Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder
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- čas přidán 10. 06. 2024
- The intestinal barrier serves as a gatekeeper to the human body. The loss of the health and integrity of this barrier influences multiple aspects of human health - including cardiometabolic function, neurological health, behavior, and more - in surprising and possibly unexpected ways. One of these ways involves lipopolysaccharide, or LPS, a bacterial product that arises in the intestine, and its interaction with far distal tissues and organs via the induction of immune mediators.
Dr. Rhonda Patrick was the keynote speaker for the Metabolic Health Summit, held May 5 - 8, 2022, in Santa Barbara, California. Her presentation described the role that intestinal permeability and bacterial products play in aging, inflammation, and chronic disease.
Get the show notes at www.foundmyfitness.com/episod...
00:00:00 - Introduction by Dr. Dominic D'Agostino
00:03:12 - Intestinal permeability
00:05:20 - Atherosclerosis
00:10:57 - Brain
00:13:16 - Circulating LPS and behavior
00:16:13 - Toll-like receptors and inflammation
00:21:09 - Factors that affect intestinal permeability
00:27:19 - Alcohol
00:29:16 - Gluten
00:32:31 - Butyrate and dietary fiber
00:34:58 - Dietary fat
00:39:31 - Biomarkers for intestinal permeability
00:40:21 - Omega-3 fatty acids
00:47:12 - Questions & Answers
LEARN MORE:
Coinciding with this release, you can now find a variety of deep resources on the FoundMyFitness website for all of the topics covered in this episode.
Learn about the blood-brain barrier:
www.foundmyfitness.com/topics...
Learn about intestinal permeability:
www.foundmyfitness.com/topics...
Learn about toll-like receptors:
www.foundmyfitness.com/topics...
Learn about cerebral small vessel disease:
www.foundmyfitness.com/topics...
SUPPORT THE CHANNEL:
Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at www.foundmyfitness.com/premium.
ABOUT THE METABOLIC HEALTH SUMMIT:
Over several immersive days, MHS brings together the world’s top experts to
present the latest science on a variety of topics related to metabolic health including nutrition,
fasting, longevity, cancer, mental health, diabetes, optimizing human performance, the gut
microbiome, and more. Learn more about their CME and CPE credited event at www.metabolichealthsummit.com.
#obesity #endotoxemia #leakygut - Věda a technologie
All of the topics covered in today's presentation is available as a deep article on our website. Please make sure to check these resources out.
Blood-brain barrier: www.foundmyfitness.com/topics/blood-brain-barrier
Intestinal permeability: www.foundmyfitness.com/topics/intestinal-permeability
Toll-like receptors: www.foundmyfitness.com/topics/toll-like-receptors
Cerebral small vessel disease: www.foundmyfitness.com/topics/small-vessel-disease
BECOME A MEMBER:
Many of these magnificent resources exist directly as a result of our premium members. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of this great resource at www.foundmyfitness.com/premium.
CHAPTERS:
00:00:00 - Introduction by Dr. Dominic D'Agostino
00:03:12 - Intestinal permeability
00:05:20 - Atherosclerosis
00:10:57 - Brain
00:13:16 - Circulating LPS and behavior
00:16:13 - Toll-like receptors and inflammation
00:21:09 - Factors that affect intestinal permeability
00:27:19 - Alcohol
00:29:16 - Gluten
00:32:31 - Butyrate and dietary fiber
00:34:58 - Dietary fat
00:39:31 - Biomarkers for intestinal permeability
00:40:21 - Omega-3 fatty acids
00:47:12 - Questions & Answers
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Silents idicte creation But viloents idcate Distructions.
I'm curious to know more about gliadin and whether the tight junctions would remain open for longer period of time for folks with celiacs due to issues with it disengaging from the CXCR3 receptor?
The craziest part is that I took a Z pack for Strep throat 2 months ago and haven’t been able to handle stress at all. Never had anxiety or mild depression like this in my whole life.
does it exist any proof for the processes described ,, biochemistry = very much claims but how do you observe the molecules interacting with the enzymes ?
Great presentation. Love that she doesn't emotionalize and demonize things or jump to conclusions prematurely as certain people in the field sadly do, which contributes to a lot of issues like eating disorders, fear about food and dogma/bias.
Thanks Rhonda, thanks Dominic!
Dr. Patrick is able to explain complicated scientific terms into one easy to understand. Thank You Dr. Patrick!!!
