Why Does Insulin Resistance Matter? with Dr. Ben Bikman
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- čas přidán 10. 02. 2024
- The focus of Dr. Bikman’s Metabolic Classroom today is to help us all better understand, “Why does insulin resistance matter?”
This week's Metabolic Classroom with Dr. Bikman delves into insulin resistance and its impact on health. Insulin resistance, involving impaired insulin function and elevated blood insulin levels, is explored as a key factor in chronic diseases. Dr. Bikman focuses on its crucial role in connecting obesity and type two diabetes, examining its effects on muscle tissue, the liver, and pancreatic alpha cells.
The delayed diagnosis of type two diabetes, due to a focus on glucose levels, is highlighted, with Dr. Bikman discussing the ongoing debate about which tissues become insulin resistant first. The complexities of insulin resistance in fat cells, muscles, the liver, and alpha cells of the pancreas are underscored.
Insulin resistance's effects on glucose clearance in muscle tissue and disruptions in the liver's glycogen storage and glucose regulation are explained. The discussion expands to its impact on pancreatic alpha cells, contributing to elevated blood glucose levels. Dr. Bikman explores the connection between insulin resistance and various health issues, including type 2 diabetes, fatty liver disease, Alzheimer's, hypertension, and infertility.
In examining these health conditions, Dr. Bikman challenges conventional views and emphasizes the role of insulin resistance. For instance, Alzheimer's is linked to metabolic factors, while hypertension is connected to insulin-driven mechanisms. The discussion also covers the influence of insulin resistance on infertility, affecting both erectile dysfunction and polycystic ovary syndrome (PCOS).
Dr. Bikman concludes by summarizing how insulin resistance influences these health conditions and highlights lifestyle modifications as a positive intervention. The upcoming discussion on clinically measuring insulin resistance and actionable steps is teased, urging viewers to share this knowledge for broader awareness.
Learn more at: www.insuliniq.com
#insulinresistance #metabolicsyndrome #metabolichealth #type2diabetes #type1diabetes #weightloss #intermittentfasting #intermittantfasting #fasting - Věda a technologie
As a doctor, my entire life it always bothered me with common medical jargons like 'Idiopathic' or like 'Primary' hypertension. It always felt like a piece of the puzzle was missing.. now it all makes perfect sense. There are so many things need to be changed in the medical curriculum. Medicine needs a major paradigm shift from focusing on trying to treat everything with a pill. And we need to empower our patients with right knowledge to take control of their health.
😂 you think??
We have the knowledge. We KNOW but sadly we just don't DO.
I love the word idiopathic-the idiots don’t know the pathology.
Last year my doctor refused to order a fasting insulin for me due to having good glucose level as well as a good A1c. At the time I didn’t have a good enough understanding of insulin resistance to engage my doctor to explain why it was important to know the insulin level. After all, she’s the “doctor”. So I went on my own and got the test. Thanks Mr. Bikman. Now I have the understanding.
I’m in the exact position as you described going for my OGTT in a few days.
If you get tested, what can you do about it? This is what I don’t understand.
@@KoiRun50 in answer to your question you cut carbs/0 carbs, fast, lose weight,exercise, reduce stress to increase insulin sensitivity. As we age we naturally become more insulin resistant and run the risk of all the modern day totally avoidable illnesses ie CVD, T-2 diabetes, cancer, dementia and altzhimers.
@@andrewrivera4029 But couldn’t you do the same thing judging by your metrics for A1c, triglyceride/HDL ratio or BMI? What’s the point of getting another test when these tests are readily available. I can get these test metrics done every 3 months or less if I wanted to.
@@KoiRun50 the thinking is that MANY people are told they’re just FINE by just using those metrics you mentioned and then years later they have a major medical problem. You and I are very interested and knowledgeable about our health from what it sounds like though you have not said, just understand WE are trying to get through to the people that MAY need to look further into their health with the benefits of these tests. I’m 58, the age where everything you’ve done your whole life starts to come back to haunt you so I believe the more testing the better even though I’m “healthy” so if nothing else I establish a baseline of testing that can be referred back to. That’s my thinking but yes if YOU feel the standard tests are good enough and you sleep good at night, fine.
I binge watched several of these classroom sessions yesterday so I am not sure which one mentioned migraines, but I made some notes and tried a suggestion you made about low BG in the brain (low energy) being causal. So I wanted to share my results this morning. Recently I have taken to eating a snack in the evening with Lily's Dark Chocolate chips combined with ~pecans, thinking that the Erythitol would not affect my BG, but in the morning my BG would be above 100 and my ketones around .4. So yesterday I decided to skip the Lily's and in the morning my BG was 88 (which used to be normal for me) - but my ketones were still .4; and about an hour after waking I started to get a migraine which would normally last 20-30 mins. So I added some MCT, butter and sea salt to my coffee and took some BH Kentones and 10 mins later the migraine was gone before it fully developed. When I tested my BG & KT again about 30 mins later BG was 84 and KT were .7. I was fasted 14 hrs.
