How do monoclonal antibodies work? Rituximab, infliximab, adalimumab and others
Vložit
- čas přidán 12. 06. 2024
- This video contains a detailed and simplified explanation of how monoclonal antibodies such as rituximab, infliximab, adalimumab, ranibizumab and trastuzumab work.
Special thanks to Harry Watchman for editing the audio in this video.
Zero to Finals Medicine book:
UK: www.amazon.co.uk/dp/1091859892
US: www.amazon.com/dp/1091859892
Zero to Finals Paediatrics book:
UK: www.amazon.co.uk/dp/1080142827
US: www.amazon.com/dp/1080142827
Zero to Finals Obstetrics and Gynaecology book:
UK: www.amazon.co.uk/dp/B08K4K2WQB
US: www.amazon.com/dp/B08K4K2WQB
Website: www.zerotofinals.com
Notes: www.zerotofinals.com/learn
Multiple Choice Questions: www.zerotofinals.com/test
Instagram: / zerotofinals
Facebook: / zerotofinals
Twitter: / zerotofinals
DISCLAIMER: This video is for education and entertainment only, and is not medical advice. This video should NOT be used for medical advice or to guide clinical practice. The Zero to Finals content should not be used in any way to guide medical decision making. Zero to Finals takes no responsibility for any actions taken or not taken based on the information provided. Local and national guidelines and senior clinicians are there to help you make decisions, not CZcams videos. If you need medical advice or information, seek it from an appropriately trained and licenced doctor or healthcare provider that can address your individual needs. Zero to Finals cannot guarantee the accuracy of information in this video. Please highlight any errors you notice in the comments below - thank you.
Being 70 and having Covid I was given this treatment. Within 24 hours was up and around with no side effects. Amazing!
I’m 63+ and this did nothing for me. Nothing. 2 weeks in and still have coughing and terrible diarrhea feeling weak, loss of smell and taste, body aches and overall feeling of malaise. Plus the virus has destroyed my vision. I was already suffering from 6th nerve palsy from a virus I had 2 decades ago and this virus has made my eye condition worse.
Hi mate are these oral tablets and where can they be bought?
it is amazing
ld.Except if from the nanoparticles on the masks you had a chemical pneumonia.
@@gasmith7486 please take fresh air, sunlight and fresh salad, vegetables and coconut water besides regular treatment.
Thank you God. My elderly father wouldn't be here without it. He came down with the fever, started going down hill the next day. Got monoclonal the next day and was up sitting on the couch the next. He's been improving everyday since then.
My brother took this right after covid diagnosis, he's doing great so far,,,my son is doing his in morning,,he's got covid bad.🙌🙏🛐
@@marlenedavidson9173 how is your son doing?
@@yellowbird500 he's doing great..no problems so far.thank you for asking! 🤗🙏
@@marlenedavidson9173 How did it go I took it day 2 and it turned my asthma around and so as that fever
@@mixytampa812 sorry took so long to answer..my son's doing great! Never had fever, any effects from antibodies..how are you doing?
They absolutely work. There is a pharmacist in my town and the hospital that are giving the infusions to covid patients that meet the criteria for their use. The results have been remarkable.
It’s giving in Florida by increasing centers against Covid, solved it within 2 days instead of the Jab
Should’ve doubled down on these types rather then the never ending doses of JJ & PZR.
@@windmill2517 and now Biden is going to limit how much states get. Insane!
After turning up positive for COVID-19 and insisted I be given the monoclonal antibodies treatment 3 hours after an emergency order was issued by Fl gov Desantis it help to change the downward spiral course I was on to a positive course for recovery. I highly oppose the toxic vaccines and affirmatively encourage folks to get monoclonal antibodies treatment as early as possible if you test positive for COVID-19. I have family members that also got Covid-19 and They experienced positive recovery results as well.
@@jobabs seems like only red states are being shorted
This video is outstanding. I took immunology in medical school in the late 80's, and was terribly frustrated by how disconnected it all was. At that time researchers had put a few puzzle pieces together here and there, but had no idea what the overall picture looked like. Obviously we've come a long way since then, but the way you teach this is wonderful. I can't wait to watch more of your videos!
Be very careful !! Look at how they are lying to you about the V !! This is also RNA , like the mRNA !! No one will mention the worked before way a dead virus in vaccines !! There are thing in here too you don’t know about !! 45 separate things they do not tell you about here either !!
