Vitamin B12 FORM - Cyanocobalamin safe? Methylcobalamin adequate? (What I recommend)
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- čas přidán 22. 08. 2024
- In addition to the huge variation in dose of B12 supplements, there are at least 4 different forms of the vitamin to choose from. The most common of these are cyanocobalamin and methylcobalamin.
But which of these is better? And why do some people argue that you should never take cyanocobalamin and that it is tantamount to poison?
Indeed, why is there poison - cyanide - in cyanocobalamin at all? Should we be concerned that this is an unnatural form of the vitamin?
Today we'll be exploring the different forms of B12 with a special focus on cyano- and methylcobalamin given their ubiquity, including manufacture, safety and conversion issues - and how I arrived at my recommendation for the form you should take.
Please note that the discussion in this video applies to healthy people with no known issues with B12 utilisation, and you should persist with the regimen prescribed by your health care provider.
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#B12 #Cyanocobalamin #Methylcobalamin
References: 5:34
The information provided on this CZcams channel is not intended to replace professional medical advice, diagnosis or treatment. The content presented is for informational purposes only. Always seek professional medical advice before starting any new health care regimen, treatment, exercise program or diet and never disregard professional medical advice or delay in seeking it because of something you saw on this CZcams channel. Always seek the advice of your doctor with any questions you may have regarding a medical condition.
Which form of B12 do you take?
REFERENCES:
EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Scientific opinion on dietary reference values for cobalamin (vitamin B12). EFSA Journal 2015;13:4150.
Martens JH, Barg H, Warren MJ, Jahn D. Microbial production of vitamin B12. Appl Microbiol Biotechnol. 2002;58(3):275-85.
DMacks. Ammonium cyanide [Internet]. 2011 [cited 2019 Jun 16]. Available from: commons.wikimedia.org/wiki/File:Ammonium_cyanide.png
Jones DA. Why are so many food plants cyanogenic? Phytochemistry. 1998;47(2):155-62.
Xu Y, Szép S, Lu Z. The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases. Proc Natl Acad Sci U S A. 2009;106(48):20515-9.
Government of Canada. Guidelines for Canadian Drinking Water Quality: Guideline Technical Document - Cyanide [Internet]. 2008 [cited 2019 Jun 16]. Available from: www.canada.ca/en/health-canada/services/publications/healthy-living/guidelines-canadian-drinking-water-quality-guideline-technical-document-cyanide.html#fn36-rf
WHO. Evaluation of certain food additives and contaminants [Internet]. 2011 [cited 2019 Jun 16]. Available from: apps.who.int/iris/bitstream/handle/10665/44788/WHO_TRS_966_eng.pdf;jsessionid=3013FF90FE1D1C733E9FEF087EFC46C2?sequence=1
Kim J, Hannibal L, Gherasim C, Jacobsen DW, Banerjee R. A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J Biol Chem. 2009;284(48):33418-24.
Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr. 2015;69(1):1-2.
Obeid R, Fedosov SN, Nexo E. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015;59(7):1364-72.
Kamath A, Pemminati S. Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give? J Pharmacol Pharmacother. 2017;8(1):33-34.
Thank you for another informative video! 👍
I'm taking cyano.
Btw, any thoughts on DHA scam exposed by VegSource?
czcams.com/video/c8_kTtWUnf8/video.html
@@lorah3005 Glad you liked it! :D I've seen it, not sure I'd call it a scam now. I agree with most of what he says - we absolutely can (and should) get all our omega-3 LC PUFAs from ALA by getting all the necessary lifestyle factors in place. Unfortunately some (probably most) vegans are not anything like this health-conscious, so for that group pre-formed PUFAs are a good idea, and certainly the pros would outweigh the cons in this case I think.
If it means anything, I'm going to keep taking golden algae EPA/DHA myself, despite having the necessary lifestyle factors for good conversion most of the time. I'll accept a (possible) increased cancer risk if it means I am (likely) helping to maximise brain protection. Supplements are by their nature unnatural, and there will always be trade-offs when taking them! I also recommend a conservative EPA/DHA dose, which should help, too.
@@DrDesHarrington Your reply is much appreciated!
Dr My BF smokes Marajuana , in bongs . Her lungs are completely destroyed. The 1000 , McGregor.
Dr . My Friend smokes Marajuana in bongs . Her lungs are so bad ,she coughing all the time. She’s going to quit smoking,but DOESNT smoke many cigarettes at all, but does put some tobacco in with her P in the bong. I bought her
1000 mcg of Methylcobalamin . She threw up so bad right after taking it . I bought “ Natural Factors “ The Most Metabolically ACTIVE FORM , sublingual under tongue.Quick Disolve . Was she sick because of dosage , or because she took it after bong , or because she has no intrinsic factor. She’s taken Multi Vitamins before. She said it made her feel really sick. I take half in am and half at night. I bought all my friends this for Christmas because it’s the best quality and it was the most expensive. B12 . So now she is quitting smoking, cigarettes and terrified of B12 , so she won’t take it. I’m scared because it’s legal here ,only 26 and her lungs are COPD / Emphysema sounding. Why would she throw up so bad ! ?