And what does that have to do with the subject, FANGIRL??? Stfu
What effect do metallic iron filings added tonthe foold supply have on the gut? What effect does it have on candida given candida feeds on an iron buffet?
@@wellnesspathforme6236 I assume you're talking about the iron in fortified refined grains. First off, if you're eating refined grains, iron should be the.least of your concerns. Stop feeding the candida all the other stuff and iron isn't a problem. Most of the iron in fortified grains is sacrificial anyways. It gets chelated by phytic acid much like the calcium fortification in almond milk is sacrificed to oxalic acid.
@@Engrave.Danger Iron is still a problem. Your are responding based on societal programming, which has been socially engineered to promote iron overload. It is not that high glucose loads aren't bad -- they are. Note that iron is always fortified into high glucose load foods... that insulin spike is meant to drive the iron in the cell. All those synthetic "nutrients" are designed to increase iron absorption. Iron then depletes nutrients required for carbohydrate metabolism...
As long as you avoid those iron filings by avoiding the high glycemic loads you will not suffer their effect -- and that's good.
this lecture is totally astounding in presenting the most comprehensive mechanisms whereby we develop health or disease; 'all disease begins in the gut', said Hippocrates. Amazing and so well done. congrats to you for putting it together Rhonda Patrick
This is one of only two lectures of this length I did *not* find boring. Indeed, this one was captivating throughout.
This is so important! They should be showing this presentation to high school kids. Chronic stress is involved in so many diseases as Dr. Patrick demonstrated. Especially as you age and your body becomes more fragile you really have to work at keeping stress in your life to a minimum.
takeaways:
-Omega3s are good.
-Whole grains are unmistakably good.
-Dietary fiber is good.
-Intermittent fasting is good.
-Stress is bad.
-Chronic inflammation is bad.
-Being fat is very bad (for your health).
-We don't know the extent to which LPS is bad.
-We don't know if nor when leaky gut is bad, but so far we believe it's more associated with bad things.
-Omega 3s from FISH are better for you than Omega 3s from walnuts chia and flax!
@@alvinc2179 yep, most of the nuts and seeds contain lectins and also have high omega-6 which pretty much defeats the purpose. I mainly try to minimize my PUFA consumption rather than aim for high amounts of omega-3.
I'd be more inclined to consume more fish if the ocean weren't so compromised.
Whole grains are unmistakably bad! When you eat them they are converted to sugar in your body! Eat more fat!
Thanks.
Whole grains are high lectin and 👎
THREE whole grains that contain gluten: 1. Wheat. 2. Rye. 3. Barley
The speaker incorrectly referred to barley as a non-gluten whole grain - Not Correct.
Thank you for sharing this recording of your live talk. It is so useful and means those of us unable to afford the costs of the Metabolic Health Summit can still learn from your wise words
Great presentation ! I'm going to go back and listen to this one or two more times to make sure I soaked in all the gems of information I am wanting to remember and pass on to family and friends.
The network effect. Exciting!
So thankful for Rhonda and the important information she generously shares with us. Just one thing here - BARLEY contains gluten as does wheat, rye, kamut and spelt to name some commonly consumed grains.
The problem is there's way too much farm raised fish out on the market. We need politicians that actually act to get this bacteria induced frankenfish off the market... And it's a global problem!
Politician's gave a green light to the gmo. Bad farmed fish...all gmo.....thanks to our house and congress etc
Even wild fish are so contaminated with heavy metals they are unsafe for pregnant women. F DA recommends nax 1x weekly. That means leave it the heck alone all the time
Daddy government
Why should you rely on the government? You'll be waiting for a LONG time...
Buy your food directly from the farmer. Talk with them. Tell them what you want. (Pay them a fair price for it too.)
Or, look your farmer in the eye!
Thank you for all you do. We (non-experts) often hear what we should do but rarely why. You lay out perfectly a bigger picture as to why certain things are good and should be done and it helps motivate the necessary changes.
Girl you were MADE for this! So blessed by you, your interests and the way you share your information. Much love!!
I agree! Dr.Patrick has given me the knowledge that I implemented and now my autoimmune disease has been in remission for over 2 years. Prior to this I was on biologics for ~20 years starting at age 24 and I was still full of inflammation during those years despite the injections and dozens of prescribed pills. NOW I take NO pharmaceuticals and my inflammatory labs are all at undetectable levels. Also not depressed anymore. I am so thankful to her and her effective delivery methods that allow the audience to fully absorb otherwise extremely complex concepts. Thank you!
