Misoprostol: Mechanism of action

In this video we explain the mechanism of action, pharmacokinetics, indications, contraindications and side effects of Misoprostol. We use simple explanations and diagrams that are easy to understand, aimed at helping medical students and healthcare professionals of all levels.
Timestamps:
00:56 - Mechanism of action - Prostaglandins
02:41 - Mechanism of action - Gastric protection
05:57 - Mechanism of action - Uterine stimulation
08:07 - Pharmacokinetics
09:42 - Indications & Contraindications
10:43 - Side effects
11:04 - Summary
Misoprostol belongs to a group of medications knows as synthetic prostaglandin E1 anologues, and a synthetic prostaglandin E1 analogue is a class of drug which binds to a prostaglandin E1 receptor and mimics the effects that natural prostaglandins would have. Misoprostol is used to protect and promote the healing of gastric and duodenal ulcers by inhibiting hydrogen ion secretion within the stomach and promoting the secretion of mucus and bicarbonate which provides a protective layer for the stomach epithelial cells. Misoprostol is also a potent uterine stimulant which causes contraction of the myometrium and is utilised in the prevention and treatment of postpartum haemorrhage, the termination of pregnancy and the medical management of miscarriage.
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Although this video is designed to provide education, it should not be used to guide clinical practice, treatment or medical decision making. These videos are designed to provide a detailed overview of each topic, and although a lot of research goes into each video errors can occur and medical practice, medical information and protocols may change over time, which is why it is important to follow local and national guidelines. These videos do not constitute medical advice, medical advice should be obtained from an appropriate healthcare provider or senior clinician.