Myths & Misconceptions of Insulin Resistance - Ben Bikman -
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- čas přidán 24. 06. 2024
- Dr. Ben Bikman, a specialist in bioenergetics and insulin's role in metabolic disorders, presents a comprehensive talk on insulin resistance. He highlights the rising prevalence of insulin resistance and its impact on various chronic diseases. Bikman stresses the importance of precise terminology and understanding of insulin resistance, differentiating between its pathological and physiological forms. Pathological insulin resistance, often linked to chronic diseases, is caused by factors like chronic stress, inflammation, and hyperinsulinemia. Physiological insulin resistance occurs naturally during periods of growth, such as puberty and pregnancy. Bikman also discusses misconceptions about carbohydrate-restricted diets, explaining that while such diets do not cause insulin resistance, they can affect glucose tolerance tests. He emphasizes the need for proper insulin measurement in clinical settings and the role of metabolic flexibility in health.
0:00 - Introduction to Dr. Ben Bikman
0:14 - Opening Remarks and Gratitude
1:13 - Importance of Democratizing Science
2:01 - Common Myths and Misconceptions about Insulin Resistance
2:35 - Prevalence of Metabolic Unhealthiness in Adults
3:19 - Historical Contributions to Metabolism Understanding
4:02 - Pathological Insulin Resistance and Chronic Diseases
5:13 - Pathological vs. Physiological Insulin Resistance
6:13 - Defining Insulin Resistance
7:59 - Insulin's Role and Impact on Glucose
9:51 - The Vicious Cycle of Insulin Resistance
11:01 - Insulin Resistance without Hyperinsulinemia
12:00 - Causes of Insulin Resistance
14:26 - Fat Cells and Insulin Resistance
16:10 - Stress Hormones and Insulin Resistance
18:24 - Inflammation and Insulin Resistance
20:47 - Hyperinsulinemia and Insulin Resistance
22:10 - Physiological Insulin Resistance and Growth
24:19 - Puberty and Insulin Resistance
27:19 - Pregnancy and Insulin Resistance
29:04 - Hormones from the Placenta
30:17 - Carbohydrate-Restricted Diets and Insulin Resistance
32:02 - Insulin Production Changes and Glucose Tolerance Tests
36:02 - Metabolic Flexibility
38:13 - Reverse Metabolic Flexibility
40:18 - Managing Glucose Tolerance Tests on Low Carb Diets
42:37 - Randle Cycle and Metabolic Inflexibility
45:00 - Questions and Answers Session - Zábava
The man, the myth, the legend, on the cutting edge of Human Metabolism Reseach! 👍👍👍
Ben should've been given more time! Can't stop listening to this guy...
I'm sure there is a reason Dr. Bikman doesn't have his own YT channel, but he never fails to dazzle when I find him hosted on CZcams.
He does have a channel: Insulin IQ
Wow, new Dr Bikman video. So good!❤
Bald redhead v Knuckleheads
Excellent content and delivery - you bossed it Ben!
The lack of a first phase insulin response with a ketogenic diet is so interesting!
It answers a lot of questions but it is very logical after all
Indeed!
I didn't have that issue for years doing keto. Until..., something else kicked in.
The GOAT
"Reverse Metabolic Flexibility" appears to be the same phenomenon that Dr. Robert Cywes refers to as "Insulin Suppression". Thank you for including this in the talk!
Thank you. I enjoy listening to this type of lecture. Being a lay person I am learning a lot.
Thanks for the post Dave! :)
I have type 2 diabetes. I went low carb, then keto. I skip breakfast. I stopped insulin and never took other meds. My overnight fasting insulin is 95. After meals I hit 122 If i don't exercise, about 89 if I do, which is most of the time. If I fast for 2 or 3 days my BG goes as low as 60.
Great and informative lesson! Thank you for posting it.
Very kind of you to share this, Mr. Feldman. Much appriciated! 💎
I really enjoy hearing Ben talk even when I've heard before. In this particular talk, notice the integration of contributions from both sides of the brain: the LHS providing a description of the biological models, the RHS speaking to the LHS to remind about the reality of the moment (being a professor, not losing the audiance, leaving time for ...).
I am in the 12%!
Finally at 69
Ketovore for 3 years less than 15 grams of carbs a day
Pickles and cheese for my dessert
Fatty meats for my meals.
Confused
I eat the very same diet. Fatty meats, short ribs, ribeye, lamb, eggs, I do eat salads some days and I love pickles, and cheese, not necessarily together.