It says lab tested , it expires in 2022 , and GMO. Free, . Would a B12 shot make her feel sick as well. I bought this at National Nutrition and I feel better on it .
Methylcobalamin is better because its an active form that is safer on the kidneys and your body doesn't have to work as hard on converting, btw this man says he suggests cyanocobalamin because it converts to both methyl and adenosylcobalamin but taking methylcobalamin can also convert to adenosylcobalamin and able to convert back to methylcobalamin , this dr said you need to take adenosylcobalamin with methyl but thats not needed as methyl alone converts to adenosyl...and can convert back to methyl
My understanding is that not everyone is efficient as converting the different types of B12
@@mateojoe6107correct.
Yes. There's something about this presentation that doesn't ring true. Now, I'll do some real research into the different forms and their bio availability. I've studied B12 for a few weeks now, and never heard anyone (including Mds) suggestion the cyano version.
I don't take cyano, but I take 3 forms-adenysol, hydroxy and methyl b12
Methyl cobalamin can make people feel worse
Dr. Des, you are genious researcher! Thanks for your work! :)
Haha, thanks man! :D
After buying a B12 oral spray i watched a video saying don't take Cyanocobalamin as it is toxic but rather take the Methylcobalamine 🙄 I'm glad i dug deeper and found this information instead of throwing it out, cheers
No problem, glad I could set the record straight! :D
Dr Harrington,
I am so confused,
Yesterday dr jaffe put out a video
saying dont take cyanocobalamin
Or mythcoballamin, I've brought a
Lot of boxes of mythcoballamin
He says only take hydroxyl cobalamin, I'm so confused
Could you explain what hydroxyl
Cobalamin is please.
I have found 5000 mcg sublingual and the doctor told me to take this amount every day..... is this safe? On the bottle, it says.. (As Cyanocobalamin) so I'm not sure about the safety.. Thanks.
If your doctor is involved I am assuming you are trying to correct deficiency, so yes in this case the benefit of a megadose like that greatly outweighs any risk added.
Recently turned vegan so B12 intake was a concern for me. Thank you for explaining the differences so clearly!
I have chosen for a dose of 1000mcg cyanocobalamin 2 times a week as my regimen for B12. :)
Way to go on the dietary choice, I wish you all the best with it! :D Glad the video was helpful in your journey! Yes that regimen could work, just make sure you make the twice a week a habit and maybe get your level checked in around a year or so to make sure this is enough for your unique physiology, and you should be all set!
@@DrDesHarrington would a blood test showing a high b12 level be sufficient evidence to support possibly reducing frequency of b12 shots of cyanocobalamin? Mine was quite high the last time I checked
I got here from ur omega 3, dha comment on plant based science channel! Glad to be here. GR8 info! Instant sub!😉🖒
Great to have you along! :D
Methyl, adenosyl, and hydroxo I take. As someone with the MTHFR polymorphism "remethylation disorder" (and 40% of the population has this) I wish you had addressed this more in relation to the active vs cyano forms. I understood that cyano can increase the blood test level results for B12 but is relatively metabolically inactive for the MTHFR polymorphic. Hence for people with the MTHFR 1 SNiP (polymorphism) there is a 40% methylation efficiency reduction and 2 SNiP variants are a 70% methylation efficiency reduction. So based on my previous research and as I understand it if one was taking cyano and your blood levels were 1000 then it would mean that your effective levels are 40-70% less, i.e. 300-600. If I am wrong then please correct my understanding. So while the use of cyano is due to stability, the deployment over an entire population is problematic for 40% of the population. It is my understanding that these decisions to include cyano as mass fortification were made before it was understood what the nature and extent of the MTHFR polymorphism issues were. Just like synthetic folic acid being not found in nature and possibly contributing to cancer this issue should be reexamined from a public health standpoint but it is not. While one can eat plant sources of folate this is not possible for B12 in the modern world. Cyano may be the best option for the 60% but what about the 40% minority? This recent article is relevant: www.ncbi.nlm.nih.gov/pmc/articles/PMC5203859/
I've seen a blend of adenosyl and hydroxo, but not methyl, do you get a blend of the two and methyl separately?
Yes, I came across this article and others like it when researching this video, and I was originally planning to address MTHFR and B12, but the topic is just too broad and really does require it's own video - that's why I mentioned at the end that anyone with remethylation disorders should be under the care of a doctor for this, including their B12 regimen. You can't make a blanket B12 recommendation for MTHFR polymorphisms, because there are different kinds.
As well as that, that article provides recommendations for remethylation disorders proper, including actual MTHFR deficiency, not just MTHFR polymorphisms. Recommendations for specific B12 forms of course are going to be a lot stronger for actual MTHFR deficiency - in this case, they are recommending parenteral hydroxocobalamin. I'm not convinced at present that those with polymorphisms need to give any special consideration to B12, but as I say, I haven't anything like fully looked into it yet!