I have heard that sugar alcohols may affect some of us with IR similar to how alcohol can (was that you?). I thought my IR was resolved because my labs had been really good - until recently when my fasted insulin went from 3 to 11! Now I know why - I have learned my lesson about those cheat treats...thank you for educating us ❤
EDIT: It will be interesting to see if my weight loss stall improves with this change.
good to see you ben! appreciate you so much ❤
Q. In the absence of blood glucose, as in a low/no-carb diet, what prevents the Alpha cells from stimulating glucogenolysis?
Q. Do other cells experience hypertrophy due to IR?
I am going through your lessons on insulin resistance…in my mid 60’s , so it’s been a few years since physiology!
Thank you for putting this information out
Isn’t the best thing to do is just stop eating carbohydrates altogether? It just seems like there is an endless stream of problems with too much glucose. Just stop it completely and let the weight and the problems all go away.
Pretty much
Fruits and veggies are where vitamin and minerals are. With thyroid problems, you have to have those. Low carbs I can do. No carbs...no thanks for me.
@@brg2743you are laboring under a misunderstanding. There are no biologically required micronutrients that are unavailable from meat and other animal sourced foods. None. Period. Not even vitamin C or fiber. It turns out that if you consume low enough amounts of carbohydrate & fiber you need miniscule amounts (in the microgram range) because your body can recycle most the vitamin C that you already have stored in your tissues. The amount you need in one day is less than the amount you'd get in a tablespoon of lemon juice, as long as your carbohydrate intake is low enough. As for fiber, an ordinarily healthy individual does not need fiber to empty the bowels. As for the beneficial short chain fatty acids associated with gut health, more than sufficient amounts are generated through the normal fat metabolism of a low/no carb diet. You eat what you want. But eat it because you want to, not because you've been misled into thinking you need to.
@@brg2743 I would favor veggies over fruits just because of the higher sugar content of fruits.
So glad I found this educator
Looking forward to your next book! I just got a CGM and learning a lot about my reaction to certain foods.
Thank you, Professor, this has value beyond words! I am in your classroom every day now trying to catch up, and I am absolutely using this information to teach others. Yes, I had to get out pencil and paper and I'm taking notes. Your confidence in your factual explanations gives me greater confidence as I repeat them. I will use everything you say! I'm so glad this is your aim.
Bravo! Ben, I could sit in your class every day. Thank you for all you do, brother!
The depth of your video is amazing
Thanks for watching.
So helpful, thank you!
How incredibly interesting, looking forward to the next video. Thank you!
Super informative! Thank you, Dr! Looking forward to the new book 😊
That was so interesting! Thank you Dr Bickman
Listened to the audio book…. Bought the book. Ben makes complete sense to me. Thank you!
Wow, this was amazing!!!
Another eloquent and lucid presentation. Thank you.
Thanks for watching and commenting!
Absolutely BRILLIANT AND NECESSARY
These lessons are wonderfully explained. My knowledge level is on the rise. Thank you.
I am 82 and have diabeties I have stopped taking glipizide as it was upsetting my brain. Trying to eat better.
Dr. Bikman, you are a very talented teacher. I appreciate your willingness to not only be a very thorough scientist, but also to share with us what you know in a very understandable way. Ive learned so much from you, and feel very empowered to improve my health. Thank you!
You’re kind. Thank you.
I recommend that you use a white board diagramming the many branches your information expands. Helping the listeners with diagrams and writing down many of your acronyms will help viewers learn more. Or you can come up with your own techniques.
Thanks for your thoughtful suggestion.
Great lecture
Great video Dr.
Thanks for your kind comment, Greg.
The explanation for erectile dysfunction and PCOS is insightful. Thanks for sharing
Just fantastic, you are the Man the bikman
You’re kind. Thanks for commenting.
Could explain why IR causes skin tags?
❤❤❤Dr. Ben!
thank u sir
Welcome!