@@daniel9907About what?
Superb presentation!
Watched originally for the great information but soon found the humor made it all that better.
Bald redhead.😂
Great video. Subbed.
The baby in the womb is wearing a diaper. This is American religious stupidity. This is American biological enforced, more than ignorance. this is amazing media representation of Miss over substance.
Should I be grateful at some kind of subtlety? I am insulted. In the name of truth and biology, please whip your graphics department into something beside religious submission. Is this because you’re in Utah? The Mormons believe the funniest things.
It’s even funnier because this comment accidentally got under somebody with a similar type of complaint. I hadn’t even read theirs until after I saved my comment.
Another brilliant lecture !!!
6:52 "insulin is unique among its class of hormones because it is capable of affecting every single cell of the body and that is rare among a lot of hormones and there are so many different types and so many different families but insulin stands apart because every single cell of the body from brain cells to bone cells from lung cells to liver cells has insulin receptors ."
19:18 "Diesel exhaust is capable of forcing 'Adipocyte Hypertrophy' even in totally independent of any calorie signal. Eat the same amount of food the animals get a little scrawnier, but their fat cells get fatter."
Small correction - "Diesel exhaust is capable of forcing *adipocyte* hypertrophy...".
@@melodyaumiller9364 Thanks, adipocyte hypertrophy: www.ncbi.nlm.nih.gov/pmc/articles/PMC4920141/
Excelent speech, thanks David for presentation!
Just subscribed, been believing all you've advised, snd feel better than i have for many years thanks.
Excellent session. Learned a lot. Love your graphics
This man is a gift to us with metabolic challenges. Thank you Sir!
So interesting again, wonderful Dr. Bikman! 😎🙏🇩🇪
Ben is my hero
It was a good talk.
42:40 Wow! This is interesting! Thanks!
This happened to me, i did my glucose test agyer a year of very low carb . 20 and under grams.
I did not know i needed to eat carbs .
My Blood sugar was ASTRONOMICAL .
ive since had to convince them im NOT having a diabetic pregnancy by testing 4× a day.
Glucose #s in 60s -90s . Perfect.
It happened to me also. My last bloodwork showed an A1c of 4.7 and fasting insulin of 5. I eat low carb/keto for years and took a OGTT. My glucose went to 230 for the first hour, then back to 75 at the 2 hour mark. My insulin stayed in the normal range. My doctor thinks I am a diabetic and should take a low dose metformin. I am grateful to Dr Bikman for his explanation of this phenomenon
@philpecoraro5458 Just like me AN a1c of 4.3 and I'm apparently diabetic? No guys.
Thankfully the mfm is receptive. And says 2 weeks of good #s and I can stop testing.
But her nurse is crazy and despite perfect numbers she thinks I'm diabetic.
@@louisacapell I have shown Dr Bikman’s videos to my doctor’s office. They do use fasting insulin and OGTTs as part of their prevention practice, which is unusual and I appreciate. They are open minded and really into lifestyle first ahead of drugs, and are interested in learning from experts like Dr Bikman. Hopefully he will help them to better understand how to interpret this test. I want to tell others that may have had similar experiences to you and I
This guy is good.
so much real information on you tube , but nothing said in my doctors office visit ,its always take your insulin or metformin , never about diet changes .
I wonder who the "knuckle heads" Dr Bikman means at 16:20 are... He seems like such a nice guy, never seen him get so worked up!!
I'm more confused what s going on. Time to iwatch this again.
Can't find the "Poul Renolds" mentioned - any link? Very interested in AGE´s
Can you please cover the Randle Cycle?
Love you, Dr. Bikman, but don’t ever apologize for God, because He is, indeed, the Mastermind and Creator of thus infinitely elegant and complex design of the human boat (and universe)!
I was thinking the exact same thing about the apology
amen
I am shure (even before watching the video), that noz "too much insulin" but "too much blood sugar over a long time" is the reason for insulin resistence.
Chronic exposure to insulin seems to be far more detrimental than a high acute exposure.
Another great talk, Dr. Bikman. I am curious what your reaction to Dr. Cate Shanahan's definition of insulin resistance is. (Any of her new videos promoting her book cover it.) She has a different way to look at it, that seems to fit all the known facts. I will try to paraphrase (so I might botch this up): she sees the problem as the body can't burn fat, and so is forced to try to live solely off glucose, but there isn't enough to fuel everything, and the insulin resistance is trying to save more glucose for the brain, and that even the liver tries to make more glucose, to raise the levels in the blood as a way of compensating for there not being enough there to fuel all of the body. I think you might find it interesting, and I'm curious what your reaction to it is, as I have followed your talks for several years now.
