The Complement System | The most COMPREHENSIVE Explanation
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- čas přidán 14. 01. 2022
- The Complement System. The 3 complement pathways are the Classical complement pathway, the Alternative Complement pathway, amd The mannose/Mannan-binding lectin pathway...Complement proteins (C1, C1q, C4, C3a, C3b, C5a, C5b, C6, C7, C8, C9)...Termknal complement is the membranes attack complex (MAC).
B-Cell (B-lymphocyte) Activation and Class Switching | Immunology | Physiology Lecture Series (Medicosis Physiology Playlist)..
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@@phonytexts2 sweet! 6:30 ho!y sh!t no I can't bear compliments!!!!!
Thank you sir!
ALMOST 1 MILLION SUBs !!! YeY
if you see a medical student saying im going to study and YET find him smiling while staring his phone or laptop..
.its not always tiktok videos he has been simply Welcomed to the famous world of medicosis perfictionalis❤️
Wow 🤩
Thank you ☺️
Sir, can I just say that you're carrying me to finish my Medical Laboratory Studies. I'm so thankful mate. You're really helping me achieving a dream here.
My pleasure 😇
This what I love to hear!
Good luck 🍀
Omg. That’s literally why I’m watching this video haha. My board is coming up soon
Same!!
I just found this, but same!❤
Can you update me about your degree like how it's going?
Note: C2a is the old name, now they call it C2b (it’s still the same protein).
Got it!
This one answered my question while watching the video because, in our book, C2a is used. Thanks for the clarification
C2a didn't change the functions is unknown thts why c2b is mostly considered.
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Some of your metaphors have me laughing in the middle of the library- and during exam season too! Thank you for making everything super digestible!
My pleasure 😇
How was your exam?
whenever im cramming for an exam (it's not like i want/like to cram, our school sched is so tightly packed), i always watch your lecture videos, and im able to understand AND RETAIN the topic SOOOO quickly in my head! thank you so much!! you make studying medicine seem so easy c: and i love the puns too! haha
Thank you so much 😊
Good luck 🍀
Never understood properly during my college days, scrached my head many times, but now understood in just 5 minutes, wonderful presentation, hope I had a professor like you
Thank you so much 😊
I am honored!
You are such an amazing teacher!!! Could you please do more lectures on immunology? It’s a hard topic but you explain things so beautifully!
Thank you so much 😊
Just wait for the upcoming videos :)
Omg ! The past few days medicosis has been uploading videos that are in line with what I am currently doing at medical school! This is amazing!!
Awesome 😎
Thank you so much 😊
I’m taking an immunology test soon and a video by medicosis to get me through this scary lesson is just a life saver!! Thank you so soo much!
My pleasure 😇
Good luck 🍀
@@MedicosisPerfectionalis thanks!
You’re welcome 😇
I swear this video was good and effective for me, especially since I have a final exam in the immune system, and I did not know how to study this lesson.
Thank you for being here, Professor💕💕
Glad it helped! I wish you all the success in the world!
FINALLY you did it !! what an amazing video covering all horizons (even that bridge thingy) btw some books mention C3 convertase of classical as C4b2a why is that so ?
There is some disagreements on the nomenclature of the complement proteins between different books written in different points in time.
Awesome content!! Was wondering if I could add another topic on your never ending list of request - a video on haemophagocytic lymphohistiocytosis? Appreciate all the learning you are facilitating here!
Thank you for letting me know!
Love your lectures and tone.Especially the tricks for remembring the stuff are awesome.....Love and respect from Pakistan🍀🍀🍀
Thank you 🙏
You are an amazing teacher ❤️.. love your videos and how you describe them with so much ease and with such beautiful examples which we can remember
You are so welcome!
Sir you're such a life saver! love and respect from Algeria
Thank you 🙏
I was thinking why I, as a medical student, study this subject, but after listening to your explanation, I realized the importance of this subject to me as a medical student, thank you Doctor
My pleasure 😇
iam travelling the whole world in your channel
from anemia to blood indices to this
the journey never ends
Indeed:)
Thank you so much for watching!
Me too
Sir, my lecturer never give this kind of way learning. Like its hard to connecting the dots from things he explained. But ur video really help a lot. Thanks sir❤
you are a genius i like when you mention philospher in your presentation but what i liked the most how you putting us in the big picture first and how you connect all systems and subjects to make information usfule and having a sence you are an artiste god bless you
Thank you 🙏
I was trying to study it within 3 days and I did not understand it. Now I understood it in just half an hour. You are truly amazing.❤
Thank you!
