How do Bile Acid Sequestrants Work? (+ Pharmacology)
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- Äas pĆidĂĄn 28. 06. 2024
- How do bile acid sequestrants work?
Bile acid sequestrants are used to treat hypercholesterolemia or high LDL levels. Anti-hyperlipidemia therapy seeks to prevent the complications heart attack, stroke and other ASCVD risks.
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Answers:
1.)B
2.)C
3.)D
4.)A
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This pharmacology lecture covers topics such as dyslipidemia drugs. We talk about Bile acid sequestrants and how they block the reabsorbtion of bile, causing the liver to make more bile thus lowering LDL levels. Also we talk about the pathophysiology of LDL cholesterol, regulation of LDL, HDL, LDL and other complications of bad cholesterol buildup. We discuss the mechanism of action of BAS and their side effects. Drugs mentioned include; cholestyramine, Questran, colestipol, Colestid, colesevelam, Welchol.
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Hopefully this video helps some of you!
Let us know if you have any questions!
I have a question plz
What about the people with gall bladder eradication ...why do they give them cholestyramine if they already have No gallbladder..?!
This video is so informative. Thank you for posting actual drug names. I was doing lots of research before. I wanted to ask you, what drugs can lower cholesterol, but be safe enough for those with high triglycerides? Thanks so much!!!
I have a question. Is Ursodial a bile sequestrant?
Yes it is!
Very well explained! I watched numerous videos prior to this and they weren't very helpful explanations. Yours didn't go over my head and it was a great help with my pharmacology course!
Thank you for this video. I was misdiagnised with IBS 15 years ago as I had my gallbladder removed and was experiencing IBS -D. I could not leave the house without running to the bathroom or feeling pain every time I ate. As a result I have developed panic attacks and agoraphobia due to the fear of having accidents in public. It has affected my marriage, my childs life, my working abilities and lead to major depression. I am now taking a Bile Sequestrant and it has changed my life. I only wish that the doctor who removed my gallbladder informed me of BAM so I did not waste 15 years of my life in terrifying fear. I now have to spend time on the emotional and mental scar of leaving the house but I am hoping I can gain the confidence back knowing my internal system can function properly. Thank God for Science, Research and Doctors.
Exact same thing happened to me! It took me 12 years to finally figure it out on my own, even after being told it was definitely not BAM causing my issues. Glad to hear there are others figuring it out for themselves too. I wish the SeHCAT test were offered in the US,
@@basedgodjoe9541 not the OP, but my symptoms that were fixed from bile acid sequestrants were focused around a false urgency I would get soon after eating. It felt as if the food I just ate had already passed through me, which obviously was not the case(although there was definitely a rushed transit time I could observe through eating corn or some greens, 10-14 hours or so at times), but I would feel the need to rush to the toilet and then would be unable to go. This was all accompanied by pain almost all the time. If the pain subsided and I'd get up, the urgency and pain would then come back. I spent far too much time on or around the toilet with no relief. When I finally went, it was almost always diarrhea. I only ate 1 meal a day for around a decade, never breakfast or lunch. I would go to basketball practice having not eaten yet that day. I avoided going out to eat or going places where I would not be close to a bathroom with which I felt comfortable. I missed so much school, and since starting sequestrants ~1.5 years ago, I have missed 0 days due to those symptoms. I still feel pain and discomfort sometimes, but it pales in comparison. I now eat what I want and religiously take my Colesevelam alongside it. Good riddance low FODMAP diet. I think the false urgency is due to the accumulation of too many bile acids in the colon that would then draw in substantial water and salts(which I believe is a natural mechanism to form stool, why 5% aren't normally absorbed as it is), which, along with the gastrocolic reflex after eating, pushes food too fast through the intestines. Our already sensitive guts would likely feel that related pain and interpret that surge as immediate urgency when, in reality, it is still not quite there. I know this is late, but I hope Colestryamine has brought you some relief.
I had a similar experience. I suffered for 20 years after having my gallbladder out before a Doctor told me to take Bile Acid Sequestrants. It changed my life! I also was afraid to go out of the house!!!!
@@3311lee Im so glad to hear of another person who has seen such wonderful improvement as well. How long have you been taking BAS?