I have had several eye surgeries and am on prednisolone. Even though being ketovore my weight has stalled at 188 for 10mos 75y f 5'3"..i. am sure stress also affects stall. Only saving grace i have not gained. 😢
I don’t understand the term or concept of ‘insulin resistance’. It makes no sense to me. We have become accustomed to a lifestyle of continuous glucose intake with very little physical activity. Not only do we consume high carbs at nearly every meal but in between meals, all day long, there is a constant intake of sugar through drinks, snacks, etc. It is obvious we are taking in more sugar than our body is burning for fuel. The glucose molecules circulate in our blood stream and are taken into cells that have room to absorb it. Once all of the cells are saturated with glucose, the remaining glucose keeps circulating in the blood stream. Because of the high level of remaining glucose, the pancreas keeps producing and releasing insulin. So you have a condition of high blood levels of insulin with a high serum glucose level. You have tons of circulating insulin but the cells are already saturated so there is no where for the insulin to deposit the glucose. The glucose keeps circulating until cells have utilized their glucose stores and are able to absorb more out of the blood but before this high level of circulating glucose is pulled out of the bloodstream, we keep adding to it all day long. This is not a condition of ‘insulin resistance’ it is s condition of cell saturation. That’s why, when a diabetic exercises, their blood sugar readings will lower. Exercise burns off the sugar in the muscles cells thereby making room to absorb sugar out of the circulating blood. Sedentary lifestyles that burn low amounts of sugar combined with a high sugar diet is going to result in too much continuous circulating sugar aka diabetes. The solution: vastly decrease sugar and increase activity. It’s that simple. The concept of insulin resistance is a deception. It makes you believe that you have an irreversible condition that can only be ‘managed’ with pharmaceuticals. The nutritional advise is criminal as most ‘diabetic diets’ have a high carb component. The medical and pharmaceutical industry doesn’t want to give you simple understanding of how to reverse this condition because the money lies in convincing the you that it can only be managed. With their help of course. This is not medical advise, it’s common sense.
Thanks for watching and thanks for commenting. To best understand the basics of insulin resistance, you may want to create a free Basic Membership on our website which gives you access to Dr. Bikman’s introductory course, “Raising Your Insulin IQ for Improved Metabolic Health”. This will really help you understand IR: www.insuliniq.com
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You present a sound story, and i appreciate the attempt. Yet, I think, that the whole theory of IR, Met disease etc still lacks some important parts. The theory can not explain the setup of my body.
But first about something else: Around @37:00 you explain that the free fatty acids in the blood, stemming from adipose tissue cells near their capacity, cause the liver to produce fat, resulting in a fatty liver. Earlier you mentioned also that this causes LDL to rise. However, fatty liver can be primary, when tons of fructose would be consumed. Fructose has only one way to get metabolized, which is first to triglycerides. The abundance of fat in liver cells can also render them insulin resistance, as the cells sense "enough" energy. The excess fat ends up in Triglycerides, not that much in LDL particles. Those trigs get stored in visceral fat before they cause adipositas. Back in the 1980ies this was known as central obesity. The limbs could really be skinny, no fat at all.
I think we should abstain from the idea that there is ONE, and even from thinking that there is ONE MAJOR, path into metabolic disease. Such thinking, also prevalent regarding blood lipids, is primitive. There are multiple etiologies, shaped by even more circumstances and life histories, that can lead to a compromised metabolism.
Biomedicine, and medical physiology has still to go some way in order to transform into a information based science. Only then, there will be a network based theory for physiology.
You have mentioned in your videos vegetables and whole fruits are encouraged how about legumes and whole intact seed form grains such as quinoa, millet, farro, barley?
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
Haha that cover picture for the video looks like some james bond villain. Does not do ben justice. Hes a great doctor, speaker and human with integrity
Doc can ya cover what happens when damaged brain Myllan, like stripped wires, touch each other. SME docs in here say, depending where in brain this occurs, it causes altheinerz, dementia, Parkinson’s, etc. Thanks!!
When you eat protein, are the effects of insulin and glucagon cancelled out ?
Thank you for this video! Question: Do artificial sweeteners like Stevia and Allulose raise insulin enough to hinder weight loss or cause insulin resistance? I trust your knowledge on this question. I've heard many different opinions on artificial sweeteners raising insulin and hindering weight loss. Thank you.
You can ask using the chat bubble on my website, if you’d like to: www.insuliniq.com My team can probably point you to some answers.
For a low carb diet the body turns to glucagon to convert the glycogen in the liver to glucose to fuel your body. Doesn’t this secondary glucose production cause its own insulin spike?
In anticipation of your new book "How Not to Get Sick" this is the perfect time to reread "Why We Get Sick".
Thanks.
Thought exercise. I played 5 hours pickleball yesterday. Is my insulin level down the whole time? Or does hepatic glucose production to fuel intermittent mini sprints alter the insulin signaling. During this time, does it affect insulin levels or is it flat the whole time?
Thanks for your question. You may want to go to our website and ask our team: www.insuliniq.com
If sildenafil enables more NO to endothelial smooth muscle dilation in ED, and essentially, there can be 'ED of the brain' because the problem is systemic (both men and women), is sildenafil ever used for dilation of small vessels in brain of women? Could this affect migraine reductions? Seems that mitochondrial function could be increased with better O2 supply by RBCs flowing better? Is this the basis mechanistically for the insurance industry mega data suggestion of sildenafil users having reduced later AD occurrence chances? Hmmm.
