10 TIMES MORE POTENT Than NMN - What Is NMNH?
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- čas přidán 8. 12. 2023
- Professor Riekelt Houtkooper presents about NAD, are there any proof of NAD decline in human and introduce a new reduced form of NMN which is called NMNH in this video.
www.ncbi.nlm.nih.gov/pmc/arti...
faseb.onlinelibrary.wiley.com...
www.biorxiv.org/content/10.11...
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DISCLAIMER: The information and opinions expressed in this video are for informational purposes only and are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor or other qualified health provider before start taking any supplements.
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where can i get nmnh ?
This is the first time youtube has recommended one of your videos to me. I really like the way you present the information. I subscribed.
A fascinating presentation on NAD and its derivatives! The discovery of NMNH as a new player in this field, boasting a potency ten times higher than NMN, is groundbreaking. Seeing how this molecule could revolutionise our understanding of cellular metabolism and ageing is intriguing. The potential applications in combating age-related decline are immense. However, the stability issues and the need for clinical trials highlight the journey ahead. Eager to see where this leads! #ScienceBreakthrough #NAD #NMNH
00:18 🧬 *NAD is traditionally known as a co-factor in energy metabolism and has a balancing role with NADH.*
00:31 🔬 *Recent research suggests NAD plays a broader role, acting as a substrate for various enzyme families and influencing multiple cell reactions.*
01:12 🌐 *NAD is estimated to participate in over 500 metabolic reactions, impacting nearly all cellular metabolic processes.*
01:51 🏃♂️ *Study involving muscle biopsies from different age groups and physical activity levels shows variance in metabolic changes.*
03:39 🔍 *NAD levels are significantly higher in younger individuals than older ones, indicating age-related decline.*
04:34 🚴♀️ *Athletic older adults maintain higher NAD levels than their less active counterparts, suggesting a link between physical activity and NAD abundance.*
05:43 🧪 *Various NAD precursors are being explored to restore NAD homeostasis, with nicotinamide riboside and nicotinamide mononucleotide being key focus areas.*
07:44 🆕 *NMNH emerges as a new and potent NAD precursor, potentially more effective than the well-known NMN.*
11:39 🐁 *In vivo studies on mice show NMNH significantly elevates NAD levels compared to NMN, especially in liver cells.*
13:40 🧓 *NAD decline is observed across various organisms, including humans, and is associated with overall health status.*
14:49 💊 *Challenges exist in translating these findings into clinical applications due to stability issues and the need for encapsulation techniques for effective delivery.*
11:39 key point with the in vivo studies was that the NMNH was injected instead of ingested.
@@PackBjammin Interesting point about the delivery method. Injecting NMNH might indeed offer different benefits compared to ingestion. It’s crucial to understand these nuances for optimising therapeutic approaches. Thanks for highlighting this.
NMNH is very new and not well studied yet, and it's not readily available in supplements, that being said, it is much more bioavailable and efficient than regular NMN.
Not a scientist, but I see 2 problems with this that aren't mentioned. 1. NAD+ and NADH are counterbalances like omega 3 vs. omega 6. When people discuss low NAD+ invariably that person has high NADH. The process described increases NADH and forces the body to produce more NAD+ as long as you have enough of the dismutase to convert it. No mention of the level of NADH is mentioned after the dosing. 2. The dosage used on the mice is 250mg/kg several times a day. Amazon has this on sale for 250mg for 2 pills. If taken 2 times per day at this dosage it would cost well in excess of $100 per day and about 150 pills. Maybe Bryan Johnson can give it a try for us.
Touche'
I've had my doubts about this channels " research" as well...but I'm patient.
hmm i didnt know this about the counterbalancing nad+ and nadh, could this explain why i have intermittent results with nr? specifically ive found that tru niagen or pure nmn to be extremely uneffective for me, wheras life extension nad regeneator which contains quercitin and resveratrol elite is much more effective, but even still, i have days where it makes me feel werid for a couple of hours before the benficial effects start to kick in.
@@Vgallo get better results from NA..nicotinic acid. Look for relevant data and research.
