T and B Cell Development: V(D)J Recombination

The first thing we will examine in our study of adaptive immunity is T and B cell development. How do these cells establish such an incredibly variety of surface receptors with which to recognize so many millions of potential antigens? This process is called V(D)J recombination. Let's see how it works!
Script by Niyati Vachharajani
Select images provided by BioRender.com
Watch the whole Immunology playlist: bit.ly/ProfDaveImmuno
General Chemistry Tutorials: bit.ly/ProfDaveGenChem
Organic Chemistry Tutorials: bit.ly/ProfDaveOrgChem
Biochemistry Tutorials: bit.ly/ProfDaveBiochem
Biology/Genetics Tutorials: bit.ly/ProfDaveBio
Anatomy & Physiology Tutorials: bit.ly/ProfDaveAnatPhys
Biopsychology Tutorials: bit.ly/ProfDaveBiopsych
Microbiology/Infectious Diseases Tutorials: bit.ly/ProfDaveMicrobio
History of Drugs Videos: bit.ly/ProfDaveHistoryDrugs
EMAIL► [e-mail]
PATREON► / professordaveexplains
Check out "Is This Wi-Fi Organic?", my book on disarming pseudoscience!
Amazon: amzn.to/2HtNpVH
Bookshop: bit.ly/39cKADM
Barnes and Noble: bit.ly/3pUjmrn
Book Depository: bit.ly/3aOVDlT

[@GrievousSpino]

I had my exam about these topics AN HOUR AGO and then you posted 🤣 ah well, I can retake the exam...!

[@watchbest75]

😂

[@AlexOrozco-vc2zz]

😂

[@AlexOrozco-vc2zz]

Y Cres que no se que todo es una mentira hermano 😂😂😂😂 asta horita no existe quien pueda engañarme

[@UPONBUTTERFLYWINGS]

Well, Hello Dr. Dave! I happened upon your channel when I perusing "flat earth" content…. A dear friend of mine admitted to believing this kooky idea. SO, randomly, I landed on Andrew Gold's channel. You were present and working hard to get a word in edge wise, debunking said idea. I kept watching because I realized that you were actually a smarty pants, hence I subscribed to your channel. Just wanted to say hello and will systematically watch your content. So nice to see there are Some intelligent individuals in this world.
Be well, Be safe. And Thank you!😅

[@yourneighbourr]

congrats on 3 mil subs Dave

[@waynesaban2607]

Hey Dave, I am always amazed by the quality of your work.
You may have already tackled the subject, but I think it would be helpful to many if you addressed some of the pseudoscientific cancer treatments. When a loved one gets cancer, the act of just trying to navigate the medical/insurance industry can be overwhelming.
I was lucky that I could be pointed in the right direction by a High School friend who became a PhD Professor and cancer researcher at The University of Pennsylvania… the late
Dr. Stephen Tuttle.
Many of us are aware that cancer is not one disease but many.
It could be a series of videos and could be helpful to many.

[@waelfadlallah8939]

Dooooooon! Biology is my favorite topic 😊

[@objective_psychology]

This is amazing

[@joeyRaven201]

Nice topic its realy fun

[@Huebert-zp8uq]

I was only thinking the other day after my lectures on this topic that I wished you covered this

[@science1004]

Dang just published I also love your teaching and am also a fan of science

[@shanobuo]

Thanks for the excellent video. But at 5:33, you said ECS while it should be ESC (excised signal circle), right?

[@_PITBOY]

What does it say about todays viewing and real world societies that a channel that has as its priority intent, the drive to be an educational channel explaining nuanced and detailed subject like this video ... being financially supported by the inflammatory debunk videos. One glance at view count between both types of videos here, makes it abundantly clear that Prof Dave has realized that in order to do the work he wants to do ... he has to do the material that attracts the general higher view count as the financial lifeline for the channel.
That says so much about ... stuff, I dont even know where to begin.

[@ToxicTubeAgario]

I like this video but his other videos stimulate more

[@aiaian_aaa5583]

Hi Dave.I’m wonder when will you respond to the content on channel named “Long Story Short “.At the first glance,those videos seem to be very interesting critical thinking and harmless,but after watching only a few of them,I found the whole channel is misleading and try to let people believe Intelligent Design instead of Evolution.Some argument in the video is easy to tell they’re misleading but others are really difficult to argue. So hope you can make a video about it.Thank you very much for the content.

[@ProfessorDaveExplains]

yep it's on the list

[@CosmicVoyage5]

cool video

[@kimsteen8185]

He does, infact, KNOW.
The science stuff.

[@desmond3828]

Survey of the adaptive cell types?

[@blindwatchmaker2345]

Congrats on 3 mln subs 🎉🥳✨️👍

[@AlbertSatnoianu]

how the - am I seeing comments from 5 hours ago when the video was published just now?

[@ProfessorDaveExplains]

Published at 7am PST.

[@Sz-xi1yj]

Evil Prof. Dave be like: The earth is flat

[@justinschafer5269]

Nah, Evil Prof. Dave would be like: “This is why Christianity is true, and America was founded upon by Christianity.” That way he could make as much money as he could ever want. Your flat Earth believing version would be the “Dumb/brain damaged Prof. Dave.”

[@getvictored1737]

at first glance i thought the image was an oddly drawn electric circuit

[@Hungary_0987]

Time to get nerdy

[@myacho7434]

could you make the chloroplasts topic (especially in algae)? ❤

[@Art-yp3xx]

You can watch tnis physics wallah english

[@Art-yp3xx]

Plant kingdom

[@ProfessorDaveExplains]

check my biology playlist

[@myacho7434]

Thank you

[@centralperk7062]

Not enough

[@Bob-the-1-and-only-blob-fish]

When's the next monke episode

[@user-il1fd6yb7n]

Second

[@outmywritemind1739]

Dave! Where's your reaction to the new Kendrick Lamar track! I promise I am interested in T and B cell development, but the new diss tracks take priority rn

[@flipvdfluitketel867]

First

[@joeyRaven201]

Thats true

[@jamiehunter2204]

Gay

[@ianlee5812]

Do you watch penguinz0? What do you think of it?