That's also the possibility though
I hear Ken Berry ;)
They're both founding members of American Diabetes **Society**
Does anyone know of a professor, doctor, etc with this much knowledge about hormones after menopause?? I am desperately seeking such an expert.....
Mindy Pelz
Read the book, Estrogen Matters. Where do you live? My female internist has no qualms about prescribing hormones. I am a 74 yr old female and take biodentical progesterone, Estrogen, and Testosterone.
I live in N Texas
Good humour
35:22 Is this initial "dump" insulin caused by the brain tasting sweet on the tongue? Or is it elevated blood glucose levels? Do artificial sweeteners even they contain no glucose cause this initial "dump" of insulin? Does fructose cause this initial dump?
I disagree with your last part… I’ve been on a very strict ketogenic diet for the last seven years - absolutely no cheating…carbs always below 20 - and my fasting insulin is rarely below 10. If you do a HOMA-IR calculation on me it shows that I am insulin resistant (2.7). This has frustrated me to no end.
Maybe some kind of rare issue?
Not really rare, been very low carb ( 8 years, A1C usually 5.3-5.5… last fasting insulin 10.7, LP-IR was 49…yes very frustrating.
Do you get into ketosis? I'm asking because i had the same problem. I decided to try carnivore, zero carbs, now i can maintain ketosis even when after meals. To be in ketosis blood insulin levels have to be low. If i eat too much dairy, i get out of ketosis easily. I can do dairy but not every day, i had to find what foods, how much and how often will kick me out of ketosis. The testing effort is worth it in my case. I hate insulin resistance where 20 grams of carbs is too many carbs ...😢
Do you fast at all. How frequently are you eating? Are you over eating?
What kind of fats do you use? If you use "vegetable" oils, you will always have trouble. Don't use any kind of fat that wasn't available in the pre-industrial era. No corn oil, no soy oil, no safflower oil, no sunflower oil, no grapeseed oil, no canola oil/rapeseed oil, no cottonseed oil, no rice bran oil. These supposedly "heart healthy" polyunsaturated oils are anything but, and contribute to diabetes, heart disease, cancer and other issues as they are oxidized and highly inflammatory. Instead use quality, extra virgin olive oil, avocado oil, coconut oil, beef tallow, pork lard, chicken fat, butter, ghee.
HGH might not cause growth directly, but it elevates IGF1 and that promotes growth.
Isn't that what he said?
The problem with this metabolic theory is I never hear any actionable take away, what should eat? It sounds to me luke what he is saying is that early life stress and hormonal changes are really what get the ball rolling and once it starts theres really no stopping it amd that fits my experience. At the end he talks about giving his kids a body that they will either "enjoy, or fight against for the rest of their lives" ... I guess I have one that I have to fight against 😢
I don’t believe that. My brother grew up eating a tonne of bread, milk and cereal as a teen. He grew v tall has had good health for the majority of his adult life, never v overweight, lots of energy. I grew up in the same household, didn’t eat nearly as much bread, though did eat more sugary snacks - but they’re all made of the same stuff at the end of the day, didn’t grow v tall, got the same mild lipedema issue as my mother and have struggled with my health and energy levels. A lot is due to genetics imo!
i have a few issues with this. #1 doctors like bernstein and mcdougal would recommend insulin for type 2. and #2
if you take a glucose tolerance test it is recommended to eat carbs for 3 days prior. and if you produce insufficient insulin you will fail the tolerance test.
I've never heard of T2D being on insulin until the last few months when I started the deep dive into all of this. I'm T2D and I do not understand why a Dr would put a T2D on insulin. If you're not producing insulin than you're T1, T2 produce plenty, they are resistant......from my understanding. Would be interested to hear why those Drs would prescribe insulin for T2.
What are the symptoms is there pryer to insulin resistant. I know I had them before it can be detected by blood test.
Elevated fasting insulin and c-reactive protein
These happen much earlier than fasting glucose and A1c
When you talk about causes you mention hyperinsulinemia. But the question is what causes that? Isn’t the solution to just stop eating all carbohydrates? If you consume zero carbohydrates how do you have hyperinsulinemiia? It seems that the cells are not resisting insulin but rather they are resisting glucose. The cells are already full and they don’t need anymore. You seem to be identifying insulin as the problem. is just the messenger. It’s the glucose that the cell doesn’t want in.
