This page is amazing. It helps me so much to learn about this different processes and mentions all the important aspects. Great! Thank you! And congratulation for the page!!
Such a wonderful video...lipid metabolism is like a nightmare for Entrance exams...thanks for such simplified video...now it would be easy to understand the text...
I have a biochemistry exam this Thursday and this video really helped but I was wondering if you had any explanation for the actual reactions occurs in Fatty Acid Synthase. I know that there are 6 enzymatic capabilities of the enzyme but don't know the actual steps. Do you happen to have any information?
I really liked this video and the whole presentation. I was just a little disappointed, that a video of that length didn't even include the actual reation of the fatty acid synthetis. don't get me wrong, the overview ist great but since you already broke the entire mechanism up into two videos I was sort of expecting to get all the details. maybe a disclaimer in the titel or the description box would be helpful.
Just a note. Although this is all correct, on a standard western diet you rarely ever produce fatty acids from glucose. You would have to be on a very low fat diet and ingest an excess amount of calories in carbohydrate alone in order for this reaction to have a notable effect. Ofc our beloved vegans could do this but most vegans are malnourished and dont take in enough calories making this quite a rare event in biochemestry.
Very helpful video, but I want to point out that for each molecule of acetyl coa that is carboxilated and activated by the synthase (7 of the 8 because one acetyl coa is used as a primer), 1 water molecule is produced, and so, there would be 7 water molecules in total and not 6. It'd also be pretty cool if you made a video in which you went more in depth on the domains of the synthase complex. Again, very helpful!
+Camila Penuela the reason it's 6 water molecules and not 7 is because once the entire 16-c chain is made, to remove it as free fatty acid from the fatty acid synthase, you need hydrolysis of the bond between the S of the fatty acid synthase and the carbonyl group of the fatty acid... you end up with a fatty acid synthase that can do the whole thing again and a fatty acid with hydroxyl group on the carbonyl group. hope that helps?
I don't want to be hung up on details too much, great vid btw, but at 5:20-ish you say we make 6 water molecules, shouldn't it be 7? like 1 water molecule for every 2 reduced NADPH??? Thank you
your depiction of the fa synthethase is wrong to my knowledge. you didnt distinguish between the peripheral and central sh groups ( acyl carrier protein). still you managed to convey the basic concepts of things really well, so that counts for something and makes the video worth watching.!
I skipped my 2 lessons of my biochem class due to medical leaves and I couldn't understand anything from the textbooks or the notes. Thank you so much this made me understood in less than one hour 🙏🙏
(On Saturday of February 18, 2023). On The Matter of Fatty Acid Synthesis And the Metabolism Therein (Chemical Reactions of Substrate-Enzyme-Product): 1) Stoichiometry of Fatty Acid Synthesis (Acetyl-CoA, Acetyl-CoA Decarboxylase [Fatty Acid Synthase], And Polymerization Therein Yielding the Product of Palmitic Acid); 2) Allosteric (Citrate Positive Regulation; Fatty Acid Negative Regulation) And/Or Hormonal Regulation (Insulin Positive; Glucagon Negative) Along with Product of Fatty Acid Synthesis; 3) Carbon-Carbon Bonding and ATP Hydrolysis Therein; PhD Jasmine Rana, es gut ist zu verheilen und kennen Die Krankheit auch aber man vernichtet sich mit Seiner Dummheit. Heil!
God bless you for saving me 2 hours of reading book/notes for my med school test.
This is definitely not enough detail for a med school exam
Not even enough for my introductory biochem course
I think this is not enough for university lvl. Now i hv to go through Lippincot biochem😭😭😭
Am in med school, can confirm that is this is one of the best videos I’ve found on Yt giving a broad understanding of the FAS1 enzyme
You have done so much for us Khan Academy ! You are the best. I don't know how I can express my gratefulness to you
damn i forgot my organic chemistry hat
That feeling you get when you finally UNDERSTAND something and have no need to memorize! Thank you so much! #LikeAboss #MyBrainSalutesYou
Johanna Cardoso That happens to me all the time except I forget it all after a week or so. #HashTag
@@VeggieBond The key to remember any piece of information is to REVIST it on intervals.
The quality of every thing here is amazing.
Thank you so much
Why can't my 60 year old PhD professor be this clear... school would be so much simpler.
Charmander MD seriously man😂
Because he is a 60 year old PhD professor
Awesome explanation. You saved me, I spent hours on the book and my instructor slides and still nothing, but this made all of them clear. Thanks a lot
i would listen to this voice all day!makes the whole thing bearable!thank you!
Hey, this girl is great...very thorough!
I already know all this stuff, but it's so nice to hear it explained so well for the first time ever :P
This page is amazing. It helps me so much to learn about this different processes and mentions all the important aspects. Great! Thank you! And congratulation for the page!!
Such a wonderful video...lipid metabolism is like a nightmare for Entrance exams...thanks for such simplified video...now it would be easy to understand the text...
very neat and smooth,
Part 1&2 are easy to understand. Thank you
Thanks for the presentation. It helped me a lot.
awesome explanation and really sweet and lovely voice keep up.
