Isotype switching | class switching recombination | Antibody class switching | antibody diversity
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- čas přidán 2. 08. 2020
- Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG.
Amazing man, that´s a perfect review of a theme that takes a long time to understand!
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@Briar James Yup, have been watching on flixzone} for since december myself :D
@Briar James Yup, been watching on Flixzone} for since december myself =)
This is the best explanation I could ever found .. thank you
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Truly an incredible explanation Arpan! I was finding it so difficult until I saw your video.. Thank you very much and take care!
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I have immunology exam tomorrow. This is so helpful and lucid to understand. Thank you 😊
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Glad to know that my connect is useful
Thank you very much. Now the concept is more clear
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Amazingly explained in detail 🙂 very easy language gud teaching helps me to better undertood I really liked this video plz keep doing👍
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@@animatedbiologywitharpan sure definitely 👍
Amazing ! Thanks to you i've understand in time for my exam this notion ! It is very well explained thank you !
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Your videos are just amazing🙌😀 Difficult topics explained in such an easy way. Sometimes it becomes difficult to visualise all the text we have read in books but ur videos made it easy for me Thank you❤️ Great job, keep up the good work👍
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Great video!!
This video is amazing. Thank you so much!!
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Thank you, sir Arpan. I am a medical student who tries to understand immunogenetics and your channel is the best thing I could hope for
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@@animatedbiologywitharpan if the subset of t helpers(viz th1,th2,th17 etc )decides the Ig to be released, by the thier specific cytokines released to the B cell(antigen presenting),then how could we say,
In primary infection,Ig M will be more and in 2ndry infection IgG will be more in serum?
ie,if Th1 is the helper subset formed,would it only cause for IgG producing effector B cell synthesis,so from the first occurance of that infection,IgG may be the main Ig in serum.Is this possible sir?
This was perfectly clear! Thank you very much. :D
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thank you so much, I'm a french med student, it was a very difficult topic to me
but you explained it in an easy way. :)
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Cool work man , clear and clean keep up
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THANK YOU FOR THIS AMAZING VIDEO
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This is soooooooo good.
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Salute to your art sir.... Your are great and intellegent teacher... I always search for your videos if I need any topic
glad to hear from you....thanks a lot for the complement
Tomorrow in my immunology exam...
The videos of ARPAN DADA... are so easy and lucid to understand that it boosts my confidence level.. 😅
Thank you DADA for ur lovely animated video's.
All the best for your exam
3 more days for me. I also enjoy the content alot! Greetings from germany
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I Tutor organic chem. For next Semester Preperation i will mention you 🙏
@@kevinbenjaminbassler9530 that would be very kind of you. Thanks in advance
Excellent i just understand each and every detail clearlt
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Thank you. I was searching our University library, and nothing was so concise as this.
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Even after working really hard I can't reach s lot of viewers
@@animatedbiologywitharpan certainly 👌
Amazing !!!!!!
Thank you for the great explanation 😢
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Amazing!
I shared the link with my friends in the faculty although we speak Arabic but the explanation deserves
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Excellent !
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Thank you!
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Thank you so much, very informative
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koszonom szépen from Hungary
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Incredible!
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Awesome explanation
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explained in details !!
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THANK YOU SOME MUCHE YOU HAVE AMAZING EXPLAINE
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Amazing explanation!!
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Amazing man!!!
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Very well explained !!❤️
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@@animatedbiologywitharpan Sure❤️
you're amazing! ty!
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Thanks a lot.
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Thank u so much
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thank you
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Nice explanation..👍
shubham kr rai please share my channel link with your friends and colleagues
Very nice and basic explanation
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Much appreciated ❤️❤️❤️
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Amazing video👍🏻
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@@animatedbiologywitharpan of course! Keep up the great work👍🏻
Woooooooow nice explanation
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Thank you sir ❤
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As far as I know both no affinity and high affinity get destroyed by negetive selection and only T cell with low affinity survives through positive selection
hi, class switching can also occur before germinal center formation
Wonderfully explained sir 🙏🙏🙏🙏🙏
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@@animatedbiologywitharpan sure sir 🙏🙏.
Wow amazing you explain in detail,what do you prefer to prepare for content
Kuby immunology
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@@animatedbiologywitharpan sure man👍.
you are amazing
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So there is a question. After the AID enzyme comes into action, what really recruits the repair enzyme? And why not any other repair enzyme with high fidelity?