Same as how do you directly measure 'resistance'. They have to measure aspects like glucose and insulin and then 'model' it to get the magical term 'insulin resistance'. This is much the same as claiming cholesterol tests actually measure cholesterol rather than lipoproteins etc. Now in studies they can get granular to test what is happening at the cell level but a person walking into a clinic will not get an exacting measure of IR.
Youre not understand what insulin resistence is.
Its an over production of insulin because you need more and more and more insulin to push the glucose into the already full cells, and finding new places to put it.
Your glucose goes up despite having massive amounts of insulin because your cells are RESISTING the insulin that is trying to clear and store the sugar. @scottw2317
So, how do you fix Insulin Resistance, how long does it take, and how do you know when it's fixed?
Watch Prev Med Health, Dr. Jason Fung, Dr. Robert Cyews, Dr. Annette Boz, Dr. Stan Ekberg, Dr. Casey Means, Dr. Ken Berry, and many, many more.
Fantastic selection. @HEARTANDSOULOFMINE
Add in more carbs (fruit only) but start slowly, 50 grams per day, then add 25 grams per day per week until you hit 150 to 200. Also, eliminate all sources of polyunsaturated fats (fatty chicken and pork, all nuts and seeds and all vegetable/seed oils. Insulin Resistance is a polyunsaturated fat issue.
This is confusing. I was diagnosed with reactive hypoglycemia at 15. I was told it's due to insulin Resistance. I've never had a high blood glucose level in my life, lol. Was I misdiagnosed? Or can IR create low blood sugar in some cases?
There are 2 physiological insulin resistance in life one in pregnancy and the other is at puberty, so ur problem seems to be physiologic insulin resistance
@@Healthwarning-ry9ql it doesn't explain my issue with low blood sugar though
@brittanywilcox737 do you consistently have hypoglycemia? Maybe try a Continuous glucose monitor monitor .
If you're eating carbs it will raise insulin to bring glucose down. So try keto for a few months. Eating low carb ( under 50grams/day) will prevent such a spike of insulin ideally preventing the hypoglycemia. Eat plenty of meat if not only meat. This will replenish any missing nutrition which will allow to better manage homeostasis
@@Healthwarning-ry9qlis it just during puberty or during the teenage years after puberty also? Does it go until age 18 etc?
I don't like the term insulin resistance/sensitive it is a construct that can be defined in many ways. I completely agree and understand the Professors presentation but just describe it as chronic elevated insulin.
Notice how he never says saturated fat does not cause insulin resistance.
So? Never known Bikman to intentionally omit what he knows as truth.
He also didn't mention that unicorns don't exist.
@@SimplyHuman186 a million unicorns a year.
20:05
So, are elevated insulin bad or just not good🤨
I’m confused about whether it’s bad or not I’m on OMAD and mostly Keto (with one cheat day a week). And my A1C is still at 5.6 after following this diet for 5 years.
@@darlenetytula2219 I think Dr Bikman explain that phenomenon, that low carb keeps the numbers high and that having some carbs a few hours before the blood test will bring them down.
@@jan-olofharnvall8760 It is fasting more than twelve hours before a blood glucose test or OGTT that he suggests drives your bg higher, but I think that longer fasts can create stress which in turn churns out more cortisol which drives up your blood glucose which creates more insulin production.
Why doesn't a type 1 diabetic (insulin dependent) burn fat "automatically"?
He or she burn if doesn't take exogenous insulin, type 1 diabetic is always in ketosis.
They do, they whither away and die if they don't take their insulin injections. Some of them have figured this out and deliberately underdose their insulin injections to stay thin (which can be very harmful, obviously).
As an observant Jewish physician/scientist to an observant member of LDS, there is no need to apologise for thanking G-d
If your tell a person that said they don’t believe in a god. And tell the you can’t say goodbye. Because it means God be with you. And ask when in war who do you call out to it’s God.
So what didn't you spell the whole word out? Apologizeing?
12:03 hm. That was the answer on the test, eh?
Robots.
It is unbelievable that this complex system evolved with no reason or purpose.
Watch out for “beliefs.” More accurate to stick with “what appears to be” and “what doesn’t appear to be.”
Seems more reasonable to me than assuming the necessity for some external agency.
Democratization of Science?
What????
It would be nice for Bikman to explain this philosophy.
@@HEARTANDSOULOFMINE his philosophy on what?
Sorry to hear that You belive in somthing that there is 0 documentation, proof or evidence of, this guy up there.. But You are good on representing your field and knowledge.
Can you elaborate further?