The same energy.
It reminds me of the time when I studied hematology with you. ❤ Thank you
You’re always welcome!
I appreciate you!
Would you please help me by sharing?
@@MedicosisPerfectionalis
Already shared with my fellow 💕
this guy is so whacky but i am HERE for it. Really funny and thorough explanation. thank you medicosis, you might have saved me in this fridays exam!!
Thank you ☺️
Many thanks from Egypt. Please, continue this work.
Thank you, I will!
I learned the C system before. Thanks for providing a different perspective!
My pleasure 😇
@@MedicosisPerfectionalis I’m looking into C5b wrt to COVID and clotting in severe hospitalized patients. Amazing how everything ties together eventually.
I’m not a doctor, and I understand that the video includes “a” and “b”.
My labs just say low 3 and 4.
Not being an MD, your presentation was well written, and easy to follow/understand.
I can't believe you taught me the thing like bread and butter what I was unable to understand for past few months❤❤❤loved this video
Thank you!
Another brilliant video. Thank you for teaching me.
Glad you enjoyed it!
And here I am studying immunology, and guy really says do not go to sleep yet... just what I needed 😫
I love Medicosis perfectionalis, it appreciates the ♥️ that I am, the bright colors and illustrations, this is my Science way😁🥰
Thank you 😊
I am honored!
You need to make a video teaching us how you manage to memorize and integrate all this knowledge and some philosophical aspects
Super always I will see all ur videos thank u so much for great videos
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Have been waiting for this!
Thank you 😊
Did you like it?
OMG! I LOVE THIS CHANNEL!!!
Thank you so much 😊
Thank you so much for the easy explanation sir..But can you tell me what is significance of H2O which is with C3 in Alternative pathway?
How do you make it so easy to understand?!?!? Thank you it's so helpful !
Thank you 😊
You made this easy to understand thank you 🙏
My pleasure 😇
how the 2nd exposure we use classical pathway who requires an antigen-antibody complex and in the 2nd exposure there is no antigen antibody complex ?
what is the video of you called about inflammatory mediators? i cant find it
thank you for you work tho! im preparinf for an exam
Thank you very much!!!❤ GOD is using you to help countless medical students
I just noticed you now but iIlike you already, it helps me more.
I appreciate you so much!
I like your voice and delivery style!
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That was so helpful thank you❤️
My pleasure 😇
You’re amazing.thank you so much :)❤
My pleasure!
Thanks a lot for ur video ur explanation is awesome it helps me a lot to understand
My pleasure!
When C2 binds to C4b C2a remains forming C4b2a and Cb leaves as anaphylotoxin...Thanks for the lecture u r
Lifesaver 🥰
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
@@MedicosisPerfectionalis Oh thanks
Thank you very much from Egypt , could you tell me a book or any source that may help to identify the best investigation for internal medicine diseases ?. We know all investigations for each disease but we can't identify the best investigation .
Thank you 🙏, Ahmed!
I don’t think you can learn this skill in a book. What you want belongs to “mundane knowledge” (based on trial and error, personal experience, clinical skills,…etc), and not something that can be taught in a theoretical book, at least in my opinion.
This is analogous to
a young car mechanic asking another mechanic: “what book do you recommend so that I can recognize the best way to diagnose a car issue.” To which the mechanic answers: “only experience can teach you that.”
So the best thing I can say is: “find a good doctor and shadow him…observe carefully…and take meticulous handwritten notes.”
You are an amazing person....Thanks very much
Thank you 😊
Now it makes perfect sense 👌 🤩🤩🤩love from Philippines 🇵🇭 💕
Thank you!
Thank you sir for this perfecto explication 💙
But I have a question please
The c3 convertase in the classical one , is it c4b2b or c4b2a ??
C2a is the old name, now they call it C2b (it’s still the same protein).
I hope this helps!
Why C1 Esterase is an inhibitor?
DO you mean that if it is present so the first step in inhibited?
I have a question on the part that say bridge between innate and adaptive for first and second exposure looks same which one need antigen antibody complex
The 2nd exposure (no immune complex)! How can this activate the Classical pathway?
