The Complement System: Classical, Lectin, and Alternative Pathways
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- čas přidán 6. 06. 2024
- We are learning about the features of innate immunity, and one that is often overlooked is the complement system. This is a very complicated ensemble of proteins circulating in the bloodstream that activate each other in a specific sequence that results in immune system engagement to kill pathogens. It's quite involved with multiple possible pathways, so this will take a while, but let's dig into this important system now!
Script by Stephanie Melchor
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This is the best video on complement I have seen. I'm not an immunologist or even a student. Just a librarian who is fascinated by the immune system. Thanks!
Wow! You've inspired me...I'm a medical student and find this stuff boring yet you're not even a student but study immunology voluntarily, congrats
@@fidelkipkoech5555 I've always said, I'll stop learning maybe, just maybe three days after I'm dead. ;)
No reason to not study various things, as knowledge is power.
Back when I was in the Army (retired in 2010), I ran into not one, but two cases of pheochromocytoma. One was recognized late, the soldier was to begin treatment after field training, but expired from a ruptured AAA. The other, I pieced together what was going on, asked doctor to do me a favor and run a couple extra tests and there it was, he had pheochromocytoma. His problem was quickly addressed and he returned to duty. So, that trivia can and does save lives. Diagnosing things, just Boolean flow really.
I do Boolean algebra and regular expressions in my head as part of my job. :)
Annoyingly, basic math tends to give me trouble, but that's what calculators or if I had to, fall back to a slide rule is for.
@@fidelkipkoech5555 same this is the class I’m hating the most so far but I think it’s mostly bc my prof is absolutely awful
Beautiful ❤
couldn't agree more- coming from a physician/scientist who's heard many (attempted) explanations of complement systems. this is pure gold. never heard such a clear cut explanation
Professor Dave, I am an MS1(first year medical student) and my first block includes immunology. I wanted to say your videos including this complement protein video are more concise than the lectures from my immunology professor. Thank you!
nibba you didn't have to say anything other than 'first year med'. MS1😵💫
This makes re-reading my immunology textbook nearly painless. Lovely stuff you have.
This and similar courses makes things a lot easier to recognize hydrophobic parts and lipophilic parts of some carbon chains. That helps me understand some odd points in the pharmacology of some medications.
This was the best video I have ever watched about Complement system. Only someone who have left a few minutes left to cover this topic knows how fantastic this work is. Thank you Prof Dave.
you don't know how much you helped me understand this topic. i was on the verge of crying going through our readings but this video really clarified a lot of things (for some reason it seemed like our lecturers were also speaking a whole different language while teaching this). thank you so much!
This is really excellent. Also the speed at which you speak is perfect for people who are trying to understand something, other videos I have to pause and re listen because they’re talking too fast, but this is perfect!
I have an immunology test next week for my first year of grad school--this has been SO much more helpful than anything my professor has said!
I really don't know how my Med School would be without you sir 😭🙏❤️🔥. A Big thanks to you for making my life easy
Thank you so much for this. In my role as a medical writer, I have been doing some programs on paroxysmal nocturnal hematoglobinuria, which is a disease of the complement cascade. This clearly explained a lot of the things I was confused about.
Very detailed and direct illustration and description. Learn more from these lectures. Thanks a lot.
no words. simplistic way to teach complex theory with best illustrations. thank you. Best video on this topic.
This has been really helpful. I've been struggling to understand the complement cascade but with how you've laid everything out, I'm subliming..
.. Thank you so much
dude you just cleared the evolutionary aspect of the complement system, great job👍🏻
Your videos are amazing, makes immunology easier, making my day😊 Thanks Professor wish u all success.
Professor Dave.... This video is great. It helped me understand the video much better.
I really appreciate the evolutionary context. Really outs things into better perspective!
Thank you so so so much! Amazing explanation and illustration! Thank you for your effort.
Love your teaching skills to visual learners. You make studying easier 🥳🥳
How am I supposed to memorize all of this?
Your videos are so helpful to me, thank you🙏🏻
I've been a subscriber since 2016. It's amazing how easy you make things seem easy for us❤❤❤ Lots of love Professor!!❤️
Hey Professor, I understand almost everything you explain so please start makin videos about music theory and all. You're the best teacher ever.
He knows alot about the SCIENCE stuff, unfortunately music theory is not a science.
Very comprehensive with just enough detail for competence but not too overwhelming!
Just on time for my quiz on this topic!
Great video. I am a pharmacist trying to help my patients with Long Covid and appreciate the excellent education here.
Saw so many videos.. But finally got clarity in this one
I had to learn all this a long time ago. Thanks for the update.