There’s not many Dr’s like you out there. I have been following you since the video about sulforaphane. Thank you for sharing your knowledge!
This channel deserves millions of subscribers in my opinion.
Great video. We're so lucky to have easy access to such information at the click of a button these days 👍
Rhonda you're a real asset for humanity 🙏🌹
Glad Rhonda's BACK!
Thank you Rhonda from San Antonio
Beautiful talk from a renowned expert. Thank you for making this available for free. I appreciate it very much.
This was terrific! Thank you Rhonda.
Congratulation for the presentation, it is very professional! I also loved the Q&A section! Thank you for spreading these valuable infos
Amazing talk! Thanks for uploading it and sharing this with us. Definitely going to give this another listen later.
Dr. Patrick, amazing breadth of knowledge on this subject. Learned much.
What an amazing delivery of info Dr Rhonda!
I would challenge Dr. Kirkpatrick and her circle of research to look at the impact of Mycotoxins, especially as we talk about things like grains and the inconsistency between various allergens and grain causation. She’s likely to find that mold is a key factor missing and the main stream analysis of disease causation as well as open up a new possibility of further research.
hey dave asprey your coffee scam has been exposed go back to school jerk! lol
Also endotoxins found in meat
@@levansegnaro4637no
Thank You Rhonda! You explain things so well even us chemistry-challenged viewers get it...
Excellent lecture. Thank you thank you thank you. Have been sharing this with my patients and online community.
As always amazing content easy to understand. Thank you for all you do !!
My pleasure! Thank you for watching!
Dr. Rhonda Patrick is my favorite!
Good stuff Dr. Rhonda Patrick.
Dr. Patrick you are amazing! I share often!
Thank you!
Love people who serves all our community. Thanks this will make a difference to our life ❤️
Thank you so much my dear Dr Patrick, straight to the point, not even a second waist inthe whole videos, thank you youtube team for recommanding this to me.
Thank you Dr. Patrick!
This is fantastic, totally explains how its NOT cholesterol after all
Dr. Patrick is such a good speaker. I'm not a native english speaker but when i listen to Huberman or Dr. Patrick it feels like they speak in my native language which is gold when listening to science based podcasts/videos! Thank you!
The graphics greatly enhance the presentation. Thank you, Rhonda for adding them to your session. Also, the timeline for the presentation is very useful as your presentations are quite long. It would help all of us viewers if you added recommendations for adjusting life styles, diets, etc. for healthy living and sited in the timeline where those are. Tim Ferris often adds "show notes" after his podcasts to them to enhance the viewer's/listener's experience...Just a thought. Again, thank you.
Hi, Tom! There are indeed in-depth show notes available at www.foundmyfitness.com/episodes/intestinal-permeability Make sure to click the "Timeline" tab. The content you're looking for mostly starts at around 21:09, which is also CZcams chaptered. Thanks for listening and the nice note!
@@FoundMyFitness interesting as always. Helpful graphics but for some reason the flying red box leaves me disoriented and distracted. I’d be delighted if you could return to a more conventional focus highlighter in future thanks.
This is an excellent LPS summary for various organs
A typically bloody excellent talk. Thanks.
Dr Patrick, please interview Dr Natasha McBride (neurosurgeon) she has been talking about this issue for more than a decade
Thank you Dr. Patrick. Great lecture! As a registered dietitian, this information was very helpful and pertinent to my practice. During my graduate coursework I came across a study of how cannabinoids play a protective role in intestinal permeability. How does the research stand up today? Is there a benefit for cannabis use in maintaining a healthy gut?
I would be very interested to hear an answer to that too
You smoke weed?
What a wonderful talk. Thank you.
Love Dr. Tommy Wood! Great comments at the end!
Dr.Bruces Ames would be extremely happy of his protege student. Great presentation Rhonda@
As always, mind blowing! Thank you
I just re-watched a video yesterday with Dr. Richard Johnson and I said the exact same words: mind blowing! I love when that happens. If you´re also interested in what he has to say, this is the link czcams.com/video/5jBsWbDGtWU/video.html
Thanks Doc....What about glyphosate causing leaky gut?
Great video! Thank you!