I've been on carnivore since July 5 2023. I lost about 10 lbs of water weight. I have 70 more lbs to lose. I've done electrolytes, etc to combat muscle cramps and weakness to no avail. Part of my issue is something you have expertise in and I wonder how I might tweak my diet (meat: beef and pork, with at most 2 glasses whole milk. I have a reaction to chicken and eggs.). I have had mild-ish symptoms (and some genes) for Glycogen Storage Disease my entire life as has my sister and mother but we've never been tested. I'm the only one that has been interested in this and sort of learned about it 2 months ago. Anyway, if I hadn't eaten I would experience the usual weakness, sweating, shakiness, anxiety but sometimes seizures. I am guessing these are what is causing my MRI hyperintensities as I don't have migraines but very rarely. Since I started the diet though, I'm experiencing hypoglycemic symptoms after I eat a high protein meal. I don't have a gallbladder and fat intake needs to be spread out. I started carnivore because I was having reactions from mouth reactions to anaphylaxis to so many foods I figured that this wasn't much of a stretch from what I already couldn't eat. I was also really hoping this would clear out my brain fog. It has not. I suspect that it isn't the insulin side of things because I don't seem to have an issue storing fat. I keep my carbohydrate intake well below 50 grams. I should be in a state of ketosis. My glucose varies from 73 to 83 and my A1C hovers around 4.8/4.9. Both have always been low. Any leads or pointers to either research or books, etc would be fantastic. I've tried all of the other armchair recommendations to no avail. I'm tired of getting hypoglycemic issues on a daily basis. My doctor is not a fan of my diet choices because it raised my ldl and since my glucose and a1c are good won't test glucagon. I'm a veteran. Any lingo I can use to try to figure this out to not trigger her but maybe get more answers?
I hope you get some answers, it can be so complicated for some of us. Have you tried the lion diet? Eliminate all the variables, just eat salt, beef and drink water. Then add one thing back at a time to see how your body will react. The milk could be holding you back, so could the pork. If you need a little sugar some fruit is okay. If your goal is to lose weight fruit mitigates the insulin spike from the sugar by balancing with fibre and other nutrients. You may need some iodine supplementation to to help counteract all the fluoride and chlorine in our environment. Good luck bro. Keep researching, keep asking questions
Thanks for sharing your story. Sorry that you are struggling. You may want to consider joining our community to get a little more support and some ideas from our coaching team and from other like-minded people working on their metabolic health. You can do a 10-day trial at no cost: www.insuliniq.com/insulin-iq-community-membership-signup
I appreciate all the info you provide but I feel like there is a huge missing piece and it feels like those in the low carb, specifically the Carnivore community are purposely ignoring and possibly even misleading people. I have been a strict carnivore for over a year. All my metabolic markers are either normal ranges or optimal, no weight to lose, and very fit but if I eat over 90g of protein in a day (even spread out, and even when my fats are at the 80 - 85% range), my blood sugars will go into type 2 diabetic levels and stay there. The only lever that I can pull to bring it back down is to reduce protein, or at least caloric intake but it is that 90g of protein that seems to be the marker for me to see it come back down out of Type 2 levels. Would love to see a completely nonbiased test around this if possible. I know you will tick off the Carnivore docs that think they know, but I am not the only one who experiences this. Dr Bikman really is the only one who comes across someone who would be real about this.
Insulin levels with glucose and A1C is the only way to go
Does dehydration impact insulin level?
Great question. You may want to go to our website and ask our team: www.insuliniq.com
Would love to see a classroom on protein.
1. Some say you should limit intake to
I am a type 1 diabetic and have no gallbladder.
I have i think I’m insulin resistance, and is an all meat diet good for me? I crave meat. What is best for me. And a good weight loss diet
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
🙏
Does it matter which CGM i get? Can I just get the cheapest?
I think a prescription is required to get one unless things have changed.
Thanks for your question. You may want to go to out website and ask my team: www.insuliniq.com
Yes bingo! Doctors spend 0 time on insulin until you have full blown diabetes, get the OGTT oral glucose tolerance test! Know your risk! Thank you doctor!
Thanks for watching.
If insulin becomes resistant and the fat cells become resistant.
Would it not make sense to totally avoid carbs sugar or starch.
I think those two cause the addiction to eat more.
If you do a total fast longer than two days per week.
It would confuse the body and force it to release the fat cells.
The American pronunciation of 'primer' gives me a glucose spike!
It rhymes with dime and I wish Ben would give me one every time he says 'primer'.
How else does one pronounce that word?
@@soniasbooks I've just explained
Since plaques are not the issue in alzheimers, is it also a lie that exercise undoes the tangles in the brain that are precusors to plaque formation? I am in total agreement about the plaques, so I'm really curious about this question. Thank you.