The Problem Of Taking A NAD Precursor Alone | Lead NAD Scientist Explains
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- čas přidán 26. 07. 2024
- Dr Nichola Conlon presents about how to use a Multi-Target approach to restore our youthful NAD production. Why NAD precursor alone cannot fix the root cause of our NAD decline in this video.
Dr. Colon's Papers:
A systems-approach to NAD+ restoration
www.sciencedirect.com/science...
The Role of NAD+ in Regenerative Medicine
www.ncbi.nlm.nih.gov/pmc/arti...
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular ageing. After a career in drug development with a leading biotech firm, Dr Nichola founded Nuchido Laboratories driven by her belief that cutting-edge science should not lie hidden.
Dr Nichola is on a mission to democratise science and is an expert in cellular health, with particular focus on the science of ageing well, helping people to reverse their biological age and improve their healthspan. Dr Nichola’s work to translate recent scientific discoveries into interventions to increase healthspan and vitality recognizes that while great progress has been made in treating age-related ailments, the focus now must be placed on reducing the burden of these diseases as we live longer lives.
Along with leading scientists at Nuchido, Dr Conlon has identified the optimum combination of targets to restore cellular NAD+ production back to youthful levels, leading to the development of a breakthrough NAD+ booster called Nuchido TIME+.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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She did not explain HOW the "factory" is updated, how was the underlying mechanism(s) of faulty NAD fixed or improved in order to make a better use of precursors such as NMN and NR.
Hi, we have several blog posts on our website which go into further detail about how the ingredients in Nuchido TIME+ work to restore the cells ability to make and recycle NAD+. In summary Nuchido switches back on the NAD+ recycling system called the salvage pathway which is the main source of cellular NAD+ and it also inhibits inflammatory molecules CD38 which is known to increase with age and waste vast quantities of NAD+.
I had just read up on the benefits / super power of parsley, but that other plant ingredient I have not heard of, will definitely be researching that. Everything else is in my regimen.
She explains scientifically why NAD levels decline with age and how restoring them could have anti-ageing effects. This builds credibility.
The data she presents on increases in NAD levels and related enzymes in people taking their product looks promising.
Her analogy about supplying raw materials to an inefficient factory makes intuitive sense.
The company appears to be using systematic drug discovery methods to identify ingredients. This is a plus.
As she is the Lead Scientist for the company, she has an inherent bias to promote their product. More independent validation would carry more weight.
The specifics of their "multi-target" formulation are lacking. What exactly is in it, and how do the ingredients work?
While the short-term blood data looks good, long-term clinical trials on human health and ageing effects are needed.
She provides little detail on the participants in the study - sample size, demographics, controls used, etc.
There is no data on real-world customer experiences and satisfaction.
Exactly. This is just a sales talk
@@sansabh Yes.
Obviously the ingredients are proprietary.
@@juliahello6673 I appreciate you sharing the transcript and context. The presenter makes some interesting points about the potential limitations of using NAD precursors alone to boost NAD levels. As you mentioned, the specific ingredients in their multi-target formulation are proprietary, so it's difficult to fully evaluate their approach without more details. However, targeting multiple mechanisms related to NAD metabolism does seem like a promising strategy. I'd be curious to learn more about the research behind their ingredient combinations and see some long-term clinical data on safety and efficacy. While the short-term NAD level results she presented are intriguing, longer-term human studies will be needed to determine if this approach translates to anti-ageing benefits. Their methodology of using systems pharmacology to identify synergistic ingredients is fascinating. I look forward to seeing this field progress as more research emerges on optimising NAD levels for health and longevity.
Hi, this is an older presentation, we have since conducted a bigger randomised, double-blinded, placebo-controlled crossover clinical trial the results of which can be viewed on our website. The full ingredients and their mechanism of action are also detailed on our website and blog. Dr Conlon also recently published a peer reviewed paper explaining the systems approach used in Nuchido TIME+ in more detail - Conlon, N., & Ford, D. (2022). A systems-approach to NAD+ restoration. Biochemical pharmacology, 198, 114946.
Ha... That's exactly what I do. Multi systemic approach.
I use L-tryptophan as it is part of the same pathway.
I use luteolin, rutin and quercetin phytosome and apigenin from parsley for activation of CD38.
I also add Inositol Hexanicotinate as it releases slowly, and doesn't cause a flush and I get the benefits of Inositol. I do also take som berberine TMG as they too work synergistically with the rest together with L-theanine.