Does a always leave the cascade ? In my textbook in some places b leaves and a stays altering the convertase formula iyk what I mean 😕
you’re saving my grades. thankyou so muchhhhhh
You’re very welcome 😊
Would you please help me by sharing?
You guys are good, you make me laugh while learning
Thank you 🙏
Love your videos 🌼 😁
Thank you 😊
Love ur videos!
Thanks a ton!
thankuuuu for that breakdown!
My pleasure 😇
Thanks for the most beautiful and excellent explanation
You are very welcome!
Simply, Thank you.
My pleasure 😇
I have a question? I received my Complement C4a blood test, it is extremly high 1100.1 Could you please explain why? Thank you
Sir I think the C3 convertase in lectin and classical pathway is C4b2a, not C4b2b. Thank you for the great video btw!
C2a is the old name, now they call it C2b (it’s still the same protein).
never thought immunology could be that cool !
Thank you so much, Nomidia!
I appreciate you!
Would you please help me by sharing?
So useful .. so interisting
Thank you 🙏
thank you so much for this
Love your videos! I believe C2a is the one that takes part in C3 convertase not C2b…
This specific protein was called by different names by different textbooks in different eras of history (C2a and C2b).
sir, can you educate me in this?? Most of the text books even my uni lecture notes say that C4b and C2a combined and produce C3 convertase.. But in your video you have explanied all the "a" parts are leaving the cascade?? what's the correct one? I'M CONFUSED??
C2a is the old name, now they call it C2b (it’s still the same protein).
Isn't C2 an exception thus 2a will join the MAC?
you made me so adaptive to your videos i dont Understand any pther person's explanation!!! can u make videos on gynae obs more for post grad?
Thank you so much!
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@@MedicosisPerfectionalis omg thanks!
Best channel ever 👌
Thank you so much!
thanks for sharing your nice information
Most welcome 🙏
Thank you for making my life easier….and that MAC and Attack..😂😂😂
My pleasure!
Excellent video
Only a small mistake: C3 convertase components in classic and lectin pathway are: C4b2a
NOT C4b2b
It was named c4b2a until scientists decided to change to c4b2b for “consistency” reasons
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
great explanation🙌🙌👏👏👏
Glad it was helpful!
why do you have that there is no antigen antibody complex under second exposure? I thought that was supposed to be for the first exposure.
i think there is a mistake in slides
Bro
C3 convertase and C5 convertase k formula me 2b ki jagah 2a nhi aayega kya?as in case of C2 the bigger fragment is specified as C2a
C2a is the old name, now they call it C2b (it’s still the same complement protein though).
Thank you!!! :)
You're welcome!
Thx very good ❤️🔥❤️🔥❤️🔥
My pleasure 😇
10:50 That WAS beautiful. Love your videos, maybe I should like them too..
Thank you 🙏
Superb !
Thank you 😊
12:44 C5b it’s a part of the MAC and the MAC will attack , I love it 😂
:)
Best explanation of the complement system
Thank you 🙏
Thanks I was really not in the mood for another huge lecture to do, talking about the little spice ( jokes u made xD )
Glad I could help!
Sir , I am from Yemen, could please tell me do you have all internal medicine videos, and how can i get all your full video
Yes! Go to “playlists” here on my CZcams channel.
Thank u man✌️
My pleasure 😇
Well explained
Thank you 😊
Thank you ❤
My pleasure 😇
Thank you so much sir
Most welcome!
Thanks a ton
Most welcome!
Hi Medicosis! Is it not C3 Convertase supposed to be C4(B), C2(A)? Thanks btw!
Im confused coz there are references that say C4B C2B. :|
C2a is the old name, now they call it C2b (it’s still the same protein).
Medicine makes perfect sense here !
Thank you!
@@MedicosisPerfectionalis Sir 🙌
I enjoy your videos medicosis 😂😂
Thank you so much 😊
thanks so muchhh
My pleasure 😇
Thank you.
My pleasure 😇
Hope we can have a tip for immunoassay
I am afraid I didn’t understand!
@@MedicosisPerfectionalis I mean a explanation about the immunoassay
Great👍👏😊
Thank you!
i wanna see your face. u r just a best medical teacher for me
I appreciate you so much!
Guys, we have the Best Teacher Ever.
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🤩🤩OH YES HE DID,
OH YES HE DID!!
:)