I started wuth resin cholesteramina powder about 6 weeks ago. I take one packet in water every morning and it helped immediately
I gotta tell you.. You're an amazing teacher!
Great video...as a sufferer of BAM these drugs have help me tremendously and as a bonus, lowers my cholesterol Win/Win
I truly wish that you were continuing to make videos. The knowledge that I am gaining and understanding for pharmacology for nursing school has come through your videos. Being an auditory and visual learner can be hard in nursing school. Reading and pictures in a book do nothing for my brain. Your videos have help so much and correlate with my way of processing information. It brings the information to life! Thank you for the videos that you have done!!! Hope that we will have more videos in the future!
Life saver and you're to the the point with photos. Excellent job!
Thank You for the support! Glad it helped! đ
Thank you for making this fun, walking me through the process and the pop quiz at the end. Reminds me of class which is nostalgic. Thank you!
Thank you so much for watching! I appreciate the support!
Omg you totally nailed it. Perfect video explanation(visual aid) for pple who need to see pictures and words together. My cousin just received the powder form today and I decided to do some research on. Your videođ„ perfectly explained the product. Thank you for your creativity!đđ
Thank you for watching!!đ
The rationales for side effects were especially helpful. Great video!
Thank you so much ...I'm currently taking pharmacology in NP school and this helped me understand the concept.
Glad it helped! Thank you for watching!đ
Drug Chug.
Your videos are 100 per cent top notch!!
Well presented
Expertly explained
Yet simple to understand and digest.
VERY well done.
I have watched all your videos and they have literally helped me a lot, Thank you so much đđđđđđđđ
I now understand pharmacology because of you!!!!! I really appreciate your effortđđ
This was soooooo helpful, thank you so much! đđŒ
Thank you for such an amazingly easy explanation.
This was so helpful and easy to follow.
An excellent lecture. Thanks, a million.
You're very welcome!
How can we absorb those vitamins if we are taking cholestyramine?
keep up the great work. love the video. thank you đđ»
Thank You!
Very informative, your all videos are amazing. Please make more and more videos.
Very helpful! Thank you!!
I enjoyed the video. Thanks!
This was absolutely amazing and helpful
Thank you so much!đ
Thanks a lot man! You are the best!
U are amazing doctor ,teacher photography, thank you for this video đ
Thank you for your support!đ
Thanks for this! Super helpful!
You're welcome! đ
Thank you for making this video.
Youre welcome! Thank you for watching đ
wow thank you for your making this video!!!!
You're welcome! Hope it helped!
Very helpful video and nice explanation....
Thank you so much for your hard work
My pleasure!
Wow amazing!
This channel is very great ...thanks
Thank you for your support! đ
Thank you for your education.
You're very welcome! Glad it helped! đ
I l really like how you describe and it clears the concept even if you have zero knowledge.looking for pharmacology of nervous system drugs. in future please.
thanks a lot, that was very helpful
Thank you for watching!
Perfect explanation
Thank You! Glad it helped!đ
Great work sir â€
OmG i never comment but that was brilliant explanation thank u so much!!!
You're very welcome! @Humi đ
Why have u stopped uploading ...these were so useful...may God bless u.
Thank you so much đ for good explanation
Glad it was helpful!
so helpful!! thank you
Thank you so much for watching!
Very helpful thanks đđ»đđ»
Glad it helped! Thank you for watching!đ
Very well described đđ
Thank you very much for watching!đ
Thank you so much!
Thank you for watching!đ
best explanation ever
Great video. I have had bowel issues since birth which has progressively got worse in the past 7 years. I have tried every IBS diet and medication there is : none worked. All my tests at the gp always come back normal. I am only now being referred gastro at the age of 27. I eat a balanced diet and exersice as much as i can (disabled). It does not matter what i eat or drink, healthy or unhealthy. They are now finally looking to see if i have BAM or IBD.
Symptoms:
Loose stools or diarrhoea (3-6+ or even upto 12+ when ill)
Yellow ish when i wipe.
Acidic or eggy smell.
Can't digest certain foods like sweetcorn.
Daily nausea.
Fatigue.
Bad days, i get chills, shakes, vertigo and feel like throwing up.
Lower abdominal pain.
Weight gain NOT weight loss.