@@diannebass1051 even this may not be ideal for covid but perhaps it is better against cancer than some Other, older methods like chemo
@@ytcomms3945 key words maybe ? NO ONE KNOWS!!!!
I went to school in 2000 and now they use virtual reality learn anatomy and a lot of biochemistry lessons look more like video games than actual work.
More people around the globe need to watch this.
Never in my life would i think i would be learning about this type of stuff. Im a mechanic but with the crazy political climate were in with mandates and sheeple believing crazy headlines, you have to win your debates with facts not feelings, convince people to ask questions and do your own research. Great video!
Lol, seriously!! This day in age you have to know stuff. Remdesivir can cause some pretty bad side effects and they are still treating patients with it.
@@shannongaines4421 whats even more crazy is this led me down a rabbit hole which gave me leads on my vision lose in one eye. Which only affects old people amd not young people. i still have to consult a eye doctor but atleast i have a little bit of hope now.
@@Dirtynuckinfuts best of luck. Praying your eye sight is restored to better than it was before!!
I'm with you.
My husband and I got covid in July he was hospitalized and just got out in September. I wasnt as bad but got monoclonals in the hospital as well. I believe they saved my life. Side effect is naseua but I had already been for days and had lost 20 lbs in one week so there was no question whether I was going to take it or not.
Early treatment is the best option. I believe fewer people would be dying from covid if primary drs were allowed to prescribe antivirals..now they are finally allowed to prescribe monoclonals since Saint faucci announced they can for any case of covid(before it was only a certain population) a few weeks ago. So I think this will prevent more hospitalizations and deaths.
@@dystopian2153 look into NAC the fda is trying to make it a drug so they can use it to treat covid. Its in phase 2 trials. You used to be able to buy it for 5 dollars a bottle as a supplement. watch they will rename it and charge 200 a pill. Big pharma isnt there to heal you they will heal you just enough to keep you hooked or addicted so you keep paying. I lost 10 years thanks to big pharma why should i trust them now. Being able to be knowledgeable about these types of things are very important. You cad be a sheep who follows or a black sheep that stops to ask questions.
You put my bio college professor to shame, he didn't really explain shit about monoclonal antibodies, and used some complicated definition, instead of pictures and simple words like you did! Much Appreciated!
If you can’t explain it to a 6 year old you don’t understand it yourself. -AE-
I think there's a lot of hubris in medicine and medical training which encourages some people to perpetuate rather than dispel the mystery thereby exalting in their "cleverness". The best teachers in any subject can break concepts down to simple steps.
GREAT video on what was going on in my body! I was diagnosed with S3 non-Hodgkin (diffuse large B-Cell) lymphoma and treated with Rituximab and the standard CHOP. PET scan after three infusions saw "no evidence of disease" (I had a total of six infusions). It's an amazing concoction and I thank God for persistent scientists and doctors who care about the elimination of this disease!
What were your symptoms? How did u discover your illness?
@@tjgrafiks looking back, I had some night sweats and a bit of fatigue - but attributed that to hard workouts. The main manifestation was a tickle at the back of my throat, which was a tumor. Biopsy, of course, confirmed it. Other than that, life was normal and great! Tumor was a sneaky little bastard!
@@eltigrechino3390 oh so no weight loss or anything like that? I had a CT and Ultrasound scan of neck and organs and the endoscopy and colonoscopy and they came back clear. they did see a 12 mm node on my lower left lung but that was there since two years ago and unchanged. I have a lymph node on the right side of my neck since i was 18 that goes up n down when im not feeling well. I’m 48 now. lots of lymph nodes that pop up and hurt in my groin too for the last 10-12 years. the tickle in the back of my throat suddenly started last march. never had that before. thought it was covid. still have it now and it gets better then worse with my symptoms. im now feeling small lumps in my throat last few days as im losing more weight last cpl
weeks. no fevers or loss of appetite either. maybe mild night sweats but only from waist down. my legs get hot and moist for about 20-30 mins then normal again always around 2:30-3 am. that had also stopped for months and started again just the other day
@@eltigrechino3390 I was in pretty good shape even though i had my back issues now and then. 160lbs of mostly muscle when this just went crazy on me last year. pain pain pain in elbows, shoulders, knees ankles and then neck from august to november then numbness in arms and weakness too. by mid november weight loss started lots of burning in my gut and organs. i’m guessing widespread inflammation. even my eyes burned. that’s starting up again the last cpl days too smh. gums just randomly started bleeding a few months ago. was good for about 2 wks then just today started again. my body is deteriorating so fast it’s crazy. did that find anything off in your bloodwork? all they found in mine was high inflammation markers. then after a few months my platelet count dropped by 100
@@tjgrafiks Hang-in, there, TJ - no; no weight loss - actually I’ve always struggled with weight *gain* and that’s not changed.