If you will go in more and more detailing you will get a pH, ions presence, and many many other factors 😑
Thank you so much! Btw which program did you use to film your display?
Obs studio
thank you for amazing explanation. you mentioned B cell isotype switching is antigen dependent and requires mhc 2 cd40 co stimulation so can we say its also t cell dependent ? is this the case where polysaccharide and conjugated vaccines differ ? polysaccahride vaccines activate b cells indepent from t cells so no somatic hypermutation and generation of high affinity antibodies and ig G thats what i understand
T cell stimulates strong b cell activation which is a prerequisite for isotype switching. Moreover, T cells provide essential cytokine signals, such as IL-4 and IL-21, which direct B cells to undergo isotype switching, resulting in the production of antibodies with different effector functions. This T cell-dependent process enhances the adaptability and effectiveness of the immune response.
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Thank you sir for the video❤i have a question please: so if i understood, isotype switching happens to the Ab produced not the BCR and one B cell either makes igM or IgD or IgE or IgA or IgG right ?
ya soluble anyibodies are generated and constant regions are changed
Well done bro.
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When the naive B cell encounters a pathogen, is this with the help of the dendritic cell traveling to the lymphoid with parts of the pathogen covering it? Or does the pathogen make its way to the lymph, and the B cell directly recognizes it and takes a piece from it?
Dendritic cells take the antigen and move towards the lymph node
Can you make a video on carrier options after msc from any life science stream in future?
czcams.com/channels/4IpyopsGWSjaPACNTZLuqg.html my second channel would deal with all of these topics
@@animatedbiologywitharpan OK but please make a video on those 3 phases of Tifr interview.BTW video was very helpful for my upcoming gat b exam and all thank you.
Sir,May you please tell me if pathfinder is sufficient for csir NET JRF LIFESCIENCE Immunology portion along with some CZcams vedios.
When CSIR NET is concerned I would suggest Kuby immunology
Why is isotope switching occur ? It only changes the conserved heavy chains which don’t bind to pathogens only to the own B cells, so why do we need different types of conserved regions if they don’t select for pathogens ?
Since the variable region does not change, class switching does not affect antigen specificity. Instead, the antibody retains affinity for the same antigens, but can interact with different effector molecules. Example : IgM interacts with complement better than others...IgG is better in terms of crossing placenta etc.
I have a question regarding the naive B cell . So it can produce IgM and IgD without encountering a pathogen ? But why does they use IgM and IgD levels to see if the patient has immunity to a specific disease?
Very good question....let me tell you that with all infection it's not true that there would be class switching as a result only IgM could be produced.Now b cell has IgM by default but its membrane bound ,after infection secreted IgM is synthesized which is specific to the antigen coming from a bacteria let's say.
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I have a doubt. The region where NK-kb and Stat1 bind , in that region is the AID recruited? I can't understand this part. Plz help me
NF-κB and STAT1 regulate B cell class switching: NF-κB activates AID for DNA recombination, crucial in antibody class change. STAT1 responds to interferons, promoting IgG2a and IgG3 production in infections. Both transcription factors coordinate immune responses, ensuring effective antibody diversification against pathogens.
@@animatedbiologywitharpan ok thank you
Arpan the GOAT
I don't understand any context of your comment.
@@animatedbiologywitharpan don't worry, it means you're the Greatest Of All Time 🐐 for making Immunology make sense 😎
Ok now I understand....
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Hello is interferon y secretion is required for all the antibody isotypes or is it only for igg
IFN-gamma inhibits the secretion of IgG3, IgG2b, IgG1, and IgE, and enhances the secretion of IgG2a.
Good lecture but B cells mature in bone marrow only and not in lymph node, I believe
No, maturation doesn't take place in bone marrow, it's always in the lymph node
Thank you for your video! Can hyper IgM syndrome generate IgD?
Nope its not possible in my opinion
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@@animatedbiologywitharpan Sure! Thank you for your efforts!
Do different cytokines all lead to STAT activation?
Yes they do
Can you please provide a reference for this video?
Kuby immunology 7th edition
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Allah yihmeek.
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So class switching is simply T dependent activation ?
Class switching happens in B cells but not in T cells. if there is no strong T cell dependent B cell activation then class switching would not happen
@@animatedbiologywitharpan wow that was a quick response ,thank you so much for clarifying it
Great video but the sound was not too good.
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Can you please improve the audio quality? Its horrible
Thanks for this suggestion....I will try to improve the quality in subsequent videos.
Thank you sir ❤
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