Immunology - Antibody Somatic (VDJ) Recombination I

armandoh.org/
Immunology - Antibody Somatic (VDJ) Recombination
Antibody Production
/ armandohasudungan
Support me:
/ armando
Instagram:
/ armandohasudungan
Twitter:
/ armando71021105

[@rusticromeo]

Hi I am a Pathologist and I should say that that video is one of the best, clear and easy to learn video of somatic recombination I have ever seen. You must be so clear in your concepts to make something like this. Excellent work. Hats off to you.

[@isikaram6006]

Felt the same +1000 thanks a lot

[@thegahd]

its not "somatic recombination" that is something else entirely. It is antibody recombination, of the antibody Fc structure

[@macaroniwithoutcheese175]

I’ve been studying biology Olympiad tests, and my ability to ignore and unwillingness to learn the immune system so far has bit me in the butt hard right about 30 mins ago. Thanks for the video from 11 yrs later.

[@veramanelli9636]

I'm glad I've found such a clear presentation. Thanks to you I have now a chance to pass the next exam !

[@drcapt]

you saved my ass on med school immunology! thank you!

[@yoldw]

hi. im on med sch also. hows your med day ? nice to know you

[@033gauthamkesav7]

OMG....I don't have words to explain how beautifully you're explaining the whole stuffs...hats off..

[@ElYu-gn2dh]

1,5 hour lecture explained in 7min. Appreciate it man!

[@Bradatimrkonja]

Also, thanks, your explanation made this MUCH easier to understand...everyone said immunology would be a breeze after biochem and cns. I got a 400 page book to learn in 2.5 weeks.

[@RudiSka]

3 years into my med lab science degree and Armando is still rescuing me!! Thanks for these excellent immunology videos.

[@cravebaby11]

Just used this video for a presentation at University of Rochester School of Medicine, it's awesome!
We wanted to point out one minor error for the sake of clarity - the big antibody, drawn at 2:17, has the structure of an IgG (with 3 constant regions). Armando is correct in stating that it is an IgM antibody, so the drawing should show 4 constant regions (with THREE constant regions before the hinge region, and 1 after the hinge region).
Thanks! My class and my professor loved it!

[@Mendoch]

got my inmuno final on friday if i pass i'm posting u on every single univerity group i know!!! thak you so much!!

[@andrewm2786]

did you pass

[@agnisuddhashaw2767]

Just wanna let u know that these videos are awesome and people like me are still using it and more students will keep using it forever

[@MsCleibson]

I love the fact that you use pictures and a flowchart. It's so difficult to just read it, some need to see it! Thank you from the visual learner.

[@armandohasudungan]

I really hope you pass!

[@mohammadadel3097]

Saving students since 2012. Armando Hasudungan.

[@armandohasudungan]

Hey man, try watching it on massive screen with quality setting on 720p. And the printed version, I will try to upload picture next week:)

[@jenshu7]

The image is no longer there :(

[@sanjuktaghosh8802]

May God bless you, for putting this complex stuff so simplistically.

[@sharinatisdale9539]

o m g you have no idea how much this saved my life

[@abderrahmanedamiri7594]

A great video.. definitely had to rewind many times to understand some points. You talk alittle too fast for me 😂 but you saved my life

[@avocadomillennial530]

If I pass my immunology test it will solely be because of you!

[@Javerick137]

I like the way you present your explanation of the topic, so easy to follow, fast paced (in a good way) and succinct. Good job, man - I will be visiting here a lot more in prep for my mid-sem.

[@armandohasudungan]

I will try to scan it one day, its a big piece of paper, so it needs orienting, cutting and editing. Will take a while.
thanks

[@ameera224]

This video and you are a masterpiece!! This was so helpful!! :) Thank you for taking the time out to educate the world!

[@lazyb6091]

Omg this is just perfect... Just look at your drawing so clean and perfect 😀... I really want to make notes like this ❤️❤️❤️... Thanks for the video.

[@jesssarah1123]

Thanks, this is great. The only thing is for VJ recombination of the light chain (around 6:30) you leave the leader segment in the complete spliced segment that makes up the final light chain.

[@RNcooley]

Overpriced med school education can be replaced by youtube videos. Thanks for making sense of this:)

[@giakolou2876]

Thank you, this is the best explanation ever. You are saving lives with these videos, I don’t know what I’d do without your explanations, (my lecturers are hmm useless sorry to say).Thank you infinite times. I’ll pass it forward.

[@user-ph9ih8qp2f]

thanks for helping me understand this process easily!

[@careleentoh3487]

Need more people so spread this video more

[@jata14]

Bless you this helped so much!

[@amerikaland]

thank you so much! been trying to figure out this bit about Ab diversity for so long. thanks for making it simple!

[@kkronschnabel]

I wish you could teach all my science classes! So helpful!

[@themrvims]

Splendid and TO THE POINT Explanation...very useful for basics and quick revision...

[@ninecalvo2870]

Em, Armando te quiero. Mil gracias.

[@BasicScienceSeries]

Hard work. Good video and great content.

[@alhaeri1]

hen 720p was the highest quality :) good old days

[@tonysantana6302]

HO, LEE, SHIT
my bone click, my mouse clicks..... but nothing has ever clicked so hard in m life

[@saketpandey3889]

Thank you so much sir very helpful 🙂❤️

[@roadtoaesthetics4253]

thank you very clearly explained.