Sounds like you are already keeping updates with your oncologist, right? Those are some pretty tell-tale signs. Some of the non-Hodgkin sub-types can be a little tricky. Trust your instincts - get a second opinion if you need to. I pray for you! May the Lord protect you and restore you, delivering you from fear and anxiety.
I am 28 years old and suffering with multiple autoimmune diseases (spondiloarthritis, Behçet’s, PFAPA, fibromyalgia) and I am about to start treatment with infliximab. So thank you for helping me understand how monoclonal antibodies work, it really means a lot to me
I wish u good luck. I am also having autoimmune disorders. Keep me posted on improvements.
Try the carnivore diet for 90 days and let me know of your results!
This was very helpful. My granddaughter suffers from sero-negative autoimmune encephalitis. She’s 6, and contracted it when she was turning 3. We’ve done IVIG and Actimra. Lately we completed plasm pheresis and are using rituximab. She’s making slow progress with rituximab. I’m so hopeful for continued research to identify her antigen. A new MAB will come along that will bring her back to us. She is so well cared for by her mom and dad. We all love her so much. It’s been a tough journey. We’re thankful for our faith in Christ which has strengthened us. Thank you for your instruction. It’s been insightful.
Might be good to look into less aggressive treatments. Check out Brooke Goldner, MD or even the Gerson Therapy.
@@jilpok1074 Thank you very much. I will look into these. I haven’t heard of these two before.
@@mulvey0731 It just involves eating (or drinking) lots of veggies. The source of most autoimmune diseases is foreign protein in the blood, so avoiding meat is key in my experience. This is because the most common way these proteins get in the blood is through the intestine. Vitamin D and breast milk (if she might be still doing it at 3) is also key in avoiding or improving autoimmune diseases (and there is much supporting published studies on this). Finally acupuncture is also useful as well as fresh fermented foods or lots and lots of probiotics. I’m not saying this will work all the time-some will show some improvements, some you might find useless, but I have 5 autoimmune diseases and these are things I have found helpful that have kept me alive and (somewhat) well. Finally, there is some evidence that early life exposure to cow dairy and wheat (gluten) can cause certain autoimmune diseases. If these sensitivities are caught early enough the illness can reverse and go into remission. Best of luck to you! I don’t think those harsh meds are the answer for the long term. I would strongly suggest delaying vaccines at least until she is fully recovered (or not at all?)
@@jilpok1074 thank you. This makes a lot of sense to me knowing the other people in our extended family that have excema , chrons, and other issues.
@@jilpok1074 milk is animal protein. Animal protein is what are bodies are made of. We aren’t plants.
Consistently producing videos of the highest quality, super clear, a real talent for making complicated topics appear simple, congrats and thank you!
Thank you!
This is one of the most useful descriptions I've seen on monoclonal antibodies. Thank you.
My wife, brother, and I all took this for COVID! It was amazingly effective!
Are you in Florida? I heard Biden cut off the supply of it to FL. Not sure if he cut off every state's supply, or how many states were using this method, but DeSantis is LIVID.
@@Pack.Leader Desantis is working on buying it directly from the manufacturer. Hopefully he's successful at it because it's kept Florida's death toll down tremendously compared to other states. Which is why Biden is seizing power over it. So he can distribute it to other states and get the credit while people in Florida are dying. It's going to blow up in his face though because DeSantis won't sit idly and let people in his state die. He'll figure out a way to turn this around. I have faith in him.
@@crazierthings3022 With this treatment, why did we need a vaccine at all?
@@Pack.Leader we don't need the vaccine. But the Dems would like people to think it's because we don't have an unlimited supply. But I'm not sure how much of that is true. I think even if the supply is low it can still distributed among the people who need it and are uncomfortable getting the vaccine.