Been doing it for some months now and it feels better than just taking NMN.
Next I will try adding in the version of NMN that Renue makes to see.kf I can boost the effect even further.
I actually find nr to be better than nmn, but both are intermittently effective for me. Like 1/4 days and most days makes me feel crappy, even with tmg supplements, now I finally understand why.
What’s that inositol you mentioned?
Seems like I would benefit from something similar to your approach, can you help me understand it better? Which exact supplements are you using and where can I get them from?
I already take Berberine & tmg.
Thanks for the info, that was very interesting! Major breakthrough!
Absolutely brilliant wisdom from Dr. Conlon. Fixing the underlying problem of mito conversion of NAD+ makes so much sense. Plus, nicotinamide conversion is what the mito was designed to convert. Very timely important health information.
Thank you for the positive feedback, glad you enjoyed the presentation if you have any questions please let us know.
@@nuchido2094Quick question if you will..so your recommendation is to take a precursor like NMN in addition to a nicotinimide? To boost nad level
Human aging is complex. I agree with multi-approach concept for anti-aging. Recently, Dr. Sinclair also use drugs cocktail for reverse cellular aging.
Would you get his cocktail with this or just his cocktail is enough in your opinion?
@@samicolgecen5310Dr. Sinclair's cocktails' content are mainly drugs. Most ingredients we can't get. Nuchido seems all natural ingredients, so I guess nuchido is a bettter and more doable choice.
I am looking in pub med and I do not see the publication of the clinical Trial, I understand that this is unpublished data. I am rigth? regards
Hi, this is an older presentation and the data presented was from our pilot study. We have since conducted a larger randomised, double-blinded, placebo-controlled crossover clinical trial with Nuchido TIME+ the results of which are currently available on our website. This study is currently in the process of being submitted to a journal for publication, which we will share once it is available.
I can't see anything different in this to a multivitamin supplement. Vitamin c , zinc, niacin + parsley etc. Why would anyone pay fir something they can get for less than $5?
What about one meal a day diet? What about daily exercise we should do? What about trans reservatrol? Omega 3? K2D3? Spermidine? Fisetine? Muscle growth exercises? Sleep cycle?
Hi, yes absolutely optimising lifestyle habits are also important to increasing NAD+ levels. Exercise and fasting have both been shown to increase NAD+ and NAD+ production is linked to circadian rhythms so sleep is also very important.
@@nuchido2094 yes, fasting and exercise can increase other functions like autophagy. Gut Biome also plays a crucial part. NAD is another important piece of the puzzle. It's surely better to have the whole body running more efficiently. NMN has helped, but I'm looking forward to my first shipment of Time :)
@@marcjames3487 Absolutely, everything in biology is connected so optimising the whole body will have the best approach.
A major reason is Older metabolism reactions create increased amounts of an enzyme CD38 which increaingly takes out NAD .. one needs to slow down production of CD38
Which substances like quercetin and apigenin can help address.
Hi, yes absolutely increased CD38 expression is a major cause of NAD+ decline, which is why apigenin and quercetin are included in the Nuchido TIME+ formulation. The full ingredients and mechanisms of action can be found on our website.
I found your presentation very interesting. Can you please let us know the links to the articles referring to the research presented?
Hi, this is a recently published paper by Dr Conlon which goes into more detail about the multitarget approach used in Nuchido TIME+ - Conlon, N., & Ford, D. (2022). A systems-approach to NAD+ restoration. Biochemical pharmacology, 198, 114946.
this talk is partly interesting information (NAD supplementation can be improved upon) but then avoids details of what to do about it for a marketing pitch for a proprietary blend of NAD with nutrients. To find the active ingredients you must visit the commercial portal offering $65 packs - to save you a click - the additions are from black pepper, green tea, quercitin etc. (from sophora japonica), R-ALA, vit-C. No particularly sensational breakthoughs there as far as I can tell - many sensible Perennials will already be taking these
So far this looks good but i rather wait for longer term studies to see if results are maintained. Also we need to understand if the placebo group was very low, because the impact is high for 1 month. At these prices, better understanding is necessary
Many of us do not have that luxury, I’m glad you do though 😊
Where can we see the contents table for Nuchido's ingredients?