@@dvdmon I'd like to know this, too! And also the price!
@@dvdmon I buy all seperately. I wish there was good guidance on the ratios of the actives for those with MTHFR: methyl to adenosyl and then the ratio to hydroxo
@@DrDesHarrington Thanks for the reply. I look forward to that video; I think the researchers themselves are still trying to figure it out. However, in the 21st Century the real jobs of doctors should be to help bring these advances to patients as soon as actionable and not to just apply routine standards of care, which more and more will be taken over by ML/AI and lower level nursing. With your curiosity you represent the next generation of medicine delivering real value added from research.
Thank you so much for this information ! It has been an eye opener !
Hello! Glad it was helpful! :D
I am trying to locate a source of injectable methylcobalamin and all I can find is cyancobalomin. Why? When 1000 mcg of cyanocobalamin is converted to methylcobalamin at only 1.8 percent? WTF?
Yeah no answer here. Also Looking deeper something is off with this cyanocobalamin uptake.
Usually the injectable forms are hydroxocobalamin or cyanocobalamin. Just curious, why are you looking for a B12 injection yourself? Usually this would be prescribed and sourced by your healthcare provider to treat severe B12 deficiency or in the case of malabsorption.
Your channel should have way more subscribers!
Haha thanks, I'd be making these videos regardless of how many were watching because there's so much of this stuff I feel has been inadequately covered!
I agree! No one is putting up content like this, and it is valuable information. Thank you!
I agree!
The Lifting Dermatologist 👍
I'm very confused after watching multiple videos, some say cyanocobalamin is good and all the bad stuff i hear about it is not that bad and it's most stable, then some say it's the worst and i should stay away from it. Then some say the methyl one is much better and safer and others say it's unstable and i should take the cheaper cyanocobalamin
From my reading I haven't seen anything to suggest that we should stay away from cyanocobalamin, but plenty to suggest that methylcobalamin on its own is inadequate. But I agree, nutrition can be very confusing!
Hi Dr Des,
I have had some weird sensations in the bottom of my feet, feels like an ant walking on it or blood randomly pumping through, I realise this could be neurological! Could it be a b12 deficiency? Can you recommend a supplement I can take to see if it helps?
Help appreciated,
Thanks
Stuart
A lot of diseases have such symptoms. You need to get checked by another professional using specific machines and tools before using any kind of supplements.
Yes, it could be neurological. Agreed, definitely needs a full work-up by your own health care providers!
I have the MTHFR mutation C677T (Homozygous) and can only methylate 10-30% of the Folate and B12 that I consume, unless they are in their premethylated forms (L-Methylfolate and Methylcobalamin).
All the more reason to focus on a good healthy diet with an intentional supplement strategy, which it sounds like you're on top of!
What about those who need to take Methylcobalamin due to taking PPIs and having significant MTHFR? Taking Adenosylcobalamin drops and Methylcobalamin shots.
This is a myth perpetuated by those wishing to sell supplements. The MTHFR enzyme is not involved in the conversion of cyanocobalamin to the active forms and, as stated in this video, methyl and adenosylcobalamin supplements aren’t ‘active’ anyway - they need to be reconverted by the body.
@@theesotericcunt5029 can I take methylcobalamin weekly in 1000mcg? I know cyanocobalamin is better cyanide is good for health in small amounts. I just bought methylcobalamin they didn't have cyano
Thanks. Dr Des! Just want to ask what is the best time to take vit b12? Also, should it be taken with food or empty stomach? Before or after meal?
Hello! This isn't especially important for B12, though I'd probably favour with food just because intuitively it seems a bit more physiological. :) The best time to take it is when you'll remember, especially if taking it infrequently like every week or so!
What is the recommended IM dose of Hydroxocobalamin for mild b12 deficiency and over all well being?
If you're looking at IM replenishment this should be overseen by a healthcare professional and titrated to your own individual metrics and personal history.
Thanks Doc, however, I don’t get why there needs to be a synthetic version to the natural one other that it’s just easier to manufacture for cheap.
There is no synthetic one, cyanocobalamin is produced by bacteria as well so it is an natural process and not synthetic.
@@bartjoboy Hi Bart,
I am so confused, dr jaffe
in the last 5 mins has put a video up
Saying both cyanocobalamin
and mythcoballamin should not
be used only hydroxyl cobalamin
and in a b complex,
Would you know what hydroxyl
Cobalamin is ,
any advice would be appreciated.
I am vegetarian for over 20 years, went and had a b12 shot 5yrs ago and almost died!
I now suffer from pernicious anemia, Hashimoto's thyroiditis, and peripheral neuropathy. I believe I could not absorb the shot and my thyroid shut down and my body almost shut down completely.
You must read dr robert morses book
Nasty additives are added to the b12 shots such as benzyl alcohol. It could have been reaction to one of them.
Damn tht sucks...