Great lecture thank you so much! One factor virtually no one is discussing is the role toxic electromagnetic frequencies (EMF's) have on dysregulating the enteric nervous system (ENS) along with micrbiome function and population. With the widespread deployment (love the industry's choice of military terminology there) of 5G and soon to come 6G microwave technology as well as AMI meter dirty electricity filling literally every residential, commercial and government environment now, this issue is likely to continue to cause a rise in all inflammatory and metabolic disease, regardless of dietary intervention. All out lifestyle changes as well as social factors contributing to stress in human relationships need to be addressed telecommunications and government will not back off on their deployment of their digital panopticon without massive public civil disobedience. Which won't happen.
Live blood Cell analysis quickly detects hyperpermeabilty quickly and accurately.
Excellent talk, thanx.
great presentation Rhonda notable ways to lower sudden death also include curcumin by 56% and infrared saunas as you covered of course by around 63%. Can you do some coverage on redox signaling molecules? Really interested to see your views they appear to really rmap up internal antioxidants in the body like sod etc
Awesome! Thank you.
trailer is the best promo you can do - well done!
Sometimes it pays to just click around in CZcams settings and see what new things they're letting us do. I love this feature. We'll use it every time now. Thanks!
Where did you see the trailer?
Fantastic talk! Thanks so much 😀🌠🌠🌠
I would like to see a video on the daily dozen, foods highest in: Arsenic, Gliadin, Furocoumarins, Cesium, Oxalates, Goitrogens, Serpins, Solanines, Cyanide, Thallium, Bergapten and Pyrrolizidine Alkaloids. Should we keep eating foods high in these 12 or try to find foods that are low in all 12?
clear explanation. thank you
Outstanding! Short, concise and authoritative. Helped me understand the doubtful standing of the epidemiology so often adorning the presumed nutritional expert opinions(The emperors have no clothes). Bart exposed them nobly.
Excellent!
She’s the best on CZcams A1
Great presentation, Rhonda! As you said, those sea creatures eat algae to get their omega 3s. Please note for your plant based viewers that we can now get vegetarian algae based EPA supplements, and for a long time we have been able to get vegetarian algae based DHA supplements. Thanks for all you do!
Get this woman out of here. Total clown
@@Roboticpycotic lol cmon bro they were pretty respectful.
@@travv88 she should resign seriously. I could make a list of claims she made about v that were that turned out to be complete bs. Just another npc, egotistical clown
Caloric restriction does not work, it is extremely temporary as the body adjusts to your intake. Eating a healthy diet is absolutely necessary no grains, as most modern grains are tainted with glyphosate which stops nutrient and enzyme use, how it kills the pests that eat it, not a good idea
So good!!!
there's so many questions i want to ask and so little i understand!!
I always believed there's a strong correlation with depression with gut health and the damage anti biotics has done in latent child hood.
1/ My first question is, we know how important butyrate is to gut lining as well as a persons health, wouldn't it be beneficial to take butyrate as a supplement to reduce gut junction and other healthy effects ?
2/ gut inflammation/ stress causes tryptophan to be converted into kynurenine and there's 2 separate interventions of exercise that can salvage the tryptophan into serotonin and kynurenic acid. When should exercise during consumption of foods containing tryptophan be done? before or after consumption to get maximum conversion also for how long? it could change the way we view eating, in Asian cultures it was customary to walk 20 mins after eating to help digest foods. This might actually be an optimisation of serotonin. This can be ground breaking in treatment of depression anxiety.
This was amazing 👏🏽
Thank you!
Educational. Listening from new Zealand 🇳🇿
Do you have an opinion about Steven Gundry's assertions about "lectins"? He advocates for eating lots of vegetables but to exclude some specific sets of vegetables. He asserts that some plants contain chemicals that destroy or lead to destruction of the intestinal lining. Should we avoid some vegetables? Is that mechanism of plant chemical destroying gut lining significantly true from your point of view? If there are these negative effects, are they outweighed by positive effects of these lectin heavy plants?
I’m aware of his theory. He raises concerns about many members of the nightshade family. I recently used a food elimination technique to test my own sensitivity to certain foods. When you reintroduce them after the period of elimination your body will tell you if you have a sensitivity. During the elimination period you may see various symptoms subside if the food you eliminated is an offender for your body. These symptoms return with a vengeance when you reintroduce the food. I am generally sceptical of his advice because he has a vested stake in the sales of his various lines of supplements. But there are tools available to test your own sensitivity to various lectins. Good luck!
@@mary-janeowen8238 Food sensitivity test results change according to what you're eating, so I'm not sure how that's useful.
@@MrMadalien true. My comment pertains to food elimination not food sensitivity testing. They are not the same thing.