Interesting video, thanks. We do have the Time+ product which we have tried based on earlier videos and information on the website. One question I have is that the amount of nicotinamide in the daily dosage (500mg) is 30x the RDA (in the US), which most people would classify as a 'megadose'. Since many people have become wary of megadosing in recent years, can you speak to the safety of such a high daily intake of nicotinamide?
Hi, we did conduct safety testing as part of our larger clinical trial and Nuchido is safe with no adverse effects reported.
Looks good, can you explain how you address changes in methylation due to the increase in NAD+ levels or is that repaired as well? Also what about gout sufferers? We cannot supplement b3 and im assuming it’s relatives, or does the NAD+ level increases enable repair of the mechanisms involved in gout?
Hi, Nuchido TIME+ does not cause methylation issues such as those associated with NR or NMN. This is because the breakdown product of NAD+ use called NAM is recycled back into fresh NAD+ as Nuchido switches back on the NAD+ recycling system called the Salvage Pathway. Therefore, the NAM is not accumulating and doesn't need to be methylated. NAD+ is known to activate cellular repair pathways, but we have not tested the product specifically in relation to gout.
So what if fixing the leak just means stopping the celluar healing process? Would be nice to see some health or life extension benefits along the higher nad. So we know it does not have major side effects and makes us healthier
if you pour in percursors only, or let me say the mandatory b-vitamins, or even NAD+ into the serum, then you get side effects... quite strong, doing just the opposite, not boosting but draining. There is a physiological role of extracellular NAD , which gets extracellular if cells die, or die soon, eg. if they got hijacked by a virus. similar with high concentrations of precursors.
If you fix the process, the story is a whole lot different. Of course, I would recommend not to boost to levels of a baby, or even pre-pubertarian. These young organisms are very different. But restoring levels as to look like from a 25y old body, I would not expect any side effect.
That being said, there is a risk for awakening cancer cells that a body has already required, like decades ago, when in your youth you have been heavily smoking or the like. Such, the treatment should be slowly ramping up, supported by anti-cancer food, and clearing senescent cells.
Hi, this is an older presentation, we have since conducted a bigger randomised, double-blinded, placebo-controlled crossover clinical trial the results of which can be viewed on our website. In this study various markers of cellular health such as inflammation, glycation ad biological age where also measured alongside NAD+ levels.
so what is multi-target approach to boost NAD , IF , more work out , etc ? , please!
Work out, one meal a day.
buying their product, additional to exercising, TRF, fasting and proper nutrition
@@monnoo8221 what is TRF?
@@samicolgecen5310 ohh sorry for using the abbreviation. It refers to time restricted feeding, which is often misunderstood as intermittent fasting, aka IF. While the boundaries between them are fluid TRF means to eat only ina certain time window of 4..8 hours., resulting in a non-eating window of 16h +/-2h . Some say it is preferable to eat early, while for some others that may not be possible due to external settings.
Some studies shows NAD is vital for cancer growth. I would wait for more trials before taking NAD supplements.
ATP is the energy created by the Mitochodria which relies on NAD to do this. All cells need NAD including cancer cells, which is why there has been doubt about it's use by people with cancer. However....NMN helps prevent cancer and has been shown to halt or send certain cancers into remission. The only time it has been shown to aggrevate cancer is when an aggressive cancer has been induced in mice. When you consider that poorly functioning mitochodria are the most major cause of cancer and that nad precursors help repeair mitochondri, you are actually tackling cancer at it's source. Also consider that all foods can help promote the growth of cancer. Weigh it up....without NAD...you're dead....with NAD you have a greater chance of fighting cancer.
Hi, there is no evidence that NAD+ causes cancer. What experiments do show is that NAD+ production can be targeted as an Achilles heel in cancer cells. If you cut off the NAD+ supply cancer cells die. The same applies to glucose and oxygen. Cancer cells are heavily dependent on a supply of critical molecules and removing the supply locally kills cancer cells, but this does not mean glucose, oxygen or NAD+ cause cancer, nor is it a sensible approach to restrict any of these critical molecules. These experimental observations are simply one of many alterations in a cancer cell that evolve to confer a survival advantage and as a result researchers are quite rightly pursuing this avenue as a potential cancer therapy.
NAD+ levels and cancer risk are actually strongly negatively correlated throughout life. Cancer risk rises as NAD+ levels decrease with age, both exponentially.
@@catman4471I thought cancer cells use fermentation and so don't utilize NAD. True/not true?