I'm sorry to hear that! :( How have your B12 levels been since? Do you just maintain with oral supplements instead?
Maybe it's your vegetarian diet. You should entertain the idea of a carnivore lifestyle?
excellent video! was really waiting for this one!
what do you do personally for B12? do you take both form or only Cyanocobalamin?
and also in case of taking both what do you recommend? like every other day switching?
Thanks, man! :D I have a few doses left of a 1000 μg cyanocobalamin supplement, so I'm just going to take a quarter of this every two days until I can get something with a lower dose. If you really want some methylcobalamin in your life, alternating daily would be a good strategy!
@@DrDesHarrington awesome thanks! since I have both now i will continue to take both
I have the liquid version though. What do you think work best?
@@greenpowertemple I think cyano- is best overall, but you'll be safe with cyano- on it's own, a combination of cyano- and methyl- or a combination of methyl- and adenosyl-. :)
@@DrDesHarrington cool thanks a lot :)
@George Ramos If your goal is merely maintenance rather than repletion, 250 mcg once a day should be fine!
You mentioned in the video that other forms have their place such as for pernicius anemia.... I have pernicious anemia and have just purchased cyanocobalamin. My understanding is that since it is sublingual it bypasses the digestive system which renders the gastrtitis and lack of intrinsic factor irrelevant. Am I correct? I tried methlycobalmin for about 2 months and it helped in the beginning, but i noticed some symptoms returning and switched to cyan upon learning that cyan converts to all the needed forms. Again, am i correct about the pernicious anemia and should i continue to take my sublingual cyanocobalamin?
Hello, I have just stumbled upon this video, and what a great channel. I love the strict evidence based approach without any additional assumptions or extrapolations.
I'm on a WFPB diet and have been taking this sublingual B12 supplement composed of 1000mcg (900 cyano + 100 methyl) twice a week. I guess there shouldn't be a problem with it being a mix, have you found anything about it during your research?
And about the dosage, after seeing your video about the risks of megadoses, am I correct in assuming that whether I take the two 1000mcg pills in one day or one pill every 3/4 days has no effect on the risks, but only on the actual amount absorbed?
Would one of the two methods be preferrable over the other?
Thank you, and keep up the great work!
Hi Max, thanks very much, yes I try to keep opinion out of it! No, there will be no problem whatsoever with that mix of B12 forms. My preference is to make your doses as frequent as possible so you can take less and expose yourself to the least amount of B12 overall whilst still ensuring adequacy as outlined in this video:
czcams.com/video/WjSdALh1YVE/video.html
Yes, the total amount ingested is what has been linked with the negative health effects, not the amount absorbed, so the two examples you give would be equivalent in this regard. Both should also work to maintain a healthy level in someone with no absorption issues.
I will be returning to B12 at some stage with an update on the latest research linking high-dose B12 with negative health effects, but on my cursory reading so far they have not been definitively proven nor disproven yet unfortunately!
@@DrDesHarrington Alright thank you for the quick answer. I will keep my eyes open for lower dose supplements for when I finish my stock, but they are quite hard to find, and often inexplicably more expensive per tablet compared to the standard 1000mcg ones.
In the meantime I have watched your series on omegas, very interesting!
Do you mind a question about those?
I see many omega supplements use some form of vitamin E as a preservative (in the ingredients list either as mixed tocopherols, or straight up d-alpha-tocopheryl acetate), sometimes including it in the nutritional information table and sometimes not.
Knowing about alleged correlations between Vitamin E supplementation and all-cause mortality, would such low doses used as preservatives be of any concern?
I had my eyes on a vegan omega3 supplement by AAVALABS, which contains 150mg+75mg DHA+EPA, but also has 5mg of vitamin E per capsule.
Being separately listed in the ingredients list as Vitamin E and appearing in the nutritional table, I guess it's not just used as preservative but added actively as additional supplement. Should I be concerned about it and look for an alternative?
@@maxolina Sorry, missed this until now somehow! Yes, the megadosed supplements have become very widespread and dominant; remember the original thinking behind these very high doses was that they would ensure adequacy for almost everyone, even those with absorption issues, most notably with intrinsic factor-mediated absorption (pernicious anaemia et al.) This was fine when it was thought that there was no down side to taking these high doses - but remember the evidence emerging now to the contrary is still in a very early phase and certainly the magnitude of potential effects are not enough to warrant a massive overhaul of B12 supplement manufacturing practices at present. I wonder if lower-dosed supplements became the norm, would we do more damage by not providing those with absorption issues enough, than the damage being done at present by those taking unnecessarily high doses? Only time will tell! And furthermore, your question is not about public health but your own situation, and I applaud you for taking such interest in maintaining your own health, it is such a rare thing to see in my experience! The best I can tell you is to just keep a look out for a lower-dosed supplement, or just get the lowest-dose one you can find and divide it up into smaller doses - this is fine to do with B12 supplements.