It's tough as the NHS in the UK is so behind in so many areas hence why it's taken so long to get help.
I have been started of colestyramine to trial and see if they work. I am on day 3 and still no change. Waiting on sehcat scan and results from bloods & stool.
Thanks for the video. Xx
Thank you
I think m going to become doctor without degree just by watching your videos âïžâïž i can debate with doctors.. Great content brother keep growing we need more videos âïž
Can you do this same video on how this works when you gallbladder is removed. Also if you have a right lobe liver resection.
Wow, it's really easy explanation đ€©đ€©
Thank you for watching!đ
you're saving me
can you suggest a natural bile absorber for bile acid diaroeha
My gastro prescribed one of these after I got my gallbladder removed. Helps with those who have IBS after surgery somehow.
How long did you have to take it??
@@jdakid156 I still do after five years. After a year I tapered down from one packet per day to one every three days. Seems I'll stay there forever according to my doctor
I have been using this Med for 38 years .
Thanks for the video I don't have a gallbladder was removed years ago.... Been told I might have "mild" bile malabsorption.......... Gooyoutubed medicent was prescribed a year ago nearly finally got my hands on pill version as sachets weren't so tasty! Anyone know how good this mediceny is no?
Bile is essential and not in sufficient levels with many people. Incidentally high LDL appears to be highly over-rated.
Interesting, so an elevated LDL in conjunction with slow/poor digestion makes sense. If the liver is full of bile but not releasing much and the gallbladder is always full, youâre gonna end up with unused LDL floating around.
Great video. I need cholesterol. My levels are too low. Sequestrants are also used for malabsorption of bile in the intestines. I have primary BAM with retention at 2%
Ah yes, this is also an indication! Thanks for sharing
What tests did you do to find the 2 percent retention.
SeHCAT test. It's supposed to be a capsule containing bile salts and a radioactive tracer. You have two gamma scans done 1 week apart. Anyway, my symptoms have long gone since my last comment. @@glengarbera7367
This was amazingly helpful I just started this and I dont have a gallbladder
Glad it helped! Thank you for watching!
Amazing sir đđđ
Thanks for watching!
So this is why Iâve had diarrhea for the past 5+ years ever since I had my gall bladder removed. My gall bladder isnât there to regulate the bile acid and my liver is just pushing it out. So esp when I eat anything fatty it makes it worse. My body canât handle all the oil.
I was out on anti acid meds, diarhea started
I'm having similar issues. Been taking cholestryamine and it's not working, Sucralfate had been working but my doctor took me off of it for some reason.
I'm taking Prevalite for SIBO and it works great for diarrhea.
I want to ask a question what happen to this whole process of breaking fats when the gallbladder is removed how does the body tend to work normal after the removal ???
What if you don't have a gallbladder. And how long do you have to take the medication.
all i need to know is that why they cause hyperglycemia as a se thanks
Is there a way to take the synthroid or fat soluble vitamins if the medicine blocks the absorption? Thanks
My life partner just passed away very suddenly. The only thing he did differently was 3 doses of colestipol.
I found him already gone in the morning. He was prescribed this for diarrhea.
He had no gall bladder.
U r amazing
I had my GB removed due to cholecystitis, a bad infection and borderline gangrene. Does this mean it's harder to burn cholesterol?
So if u have sludge and small gallstones in your gallbladder will this help with that..!
1 lower ldl 2- cholestrol 3- B12
what happens when you have had your gall bladder out i had stones in mine and i have been put on colsevalam
I have been gallbladder-less and drugless for over 15 years, if you stick to a low fat diet (low processed foods), I have no need for meds
saved me!!
i always have HIGH HDL, and LOW LDL ,,, what does that mean ?
How does it cause increased of triglycerides?
Have you found an answer?
They should tell us when we have are gall bladders out it would speed up the help we need twice I was taken in to hospital by ambulance after bad extreme bouts of diareha wouldnât of happened if I had be told about it but thankfully I had a sechat scan yesterday got to go back in to hospital one week later then get the meds to start living again any questions please contact me your not alone.
Question: could lowering a person's LDL naturally help them with BAM?