@@dwdwone Simple answer: Increased NAD levels enhance glycolysis and fuel cancer cells. And....Cancer growth is predicted to require substantial rates of substrate catabolism and ATP turnover to drive unrestricted biosynthesis and cell growth.
And....emerging evidence suggests that cancer is a mitochondrial metabolic disease.
It follows then that looking after the mitochondria helps prevent cancer.
NAD precrusors have been shown to halt or reverse certain types of cancer but have also been shown to aggravate cancer in mice who have purposely been given an aggressive form of cancer.
NMN helps prevent cancer but accellerates aggressive cancer, so as I indicated before it may become a race between repair or worsen. Anyone with cancer thinking about taking a NAD precursor would be well advised to take advice from a a doctor, especially one who is familliar with such pre-crusors.
@dimwillow7113
If you feed the cells, you also feed cancer cells.
But you also feed the immune system, which fights cancer.
I guess that it's positive if you don't already have cancer.
But negative if you are trying to starve cancer, as you do with typical cancer therapy.
I saw niacin but no NAD on the Nuchido ingredients label. What did i miss?
@dwdwone
You shouldn't expect NAD in the ingredients, because that large molecule don't go into the cells.
That's why you use the precursors, as the video says.
They utilize NAM as precursor, which relies on the salvage pathway. And a few ingredients which are intended to reduce the consumption of NAD.
I don't know if their product works, because I don’t see why it would improve the salvage pathway, though.
Hi, as the other comment states NAD+ itself is a large molecule, which struggles to enter cells. That is why cells have in built NAD+ production pathways like the salvage pathway, which is the main source of cellular NAD+. Our formulation contains the precursors NAM which is the natural breakdown product of NAD+ use by the cell and is therefore the body's preferred precursor as it can easily enter cells without a transporter. Our formulation contains ingredients to switch back on the NAD+ recycling systems and inhibit waste of NAD+ via inflammatory molecules like CD38. We have conducted a clinical trial on our product which showed an increase in NAD+ within just 7 days. A reduction in inflammation and glycation., activation of NAMPT (the enzyme that powers the salvage pathway), increase in sirtuins and a reduction in biological age after just 28 days. Full details of the ingredients and our trial results are available on our website.
this is my 2nd month of using nuchido as I tried NMN doesn't work, I do feel more energy especially notice when I'm on my weight training. I guess depends on person, my girlfriend is OK on NMN.
There’s a fava bean peptide that is called PeptiStrong that really works well for me and I have had below average response to NMN. It gives me the feeling people describe when they say that NAD+and/or NMN works for them. Hope you’re doing well today
Great to hear you have been enjoying your Nuchido TIME+!
There was 10 minutes of explaining why precursors alone are not enough, but no explanation of what the "multi-pathway" approach is actually doing, what is in it, or how it works. I'm sure there is legitimacy but this is a sales video, not helpful information.
ohh it is very helpful.!!! hehehe you now know where and what to buy.
Apigenin to inhibit cd38 enzyme and 5 amino 1mq to help the nmnt pathway. There may be better ways to do it but those are places to start
there no explanation in this one, but there are others, just search for her, not only a sales video, the whole channel is sponsored by a few start up companies. they use NAM, a plant compound, which helps the rate limiting enzyme of the salvage pathway, and apigenin == 3 targets here. + some trivials
So what are the compounds used in a multi Targeted approach?
This seems to explain why nmn & nr have been so ineffective for me.
Hi, the full ingredient list and the mechanism of action is explained in greater detail on our website.
There are many molecules that decline with age. All of the simi essential amino acids and non essential amino acids decline with age. Supplementing helps but doesn’t cure the problem.
De unde pot cumpăra NUCHIDO TIME+?
Link it with diet as how to increase NAD through diet and not prescription.
I dont understant very well english, what is about this cocktail ? Any new supplements😂? I have just bought Nmn and resveratrol and they are very expensive...if someone can explain me about this cocktails i would be grateful
What about niacinamide? Is it a good way to boost NAD ?
Hi, yes niacinamide/ nicotinamide (NAM) are both precursors used by the cell to make NAD+. NAM is actually the natural breakdown product of NAD+ being used by the cell and is included in the Nuchido TIME+ formulation.
Meravigliosa!!!!
I guess maybe you’d get near this if you combine niacinamide, parsley, green tea powder and ALA? And for less $£
But doesn't the salvage pathway also suppress excess NAD?