On to your question about omega-3 supplements, ah yes you are aware of the phenomenon of the negative health consequences of taking supplemental antioxidants including vitamin E! You are quite right to point this out, and when it comes to supplementing pre-formed long-chain polyunsaturated omega-3 fatty acids, including antioxidants in the supplement is simply going to be a part of the package deal - the molecules are simply too delicate to formulate into a supplement without this protection. This comes back to the ostensible axiom that getting our nutrients from whole plant foods is best - indeed I advise getting enough ALA and having a healthy enough diet to ensure adequate conversion to the LC-PUFAs as the absolute optimal way to get them, and you would get to skip including the extra vitamin E in that case. Having said that, if I was going the pre-formed EPA/DHA supplement route, I would much rather take in that little bit of vitamin E to ensure my omega-3s were well-preserved that skimp on the preservatives and take in rancid fatty acids. Also note that you're right in saying that 5 mg is probably more than is necessary for just preservation and I have seen supplements with much less than that so they probably are including it as an actual supplemental nutrient here as well. If you're really worried about it, you could certainly find supplements with less vitamin E or other antioxidants than this, but if you can't and you're going this route for your EPA and DHA, taking any supplement will be better than taking none, however much vitamin E it has. Sorry for the rambling answer, hope this helps!
@@DrDesHarrington Okay, thank you for your insightful answer!
My question about vitamin E in omegas was mostly out of pure curiosity. Having never supplemented omega3 before, I'm using a 250+125mg DHA+EPA supplement from myvegan right now, whose dosage is perfect for my current needs, but as I get used to eating more flax/walnuts and especially making a habit of it so I don't just forget about it, I was looking for slightly lower dosage vegan DHA+EPA capsules. That's when I found the ones with added Vitamin E which sparked my question. I have found others since, which fortunately come with significantly less vit.E. Still I thank you for your thorough answer!
One more thing if I may ask:
Do you know anything about which DHA to EPA ratio is preferable? All the vegan omega3 including both are either 2:1 or 3:1, and digging deeper it appears that it's dependant on the actual source of the algae oil (Life's Omega appears to be 2:1 DHA/EPA, while another brand is 3:1, Lus Ingredients).
Does it even matter at all, considering our bodies can supposedly convert either to the other?
@@maxolina Yes, it seems going to the source of these molecules in the marine ecosystem the algae we farm produce 2 or 3 times more DHA than EPA. Once your supplement does contain both molecules and the ratio is no higher than this I am perfectly happy with it!
And for those with an MTHFR mutation? Is it not correct that they won't be able to use the cyano form well?
I have meant to look into this in detail but I haven't seen anything convincing to suggest that cyanocobalamin will be inadequate for those with an MTHFR mutation. You could always look at trying to source a combined methyl-/adenosyl- supplement if you're worried!
I work in genetics and people with the methylene tetrahydrofolate reductase genetic mutation absolutely cannot absorb cyanocobalamin.
They cannot process any B vitamins that are not methylated. This includes folate. A person that has the MTHFR either hetero or homozygous will not be able to process folic acid and therefore will need to take l-methylfolate instead otherwise it can lead to a toxic buildup in the body.
Thanks Des. Nice to see some actual science!
It's made from the foam on top of raw sewage. Most doctors don't even study nutrition, they just hand out whatever medicines the drug reps tell them to push. Alot of doctors are full of sht
Very interesting, full watch, m8!
Thanks very much, glad you got something out of it! :D
i had a doctor the other day tell me that there is no cynide in b vitamin i told her she was wrong . but she started to around about way call me a lie .
Haha it's not common knowledge, for sure! Certainly there is no physiologically significant quantity of cyanide in these supplements.
Thank you for your wonderful video and explanation.
So glad you found some value in it! :D
Excellent presentation; thank you kindly.
Thank you very much!
Sir my vitamin b12 level is 110 pg ml plzz suggest medicine
Hello! This needs to be followed up with a healthcare professional; you will probably need injections.
I love these videos, thanks Dr dez!
Glad you like them! :D
Great video as always!
Thanks so much for the support, glad you liked it! :D
agree100%
Can I ask something please? When I take a 1000mcg Cyano B12 sublingual tab twice a week I feel really sick in my stomach and it gives me 'bad movements'. I have yet to experiment with lower, more frequent doses, like you recommend. I was wondering why I would have such a problem with this supplement when other seem not to. What could the problem be?
Hi Nick, it might be something as simple as a reaction to one of the excipients in the particular brand you are taking. As well as trying out a more frequent, lower dose regimen, you could also experiment with a different product - it might be as simple a fix as that!
Additives such as titanium dioxide can cause similar reaction. Check if there is any other harmful additives and use another brand.
@@DrDesHarrington I can't find anything that is lower than 500mcg.
@@subliminalfalllenangel2108 me either. I just take the 1000mcg twice a week. Seems to be going well
Same happend with me in stomach changed the brand and its fine now
Great info Doc
Researching which to take as I am a vegetarian. What is the difference between cyanocobalamin and Cobalamin? I imagine it is because there is no cyanide added but other than that?