I have a biochemistry exam this Thursday and this video really helped but I was wondering if you had any explanation for the actual reactions occurs in Fatty Acid Synthase. I know that there are 6 enzymatic capabilities of the enzyme but don't know the actual steps. Do you happen to have any information?
thank you. excellent presentation
thanks... it's so clear. am ready for an exam now.
beautifully done, thank you.
Thank you very much this was very helpful!
That was amazing...thank you!!!!
Very nice.! Cheers. Its good if u explain the lase reduction steps too. Anyway nice😍
Thank you
why her voice is so soothing
This is very good
Thank you so much miss. I love you to be my teacher for life ahehe. ^_^
isn't it supposed to be acetyl-co that comes to replace the empty space (instead of malonyl-co)?
I really enjoy your videos, but it would have been nice to mention required cofactors to keep vitamin deficiencies in context. thanks tho
hey! why isn't it -ch3 at the end of 16-c palmitic acid when it is drawn at the end ?
I really liked this video and the whole presentation. I was just a little disappointed, that a video of that length didn't even include the actual reation of the fatty acid synthetis. don't get me wrong, the overview ist great but since you already broke the entire mechanism up into two videos I was sort of expecting to get all the details. maybe a disclaimer in the titel or the description box would be helpful.
Thank you
11:37 Is insulin necessary or would the carboxylation move forward with just the action of the allosteric, citrate?
Thanks very much ❤
Just a note. Although this is all correct, on a standard western diet you rarely ever produce fatty acids from glucose. You would have to be on a very low fat diet and ingest an excess amount of calories in carbohydrate alone in order for this reaction to have a notable effect. Ofc our beloved vegans could do this but most vegans are malnourished and dont take in enough calories making this quite a rare event in biochemestry.
Very helpful video, but I want to point out that for each molecule of acetyl coa that is carboxilated and activated by the synthase (7 of the 8 because one acetyl coa is used as a primer), 1 water molecule is produced, and so, there would be 7 water molecules in total and not 6.
It'd also be pretty cool if you made a video in which you went more in depth on the domains of the synthase complex. Again, very helpful!
+Camila Penuela the reason it's 6 water molecules and not 7 is because once the entire 16-c chain is made, to remove it as free fatty acid from the fatty acid synthase, you need hydrolysis of the bond between the S of the fatty acid synthase and the carbonyl group of the fatty acid... you end up with a fatty acid synthase that can do the whole thing again and a fatty acid with hydroxyl group on the carbonyl group.
hope that helps?
Yes, thank you very much, my bad :P
is it true that oils high in palmitic acid contribute more to wheight gain than shorter chain fatty acids such as lauric acid or butteric acid?
Good job khan KEEP it up
I don't want to be hung up on details too much, great vid btw, but at 5:20-ish you say we make 6 water molecules, shouldn't it be 7? like 1 water molecule for every 2 reduced NADPH??? Thank you
so nice
it gives an overview,but nothing on the reactions occurring while biosynthesis of fatty acids.
Perfect
your depiction of the fa synthethase is wrong to my knowledge. you didnt distinguish between the peripheral and central sh groups ( acyl carrier protein). still you managed to convey the basic concepts of things really well, so that counts for something and makes the video worth watching.!
What does “thermodynamically favorable” mean?
It means that the reaction doesn't use up energy. It's spontaneous and has a negative change in free energy.
anyone care to explain how essential fatty acid (eFA) is build up? or is it ALWAYS supplied from outside (food) and absorbs as eFA??
I didn't understand the carbon bond making part 🙁
I skipped my 2 lessons of my biochem class due to medical leaves and I couldn't understand anything from the textbooks or the notes. Thank you so much this made me understood in less than one hour 🙏🙏
"Plop off"
So we make bad cholesterol?
***** LDL and VLDL are bad cholesterols. Keep it professional
17:15 *using bad cholesterol to transport.
Nobody !nobody !!nobody!!! Does it better. Ehee ehee ehee :)
At 16:10 - Isn't it a new acetyl-CoA that comes in, not a new malonyl-CoA??
how could evolution come up with all this?!
not much detail...
You're a goddess
Thank you so much Lana Del Rey
(On Saturday of February 18, 2023). On The Matter of Fatty Acid Synthesis And the Metabolism Therein (Chemical Reactions of Substrate-Enzyme-Product): 1) Stoichiometry of Fatty Acid Synthesis (Acetyl-CoA, Acetyl-CoA Decarboxylase [Fatty Acid Synthase], And Polymerization Therein Yielding the Product of Palmitic Acid); 2) Allosteric (Citrate Positive Regulation; Fatty Acid Negative Regulation) And/Or Hormonal Regulation (Insulin Positive; Glucagon Negative) Along with Product of Fatty Acid Synthesis; 3) Carbon-Carbon Bonding and ATP Hydrolysis Therein; PhD Jasmine Rana, es gut ist zu verheilen und kennen Die Krankheit auch aber man vernichtet sich mit Seiner Dummheit. Heil!
i didnt understand this part at all
This aint it, khan academy.
Wow, what an annoying lecture style. "I want us to put on our organic chemistry hats on for a moment!"