Binding the bile acids should prevent them from having the effect of drawing in excess salt and water that cause the urgency and diarrhea of BAM. From what I have read on the matter, the 3-5% of BA that are not reabsorbed help to form proper stool in a healthy person, but in excess, they cause these symptoms. When they are bound by BAS, they do not draw in water and salt, which I think is why constipation is a side effect.
Hi, I had a gallbladder removal before 3 years. I am having bile reflux since then. Can bile acids sequestrants help reducing flow of bile in the stomach or worsen it ? Thanks.
What I don't have a gallbladder so how does that work for me
This is actually one of the other uses besides lowering LDL. With no gallbladder, the liver can continuously drain bile, and it can cause "bile acid diarrhea" and there is also "bile acid malabsorption" there the body does not recycle the bile. If it isn't bound to anything, it is a powerful laxative. So taking a BAS can bind to all the excess (that would normally be kept in the gallbladder until you eat food) and prevent the laxative effect.
What if your gall bladder is removed?
Any role of Ursodeooxycholic acid
It is a bile acid
at 9:36 it should be said deciliter, not decaliter
Great instruction....however, please highlight the answers to the quiz. Thank you!
Thank you for your support! @Rhonda
I put the answers in the description below, only because I want to give everyone time to answer them without accidentally seeing the answer!
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@@DrugChug That would be good. I looked in the description thinking I would find them there,but I did not see them.
@@rhondagregory5253 They should be there! (You have to click on "Show More" on the bottom and it will open up the entire description with the answers)
You had your gallbladder removed and donât have enough bile for fat digestion, wouldnât take inch this medication make this worse?
People here describe taking cholestyramin for BAM (bile acid malabsorption), too. So I'm a bit confused....
Edit: in BAM it "just" prevents the laxative effects of BAs
is ursodiol a BAS
My dr has prescribed cholestryamine because I donât have my gallbladder any more itâs been yrs since I had it removed they didnât tell me that I would experience bam I constantly have the runs to the bathroom after eating along with a lot of mucus and cramping which I thought ibs-d the Gi dr never gave me anything for this I have notice after 2 days of taking it I donât have the runs yet and iam extremely full with just taking 1 -2 grams daily with just water I donât know if this is an appetite suppressant or not so hopefully this medication will work
MOA was brilliant brođ
Appreciate it Gâ
I take cholestyramine to bind to mold. Great video, but didnât answer my question.
Mold? What symptoms? Does it help?
I wonder if this helps as well because I was exposed to mold for 4 yrs before then I already had issues with my digestive system due to not having a gallbladder and mold exposure made it worse even though itâs been a yr since I moved out of that toxic environment
i dont have a gullbladder i just want the diarhhia to stop
WHAT IS ANTIHYPERLIPIDEMIC DRUGS
What else does our body need cholesterol for? A form from skin is made into vite D? Wonder if hi lipid people have low bile. SO they need to take (or put on skin?) the fat soluble vitamins (A,D,E,K) if take this.
Cholesterol is literally part of each cell's membrane, FYI đ
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Thank you sir đ
Hey man I have a question, hope you can give me a advice? Iâm taking 625mg colesevelam for one year and I have man boobs and belly fat. Do you think colesevelam can caused fatty liver ? And can I take choline (as itâs good for fatty liver) while Iâm on colesevelam. Thanks
So if 97% of it is reused how does that work for people that donât have a gallbladder anymore? The liver is still what produces the bile so how is that reused?
The different bile acids are reabsorbed (to the blood stream) in the small intestines (terminal ileum). Then the liver filters it out (probably it has some storage capacity too). Gallbladder has nothing to do with reabsorption. It's there to store and regulate the release into the guts (duodenum)
...but honestly I don't know how one functions without it. Going to look it up.
Are there foods that have similar effects ?
BEANS AND LENTILS, OAT OR RICE BRAN. BENTONITE CLAY, ACTIVATED CHARCOAL..
why does it increase TAG's?
Have you found an answer?
@@Littleprinceleon nope, mystery of med I guess
I have just been diagnosed after 20 years, all my hair has fallen out due to malabsorption !!!! Now I cannot get the prescription drug needed for this condition. I was told by the pharmacy that because of brexit. Also Colestryramine side effects are bad, causes malabsorption of vitamins ADEK Zinc. Which is useless.
San TIVA prarmacy practice
Salt protein