How does Niacin (B3) Work? (+ Pharmacology)
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- čas přidán 28. 06. 2024
- How does Niacin work? How does Vitamin B3 work? How does nicotinic acid work? All of these questions are asking the same thing! Niacin = B3 = Nicotinic Acid. This vitamin is used to treat dyslipidemia. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)C 2.)A 3.)C 4.)B
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This pharmacology lecture covers topics such as Niacin, pathophysiology of dyslipidemia, regulation of LDL, HDL, Triglycerides and other complications of bad cholesterol buildup. Mechanism of action of Vitamin B3 drugs and their side effects. Drugs mentioned include; Niacin, Vitamin B3, Slo Niacin, Niaspan, Flush Free Niacin and their brand names.
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![Niacin (Vitamin B3): Flushing Away Heart Disease. [4 Studies]](http://i.ytimg.com/vi/N17cmKCVxcw/mqdefault.jpg)
Fishermen in Alaska take b3 the night that the herring fishing season opens. it's so cold they take it to stay warm in the wee hrs of the morning
That is interesting. I noticed when i take niacin or high dose multi B vitamins.. I regain warmth to my feet and hands. and i have a warm relaxing feeling when sleeping
Thank you. My feet always cool. It may help me
@@manp1039 same me
I feel erected too lol
I don’t need the electric blanket after taking niacin and my sleep is so much better
That may be flushing niacin. You can get non flushing too. High doses of Niacin improve depression.
The first time I took niacin I did not know you were meant to flush so I started panicking, then started googling it to find out it is a normal reaction and harmless. Ever since I really actually value the feeling of the flush, when the peak of it ends I start becoming deeply relaxed and free of anxiety and just overall tiredness, it makes me very calm and energetic. I'm taking 500mg every day now in the evening and it also helps me with insomnia from past benzodiazepine use. It's almost like my brain and chest are taking a really deep breath.
So you must have taken the jab. Do your research 😅
To everyone asking about harmful dosage it works like any other drug. You start off with a small dose to build up your tolerance. You don’t immediately start with 2000mg. I recommend taking 250 mg to start off with for a couple days and then bump it up to 500 mg ONLY if you feel your body is ready. Remember everybody is different.
I started at a 1000mg. I was fine with the flush but my legs swell and if I take it a day after or consecutively for 2 days or a day after I still get that swelling. I'll restart next month and start with 100mg and increase it from there after a few months to get my body used to it.
@@or6144 see your uric acid
@@hannaishak7206 Uric Acid not bad. I guess it was because I jumped the gun by taking 1000mg before saturating from a low dose or it can also be due to the brand of Nicotinic Acid I used which was Piping Rock.
I'm up to 600mg now Nature's Way brand twice a day (Morning/Evening) working my way to 1000mg. I suppose my body is adjusting better to it since asides from the expected flush that clears up I've no other side effects.
I take this with Bilberry (eyes) and Vitamin C for the Arteries along with my 2 Tbs of Sea Moss in the morning since your vasodilating your arteries no better time to infuse it with other nutrients.
You are absolutely irrefutably spot on correct. I could not have said it any better.
Cholesterol dropped 86 points after taking Niacin.
Are you still taking it? What's your mg dosage?
@@outofthebox5441 once your LDL is stabilize you can take 3 times a week. You don't need to take it everyday. It should keep your LDL at a good place
@@christymartinez2078 sounds good. Thanks
I've been taking 500mg 2x daily for at least 10 years. Heart disease runs deep in my family history so I decided in my early 40s that I wanted to protect my vascular health as much as possible. Niacin, fish oil, D3/K2, CoQ10, and a few other supplements have really helped me preserve my overall health, along with exercise and regular fasting. I only take full flushing niacin because it's the only one that really works. I've been taking it for so long that I almost never experience the flush anymore, only when I take it on empty stomach.
You have Hypocholestromia
That much taken for that long, especially, may increase your chances of developing Type II diabetes according to a couple of studies, unfortunately.
