How does Zetia (Ezetimibe) Work? (+ Pharmacology)
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- čas přidán 4. 08. 2019
- How does Zetia Work? How does Ezetimibe work?
Zetia (Ezetimibe) is used to treat Hypercholesterolemia or high LDL levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)C
2.)B
3.)C
4.)D
Statin Video Here: • How do Statins Work? (...
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This pharmacology lecture covers topics such as dyslipidemia drugs, they block the NPC1L1 receptors in the intestine to lower cholesterol absorption. Also we talk about the pathophysiology of LDL cholesterol, regulation of LDL, HDL, LDL and other complications of bad cholesterol buildup. Mechanism of action of Zetia and their side effects. Drugs mentioned include; Zetia, Ezetimibe, Vytorin.
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I took Crestor and Zetia for six months. I’m 82 and a diabetic. My total cholest is 105, ldl is 48, hdl is 40, tri is 88. No problems. Good look
I literally cannot thank you enough! You break it down and make it so easy to understand! :)
Thank you for the support!!😁
Pls don’t stop making videos!!! They are super helpful
More videos are planned to come!
These video are a great resource for studying for pathopharm exams!
I really liked how detailed you were in this video otherwise I wouldn’t have understood it as well as I did. The way you thought it will always stick in my head from the examples you gave us. Also,
It’s really cool how zetia’s dosage is only 10mg’s. Now I know that Zetia helps lower the LDL cholesterol.
your videos are life savers! thank you for being very detailed
Nice, simple and clear. Thank you.
To tell the truth you have the best channel ♥️♥️♥️
Very clear explanation.
Thank you for your knowledge I found it very informative and easy to understand
Clear and easy to understand
Your method in explain is very simple and useful . Thank you very much
Glad you enjoyed it! Thanks for watching!
love it. thanks!!
This channel is the best one on drugs of the hundreds there are on YT. I have three things to talk about or express :
1) You mentioned Ezitimibe blocking the *dietary cholesterol* what about the one created by the liver automatically, does that mean that ezetimibe can't block the cholesterol that our livers produce ?
2) It's funny how easily we at India can grab any drug without any prescription at 1/50th the price in US. I self change and try drugs on myself being a testing space. I got a combination of Rosuvastatin and Ezetimibe (10 mg each) for $1.50 for a strip of ten tablets. So, Simvastatin is the only drug that is used in combination with Zetia alone.
Lastly,
3) You have an amazingly sexy voice and I am not actually hiting on you ( I think i am !) , And Thank you very much for this elaborate explanation. God bless you.
Great Questions!
1.) That is correct. Ezetimibe only affects dietary cholesterol. That is why we typically use it with a statin. That way the ezetimibe blocks the dietary absorbtion, while the statin blocks the production of cholesterol (we target both pathways).
2.) Yeah that is crazy about the price of drugs around the world. And the only combo product is Vytorin in America (Ezetimibe + Simvastatin). You can take Ezetimibe with any other statin, but the drug companies have only done trials with simvastatin to be able to make this combo product specifically.
3.) And thank you! I'll keep making more of these videos then!
Cool video, very helpful.
Thank You! Glad you enjoyed it!
love this video very informative thx
Thank you for watching!😁
Very good explanation thank you
Thank you for watching Atiq!
Wow, I like this video!
Why if its so good do i still have to take statin morecside effects taking both why cant i just take the one tablet
Very useful .. thank you
You are amazing !
Thank you for the support! 😁
My trouble is that my body produces cholesterol a LOT , blocking the dietary cholesterol absorption doesn’t really help.
It will
I'm the same . Best wishes
increase soluble fiber and add Amla and Niacin a day and it will go down@@jupiterthesun3217
The first thing you must do is find out if you are a hyper absorber, or a hyper producer
If you are a hyper producer you use statins, pcsk9 inhibitors, bempedoic acid.
@@tesos2866 are pcsk9 safe?
Please make more you make the best pharmacology videos on CZcams!
Thank you! @Colton More videos will come in the future, thanks for your support!😁
Absolutely, I agree
Can you use this as a preventive measure? and would it block Omega oils or Vitamin E supplements?
Very nice job really 👍👍👍
Thank you for the support! 😁
@@DrugChug you welcome I am going to watch all your videos 😊
Just subscribed
Wow this is awesome! I passed the quiz btw 😂 My doctor is putting on this medication as of today and I needed to know what was up with it. I’m already taking Cholestyramine and I guess it not working because my LDL’s are elevated . I’m allergic to the Statins. We tried that first my body was so sore, thought I aged in 3 days to about 99 years old 😢 I was like absolutely not. Trash this medication immediately 😥 But this was a great video. Praying I don’t get that fatigue side effect 🤞🏾🤞🏾
how you finding it so far? ive just been prescribed this + 180mg bempedoic acid
Wow I have just started this tab today came across this video today beautiful was a pleasure to watch have peace of mind taking it thank you ❤
He makes a lot of sense this is the best video I have watch but I do have pains in my knee in my nick while taking this medicine I don’t like that part I can’t tell if it working or not I’m not for sure🤦🏽♀️💁🏽♀️
Also raises Alt and Ast at least for me and some others. Had to get get off this drug immediately.
Nice bro
Thank You!
Does it help prevent strokes or heart attacks
Can you take Ezetimbe (Zetia) if you donate blood platlets?
What about a combination of retrovastatin + fenofibrate. Sir.
so what are the side effects
Ezetimbe made me ill. Stopped it. Got all side effects. Thought i was dying.