There is also nothing that proves there isn't a G_d
The important thing is for you to take the fourth booster because it's safe and effective and enjoys significant supporting documentation.
Proof is not necessary to believe in God. All that is required is faith.
Ray peat fan club should watch this. Oh and Snake diet dude
He's wrong about almost everything and don't want to recognize the obvious of his final statement: LOW CARB DIETS LOWER GLUCOSE TOLERANCE AND TAKING GLUCOSE IMPROVES IT.
That's the meaning of his last statement. Literally what Peat said
@@alpema144 you didn't watch the video I see
Unfortunately there is more to it then Ben thinks and it is obvious because there is many people that reduce fasting glucose and insulin when they eat healthy carbs with a heathy diet. This alone lets you know there is more to it. I know it’s fun to join a camp and say this is it, it’s the answer but that’s just not what the facts are saying.
"There is many people"
Its a stretch to take any comment seriously from someone who doesn't know the difference between "then" and "than" or the use of other 4th grade words in singular or plural form.
@@jaymehatfield9540 Thanks for the grammar lesson, but that has nothing to do with the subject at hand and does not change the fact that what I stated is still true. You can launch a personal attack as opposed to facing the facts if that makes you feel good but it doesn’t change the facts.
I started as keto, lost 120# tracked nothing.
Jumped on the “carnivore” bandwagon (bc i wanted to lose last 5lbs) and gained 30lbs. I’m stuck tweaking between higher protein lower fat and higher fat lower protein.
I lift heavy 1.5hrs 4 days per week
I wear a CGM and glucose levels are now always 90-110. I tweak weakly but I can’t find a sweet spot 😢
I’d be okay just dropping 15lb of the 30.
My Renpho scales say I gain fat (doubt they’re totally accurate) I use to do a lot of fasting when keto.
Last insulin level was 4 but haven’t had labs in over 6 months.
Look into Biogenics and Ray Peat.
Meh - he's a little to "authoritative" to his audience. Everyone has different POV's and definitions of things, and when you are attacking a definition you need to explain why another learned person would take the other position. Insulin Resistance is not just "High Insulin". He actually talked about 1/2 the equation when he was mentioning the different resistances per cell type. That implies that insulin resistance is measured by the cell's response, and not how high insulin is in your blood. On a low carb diet - you can become insulin resistant! Why? Because even though your insulin is low, your body, triggered by ketones, has made muscle cells (for example) insulin resistant, which means the gluclose's uptake can go to those cells that need glucose as their primary fuel source. The brain is one of them.
I have no problem if bikman has a different POV on that - but a declarative lecture should include compare contrasts for the laymen, who won't have their noses in endicrinology books and studies like researchers can. And of course since I get my information from researchers, there are a lot of people in that audience who will have a different POV.
Having said all that, given that he's a respected endricrinologist, it is great to hear his POV.
My mother would have grown up on a VERY healthy diet with probably almost zero fast food, seed oils or excess sugar. She was very slim in her 20s. But from her 30s on she steadily gained weight and now in her 80s is obese, has arthritis, lipedema and struggles to walk very far. I don’t think her diet as a teen really has been much of a reflection of her health as an adult. She also never smoked or even drank alcohol as an adult. My husband also would not have eaten much sugar, or fast food - but he now has type 2 diabetes similar to his father and brother. Genetics does seem to play a part.
Ketogenic diets would help both of them immensely
Maybe he needs to heal his hair.
Don’t encourage him with the god stuff pleeeeease
There was no practical or practicable advice in this talk . . .
There are a million health hucksters on youtube giving "practical advice" with no proof, which is totally wrong. Chiropractor Eric Berg is chief among them. Try to see the value in understanding the hard science. Once you understand what insulin resistance is and why it happens, you wont need a brilliant researcher like Dr. Bikman to spoon feed it to you.
But if you do, here is the upshot: Eat low carb and fast, and insulin resistance will resolve.
What do you mean? It clearly states insulin is secreted by the amount of glucose in the blood. The more glucose, and persistent, the more insulin. Over time, the insulin is less effective, so it needs to secrete more. Thus it spirals.
He also states other causes. Stress, and other sources of inflammation. Which is less specific, but whatever can cause inflammation, may also contribute to insulin resistance.
Good start is to eat less carbs, which are all glucose.
The practical outcomes to this talk: limit if not avoid refined carbohydrates. They cause T2D.
Fear monger.
Only about as much as someone telling you that putting your hand into a fire causes third degree burns is a fear mongerer.