@@ReflectedMiles I've never heard that in my life. I research every supplement that I take once or twice every year to keep up with the latest data and there is virtually no risk with 1000mg/day of B3, as long as you also fast regularly and take CoQ10, Omega3 which protect the liver. My metabolic profile is perfect and has been for as long as I can remember. I'm not concerned.
@@dlg5485 That is certainly your choice, but social media sources are rarely scientifically literate and thorough--including many who are supposedly in healthcare in one form or another--and many GP's don't have the time to be. So it's just important to be aware of the current evidence on the subject, and that is why I mentioned it. Certainly not everyone who takes significant amounts regularly will then develop Type II, but current evidence shows that there is an increased risk. It is probably the single significant downside of using it for its benefits--it seems there are nearly always some risks or trade-offs.
Good to know, I am starting with Niacin from tom and was a little bid concerned about this developing into TypeII diabetes. Anyhow what other benefits have you seen over the years of consp. of 1000mg/day niacin?@@dlg5485
I’m so glad I found this channel! Someone shares my love of pharmacology 😀
*Thanks for updating,God bless you.
Anothers benefits Vitamin B3
1. Regulated digestion
2. Treats pellagra
3. Improves skin
4. Reduces the symptoms of Arthritis
5. Prevents the risk of heart disease
6. Mental health
7. Diabetes*
Thank you
Thank u! Do you have information about B3 regulating digestion? Which dosage? I want to take it to improve my stomach acidity on the long run
@@HBToastedAlmond it's D3
@@leximohamed9532 We are talking about B3. not D3.
@@thetahexhodlhands4550 thank you so much
I kinda like the flush. It increases circulation and it also renews dead cells...😊
I used to regularly take large does of Niacin just before my weightlifting at the gym( 1970s-80s) it seemed to help with many things even though I was flushing, now decades later I am taking it to hopefully lower my cholesterol levels instead of taking stains
take fish oil high in EPA see iherb. minimum 2g epa per day or more, in few months will lower tryglicerides and cholesterol nicely. dont get on statins
How much are you taking? Also try taking large constant doses of vitamin C. Your body uses it to repair arterial walls. If your low on C your body will use a poor version of LDL to repair arteries
@@Test7017what is a high dose of C? I pretty regularly take 2-3 grams/day.
Carnivore, no problem .😅
You should inform people (since you state it several times) that LDL is not bad because it is the same as HDL just with higher concentration of fatty acids (same protein structure) just the phenotype of LDL is something to watch. Differentiate the LDL into it's 7 components and see if you have high glycated end products. Maybe that is beyond this video but people should not be afraid of LDL. You cannot live without it.
Welp, I guess I’ll be adding your vids to my binge list. Great stuff. 👍🏻
BEST VIDEO I FOUND ON CZcams ON THIS SUBJECT
Thank you. Your explanation was absolutely informative, and comprehensive.
You have really done an excellent job with this video. I am a nutritional therapist and this was even a reminder to me about niacin
thanx for these videos. You make everything so easy to comprehend. Love ur voice btw!
Thanks for watching! Glad it helped😁
VERY WELL DONE....great narration and graphics
Thank you Lewis! Appreciate the support!😁
This is wonderful information for the concerned novice. Thank you.
Great job bro!
Hi, please post more content!! Your videos are literally the only ones i can find on here that properly explain each topic with perfect visuals!
Life saver! Need more content !
I leave a comment for the algorithm gods!
Thank you some much for the support! 😁
twitter.com/3PIDEMIOLOGY Dmitry Kats, Ph.D., M.P.H. he will lead you to tons of research papers.
Been waiting for this! Found it today!
Woohoo! Glad it helped!😀
Slow ride.... slow ride........ sloe ride
Good video sir. I have been taking it for years. Getting the flush is desirable as it indicates it is working to dilate the capillaries on the skin, but MOST importantly the capillaries around the heart and in the brain. Obviously very desirable to dilate one's capillaries for enhanced blood flow!!