Good video actually eating cholesterol can only raise cholesterol in a small way it is eating saturated fat that raises it.
Why have i read this tablet increases risk of deme tia. Is tbis true or notv
Does Zetia reduce the chances of getting a stroke or heart attack? Is Lipitor better than Zetia? Please advise.
Ipitir has lots of side effects invading lip and face swelli g. I had to come off
Hope you guys Enjoyed!
Did you get the Quiz questions right at the end?
Let me know!
Drug Chug yes!! Thank you for another great video
Are you still making videos? You should make a education website, I’ll totally subscribe!! Your videos are straight forward and very helpful!!!
@@karlvillaluz7933 - I agree. Informative yet concise. Just subscribed, will follow from now on. A website will be great, then we can search when needs arise.
If the drug is blocking intestine uptake of LDL, why is it taken at bedtime? Breakfast, lunch and dinner are long gone by then. A sincere question.
Great Question! @ Canada Calling
Yes you can take this medication at anytime because the half life of Zetia is about 22 hours, which means it only requires once a day dosing.
However, if a patient is also taking a statin (which is a high probability) it is best to take this medication with the statin and this is where we can see a preference on when to take the medication:
If a patient takes a night time statin, such as simvastatin, then they should take Zetia + Simvistatin at bedtime (Again only because the Simvastatin has a short half-life and cholesterol synthesis happens at night.
We even see the combo product Vytorin which has Zetia + Simvastatin.
But if a patient takes Zetia with a long acting statin (Like Atorvastatin) then they may take it at any time of the day!
Hope this clears things up! :)
@@DrugChug thx for the reply. I am refusing to take the statin because previously it was wrecking my brain and a few other unmentionable things. I am about to take Ezetimibe today. I am hoping all the side effects listed will not occur. Thanks again for the reply.
@@canadacalling6892 No problem! Zetia usually has a better side effect profile! Hopefully it works well for you!
@@DrugChug - Indeed this answer is important but no other source mentions it that I've noticed - Simvastation and Atorvastation have different acting half-lifes. Thank you for the clarification.
I take Crestor and Zetia 20/10
Can it be mixed with Crestor?
Yes 20 mg / 10 mg
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Cometa o remédio que chama zete em português
When to take ezitimibe tab
Best time
Night Before dinner/After dinner
Or in breakfast/lunch
Suggest best time in whole day for 10 mg ezitimibe to minimise any meal cholesterol absorbtion
??
It doesnt matter
Zadia dropped my APO b 41%
I am a hyperabsorber not a hyper producer. And ZERO side effects.
I also take a very low dose statin to avoid a bounce back. Less than 5mg.
So a phytosterol hyperabsorber would not benefit from zetia then - someone with variations in the SNPs for ABCG5 and G8 receptors? Fatigue, loose stool and nausea may be common but those are NOT small side effects. If you had those without the meds you would be trying to figure out WTH is wrong. HMG CoA reductase (mevalonate pathway) being disrupted also reduces production of MK4, geranylgeraniol and CoQ10. So perhaps doubling down on living better should prevail over meds.
OK, pay big pharma for the rest of your life instead of improving your diet.
It’s not a dietary issue for everyone. I have a family history and have always had hi ldl and low hdl. I have always been a healthy eater and exercised. Not happy about getting out on this medication but going to try it and see what happens.
@@markthurlow6223 Sorry to hear that, but we all know that the medical industrial complex does very little in the way prevention. My cardiologist told me to start taking statins. I told him I wanted to try lifestyle changes first or else I'll never know if they did anything or if it was the statins. I'm muscular, 6' 195, so not obese or out of shape and always ate a "clean" diet. I changed my diet and lowered my LDLs over 25% in 3 months. There are foods that raise cholesterol and others that help lower it. Red meat, whole eggs, whole dairy, etc. are all "healthy" foods, but I reduced my intake of them by 90% added ground flax seed to my daily oatmeal, started using plant stanol spread instead of butter and increased the amount of cardio over a day that I was doing. Everyone is different, but I wanted to see if the changes would work for me before committing to a life of drug use. Glad I did.
I thought the diatary cholesteral myth was debunked.
Then if this drug help us by make foods not digested whe we don't use it to prevent obesity 🤔
I was on Zetia several years ago...I was noticing a weight reduction, so I kept a daily log...lost 17 pounds in one month !!..
Doctor took me off Zetia and the weight came back on within 2 weeks ! ..
Apparently it absorbed all the fat (cholesterol) so my body then took it elsewhere to maintain metabolism....just things I noticed...
I've been a vegan for many years and I don't used cooking oils at all and then only cooking oil is use is avocado oil and as my lover can't process oils I am used to no fat diet but my cholesterol is off the charts ! I think it's mainly bad genes.
What if the patient is on a healthy diet and have been on a healthy diet for years for instant they don't eat any animal products What about that Sometimes I think they just wanna put you on drugs you don't need
There are those doctors around unfortunately.
A completely vegetarian diet not necessary a good all my life have eaten good diet so dhy ha e I got diabetes and high colestral is it because I'm old
Statin must take with food....well absorption with food ...any day time ...there is no specific time for taking this Medicine
I take at night that whst my dr said
Ezetimibe undoutedly gave me explosive diarrhoea fortunately in the doctors surgery!
Ezetimibe should only be taken in association with statins.That’s why vytorin also has simvastatin.
Sexuiol
Hahaha "simis-sta-uhn" another millennial that cannot pronounce consonant "t" in final syllables