Omega 3 and 6 aren't counterbalances omega 3 is 1/3 the size and flexibility of omega 6 but they are both the same outside of that
@TheAnzack
On good authority...I've been taking 1 gram each of L.cysteine, taurine, glycine and TMG daily with an adjunct of real niacin ( nicotinic acid) and my body produces the needed NAD.
3 friends ( 69/ 63 + 47) on the protocol that have a flushing response take niacinamide with similar results. This protocol bypasses the BS and gives you what you need.
64 yo and twice the energy and health I had prior.
Cheers
Doesn’t mention that NMNH is cytotoxic in small doses
10 Times so just need to take 100mg instead of 1g but get same effects, pretty cool!
Injected though, right?
You'll want to take an electron acceptor with it, or it can cause issues.
Hold your horses 🐎, sharp Increase in NAD may be harmful, it's better to stay in the youth physiological levels
Where does one buy NMNH? I’m, thus far, unable to find it from a reputable source.
Bontac Alibaba. 1600 USD/100g.
Donotage - is fine to buy at.
@@beritmunk1275 They dont have NMNH!!
@@karelorel2405 I said “reputable”.
@@beritmunk1275 I was only able to find NMN and NR there.
Great!! Just tell me where to get it and how much to take..........for those who aren't "big brained"
Does it increase blood sugars like reported with nmn
so where do you get it from
"NMNH" 🎶 ... almost like that Muppets song ...
😂
I just knew little. Can you let's me know take how much take max every day NMNH ? Can I take NMN with NMNH ? Thank you for your help.
What about nad+?
Did you use the salvage pathway?
Salvage pathway is the KEY! NMN falls short and that is why the decline happens so quickly. I don't think the NMNH fixes the SP which means when it clears out of the body the levels decline but on a much slower pace.
@richie1416 Without the salvage pathway it's once and done. It has to be re-oxidized. Oxidation means loss of electrons. NAMPT, methylation, and blocking CD 38 are the three steps. Also EGCG blocks NNMT which eats up Methyl like crazy. 1 Quercetin and or R alphalipoic acid, 2 TMG trimethyl glycine, 3 apigenin from chamomile flowers, 4 EGCG from green tea.
@@markfischer3626 💙
i am exhausted trying to follow and keep up with these reverse aging videos. it is tedious and difficult to follow since i don't spend my days in a lab with the stuff. and who do you trust? some day they may be worth listening too but so far i am unconvinced. what is the point if you can't get nmnh?
I assume you are confused with what food to eat also
What about NADH supplements?
Thata what I want to know.... I have been taking it for over 2 years.... NOW brand NADH and feel great! Haven't had any testing however....
This video is very confusing. NADH is the non-oxidized version of NAD+ and the low ratio of NADH:NAD+ is highly correlated in torpor and obesity. The slide at 10:30 shows NMHA as a precursor to NADH, which would seem to drive down that key ratio but all the other slides claim NMNH increases the levels of NAD+. There’s some gap here that’s not well explained. Can you please address this in a later video or in the comments? For those looking to understand the NADH:NAD+ ratio please view Brad Marshall’s videos at his Fireinabottle channel.
@@samanthaporter6662 hi where do you buy nadh?
What does it do for a person?
You get to choose 1 super power: fly, be invisible, time travel, mind reading, super human strength…
@@hansgullickson4080
Decisions, decisions...
Wow, that sounds GREAT, I'm gonna get some! ROFL
Sarcasm and wit is a virtue, never lose it! @@hansgullickson4080
65 yo 22,000+steps
Are you even remotely serious? if this is similar to NADH then I DO NOT want reductive stress in my fused mitochondria running on stearic.
Nmn+레스베라트롤 대신 nmn+nmnh조합인가 아니면 특허 분쟁 피할려고 nmnh를 탄생시킨것인가 지금 nmn이 은보다 비싸다 시간이 지나면 금보다 비싸질까봐 겁난다 젊어질려고 평생먹고 평생 일하며 살것같다 자본주의노예인생 ㅋㅋ
impaired older adults who take over 6k steps a day?
🤔
6k steps, what is that going to do for you more then make you tired. Its not like you are lifting heavy weight and trigger hormetic responses
i am a senior and i get no where near 6000 steps and by no means do i consider myself impaired.
" ...research suggests" or narrator strategically guides😂
sounds sketchy