[@msjalan]

during light chain recombination, at the last stage after intron removal, the J segment is removed as well so only V and C remains in the end product.

[@victoryj8595]

Your videos are really brilliant and helpful. Thanks !

[@toreassuremyheart.5252]

czcams.com/video/pTeK3avkbuo/video.html

[@arifdina9069]

Really helpful...thank you sir

[@aashnakumari3497]

You just blew my mind❤️

[@mohammedmonzurmorshed2896]

thank you so much for your effort...amazing

[@jameslongbui]

100x better than my lecture in grad. school

[@AliSalman-ye9sq]

You are a hero!!

[@sorayabadrie2180]

Omg this video was awesome!!!!!!

[@Mendoch]

i passed!! got an 8 (out of 10) thanxs to you!!!!!! so very happy :) i shared you everywhere i know of lol

[@emilyaigner1646]

Great video!! So Helpful

[@mikeLmula]

You're amazing! Thanks for the video!!

[@alessandroduse5645]

That was quite useful! Thank you so much!

[@khangelang6106]

Is it possible to get this picture anywhere? The "IMAGE" link on your website under VDJ pt. 1 is actually VDJ pt. 2.

[@mcatterall93]

yep, it's on his facebook page

[@rimshar.755]

This was amazing!!!!! Thank you so much!!!

[@monaelwassefy166]

wonderful work i love it thank you

[@Orius25]

You don't describe RAG1/RAG2, recombination signal sequences, the "turns" (12/23 rule), or the addition of nucleotides after splicing. Those are really important to this process.

[@lionsinescanor373]

Very helpful video!!

[@prerithprabhu8359]

Thank you very clear explanation

[@brittophone6219]

Amazing job thx 🥺

[@arinarakhteenko579]

Thank you!

[@princerainier]

if i receive at least a B on my immuno test by watching youtube videos the night before, then i am going to completely lose faith in most bio professors. props on explaining fairly in depth material through simple and orderly depictions.

[@abirnina7346]

thank you so much

[@piumiwickramasinghe6514]

really helpful video.

[@myuniverse367]

Thank you

[@teallantern2814]

this guy is great. helped ridiculously

[@munyaradzinyarugwe8769]

thank you soo much. this is golden !!!

[@matttzzz2]

Video starts at 0:34

[@emmam.2784]

Love this guy 💚

[@pluiemd8375]

Shouldn't there be a fourth C segment in the ab heavy chain??
cause it is an IgM, and both IgM and IgE got four C segments in their heavy chain, you drew only three :/

[@gx6iium24]

yeah.. me too.. i was just wondering where is the other C segment ??..

[@majda2992]

This is so helpful! Thankyou

[@yasmine_boutemine]

wonderful!! thanks so much

[@MaryamEemaAli-to3kc]

Thank you !!

[@mrsiddhartha6]

thank you. The video was really helpful!

[@kurtcurtis511]

Hi,
This video is fantastic. Thank you!

[@gmcwhir]

The symbol you use in the beginning of your video is not the symbol for medicine. The symbol for medicine has only 1 snake and is called the Rod of Asclepius. The one you show is a symbol called the Caduceus which is the symbol for commerce and is carried by the Greek god Hermes.

[@mmaking8664]

who gives a shit

[@FedeB932]

@@mmaking8664 *gives a shit*

[@NieceyWeesey]

This is so perfect! Thank you!!!!

[@jannat1583]

Thank you SO much!

[@yasminechaimaa6856]

Thank uu so much it helped me a lot

[@sumblaateeq4009]

Amazing

[@cattycatterson]

Thank you very much😊

[@karkaspir2102]

God bless you

[@hudafatima224]

It’s wrong to say somatic recombination occurs in B cells . It occurs in both b and T cells

[@DuckODuckProductions]

Thank you sir.

[@xJustKeeepSwimmingx]

incredible!!!! thank you!!!!!

[@hanaakhatib7098]

thank you so much

[@maryamalamodi9717]

amaaaaaziing, thank youu!!

[@RAyano]

Thank you so much!!!

[@Etrusco15]

well done

[@CktopShoOter]

Thanks dude, you rock

[@sandeepkaur-nn6mb]

it was really helpful thankyou so much :)

[@prashantj50]

Thanks

[@danspitalnik]

Very useful.

[@selmam9676]

Amazing !

[@ILOVEBGM888]

this is amazing!!

[@foundfindfinding5377]

THANKS.

[@yusufcabuk66]

I'm not sure if you ment this but I guess after the dna recombination we still have a DNA which now is locked until class switch. After the recombined DNA is transkipted we get the RNA and splicing etc..

[@ebrarkantar3600]

perfect

[@radrad5885]

great.thanks a lot

[@GR-bt3et]

EXCELLENT!

[@kart6320000]

very nice presented but you showed DJ rearrangement in DNA and VDJ in RNA.please explain

[@maxblack7778]

this video literally saved my soul but i do have one question. since an igm antibody has 4 constant regions, and the big antibody drawn in 5:01 only has 3, is that an error? Also, why was the second C region colored in with red... does it not participate as a constant region subunit, and thats why there were only 3 drawn in the antibody?