I just need a daily eating plan for the year.
I'm genuinely so excited to see this haha. I have like 3 alarms setto remind me 😂
Well done
This is a very good talk as LPS and endotoxin are usually minimally discussed. Can you elaborate on LPS and endotoxin from the mouth.... Please.
You are the best, my life has improved because of your first visit on Rogans show!! My blood pressure has improved significantly and every thing else from being pre diabetic to lowering my bad cholesterols and raising my good cholesterols.. Thank you Rhonda
Can you share what you have done that has worked?
Thank You!
Dr Datis Kharrazian has been saying most of this for probably a decade now. Guy was ahead of his time.
LPS producing Bacteroides represent 30-40 % of gut bacteria and are an essential part of immune function. The sustained inflammation is caused by a different mechanism even though LPS initiates it.
Great talk. The last question is cut off though, what was it about?
As a person over 65 who has been a vegan and used alternative medicine on my life I do not have gray hair and I do not wear glasses. I am in better shape than most 30-year-old as I do martial arts and compete with a lot younger people. When you look at different societies and their mortality rates America’s falling while Asian countries their life spans are increasing. If you want quality of life diet is the key otherwise you can spend your lifetime visiting doctor offices.
Muscular health might have something to do with this
Thanks
Hey, Dr. Patrick. Thanks to you, I’ve had big green smoothies 6 days a week for the past 5 years.
I did that and my body didn’t like it. I really tried for 4 years. When I moved to more meat, cooked vegetables and a carb 3 meals a day is when I started to feel 1000 times better. Everybody’s put together differently it’s interesting
And you haven´t developed kidney stones, yet? Maybe you´re not using a lot of spinach in your smoothies as many do. The high oxalates in things like spinach, almonds, etc. almost invariably lead to kidney stones, so whatever you´re doing seems to be okay for now. Who knows?
Totally agree with all that has been said. There is an obvious link to gut and brain activity. Most ppl who have pychological issues probably also have intestinal issues as well.
I have been commenting on various health podcasts to ask to have Kiran Krishnan on. I would especially value your point of view on his assertions concerning leaky gut and its causal role in a variety of disease pathways. And also about his assertions surrounding the effectiveness of bacteria like bacillus subtilis. Have you looked in these studies he has done. Kiran seems very confident and cites studies to back up his case but i would like some more interaction with research scientists like yourself.
Brilliant!
1. I bet LPS is different depending on gut bacteria, also you can add fiber to a diet and increase inflammation in that person -> some people with good gut bacteria will do fine with a ton of sat fat diet and other people will feel shitty.
2. Omega 3s should be taken from pickled fish , i bet any type of heat will destroy the omega 3s that we need. Same goes to animal meat/fat ( especially bone marrow and brain ) but that's a different story. Also AGE's will go through the roof when you cook meat, i'm pretty sure we need to eat it as raw as possible, just like most choline remains in a very soft cooked egg.
3. I think Dr. Zsofia Clemens is the leading entity when it comes to intestinal permeability and she is the leader of the "group" that uses peg400, she would answer a lot of the questions.
Excellent, I agree with numbers 1 and 2. I’ll checkout the Dr. You mentioned on #3. I thought Dr. Natasha McBride was the leading advocate on leaky gut. Check her out when you get a chance she’s brilliant!!
@@fekadugirma9692 From what i read seems like the Gaps diet is pretty reasonable. There should be properly done tests with peg400 ( seems to be the best one at the moment ) to check if it resolves leaky gut. if it's so, then it's better than the one i was talking about because that is much more restrictive and hard to do but it does get you into deep keto, at least 3.5mmol
"I bet LPS is different depending on gut bacteria"
Your bet is correct
You will be amazed how close you are!
I already have a comment but would like to add some more stuff.
1. Butyrate seems extremely important but since a lot of people have dysbiosis a lot of people can't really make butyrate for health, that's why some do good on vegan - high plant foods diets and some do worse. Check out Sonnenberg studies on fermented vs fiber diet. Some people can do well on keto diets since they can make beta hydroxy butyrate as a ketone body BUT there are studies showing that if you don't have certain type of bacteria the keto diets stops having benefits ( mouse model for epilepsy studies ) . So even keto/carnivore works only if you have some specific bacteria, answering the question why some people can't handle a keto diet.
