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Furosemide: Mechanism of action
In this video we explain the mechanism of action, pharmacokinetics, indications, contraindications and side effects of Furosemide. We use simple explanations and diagrams that are easy to understand, aimed at helping medical students and healthcare professionals of all levels.
Timestamps:
00:37 - Mechanism of action
10:22 - Pharmacokinetics
12:21 - Indications & Contraindications
14:47 - Cautions & adverse effects
17:53 - Summary
Furosemide belongs to a group of medications known as loop diuretics. Loop diuretics cause an increased production of urine by inhibiting the reabsorption of fluid and electrolytes. This is achieved by inhibiting the sodium/potassium/2 chloride co-transporters located on cells within the ascending limb of the loop of henle. Inhibition of these pumps causes fluid and electrolytes to remain in the kidney tubule so they can be excreted in the urine. Furosemide also has vasodilatory effects which contribute to its therapeutic effectiveness. Furosemide is used is oedematous states such as acute pulmonary oedema, peripheral oedema and ascites as well as resistant hypertension. The adverse effects are mainly attributed to the loss of fluid and electrolytes.
Thank you for watching and I hope you found this video helpful, be sure to check out our videos on pharmacology, and if there are any topics you would like us to cover then please leave a comment in the comment section below. We really appreciate your feedback as it helps us to design better quality videos.
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Although this video is designed to provide education, it should not be used to guide clinical practice, treatment or medical decision making. These videos are designed to provide a detailed overview of each topic, and although a lot of research goes into each video errors can occur and medical practice, medical information and protocols may change over time, which is why it is important to follow local and national guidelines. These videos do not constitute medical advice, medical advice should be obtained from an appropriate healthcare provider or senior clinician.
zhlédnutí: 5 729

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Rhabdomyolysis: Causes, Signs, Symptoms, Diagnosis & Treatment
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In this video we explain the causes, symptoms, investigations, diagnosis and treatment of Rhabdomyolysis. We use simple explanations and diagrams that are easy to understand, aimed at helping medical students and healthcare professionals of all levels. Timestamps: 00:21 - Causes 03:49 - Signs & Symptoms 06:07 - Investigations 07:23 - Diagnosis 09:21 - Management 10:48 - Summary Rhabdomyolysis i...
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Komentáře

  • @johanwessels5257
    @johanwessels5257 Před měsícem

    Yip, finally got my Rhabdo badge. Have exercised before that i know why the Trex was probably an angry dinosaur. First time having coke coloured pee. Muscle soreness weirdly is enjoyable untill you cant dress yourself or its a mission to wipe your ass. 😅

  • @loutube232
    @loutube232 Před 4 měsíci

    Never knew over training was a thing aka Rhabdomyolysis aka Rhabdo 🤡🤮☠️ ...especially a deadly thing!! Doctors said I was lucky to be alive☘️ My shoulder coming out of socket saved my life! Otherwise I would have stayed home and died☠️ I guess training 7 days a week with 4-5 days twoadays while Fasting 7 days a week for 16-24hrs and drinking 1-2 pots of coffee and a heavy dose of Kratom for pain has taken its toll on my old ass of 56 years young in da House! I felt like superman but now I'm seriously rethinking my next comeback #whosindahouse #Fitover50 Crazy how life can turn on a dime. But in every negative there's a positive, it just sometimes takes time to figure out! Time for another comeback💪This one is gonna be another tough struggle! I basically can't do anything. If my arm moves the slightest in anyway the broken pieces move and the pain is significant😱 Wearing a shoulder brace for 6-8 weeks which will set me back back!! Any help is much appreciated 🙏 www.gofundme.com/f/help-for-lou-while-he-recovers #healingjourney #whosindahouse #fitnessjourney #fitover50 #redlighttherapy #saunatherapy #grounded #NikolaTesla #fountainofyouth #ninelives #wellness #fuckcancer #intermittentfasting #healthylifestyle #overtraining #Oxygentherapy #vibrationalhealing #frequencyhealing #healthy #intermittentfasting #fitness #fountainofyouth

  • @ShikharMan-mh4tw
    @ShikharMan-mh4tw Před 5 měsíci

    Crystal clear.THANKS

  • @alinadorpan6673
    @alinadorpan6673 Před 5 měsíci

    Please upload video on the drugs used in cardiology . Your videos are really helpful

  • @nahimotrajicoleman6331
    @nahimotrajicoleman6331 Před 6 měsíci

    ❤❤❤

  • @justincruz5057
    @justincruz5057 Před 2 lety

    I really need advice , I’ve been out the hospital for at least a month now but I still feel week in my legs and the soreness only gets bad when I lay down . Me getting this was because of drug induced . I don’t know what to do where it actually annoys me at night and not being able to walk property up and down stairs like my balance is not there . I’m ready to fall if I don’t try

  • @Iamthedoctor10
    @Iamthedoctor10 Před 2 lety

    watching this bc i’ve been taking this medicine for 2 years and i feel like i should know more about it 😂

  • @The24winter
    @The24winter Před 2 lety

    Thank you so much. Your explanation is concise but easy to understand.