Cobalamin has multiple forms, one of which is cyanocobalamin.
This is correct, the molecule is unstable without a functional group in that position and the cyano- functional group results in the most stable form of them all which lends itself to making good supplements.
Great video. Thanks, from Canada.
What about time-release b12 ?
What about sublingual b12 ?
I'm vegan, middle age man. No b12 problem.
I take 1200 mcg methyl b12 (Costco).
I usually break the 1200 mcg tablet into 3 pieces, and take the 3 pieces at around 6 hour intervals.
Hello Marty, thank you very much for your comment! Greetings from Ireland! Kudos on your diet, always delighted to hear from vegans - my goal is to keep us all as healthy as possible! :D If you have no problem with B12 (absorption, deficiency, etc.), that high of a dose might be overkill given the recently-characterised link with cancer as I outline in this video:
czcams.com/video/Aq8V2SZdWRI/video.html
I think it makes sense to expose ourselves to the least amount of B12 possible whilst ensuring adequacy if you are already replete and just looking to maintain, which I explain how to do in this video:
czcams.com/video/WjSdALh1YVE/video.html
However, my B12 position has not been updated since this video series and some new stuff has emerged since then that I will be making some update videos on soon. Until then, only on my cursory reading on the topics you ask about, time-released and sub-lingual B12 preparations are innovations pertinent to B12 malabsorption and the efforts to circumvent it somewhat, so might not be as relevant to the situation you are lucky enough to find yourself in. But don't take this as gospel yet, I will be fully researching these very questions you ask when I finish my current vitamin D series and revisit B12!
Wow. Quick answer.
I'll look into your idea of a reduced b12 dosage. Thanks.
@@marty3138 No bods, best of luck with it! :D
Cyanocobalamin is it destroyed by heat? just like Vitamin C. Ty. for sharing this data.
Thank you for stopping by! :D
I was diagnosed with a severe B12 deficiency of 87 about 6 weeks ago. My neurologist then referred me to my GP for b12 shots. I have ulcerative coilitis. She is prescribing monthly shots of 1,000 mg of cyanocobalimin but my balance and trouble walking is getting worse. I have read other standards of treatment in the uk are more aggressive and stress hydroxocobalamin. I am located in the us. Do u know of any publications that can address treatment for patients including dosages that I can show her? My GP. Said she never heard of hydrocobalAmin.
Just eat plenty liver ,or get the nuritional yeast from Sari foods on Amazon .i have nerves isssues from my family as an african we have severe b vitamins deficiency speciLy at old age most of my family, have bad leg or back issue but again bome nerves etc.. one of my Aunt has paykinson im in NY .I USE BENFOTAMINE, NUTRITIONAL YEAST ,LIVER,ALPHA LIPOIC ACID AS WELL,MAGNESIUM ,ZINC POTASSIUM ,VIT D3/K2.I DO LOW CARB DIET AND INTERMITTED FASTING. 2YRS NOW ,more improvement i just went natural eating as much .avoiding gluten sources at best.
Doctors have no clue about health most times.
The best thing to do to improve your health is to AVOID doctors and start learning about the human body and the necessary minerals and vitamins we actually need (e.g. Rezveratrol).
T. Lukács It’s resveratrol. It is found in high concentrations in Japanese Knotweed, Cacao, Pinot Noir Grapes, and surprisingly in Camu Camu berry😁. It is not an essential nutrient although it does confer many benefits to the body such as the activation of the Surtuin 1 genes which are closely linked to life span.
@@bybbah First let me Thank you. 🙏
yes as an African/ American this B12 deficiency is often in our lifetime. Probably because of the people stolen from Africa into slavery. Also the slaves hardships in America. So both continents suffer stress. Important fact why our families suffer. However I believe those other cultures that were not a participant of slave ownership but that knew of the slave trade the traumatic experiences also suffered because they were forced into fear silence and not to speak for African/Americans. No one talks about the innocent ones even in the mist of your own family some still could voice their discernment . That was a double shotgun at them. I love all people . Hopefully we can forgive the unforgivable. We have to find that common ground to build trust and that could still take decades. We have to start somewhere somehow. We are all unique beautiful people.
Yes, hydroxocobalamin is the form we use here in Ireland and presumably the rest of Europe, but the aggressive repletion strategy you were prescribed would have rendered moiety not as important. How have you been since?
Thank you. That helps me a lot
Delighted to hear it! :D
The cyan can was in my monthly B12 injection 1000, but not I just supplement with B12 methylcobalamin
Methylcobalamin on its own may not be adequate, I'd look for a cyanocobalamin supplement if you can!
Thank you for this information. My lab results and my low energy indicated that I needed B12. I wasn't told which form or formula. I took B12 (methylcobalamin), drops, 5,000 mcg. per dropper full, and there was no improvement. 3 days ago, I began taking 500 mcg of B12 (cyanocobalamin)capsule per day with food and experienced more energy within the first 24 hrs. of the first day of taking it. I hope this helps someone.
