Thank you so much for these videoes! They have helped me a lot! But I was wondering if you could make a video about what happens to the fat particles after they have been in the liver? (Covering VLDL, LDL, HDL, Cholesterol and so on)
Im a software engineer also a health enthusiast, feels so excited to finally learn about how your machine, the body, works! Thanks cant wait to learn more
Isn't the "shell" for chylomicrons and VLDL particles actually predominantly phospholipids and not protein? Of course, Apo-proteins are present. However, there was no mention of the phospholipids which are a major component of the "shell" for Chylomicrons and VLDL particles.
thank you I have a huge exam in August! Biochem is not my cup of tea... :( thank you for a very clear discussion. what I do I read my review books then watch your lectures.
Maybe it is a bit hard to understand because these drawings are 2D. Actually, the same cell makes contact with both blood capillaries and lymphatic capillaries through different parts of its membrane. Wish you good studies. Greetings from Brazil.
Very good video! I have a follow-up question. When fatty acids are released into the bloodstream and attach to albumin, they are just fatty acids and not triglycerides, right? In other words, they wouldn't contribute to the triglyceride count on a bloodtest, correct?
so free fatty acids from adipose can float around the blood stream cause they're small, but cholemycrons, and other lipoprotein can't. So lipoprotein lipase cuts them into fatty acids so they can. Then do lipoprotein never enter capillary circulation due to size?
So is the excess carbohydrate consumption is what causes an excess of VLDL to pass through the capillary and overtime some of it clogging up as the lipoprotiens can't get all of them?
I found these videos very helpful and easy to follow! Thank you for uploading this! However I do have two minor details I'd like to point out. I would have found it immensely helpful if you'd talked a bit more about the structure of the chylomicron and its synthesis within the epithelial cell. (Maybe this is covered in another video?) And the little character you depict as the lipase is called Pacman, not Macman. Thanks a lot for this, I'll share this with my class.
MrProgrock Sorry for being late to the party, as you probably answered your question already, but this may help a bit; it is not the full explanation, but it is something. FAs and cholesterol come together inside of the epithelial cell and are packed into chylomicrons by the smooth ER, as it plays a role in lipid synthesis amongst other roles. The newly packaged chylomicron then gets modified and sent out of the cell by the golgi apparatus, and then enters the lymph. If you haven't already learned this, I hope this helps!
I have a question. If capillary beds are the only place where nutrients and oxygen can be exchanged, how does the cells located around the arteries get their nutrients and oxygen? Are they supply by another branch of capillary bed? 🧐
Matthew Sonnega What I mean is I consume less than 40g of dietary sugars every 24 hours, out of which I'm fasting (no food) for 10+ hours. 10 hours fasting, 14 hours low-carb diet consisting of only 40g of sugars. My understanding is that I'll be in a keto state where ketone bodies are providing the fuel to cells instead of carbohydrates. How does this effect serum VLDL?
Very good explanation. It might help if you raise the voice a little bit. Now, I appreciate why the hell FAT usage in the body is so complex. Now, I want to know why KETO DIET is promoting FAT compared to CARBS.
did she say Mac Man instead of Pac Man in both first and second part? what on earth? did you even have a childhood, Miss? Great content though, thanky ou very much!
Thank you for the video..very helpful! However, I believe the lipoproteins are not covered in a protein shell. Rather, the lipoprotein is covered in a phospholipid layer with some cholesterol, with some proteins (Apolipoproteins) embedded/attached to the phospholipid shell. They act more as ligands and enzymes, not as an amphipathic molecule to shield the lipids as this video suggests. The phospholipid layer does that.
Obviously shes never played the game before so id assume she'd ask someone before hand that the character's name is correct. I guess when you are a Harvard graduate, you dont feel the need to ask for help.
1:57 Mac-Man??? AGAIN ????? NOOOOOOOOOO no no no no no no no non o NOO. NOOOO. NO NOH!! NOOOOHHHH!!! No. Pac-Man.... P-as-in-Papa... Not M-as-in-Mama.. Otherwise, great video... Breathtaking!
Thank you so much for these videoes! They have helped me a lot! But I was wondering if you could make a video about what happens to the fat particles after they have been in the liver? (Covering VLDL, LDL, HDL, Cholesterol and so on)
Im a software engineer also a health enthusiast, feels so excited to finally learn about how your machine, the body, works! Thanks cant wait to learn more
Merfect.
savage
LMAOOOO
Lmfaooo
Dears, thank you so much for making this videos!!! They are just great!!!