It seems to improve my scalp hair growth, as my hair is thicker(?). Perhaps, someone may research this hypothesis?
Glad to find your channel. I have been taking flush free niacin for years and didnt know the effect until now! Thanks for sharing.
Flush free does NOT reduce triglycerides - refer to end of video.
Thank you very much for the clearest valuable information ❤
Well explained and very informative
Awesome content! Great useful information. I love the way you simplified the science and understanding of how to use Niacin, Vit B3 and how it works. Do you have any more video's on the Vitamin supplement topics? I am preparing to teaching nursing students Fundamentals and nutrition and you were right. We basically tell them B, metabolism and nerves. But you get to the science on how this works simplified to understand why. Love the presentation and I will guide students to this video in case they want info to the point and clearly presented. I will look to your other pharmacology videos when I get to those topics. Thank you.
Get rid of vegetable oils and most sugars
What about peanut oil filtered at home?
Wow thank you its great video n thanks for doing the quiz in the end .Thank you so much
very very succinct! Just the way an explanatory video should be! No BS, no fluffy stuff, just the useful content. One of the very few on youtube who really aims to educate, not marketing or showing off. Love the animation!
YOU DID NOT GIVE THE ANSWERS
Inspires confidence in medical education.
nice one - any views on the better versions (least man-made "natural"/less chemical) versions of B3?
Great video,very informative,thank you. 👍🏽🌺
Thank you so very much for explaining what niacin does🥰💕
Excellent video !!!!!
Thanks bro, a brilliant presentation without the bullshit, excellent.
Thanks man! Appreciate the support!
Some people claim that Niacin increases Nitric oxide and could be used as an alternative of L-arginine and L-Citrulline
It does. Take it before sex and viola
Love the flush!!!
Excellent presentation of the content
Great video, answered some important questions. Thank you:)
Glad it helped!
Thank you, very helpful.
I took a pretty good amount of niacin last year when I had covid, because my body wanted to get out and breath fresh air. It was an average of 10-15 degrees in my area. I had just watched Andrew Saul and he seems to think niacin and vitamin C can cure everything except death. I didn't take it for covid I was taking it to keep me warm which it did. I'm anemic and I felt so good I walked on average two hours every day. I barely had any symptoms of covid. This year had a severe case of covid forgot to take niacin because I try to cycle my supplements. First week too sick to get out of bed least of all go walking. Took me 3-4 weeks to recover taking the same supplements except niacin. . Coincidence I don't know, what I do know no matter what I'm keeping niacin in my supplements stack 🤣
Very informative 👍
Good stuff!
Very thorough. Thank you!
For first timers, get B3 500mg in tablet form and break it in half. Start off low and work your way up. It also helps to eat first and drink lots of water before taking it.
Because I had a bad flushing reaction years ago when I took 500 mg, now I started off at only 100 mg...and will increase a bit at a time.....That flush reaction can be scary the first time.
Niacin is a vitamin you must start slowly and gradually work your way up to your desired dose. The first time I took it it startled me because I wasnt expecting the side effects. The flushing doesn't last long and as you increase your dose the flushing can eventually go away completely. I have found all the "Take with X and you wont flush" to be bogus. The only thing that worked for me was dosage saturation. I am currently on 4grams and I no longer flush at all. I had debilitating arthritis and am mostly pain free now. I also noticed an increase in cognitive function. 3 years now and no down side except peeing a lot. Stay hydrated.
Ha ! Same with me. The first dose was a doozy ! I now use _SloNiacin_ .
@@jamescalifornia2964 i take Endur-acin and very little flushing. i took Nialor prior to that.
@@dwaynemorris3079 - Sustained release niacin should not cause flushing 👌
@@jamescalifornia2964 but it does. Go figure.
@@osopapi ~ Sustained release does not cause the uncomfortable flush for me. Try splitting the does 2 - 3 times daily. _SloNiacin_ comes in 500 & 750 mg.