Hi, there are various feedback loops within cells but the salvage pathway recycles NAM back into fresh NAD+.
What is that music I like the music
What about the Brexit. Do you have storage facility within the EU to ship from? So that the customer may have a good customs experience? Are you going to lower the price over time as sales go up, or is this price staying? Label mentions quite a few cheaper raw materials. Like the quercetin source seems to be the cheeper raw material out there. How do we know this is not another snake oil? I don't mean to say that more affordable raw materials is a negative thing. But then you can find a middle ground for profit within time as well?
Hi, we do have an EU warehouse so shipping to European customers is not an issue. Nuchido TIME+ is based on years of preclinical and clinical research. Conducting this level of testing is very time consuming and costly. There is also no legal requirement for a supplement to be tested in humans before being sold, which is why most supplements have no data to support their claims.
Furthermore, we invest heavily in the manufacturing, quality control testing and ingredients in Nuchido TIME+. For example, Nuchido TIME+ only contains R-ALA, this is the form of ALA which is bioavailable (can enter cells) and has beneficial effects. It is much more expensive than S-ALA, the synthetic form which has no effect on cells and is commonly found in many other supplements.
Nuchido TIME+ is a long-term investment in your cellular health which is why we offer a subscription which provides a built-in saving.
How about subq NAD injection?
or even intramuscular?
i see where Dr. Sinclair will have a problem... with NMN
Timestamps would help your nice videos ❤❤❤
Does your approach reduce CD38?
Hi, yes Nuchido contains apigenin and quercetin which are known to inhibit CD38. The full ingredients and mechanism of action can be found on our website.
Look at the yams on this stallion. She definitely maintains her youthful NAD+ levels, and uses much of her ample energy to never skip leg day.
Who on these days presents studies of a single person?
Hi, this is an older presentation we have since conducted a randomised, double-blinded, placebo-controlled crossover clinical trial on Nuchido TIME+, which can be viewed on our website.
Ube des solutions les plus benefiqies selon mon expérience et expertise = mixer JEUNE SEC 36 H PAR SEMAINE et boire de l.eau dynamisee pauvre en mineraux
Aminos- B3 -Enada NADH and some medical mushrooms do work much better...🤩😁🥳
isa-manuelaalbrech2951 By 'medical mushrooms', did you mean things like Reish, Turkey Tail, etc., or things that are...not available in stores? Also, NADH comes in different strengths. What strength are you using?
Use mega hydrate water and crystal water u Se
I do
thansk for suggestion - can you clarify what this is?
Astraxanthin
astral body is sth different 😁
you meant astaxanthin . but why are you throwing in a single compound?
@@monnoo8221 i thought it was helpful maybe someone for me it is so good for preventing
Why decline in enzyme? What’s the natural solution? Prescription of drug does not make sense as you don’t know fixing this will damage another factory line. Half knowledge is more dangerous than no knowledge…Best bet focus on lifestyle n nutrition
Hi, of course lifestyle changes will support NAD+ production, but for some people they may chose to also use supplements to support them.
Thank you for allowing access to your papers
What a waste of a video. She did not explain how to boost NAD at all
Dr Conlon has featured in several other videos on this channel explaining how the formulation in Nuchido TIME+ works to boost NAD+.
This video could have been 2min long. These scientists need media training.
What the gell what’s the cocktail consist of so annoying
Hi, the full ingredient list can be viewed on our website.
ONE WEEK THEY SAY TAURINE IS ATI AGING AND OTHER WEEK THEY SAY NMN SO WHAT IS THE TRUTH ???
both are promising my friend. Aging is complex and there is no one chemical that is "anti aging". the supplements are used to optimize cell functionality.
@@BakamonNO and what about rapamycin and metformin
@@tedschwartz2142 IIRC You have to carefully balance those meds suppression of muscle creation with the aging body's tendency to suffer sarcopenia
Niacin, N aceryl Glutamin and folic acid is the truth.
I would stay away from rapamycin and metformin unless I could be monitored thoroughly by medical professionals. But that's only my opinion. I'm not an medical expert
so what's the 'multi targeted approach'? what a waste of time. go into specifics or don't make videos.
Dr Conlon has featured in several other videos on this channel explaining how the formulation in Nuchido TIME+ works to boost NAD+.
Time for some TMG 😌🫶🏻
@@Derby08 Thank you for your thoughtful response. Where could I find more information on this if you don’t mind sharing ? 🙏