Don't bother cyanocobalamin vs methyl b there is no difference. Not enough evidence to jump to conclusion. // edit also wanted to mention cyanocobalamin where I live costs a lot for just 10mcg or 20mcg (120 tab)taken double tablets. What I got is methyl b12 800 tablets 100 mcg for almost 10x cheaper in same time 10x
Yes, certainly the differences in effects pale in comparison to a price disparity that big! I would have made the same choice!
What about ckd and Cyanocobalamin
B12 and B17... Cyanide is an important nutrient and I take them daily.
You probably already get cyanide in your water.
Is that what your significant other gives you?
Can a CKD stage 5 patient take 15 mcg of cyanocobalamin daily which is included in b complex
Tablet?
...what are your feeling about the injectable forms...
They are excellent for correcting severe deficiency and for certain malabsorption syndromes, as directed by your doctor. Not needed for maintenance of already healthy levels with normal absorption!
Kindly speak bit slower I am B2 level English Which is not bad and having hatdtimes to cope with you I just made the video x0.75 to be able to listen
You've already solved your own problem
As a vegan can i take cynocobalamim 2.4 mcg tablet daily?
Some people harvest the 'Spirulina' algae at home and sell the tablets commercially. My question - Is such consumption of tablets made from 'Spirulina' algae is safe ? Does it contain consumable vitamin B12 ?
I have not researched spirulina in much detail. The only time I have come across it was during my research on LCPUFAs, for which it compared unfavourably as a source against golden algae. Spirulina is getting super-popular as a supplement and in smoothies and protein powders and stuff though, so I will definitely have to look into it in detail at some stage!
I take a multivitamin that I found in a discount pharmacy for only $6.99 (35 count). Cyanocobalamin works just great for me.
How do you know it works great? How long have you been taking it? I have been using a cheap store brand multivitamin for 4 - 5 years, and in the past 2years seen a slow decline in my health, now culminating in peripheral neuropathy. I cannot say for sure if the supplement is the cause, but all things being the same in my habits, that is the one most suspicious factor. That and possibly the alcohol based mouthwash I have been using for 5 years. The food and drug industries are more than willing to kill us in order to take our money.
Well done on taking control of your health! 💪
I hope you have had this checked out, there is likely so much more at play here than your supplement regimen.
Ckd and Cyanocobalamin?
Unfortunately cyano cobalamins is the form that is added to cattle feed vitamin supplements.
Yes, but that surely that speaks to its efficacy! Just skip the middle cow and take the cyanocobalamin directly!
Thank you! What to do if you have MTHFR mutation?
Then get one that has BOTH methyl and adenosyl.
@@Web720 Thank you!!!
@@Web720 what if you don’t have MTHFR mutation? Would it change if you still take b12 that contains both Adenosylcobalamin and Methylcobalamin?
I intend to cover MTHFR mutations in a video in the future!
Methyl- is best for bioavailability, but real food micronutrients, especially animal-based, will always beat supplements.
Can't get b12 from meat
@@larryc1616animal-based = meat, fish/seafood, eggs and dairy
If you are deficient, then you need supplements
Damn, cyanide and cobalt can’t be good
Don't worry, the amount of both found in these supplements is physiologically insignificant!
What can someone do if they’re allergic to cobalamin?
How do you know you're allergic? It is much more likely that you could have a reaction to an excipient in a particular preparation, in which case you need to try some other brands.
Why didn’t you talk about the hydroxocobalomine?
You just talked about Cyano and Methyl!!! Aargh 😡
This is because it's not usually used in oral supplements due to its inferior stability in these preparations - its main use cases are as injectable B12 and as a treatment for cyanide poisoning. Stick with cyano-!
Very good, thanks. Unlike in the past, now I cannot find any supplement of cyanocobalamin unless it is together with iron and other micronutrients or as B complex, not alone so I have to take methylcobalamin. In recent videos Dr. Michael Greger and dietician Brenda Davis recommend 1000 mcg *per day* for those above 65 years. If you have views on this I would be grateful if you could share. Thanks.
Yes, the specific B12 absorption mechanism is very complex and as I mention in this series is vulnerable to failure as we age. This is where megadosing comes in - of course the small increased cancer risk from high doses is dwarfed by the risk of problems if we don't get enough B12!
@@DrDesHarrington 👍
maybe industry smoke put some extra cobalt atoms in the air and soil for B12 production by the microbes.
Haha, they've certainly managed to pollute our World in lots of other ways! :(
Very disappointed to see you using solgar in your videos, there are much better companies with much better products, they are a company to stay clear of for many reasons.
That aside, great video and i think for those who maybe have been confused, you have cleared everything up, great job Doc.
Can I ask why solgar is a company to stay away from?
@@taeyongisangel have been involved with monsanto, also the poor quality unnecessary fillers they use, are no good to anyone, they are under the umbrella of the Carlyle group which is again a multinational to steer clear of, they used to be a good company but once the father died the son took over and did all sorts with it, sadly people are still attracted to the gold label.