Wowwww. Saw ur first video and enjoyed the presentation effects .good info and a subscriber too now .gd job n gd luck 👍
Thank you for watching! 😁
this was very helpful. thanks
Watching this video while my ears are magma hot from the flush lmao
Hahaa hopefully the video helped!
Lol
I definitely popped 2 pill first day not reading the label. I know the feeling 1000mg at once ain't it. 😂
@@XWDaniel 500 mg already white me hard xD
Same
Hands down best short lecture on Niacin I have ever seen
Excellent information
Several older clinical studies have demonstrated that IHN may have a beneficial effect on endothelium-dependent vasodilatation. The clinical research literature includes several positive studies on the use of IHN for improving blood flow in conditions where blood flow is compromised (Ring and Bacon 1977; Head 1986; O’Hara et al. 1988).
Thank you
That was so good
A no-flush type of niacin is inositol hexanicotinate, which I take daily. It is a slow-release form that ensures the body always has niacin in the bloodstream.
good stuff, thank you
Excellent!!!
BEFORE TAKING SLOW RELEASE OR NO FLUSH OPTIONS INSTEAD OF REGULAR NIACIN DO YOUR RESEARCH ABOUT THE DOWNSIDE . Regular niacin will not cause flushing if you slowly build up your dose over days or weeks ---- FLUSHING DOES NOT HARM YOU --- ITS JUST UNCOMFORTABLE FOR A SHORT PERIOD --- YOU FEEL HOT AND ITCHY FOR 15-30-60 MIN OR SO. it depends how sensitive you are to it so start with the low dose maybe 50mg/day and build up.
Great suggestion, thanks!
first time taking niacin, i experienced flushing for about 2 hours and days after that just 20mins max
I always take with food about half way through a meal and chew up the tablet completely, no flushing, If flushing occurs drink lots of liquid.
I experienced flushing(scary red all over the face and hands) right away after taking 50mg of Niacin the first tiime!
I enjoy gentle scratching, just be careful to keep it gentle
I enjoy that niacin "flush" when I hit the hay. It feels cool & refreshing ... as if I'd just completed a steam bath (even when that's far from the case). People are always startled, scared and misjudge it when they don't know to expect the flush. When they DO know ahead of time, however, they can enjoy its uplifting effects ... presented at the RIGHT time & environment . Best to take it just before you go to sleep. It's so comfortable while you just lay there motionless, you won't feel like moving. Even feels like it reboots the mind ... feeling more rested afterward ... both physically & mentally. (Just be prepared for its slightly extra cooling effect ... with an adequate sheet or light blanket.) :)
I agree , how comes I don’t get the flush every time I take it ?
Do you feel the itch on the chest and arms too?
@@Chip_eater48 You could be taking the flush free niacin
Last week I started taking non flushing Nature’s Bounty brand but unlike video, it has 400 mg of niacin with inositol hexanicotinate for flushing. I’ve thus far had no flushing. Was taking it at night and found interrupted sleep and mild stomach issues. Started taking in morning and wow super energy. Noticeable lowering of BP too.
Non flushing niacin is not effective for cholesterol control.
Nicotinic acid also has a pathway to help recharge the NAD+ which powers the mitochondria. It is a cheap version of NMN or NR. Not sure about the dosing but I take 200 mg in my daily STAC.
Perhaps 500 mg will be closer to optimal. I am not an expert though
Great Video
great info and visual mapping but where are the answers to the 4 quiz questions?
Awesome channel
Thank you A. Gharairi!
Pls discuss how to take K2 and should take calcium too.
It relaxes me helps for anxiety Better then an antidepressant or valium
Im on keto and HDL gone up and tryglicerades gone down LDL is still high.
How much do you normally take at a time?
check dr. Berg's "why your LDL is high on keto",,,,,then you would relaxxxxxx.
Totally agree!
What dose do you take?
Niacin helps with tinnitus, lowers the ringing big time especially if you're fit and are No Fap
Research study on the correlation of tinnitus with fapping?