With the exception of fats being emulsified by the bile in the stomach, these videos are incredible
Thanks so much!
Thanks! This was such a master class. Really enjoyed it.
THANK YOU , YOU`RE THE BEST TEACHER EVER !!!!!!!!
very, very helpful. Exactly like what I had in class today, but easier to understand and clearly explained. Thank you very much :)
Thanks dearie..you've done well. May your knowledge increase as you study further.
ur videos are the best :) Thanks!
Great instructional video.....you are a lifesaver!! :)
Thank you, for making those videos. Nicely explained.
so nice and easy at the same time...with so many informations! Thanks very much! :)
thank you very much for this video! great job and very helpful! :)
Taught way better than my professor!
Very good video!! Thanks a lot!
superb, really its the first time that, really enjoyed while studying the concept of Bio-chem.
Very helpful for refreshing my memory. Thank you.
As clear as it can be...
Digestion, Metablozation, and Transportation Part 2
* The Return of Mac Man *
Wow this was incredibly helpful! thanks so much
thank you so much for this!!!! THUMBS UP
Awesome set of videos that explain the process very well. *tips hat*
I forgot all about the burger until MacMan appeared again ;)
Super video! Thank you
Greatly illuminating. Thanks. Curios to know what software you use for the animation, if you could share.
Excellent explanation, thanks!
Isn't the "shell" for chylomicrons and VLDL particles actually predominantly phospholipids and not protein? Of course, Apo-proteins are present. However, there was no mention of the phospholipids which are a major component of the "shell" for Chylomicrons and VLDL particles.
Thank you soooo much!
thank you I have a huge exam in August! Biochem is not my cup of tea... :( thank you for a very clear discussion. what I do I read my review books then watch your lectures.
Great Video, How does the chylomicron get through the first layer of the holes are smaller? I’m having trouble picturing it
Maybe it is a bit hard to understand because these drawings are 2D. Actually, the same cell makes contact with both blood capillaries and lymphatic capillaries through different parts of its membrane. Wish you good studies. Greetings from Brazil.
Very good video! I have a follow-up question. When fatty acids are released into the bloodstream and attach to albumin, they are just fatty acids and not triglycerides, right? In other words, they wouldn't contribute to the triglyceride count on a bloodtest, correct?
wow , it cleared my mind , nice demonstration
Amazing!✨🙏
awesome! thanks ma'am.
Very, very helpful and informative.
Simply perfect ✨
so free fatty acids from adipose can float around the blood stream cause they're small, but cholemycrons, and other lipoprotein can't. So lipoprotein lipase cuts them into fatty acids so they can. Then do lipoprotein never enter capillary circulation due to size?
Brilliant, Thanks
First video I watched without Khan's voice, felt so weird at first ^^
American pronunciation of capillary is so different! In England, we say cap-ill-er-ry!! But thank you very much! Great teaching!
hes called Pac Man.
great job though! well done!
really helpful!!thanks
Really great......
Very nice lecture ma'am, also sufficiently brief. Also ur voice is cute.
Pac man, not mac man, but great job! Very very helpful video.
We all know that wasn't really necessary, you got the point, but still you felt the need to correct her..good job Jordan.
Jordan Louis Edmunds mac man as in it eats big macs (like the one she drew). It was a play on words
wow! I can loose belly fat with this video!
greate drawing : )
Fabulous!
Wow ppl are so mean
Anyway thank you, u literally saved me
I dont get it! So, how is the responsible for transporting fatty acids in blood chylomicrons or albumin?
So is the excess carbohydrate consumption is what causes an excess of VLDL to pass through the capillary and overtime some of it clogging up as the lipoprotiens can't get all of them?
Very helpful thanks
Most detailed explanation on how intermittent fasting actually causes people to lose body fat!
Is that all that matters to you? Trending ? 🤷😂
Yez too much info. Nayways, much appreciated.
I found these videos very helpful and easy to follow! Thank you for uploading this!
However I do have two minor details I'd like to point out.
I would have found it immensely helpful if you'd talked a bit more about the structure of the chylomicron and its synthesis within the epithelial cell. (Maybe this is covered in another video?)