@@Pack.Leader Certified Florida Man here. As I understand it, it was so effective that the Biden administration stepped in and cut the amount of it going to Florida, presumably so it could be used elsewhere. Thats the most charitable interpretation, that Biden believes lives in other states are more important. Thats the best I can do for him.
Thank you for this. I'm studying for my med school entry exam and this was the only video that actually explained this concept properly
I can not THANK YOU enough for this video! So incredibly helpful for me as I just began my journey with Rituxan. I have Follicular Lymphoma, Stage 3. Since diagnosis in December last year, I have been swimming in a sea of information, and sometimes get overwhelmed with the specifics of it all. This video and explanation helps me better understand why Rituxan was suggested to me by my Oncologist and also puts my mind to rest as to why this should be so helpful in my case.
Please know that you've helped me immensely!
I know this comment is 2 months old but I wanted to wish you luck with your condition, and to say that it's great that your so invested in learning about your medication rather than just accept your prescription and never wonder how or why it works or was even prescribed. Hope it all works out for you in the end!
@@Ghost.Spectrum Thank you so much, and bless you 🙏
hows your progress Mr Bobby
My progress is pretty good and I'm on a two year plan of a Rituxin infusion every other month.
I've had a few delays in staying on that plan because my ANC labs are low but overall it's going well.
Thank you again for your help and concern
stay healthy Mr Bobby,, avoid crowded place / public toilet / eat home made food ( hygienic)
I had Rituximab for part of my treatment for mantle cell lymphoma, then Stemcell transplant!
Great presentation, thank you!
How was it? Did you notice a benefit or even a side effect?
This is really a clear, no-frill kind of educational video! Thank you so much for making this for us, thumb up!!👍
Thank you for helping me learn about monoclonal antibodies. I was diagnosed this month with systemic Wegener’s Granulomatosis with polyangiitis. The day after I had my 2nd Rituximab infusion for it I tested positive for Covid-19. The day after that I got a Sotrovimab infusion, and the next two days after that I received Remdesivir treatments. Because of this video I now know that at least the first two medicines were monoclonal antibodies each targeting a specific protein for my two separate diseases.
damn perfect and consistent explanation throughout the video. As a current med student who is struggling with immunology, big thanks to you
This really helped me understand how this can also put patients receiving this at an increased risk for infection, great stuff!!! I learned a lot (:
This was brilliant thanks for sharing... LOVED that twist, jump scare ending bahaha much respect and love from Scotland xxooxx
WOW, I really enjoyed your presentation, the graphics, the flow… Very easy to follow! I look forward to watching more of your videos.
Thanks so much for this video, I've just started working for a company responsible for making a lot of these monoclonal antibodies, and I'm trying very hard to catch up and truly understand and appreciate what they're all doing.
Glad it helped Abraham. Good luck in the new job!
Hey Abraham, is your company working overtime during the pandemic?
@@tashadotson912 not sure, not in my department at least!
Thank you for the video! I’m doing revision on immunology and this video greatly helps!
You’re an excellent teacher; thank you for this.
It’s been a pleasure. This lecture has helped me so much on my assignment. Thanks 🙏🏿
Glad to help :D
Outstanding! I am a cancer patient (mantle cell lymphoma) and took rituximab as a maintenance therapy. I also am researching monoclonal antibodies for COVID treatments since vaccines have greatly reduced effects for those of us with sick immune systems.
Hi Max , can I dm you?
There is one developed by an American pharmaceutical company.....the combo is called casirivimab and Imdevimab..... available as a cocktail drug......the catch is it has to be given within five days of the person getting a positive test....and is pretty expensive....
You likely already know this but a CAR-T cell therapy Tecartus was also approved in July 2020 for treating MCL. It utilizes autologous genetically engineered T cells that attract to CD19 antigen expressed by B cells (including MCL cancer cells).
@@GreatKeny I'll also run you ~$1.5 million for the therapy by the time everything's said and done. Good lucky getting someone to help pay for it. CAR-T is a great idea in theory, but in practice, you'd better hope you're at a medical center which is really good at getting money for this kind of thing.