Should have mentioned Endur-Acin 😉 great video!
Thanks for watching!
ABSOLUTELY, worked extremely well on my cholesterol 👍
Be careful when taking Niacin. I took regular flush 500mg of Niacin and within 30 mins, the flush effects were crazy, my heart rate went to 120 and I felt dizzy and blacked out for 5 mins. Luckily, I did not hurt myself. Effects were gone in an hour but it was a torture. So start with a small dose to see how your body tolerates it.
Wow, u r brave...when taking any supplements, start with small dose, and then up it. At lease you didn't stop taking with the bad experience you had. Smart move. B3 is very good for the body.
If you are interested, there is a video how flushing occurs. czcams.com/video/BXU370RA1C4/video.html&ab_channel=Foxterrier
@@Foxterrier Thanks. One lesson I learnt the hard way is to be very well hydrated when taking Niacin and never take Niacin if there is any significant alcohol in your blood as it greatly exacerbates flushing.
@@enmukeeenmukee3254 Also antibiotics and even grapefruit juice can potentiate niacin effect. So be aware of such drug interactions.
same! had an awful reaction and i didn’t even realize jt was the niacin just thought it was the hot sauce i had lol. so i took it again and ended up crying in the school bathroom. side effects are awful!!!
First time I see you. Very good job.
Is niacinamide the same?
No, one doesn't get the result to reduce cholesterol. It has to be Niacin
Can niacin be taken with other vitamin supplements like magnesium and cod liver oil?
Thank you.
My doctor prescribed niacin years ago. I took one pill. In an hour by arms were on fire, my legs were both vibrating. An hour and a half later it subsided and then within the next hour it started over again. It was so painful I was ready to go to the emergency room when it finally quit hurting. It was like the worse sunburn of my life. I don't remember turning very red though. Just a burning sensation.
I love the flush now. I take 2-4g a day. My neck burns and my chest itches so bad if i take it at night. I mix more than 1g in my citrus flavor fiber powder drink. After a nice hot shower before bed with the niacin flush, it's super rejuvenating. Once you get used to it, it's a game-changer. Like my brain fogs completely disappears after the flush, it is super sauna-like and relaxing in a good way... something about opening up the capillaries and flushing fresh oxygenated blood to my brain and under my skin makes the post-flush feeling really youthful. Biggest plus is my HDL went from 52 -> 84 and VLDL 102 -> 83.
This made me laugh. I would have had a major panic attack with those symptoms. It sounds as bad as my atrial fibrillation, which is why I'm looking into niacin....
what are the foods rich in niacin?
This help me a lot an I bought the wrong kind I didn't no it said flush free til I watched this video know I no what not to buy thank you
Is it safe to use it in combination with pycnogenol ?
Thanks dear🙏
What is the effect of Niacin to Hs CRP?
Thank you
Why no mention of dr Abram Hoffer's work on niacin for schizophrenia?
Also use for ADHD?
My radiologist recommended 500 mg regular release to treat skin cancer. This is common practice in other countries. My Bowens skin cancer has virtually disappeared but other skin cancers are down but not as significantly. I understand this is a common recommendation in Australia where skin cancer is prevalent. Flushing becomes less with regular use. I do use low dose aspirin but I will try homemade no sugar applesauce. I do not eat sugars.
How do u avoid sugars in fruits? I’m guessing u mean other types of sugars but I’m curious how u do it as I’m interested in cutting out sugar. Thank you
My son thinks that's so funny when he hears that from people. He always says, almost everything breaks down to sugar in your system.
@@katesun2957 then we dont need to add sugars in the products if our body converts it to sugar anyway
Thank you so much for your post. I didn’t know it helps with skin cancer which I got. I came here for high cholesterol but found this piece of information by chance. 😊
Supposedly "CrabApples" are the ones to go to all others are full of sugar..
I take niacin regulary. It makes me feel extremely warm. Too dark to flush lol. But it really helped lower my high cholesteral.