2. There is nothing said about vit A ( especially in balance with vit D ) that has profound effects on gut lining/mucus production/immune system which is astounding. Not to mention adding vit K2 and magnesium will improve bone health ( and i venture to say reverse atherosclerosis or any kind of calcification ) BUT you need copper/zinc for it to work right, and who know what the other minerals do to. And i'm talking 50k UI/day of vit A. Weston price has very good articles on it.
Thank you! 🤩👍
I would love to see Dr Rhonda interview with Dr Gundry?
yes
Dr. Zsófia Clemens has done quite a bit of interesting work regarding intestinal permeability. According to her, the most reliable test is not zonulin or lactulose/mannitol, but PEG400.
Edit: Whoops, just noticed this also pops up in the questions at the end.
This is it! I had been suffering for years -- but after antibiotics and the time needed to regrow and repair the gut and lining, my body might be pumped with nerves sometimes but it doesn't effect my mental state at all, a while ago I almost got run over while cycling but head remained calm and clear - it's suddenly like i'm james bond or something.
33:22 - sources of fermentable fiber - you forgot to include my favorite - acacia fiber
Excellent presentation. Thank you Rhonda.
You are so welcome! Thank you for watching!
You can find EPA and DHA in algae too.
So what is the solution for people who have this issue? I hear so much about the gut brain connection and the link of gut health to "autoimmune" conditions.
Absolute gold, as usual
caloric restriction is a great way to destroy your metabolism. if you are operating on a daily basis with calorie restriction, then your body is going to make an adjustment to avoid catabolizing your muscle tissue (something that has been critical for survival for eons). the adjustment will be slowing your metabolism. this cycle continues until you are able to basically just surviving without eating up too much of your muscle tissue through autophagy. this is a miserable way to live. the alternative is to occasionally fast and then re-feed carefully and eating each meal there after to satiation. this will put you in an anabolic mode instead of a catabolic mode. as humans, we react better to a contrasting quantity of food consumption. when we were hunter gatherers thousands of years ago, we went through periods of feast and famine. this is where insulin comes in: during the feasting periods, it increased nutritional uptake in the cells and prevented fat burning in adipose tissue. conversely, during famine periods, insulin goes down and we are able to access our fat stores in the adipose tissue. if you compromise the usefulness of insulin by constantly eating, then you get insulin resistance and metabolic dysfunction. when you further compound the problem by consuming polyunsaturated fats from seed oils (vegetable oils) which are also oxidized right in the container and then further oxidized by heating and cooking, you get a vicious cycle whereby the fat tissues are dysfunctional and insulin resistance is wreaking havoc and your caloric restriction is causing your metabolism to slow down. we did not get exposed to industrially produced vegetable oils when we were hunter gatherers or even for most of historical time before about 100 years ago when these oils were introduced into our diet. now these oils are ubiquitous and our health problems are skyrocketing. solution: cut out all seed oils, consume saturated fats from ruminate sources (cows, goats, deer, etc) eat nutritionally dense foods (meat and organs) and the least toxic plant products: fruit and honey and occasionally do some dry or water fasting.
The hard to find answer is what kind of OTC Omega 3 is actually effective?? I've been taking Krill and recently learned that isn't going to meet the minimum bar but I also hear that most OTC Omega 3 supplements offered on the market are either rancid or contain dosages which aren't effective. If one can't get a doctor's prescription for Omega 3, then where should we be investing our dollars?
I do a combo of the fatty fish, chia and flax in my smoothies/salads and doubling or 1.5x OTC dose
Some of the btter brands I noticed are Now and Dr.s Best and are on amazon
Life extension foundation or cans of sardines
brilliant
RE: No. of alcoholic drinks (3,4 or 5) plus stress affecting LPS development & leakage is = to sports-tailgates … drinking all afternoon then attending a stressful football (etc.) game for 4 mos. out of the year annually. The same might be said for doing the same at home, but watching the sporting event on TV.
About the heavy cream, consider casine and its exorphins.
LDL binds toxic LPS 7:00 (small particle LDL doesn't recycle as effectively so bound LPS stays in circulation more, large particle LDL is vital) - (Seems strange though as people with higher total cholesterol levels have lower risk of mortality , and you'd think they'd have more small particle LDL too packaged into that . So is this theory incomplete?)
LPS breaks down BBB makes it more permeable
Reduce intestinal permeability to lessen impact of LPS (raise intestinal ATP?)
50:00
52:45 other things in studies combined with saturated fat to make it look bad (seed oil industry)
👍