@@kma3647 Yescarta and Breyanzi are 375k each (and charged less in other countries like China). And I think insurance would cover at least half the cost in the US. Not saying it's cheap or affordable by any means but other options like HCT aren't cheap either. There are also allogeneric CAR-T currently in trials and would be potentially cheaper.
Crystal clear explanations and animation. Thanks!
I was a nurse in haematology and retuximab was used a lot....with chemotherapy...this video is terrific
Thank you! A very concise and elegant explanation of "mabs" with specific PTX examples. I needed this review as I forgot how "mags" could both target specific pathogens and also inhibit WBCs. Know I know! Thank you!
No problem. Glad you found it helpful. MAbs are cool!
the monoclonal shot was the best decision I made. it saved my life!
Fantastic! Thank you. Appreciate your work. By helping us better understand Medicine, you are positively affecting the care of numerous patients and helping fellow health care providers of all stripes understand complex and difficult concepts.
Was treated with ranubizimab for my diabetic retinopathy. Was great to get a treatment where I actually understood the mechanism. I’d used mAbs in a protein detection method when I was a research tech.
Very helpful for someone who recieved rituximab and potentially regeneron. Thank you!
I’m having an oral exam tomorrow insha Allaah I’m gonna pass this time
That was very helpful, thanks you very much for making and sharing this.
Excellent video, very informative, and concise.
I get monoclonal antibody injections once a month for my autoimmune disorder. I’m SO thankful for it.
Thank you! Maybe this can save some lives!
Thank you for making this topic easier to understand.
Thanks for all this, u broke it down my g big props keep it up ma guy
Thanks!
Beautiful and comprehensive presentation.
I have to tell you, thank you so much for breaking this down I had no idea what this was untilthis video. See, my mom has covid with pneumonia on top of it right now and the doctors want her to take this and I was worried that it would just make things worse but now I know what it is, thank you soooooo much!!! Now I feel less worried.
Very informative and education presentation. Thanks for your hard work!
glad you liked it. thanks
Thank you so much, so helpful, clear and concise!
Thank you very much! A simple and a good explanation :)
Thanks so much ! ~ this video was super informative and easy to follow
I've always wondered and now I know. Ty
As a sufferer of both rheumatoid arthritis and age-related macular degeneration, I have been taking forms of these meds for years. If I asked my docs how they worked, I'd get the deer-in-headlights look, and they'd change the subject. I'm not sure they didn't know, but they surely couldn't explain it.
Thanks for explaining it. I had to watch it twice to absorb the applicable-to-me parts, but I'm grateful for any understanding I've gained.
most have no idea
@@meisterbear5275 about what?
I AM JUST BEGINNING WORK ON ADALIMUMAB`S FOR TREATING SKIN INFLAMMATIONS.
YOUR TREATISE HELPED ME TO SPECIFICALLY TARGET THIS AREA FOR STUDY AND FORMULATION DEVELOPMENT.
Tom, thank you so much. Your video has really helped me a lot.
Glad to help!
I just received monoclonal antibodies for covid and i believe they saved my life. i didnt know Rituxan was one also, i receive that as well as ivig. I have Stiff person Syndrome, i also have glycine receptor antibodies, lupus, discoid Lupus, hemolytic and pernicious anemia. sure appriciate all the work you all do to save lives.
Extremely helpful. Hats off !!
This is simply the best, I'm super happy I found this ! THANK YOU SO MUCH
Truly outstanding not sure if you were going to be are doctor or a doctor or are scientist but I have to say you’re very good at explaining things thank you so much I appreciate the hard work that you put in to make this video understandable for people that are not doctors or scientists have a great day
this was so helpful, thank you
Great explanation! Thank you!!!
Thank you for making so much sense
Great video and info! Thank you.
This treatment is really helpful for Lymphoma and Rheumatoid arthritis.
This therapy saved my life
Best explanation ever !!
Thank you. This was very helpful.
Thank you fir this excellent, informative video,🙏
They work wonderful! I was fine on the second day after this treatment.
Brilliant information. Priceless.
Thanks, it's so informative..
Thanks
this is beautifully explained. thumbs up
I don't know about the mRNA treatment for Covid, but this sounds really promising for a lot of things.
This may rewrite the whole discussion around covid treatment.
@UClApdpLckoR1nxjq6vHwJgw if our EVIL SACK OF SHIT GOVERNMENT WILL LET US HAVE OUR MEDICINE
Excellent. I have a friend with Diffuse Large B Cell Lymphoma. This helps me understand the MAB component of his treatment.