Lucky you 😭
Didn’t knew grabbed a mtn dew kickstart And I’m like wtf is that just by curious but still drank it
@@texanboiii562 🤣🤣🤣🤣🤣🤣
@@dauseanadoingme3824 how much did it lower your cholesterol and how fast it did it ?
Just take omega 3 krill oil and healthy fats also take soluble fiber for cholesterol
I need to know WHAT İSTHE DIFFERENCE in between of Niacin and Niacin hexagonite?
Hexagonite? Surely?
Non-flush version has six (=hexa) niacin molecules chemically bonded to one inositol molecule...
The nicotinic acid (= niacin) is slowly and not very efficiently stripped off of the inositol.
God Bless you
Tank you
Don’t take 1000mg!! Start at 50mg and gradually increase as body adjusts.
That's exactly how I've started 👌
In the shopping, a few years ago, Niacine was the threefold price of Niacinamide. Later on, this difference went the other way around and today, Niacinamide is the one which price is the highest. Any one there to explain this change?
Fantastic
Thank You! 😁
I took swansons 100mg Niacin within 10 mins i feel like i have taken a shot of brandy but a little milder. my body feels hot but nice to take in cold weather.
The Irony is that brand makes their products from harmful to toxic ingredients. They use an ingredient that are found in cement compounds. You toot and praise them all the way to your grave.
Was it nicotinic acid?
Bless You,
Soo… out of curiosity here, you mentioned that Niacin increases the uric acids, but since uric acids are broken down purines waste in the blood, wouldn’t niacin assist in easing the pain of gouts and such? Because it breaks down the triglycerides, assisting with better blood flow and giving less chances of uric acids building up.
While great that you are trying to deduce some connections: As a biologist I don't think that these can be such straightforward.
The level of TGs in blood is regulated...
Certainly the pathway mentioned is only one of those that lead to the formation of TGs.
But may be that this one is mainly responsible for elevated TGs. Maybe.
Where have you heard that lower TGs alone would increase blood flow? 🤔🙃 There are so many, much more voluminous or dense constituents in the blood. Also, lowering the "bad" cholesterols (actually there is a whole range of different densities, sizes of good and bad...) doesn't always lower the clot formation. Things in biology are always more complicated than one can think of ... 🤫
Thanku for the info
Thank you so much for watching!
Natures Way nicotinic acid 100mg capsules is the easiest to split into 50mg starting dose on empty stomach first thing in the morning before coffee. Allow yourself the chance to see if you are sensitive to the flushing/heat effects before upping the dosage.
Thanks
Welcome!😁
Why is the very slow release drug prescription only ? How slow can be bad ?
I've been taking a B3 supplement for years and not for cholesterol. I take it for skin and DNA repair. No side effects at all
It was niacin or other form called niacinamide?
Both
so how was it?does it gives you nice skin?how old are you?
I also heard of anti aging benefits from b3 100mg
It does because it flushes toxin from your body and it also helps your hair grow
Does it spike blood sugar? My FBS is consistently between 5.3 to 5.7. I took niacin the night before and had a considerably higher FBS in the morning!
Does time-release Niacin reduce cholesterol as well or do you have to take instant-release? Is one version worse or better for the liver? I purchased Nature's Bounty time-released Niacin 250 mg.
I would read more about it, but I think actually extended release is supposed to be worse
I hope to get a response... I purchased a flush free niacin, by accident (flush free is in small print), and I’m using it to help my vascularity in transporting other nutrients throughout my body. Towards the end of this video it was mentioned to avoid those products. Is the flush free version entirely useless especially for what I am trying to do with my diet? I’m not too concerned with lowering or raising cholesterol at this time.
You may be able to use it for that purpose, but I havent seen much evidence for helping vascularity. Give it a shot and see if you feel any improvements, we still need more well designed studies!
any progress?
Some news?
Ty
To avoid flushing Tab Aspirin can be taken but still it is not friendly