@@hirawstra8edge137
Thanks for the confirmation on that company. I have heard the same . Truth is always going to live.
Hello, thanks for your comment, I intend to return to specific supplements I recommend for each micronutrient in the series before I finish it out. I will bear in mind your points on Solgar, I was unaware of these issues!
My doctor recently gave me that one. B-12 Liquid Drops of 2000. I got dizzy twice and it has cyanide in it. Basically 83,333% of cyanocobalamin. Should I just stop and return back to my other one that didn’t have cyanocobalamin
In india only cyanocobalamin injection are available no manufacturer makes tablet 😑
what? Methy l is everyhwhere in india. It's cyano thats hard to come by.
Hi Harilal, did you ever manage to find a cyanocobalamin supplement? Remember, you could use methylcobalamin and also include other B12 sources in your diet if needed that are fortified with cyanocobalamin like nutritional yeast or plant milks!
@@DrDesHarrington sir i think i have allergy to methycobalamin as whenever i take in oral form the next day my nose starts running and sneezing stays 2 to 3 days.
@@harrypatel1987 Well that won't do! In that case I'd try to source your needs through diet (which is probably the best way if you can get into the habit!) or try to source a cyanocobalamin supplement. It's amazing it's so hard to find in India, it seems to be ubiquitous most places!
What about people with mtfhr mutation gene...will they need methyl cobalamin
I intend to cover MTHFR in a video in the future! Do you have a mutation?
can i take cyanocobalamin with pain killer like co codomol
Yes.
My preworkout contains 400mcg Methylcobalamine. I am experimenting with plant-based diets (eggs and whey, but no meat). Is this okay?
No. Meat has many vitamins like A. Fat is important for liver functions etc. Try keto diet, that makes more sense.
T. Lukács I eat fat and I get my vitamin A already. Why would I try Keto?
@@williammuirhead6927 Because you seemed like on the wrong way of diets and also asked for a confirmation of your acting if it"s the correct way of doing it. Since your answers are confusing than never mind.
T. Lukács I was just asking if methylcobalamine was okay as a sole source of B-12... and I’m managing quite fine without meat, thanks.
@@williammuirhead6927 Alright, than you should delete your 2nd sentence, thanks
Thank you
just because she calll her self a doctor . she must been thinking ..... i am a dr i will tell u it is a lie . i drop the topic then
For me, cyanocobalamin works best, I can't sleep with other b12, I don't know why.
Great you've found something that works! 👍
How about ..10 mg a day is safe
Yes it's probably safe, but it's extremely excessive for most purposes! Unless you're treating deficiency with specific absorption issues, there is no need for a daily dose so high, and indeed given the recently-characterised association between cancer and high doses of B12 you might want to minimise the amount of B12 you take in whilst still ensuring adequacy, as outlined in this video:
czcams.com/video/WjSdALh1YVE/video.html
I heard its human sewage
Hii sir my b12 is 96 very low i take Aden and mythl 750 MCG each with folic acid
Hello, Rahul! Without knowing anything about your background the first thing I would be asking is do you have a malabsorption syndrome? How long have you been taking that dose of B12? Is this a daily dose? There are a number of things that could be causing this discordance between ingested dose and achieved level, but if you have been on this dose for a while and not achieved a healthy level you have to start thinking about problems with absorption. Whatever is going on, this level is too low and should be followed by your own medical team to try and figure out why it's happening, and also to ensure you have a strategy in place to get this level up to a healthier range (possibly by injection depending on the cause).
@@DrDesHarrington I am about to start the doses, my doc prescribed me 1 tablet daily .
@@rahulmojumder6936 Ah yes, I was thinking that would be an unusual preparation for over-the-counter. If you're only starting then just give it time, hopefully that high dose will have you back in the healthy range very soon!
@@DrDesHarrington thanks . I feel very lethargic and tired. Actually I am medical student , so i have done many tests like lft, CBC, amylas e, lipase, usg . All reports are ok then I went to a doc he gave me b12 and d3 tests, my b12 is 96 and d3 is 11 .I am about to start my medication .
@@rahulmojumder6936 Ah, good luck with your studies! :D Yes, you could certainly feel lethargic with that level of B12. Had it affected your CBC? I don't suppose you have access to the holoTC or MMA tests for functional B12 deficiency? That level of vitamin D is definitely too low, as well - check out my current series on vitamin D!
czcams.com/play/PLDwS-3eT1ITE-NonhiqrRFCF64-ytMyF8.html
👍
You are talking too fast, please slow down! I could not follow at all with this speed... ! Especially when showing medical papers and so much medical terminology! If you do, I will be able to understand what was the point of the video...Thank you!
Always trying to get the balance right between talking too fast and not boring people! If it's any help, I always include subtitles with my videos. :)
Poison in the dose is crap, it doesn’t take into account daily exposures to the poison...
This man is sounding as though he's running from someone while speaking!
Haha, how do you mean?