Very clearly explained concepts. Thanks
When my COVID turned to pneumonia, I was given the antibody infusion. It was around 10 days since I first had symptoms, which I was told is toward the end of the effectiveness window. I had to drive over an hour to get to the place. And, then back home. The last probably 20 miles, I had terrible chills. I went home and straight to bed. I slept about 12 hours. Mind you, I'd been up since about 1:30 a.m. and got home around 7 p.m. So, I was tired. I woke up not knowing what day it was or what was going on. Then, I remembered that I had COVID and had had the infusion. I never had the instant recovery people speak of. I do believe it helped, though. I was pretty sick, but I wasn't admitted or sent home on oxygen.
thank you Sir for the beautiful an simple work°!
Thanks! I really like this video and so glad to hear you did too!
Very interesting, informative, and worthwhile video.
it was a fantastic video, well done
I was diagnosed when I was 13 with ulcerative colitis and I started infliximab today wish me luck!
god with you buddy... amen
@world me thank you
Best of luck buddy.May God bless you 🙏
Dr. R .S I started yesterday and it seems to be helping I’m still in pain but it’s tolerable
How's it going today?
Great video explanation of monoclonal antibodies. Many of these have vary serious side effects, and it would be helpful to briefly cover these too.
What are they
Please tell me. I got the one for covid and I've been sick for 15 months now.
Nice!!! I love these videos!
Absolutely brilliant. First-time visitor. I will be back.
That's great to hear. Thanks Dennis
Very helpful! Thank you!
so simple and so useful presentatin, thank you
Thanks! Glad to help
wonderful explanation ever, thank you soo much
Glad you liked it
Thank you so much for valuable information... 😊
Best and simple explanation of antibodies
Thanks!
Thank you so much. I wish I was taught this way when I was in high school. I would have enjoyed studying and learned a lot. 🙂
Dude your videos are a life saver during my exams😊
Thanks Subhiksha!
I was a part of Cleveland Clinic's blood draw of remicade patients in 2020 to see how covid affected those of us who take remicade here in the states.
I caught covid in November of 2020. I barely had any symptoms (loss of smell) for 24 hours. Had my husband not been really sick with covid I could have easily been a super spreader. Instead I stayed home for 2 weeks and even now I take covid tests twice a month.
hahahaha well done comrade! Keep those tests up Fauci and Pizer need everyone's help boosting numbers to max profit! Don't forget to double face diaper!
I am a transplant nurse, kidney and liver, we use this treatment for rejection and it is very effective. My son is 43 and has multiple myeloma
, I am hopeful that at some point they will be able to develop a treatment.
Great explanation!
I did 9 months of a clinical trial 2 years ago when my M-Spike was 1.4 and today it's still going down or staying the same . It's at 0.86. When I quit the trial it was 1.0.
I finally convinced my wife to bring her mom for treatment on 5/10/22. I'll let you know how fast she will recover. But thank you for the information and education
Hello I have a question. How does the treating team identify the antigen on the surface of respective pathogens? Biopsy?
Our physical bodies are amazing. What medical science has learned and can do is amazing. It is difficult to imagine the intricacies to be the result of chance...I have tested positive for anti bodies to sars 2019 for the second time...I am 74 years old...in the last 20 months I have had Legionnaires pneumonia, covid
10/ 2020, quadruple heart bypass surgery, and I am fully recovered. I told my cardiologist how thankful and amazed I was at what they were able to do. He said, "after what we do I am amazed people walk out of here".
So I believe that ultimately God made us and we can learn more about what we are and just learn to be thankful. I know I am.
This great video... Help me under stand more what's going on in my body and I'm going to start taking amalimumab for my IBD (joint pains) in next 4 weeks
I'm glad it helped
wow amazing, so informative!!
I love it so specific 😍
Infliximab changed my life!!
Thanks for this. I have Erythroderma, and have just gone onto Adulimumab. I don't like to take a treatment without at least a basic knowledge of what happens and why. Reading the Patient Information scars the bejebbers out of you. This was clear and understandable.
And tocilizumab, that is an mAb for IL-6 receptor and used to treat COVID induced cytokine storms.
I just got mine and I feel better already