@Professor Dave Explains, I have come to purchase your book through my enjoyment of your CZcams content. I must say that I find it very insightful, succint and a refreshing read overall. I look forward to more from you, as you definitely posess great talent.
P.S.: on page 18 there is a helium atom representation with the subtext implying that it is in colour, when in fact at least my edition is grayscale. Just a (hopefully) helpful note.
Thank you thank you thank you, was not understanding this from textbooks or my lecturers! your videos are the best!
Very well explained. Thank you!
really made such an intimidating topic so easy to understand! thank you Professor Dave :))
Really good review of the complement system...
Thanks for posting!
This amazing! and easily to follow, thank you prof Dave
Excellent video!! I have a better understanding of the Complement system now. I'll recommend this to my classmates to watch. 👏👏👏👏👏👏👏👏👏👏
Extremely good video about Complement, saved me. Thank you!
Excellent sir. You are doing extremely well. This is really great and highly explanatory, infact completely.
Animal immune system are really well made... Amazing presentation!
Superb explanation on Complement System. I love this video
WOOOO YEAAAH, BABY THAT'S WHAT I'VE BEEN WAITING FOOOOR WOOOO!
Oodles of thanks, Professor Dave.
Thank you so much for the explanation!
Thank you for helping me learn our lesson in Serology
ur awesome and this is the best video on complement i have seen
thanks for making this video.Very helpful.
Thanks professor Dave!
Well done Dave! 👏🏽
Great explanation , thanks 💕
This is amazing. Thank youuuu 😍❤❤
Great presentation on complement pathway!
Really great job, thanks a lot!
I would like to give you a huge thank for this video! you saved me fr
You're doing really good. Best wishes
Great video Professor!
BEST EXPLANATION EVER!!
It is very helpful. thank you so much
this vid is superb, it's best for understanding
Just the best I heard about the compliment system , long live
Thanks...Great knowledge..
I'm so glad that you're making these lectures. I considered months ago that the US population (from high school and up) needs to learn how the immune system works. If we know how the immune system works then we will all understand and agree on something like a vaccine. Thank you for spreading this information.
Indeed, the problems with COVID seems to be that leukocytes are being infected, interfering with their response, while innate responses are also being blunted. By the time the immune system notices that the infection was unaddressed, it went into scorched earth mode (to oversimplify it by a lot) and that's the cytokine storm of COVID-19 and the Spanish Flu.
You are so spot on! If more people understood immunology, we would haver far fewer ridiculous conspiracy lies circulating about vaccines!
Really good!
Very explicit and comprehensive.✌️👍👍
Hey, really like your videos, especially the ones where you debunk conspiracy theories. I recently saw something about Tesla's radiance energy curcuit. It is suggestet that this would be able to supply everybody with free energy but companies dont want us to know about it because we should pay for their energy. Maybe that could be a video idea. Keep on the great work!
Thanks for the complement
this is amazingggg thank you!
You're a God send
Save my life!!! Thank you!!!
Professor dave I learned a lot from this video, but I have just one question.
I know that there are a variety of proteins that regulate the complement system. Some of these proteins like C1 inhibitors displace and inactivate many proteins.
however,
Do any bacteria produce these proteins as a defense mechanism
Thank you professor ✅👍🏻
How can one fail to subscribe. Best video on Complement
great video
Amazing video
Your videoes better than faradars immunology course
Prof Dave, Could you please make a video on test for gases in chemistry.
Wow loved it
Great video.
This has been so helpful. MY TEXTBOOK uggg!
So currently, 12/10/2022 has C4b2b been officially adopted and is now officially used or is C4b2a debatable?? Prof please?🙏🙏
Thank you so much
My man has the best intro ever 👍
great job!!!
better than my uni lectures!!
Super helpful!!!!!
Can't thank you enough..🙏🏼
best video EVER
thy so much! so clear
Thank you very much❤❤
Thank you❤
Thank you sir🙏
Thankyou thankyou sooo muchh !!!
Thnx for this video
Damn
Man just explained the gibberish in my Professor's slide perfectly.
Ready for this exam now.
Best video ever
Excellent video! so helpful.
I have one important question: do these processes work like shown with viral pathogens? These examples showed microbes with a cell wall (I think?) but I don't know if virus wall works the same for this purposes.
good point! Not sure if the complement system is as effective against viruses as it is with bacteria and fungi. Anyone shed some light?
thank you
Thanks!
I am a licensed medical technologist and I'm studying for my second license this coming October. Complement system always ALWAYS aggravate the shit out of me. This lecture gave me atleast an idea what to remember 😅
Thankyou somuch
Prof for a reason
Sorry sir i don't know if EAC1qrs is a part of C3 convertase?
Is there any way you can explain a bit about alzheimer and things in that way, i have it in school but i don’t really get it