Cytokines and Chemokines
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- čas přidán 7. 08. 2024
- We've talked about how immune cells communicate with one another using cytokines and chemokines, but we have not yet gone into detail regarding these soluble protein signals. What are the names of these molecules, which include interferons, interleukins, tumor necrosis factors, and more? What do they do specifically? Let's take a deep dive!
Script by Stephanie Melchor
Select images provided by BioRender.com
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9:24
(TGF-β) - Transforming growth factor beta
Great stuff. In college I got to take an immunology class from the guy that discovered Interleukin 1 which was pretty cool.
We all know how the saying goes:
The more from Dave, the better the day.
Eid Mubarak professor Dav
Love that 😂
i am like prof after watching prof dave
This series has been a heck of a journey, Dave. Looking forward to your insights on innate immunity! Thanks so much and have a glorious day.
This was very timely for a paper I’m currently working on
Thank you so much for the explanation of the nomenclature.
Thanks dave for providing information to my studies
Swipe, swipe, swipe, swipe... heheh funny, swipe, swipe, oh Professor Dave just posted! Finally something worth watching!
Bdfu
TGF-beta (9:25) should be transforming growth factor-beta, not tumor necrosis factor right?
I believe so-- I thought it was a typo to begin with, but when I heard him also say it in the script, I figured he must've meant it. I did some searching, thinking TGF was a synonym for TNF, but was still confused at the change of letter. Came to find what you had commented about, and wanted to add that TGF stimulates the production of extracellular matrix (ECM) fibroblasts, whereas TNF has anti-fibrotic activity.
source: www.ncbi.nlm.nih.gov/pmc/articles/PMC8766837/#:~:text=TGF%2D%CE%B2%20can%20stimulate%20the,TGF%2D%CE%B2%20(86).
If you are a student and watching this,
''HE KNOWS A LOT ABOUT THE STUDENTS' PAIN
PROFESSOR DAVE EXPLAINS''
Watching before exams, surely deserves this channel. Thank you professor
Thank you Dave
THANK YOU SO MUCH DAVE EXPLAIN OH God INCREDIBLE EXPLAINING
Nice video sir you make microbiology easy 😊
Thank you sir
Good to know that not everybody on CZcams is completely incompetent nowadays. Keep up the good work, Dave.
Dear Dave I enjoyed this video I would hear some explanation about the details of this classification of cytokines and their roles in detail through mentioning any articles as ur reference.
Please share the details of the information you have mentioned in this video.
Thank you 😊
thanks very much!
Thanks!
At marker 9:45, TGF-Beta should be "Transforming Growth Factor-Beta", not Tumor Necrosis Factor-Beta
I was also thinking this! Came to the comments to point it out. Thank you for pointing this out, too
thanks to you !
Thanks 🙏
Thanks . 😍
Thank you Professor Dave! I love your videos, you are so clear and precise. Regarding this video, I found it hard to follow, I have the basic knowledge of chemistry, biochem, biology, microbiology, is there some basics one should study to fully understad and easily follow this video?
Thank you as always for your work😃
try crash course immunology to start
@@byjohar thanks
Preparing myself for university.
Currently in university
Oh my. you could write a textbook with this stuff.
Great video! When a chemokines come in contact with a ligand, how does the cell know where to go? Does it have a gps of sort or does it roam on autopilot in a certain direction until it encounters another chemokines? Thanks!
The cells utilise chemotaxis, which means they move towards the area where the concentration of chemokines is the highest. This happens because if you imagine the cell as a sphere with chemokine receptors uniformly spaced out all across it, the area that is facing the highest concentration of chemokines will have the most receptors activated. Therefore the cell will move according to this asymmetric activation of these receptors, moving towards the side that has the most receptors activated.
@@JG-lf6mk wow this so cool
At 9:35, TGF beta should stand for Transforming Growth Factor beta
I figured somebody else caught it 😉
love you professor 😘
Nice
could you please put this in your immunology playlist?
It is in there.
It may not have to do with the subject, yet I´ve gotta ask, where did you buy that Led Zeppelin picture frame, which you could see in some of your videos? Btw, keep up that great science-content, and take and time and rest if you need to :)
Oh I just got the poster online somewhere for like 12 bucks, then took it to the frame shop!
In d last vid u said th17 Cytokine is named so as it's dominated by 1L-17 which is u said cxcL8 (cxcL8=1L-17)
But here u r saying cxcL8 is = IL8.....
Pls clarify
TGF is transforming growth factor not tumour necrosis factor
GOOD
Could you confirm if you meant to say 'Inflammatory bowel disease' instead of 'irritable bowel syndrome' at 7:58?
make a video about lipid nanoparticles in covid vaccines
Ah big words! My brain is not available now!
why am i not able to watch the next videos in the series? :/
to be released soon
@@ProfessorDaveExplains thankyou!
Dude dave its summer time take a break big boy
Pulling back to one video per week is a break for me!
Professor Jesus helped me again in my exam preparation
you made a mistake. TGF-B is not tumor necrosis factor
3:36
I hope
👍
I couldn’t get the function from it 😅
Looks like the TGF beta has to be tumor growth factor Beta.
Transformating Growth Factor, not Tumor
I didn't know Cr1TiKaL had a science based channel.
he looks similar!
Dave, are ghosts real? Just askin
Can you tell how to do 73/4 divided by 62/5+8/3 plssss 🙏🙏🙏
Its advanced version beginners can't understand easily without proper basics of immunity
You have to start from the beginning of the immunology playlist.
@@ProfessorDaveExplains thankyou sir 🙏🙏🙏🙏🙏
Love your content, but way too high for this video rn. I'll be back later
This is quite off-topic, but i have to ask.
Let's say I have a rifle of an arbitrary caliber, with two wire-like extensions on the front.
Is it somehow possible to shoot out a bullet, and electrify it using those extensions, without the bullet touching anything in the process?
Earlyyy
Why do I watch these...?
Because knowledge is power. Hide it well
Because it's pretty awesome
debunk gematria
booooo 👎