos. :)
Cannot keep up too too fast
Ha I know, I'm always trying to strike a balance between going too fast and not wanting to bore people and have the video become excessively long! I always upload subtitles too, if they're any help!
How about 1000mg every fourth day?
Yes that should be fine - remember, you will get the biggest incremental health benefit in going from no B12 supplement to any B12 supplement, rather than worrying about subtleties in dose and regimen. Additionally, these higher doses are far better if your goal is repletion rather than maintenance - this video was made more with maintenance in mind. Hope this helps, and good luck with your health goals!
@@DrDesHarrington I'm just doing 2000mg once a week
I have 500mcg tablets, your math tells me it is one every 2 days
Actually according to my math, it's every 2.7 days, which goes to 2 days without risk of low intake
@@JG-xm8jy Perfect! Combine with an occasional test maybe for even more peace of mind!
WHAT ARE YOU TALKING ABOUT i f you have serious nerve damage you need injections every day high dose !!
You are speaking too fast
You can rewind/ repeat the video
Or put it on 0.75x speed
People like to moan about everything.
Sounds like Ivor on 1.5 speed.
Haha, who's Ivor?
So meat just doesn't exist in this timeline of the video 😂
There is no justification for eating meat to get B12 when there are perfectly viable supplemental options, and B12 deficiency is absolutely epidemic in lifelong meat-eaters.
I don't get what's wrong with supplementing 2000mcg a week, if only 20mcg is absorbed (meaning the rest passes out of your gut as poop) and most of the 20mcg is used up over the week 🤔
I suppose all the excess could still have effects before we eliminate it, even if not absorbed into the blood! Intestinal microbiome springs to mind!
B12 is water soluble so what are you talking about
Não entendi nada kkkk não entendo inglês uma pena
Dude a bit slower narration
Noted, always trying to find that balance between talking too fast and making the videos boring! Remember, I always include subtitles if that's any help! :D
Speak too fast…lost much of it.
Play @ 0.75 speed😂