And the little character you depict as the lipase is called Pacman, not Macman.
Thanks a lot for this, I'll share this with my class.
***** Not really. It is touched upon, it is said that it happens, not so much the details.
MrProgrock Sorry for being late to the party, as you probably answered your question already, but this may help a bit; it is not the full explanation, but it is something. FAs and cholesterol come together inside of the epithelial cell and are packed into chylomicrons by the smooth ER, as it plays a role in lipid synthesis amongst other roles. The newly packaged chylomicron then gets modified and sent out of the cell by the golgi apparatus, and then enters the lymph. If you haven't already learned this, I hope this helps!
I have a question. If capillary beds are the only place where nutrients and oxygen can be exchanged, how does the cells located around the arteries get their nutrients and oxygen? Are they supply by another branch of capillary bed? 🧐
expected some details about apolipoproteins.
3:02 So where does the glycerol backbone go from this point ?
malak ezzawi
To the liver for phosphorylation by glycerol kinase.
may go to glycolysis
Nice I like it
I wish they had time stamps
great video tho
excellent and simple
❤
gah pacman not macman lol
oliviapatterson1 pun pac man eating big mac
I wouldn't want to compromise a great video due to copyright issues over a side comment either.
Cool
Hmmm... so is there a glucagon pill I can take? Or is starving the key to mobilizing fatty acids out of adipose tissue?
or if I increase my glucagon levels will I just be giving myself diabetes? :/
Exercise is the key.
If I start fasting 10+ hours with low carb diet in the remaining -14 hours, will my VLDL go up or down?
KatariaGujjar your body can still make carbs from other sources (acetyl CoA) so it depends what you mean by "low carb".
Matthew Sonnega
What I mean is I consume less than 40g of dietary sugars every 24 hours, out of which I'm fasting (no food) for 10+ hours. 10 hours fasting, 14 hours low-carb diet consisting of only 40g of sugars.
My understanding is that I'll be in a keto state where ketone bodies are providing the fuel to cells instead of carbohydrates. How does this effect serum VLDL?
i love you so much
macman= mcdonalds pacman remember she started with a burger
How does diabetes affect this process?
What about Ketones?
Macman looks awfully similar to Pacman
🤗👍👍
Very good explanation. It might help if you raise the voice a little bit. Now, I appreciate why the hell FAT usage in the body is so complex. Now, I want to know why KETO DIET is promoting FAT compared to CARBS.
did she say Mac Man instead of Pac Man in both first and second part? what on earth? did you even have a childhood, Miss? Great content though, thanky ou very much!
You mean in between meals not after meal insulin level goes down
Thank you for the video..very helpful! However, I believe the lipoproteins are not covered in a protein shell. Rather, the lipoprotein is covered in a phospholipid layer with some cholesterol, with some proteins (Apolipoproteins) embedded/attached to the phospholipid shell. They act more as ligands and enzymes, not as an amphipathic molecule to shield the lipids as this video suggests. The phospholipid layer does that.
Mac Man? jajajaja
outstanding explanation and very nice voice
So eating excessive fat can make you fatter.
To lose belly fat, I had to know my enemy.
WHY DOES SHE KEEP SAYING MACMAN
LuckyWings cause the person in part 1 ate a big MAC
Obviously shes never played the game before so id assume she'd ask someone before hand that the character's name is correct. I guess when you are a Harvard graduate, you dont feel the need to ask for help.
macman ? PACMAN no?
1:57
Mac-Man??? AGAIN ????? NOOOOOOOOOO no no no no no no no non o NOO. NOOOO. NO NOH!! NOOOOHHHH!!! No.
Pac-Man.... P-as-in-Papa... Not M-as-in-Mama..
Otherwise, great video... Breathtaking!
I was wondering if there might be a legal reason why they can't say Pac Man lol. Threw me off, too LMAO
McMan
It's PacMan. PAC.MAN!!!!
PAC MAN….PAC
ahhh.. macman.. can't stand it...
Maybe copyright?
I cringe so hard every time she says macman.
+Addison Frazier
It's because it is a Pac-Man eating a "big Mac" from Part 1 =)
Her voice though!! Headaches and anger!!!
it sounds like you're going to cry after every word
And it sounds like you’re a tool
Too sexy voice.. not being sexist sorry..