  • @user-cl9rv8uj9h
    @user-cl9rv8uj9h Před 2 lety

    Sooo great work

  • @user-cl9rv8uj9h
    @user-cl9rv8uj9h Před 2 lety

    Thhhhhhaaaaanks a looooot

  • @Chelsea-gs7qj
    @Chelsea-gs7qj Před 2 lety

    Phenomenal

  • @deanburney
    @deanburney Před 2 lety

    Now I do 28 push-ups a day, not 140. And none of my sets are “To failure” now. Forget it! I’m not losing my kidneys over this! I’m sixty years old, by the way.

    • @MeeJunksEavy
      @MeeJunksEavy Před 12 dny

      Don't think a nerdly 140 push-ups will put you in a high-risk factor for rhabdo. How did you land on 28 reps 😂. No pain...

  • @eman5669
    @eman5669 Před 2 lety

    Excellent presentation thank you

  • @essexandy189
    @essexandy189 Před 2 lety

    I’m sure this is what i have i get severe cramps in my chest and side off my body that are so painful sometimes i just want to die, I’m always tired and get swellings around the bottom off my legs am always desperate for a wee but when i go i don’t wee a lot and have a fatty Kidney. I take statin’s also Amlodipine for high blood pressure and work with health and safety clothing so my body get’s hot a lot off the time. The one thing that makes me think it might not be this is iv’e had this for quite a few years now especially the severe body cramps

  • @BigB36024
    @BigB36024 Před 2 lety

    I ended up getting rhabdomyolosis about a year ago. And it was all because I did two and a half months in jail with covid so there was no rec center. Got out of jail, with no vehicle, and had to walk 12 miles to a hotel for the night. So two days later after the whole time my legs being extremely sore and weak. I take a shower everything's fine, I get out go to put my socks on and realize that my feet were almost one and a half times their original size. I thought no big deal it's just from walking too much it'll go away. So two more days and I start noticing I haven't urinated in over 48 hours. And I started getting kidney pain. So I go to the hospital and they do blood work. And it turns out my CK level was over 10,000. So they admitted me and I was on constant IV fluids for a little over 3 days until I can finally urinate a decent color urine. So a piece of advice to anybody that does even a month in jail where you can't move around as much because a covid. When you get out do not over exert yourself in any way. You can end up going into kidney failure like I almost did

    • @BigB36024
      @BigB36024 Před 2 lety

      I apologize I forgot to mention two more symptoms that went unnoticed until I was diagnosed. I didn't realize I couldn't think straight. And I was sweating profusely Non-Stop

  • @zhankunqi236
    @zhankunqi236 Před 2 lety

    This is very straightforward and informative. Thank you! Please keep up with the good work!

  • @NargisTheViking
    @NargisTheViking Před 2 lety

    So I had it and spent 5 days in the hospital. How long does the soreness last?

  • @vandalynfleming8189
    @vandalynfleming8189 Před 2 lety

    8 7oup

  • @joannavila5144
    @joannavila5144 Před 2 lety

    Thank you for explaining Rhabdo ever so simply and and clearly.

  • @jennygibbons1258
    @jennygibbons1258 Před 2 lety

    Just what I needed to know. Thanks. Ten years after stopping statins I still have weakness, wasting and pain in many muscles - palpitations, hand and leg cramps and spasms, extreme fatigue and breathlessness with slightest exertion. Vitamins B1 and B12 plus potassium and magnesium are helping me noticeably over the past couple of months. However, I'm still researching to see if I can get further gains. Thank you again.

    • @billy3650
      @billy3650 Před 2 lety

      How did you get off of statins?

    • @jennygibbons1258
      @jennygibbons1258 Před 2 lety

      Just stop. No tailing off - not necessary despite what people say. Join a F/Book group for statins damage if that’s helpful.

  • @fornewiraq8765
    @fornewiraq8765 Před 2 lety

    Very good continue with this very useful video

  • @craigymc2011
    @craigymc2011 Před 2 lety

    Very helpful, nice clear and well timed delivery in a non distracting diagram. Thank you

    • @titusdaniel
      @titusdaniel Před 2 lety

      It's funny you say that because I agree with everything except the non-distracting part. I spend most of my time trying to figure out why the hand is there when it's clearly all computerized versions of the original drawings and handwriting.

  • @waqarhussain6932
    @waqarhussain6932 Před 2 lety

    if i am mot wring from 15:30 less insulim relase due to less pottasium will cause hyperglycemi not hypoglycemia!! ? can u techek plz

  • @lisapelle793
    @lisapelle793 Před 2 lety

    Excellent 👍🏻 Totally enjoyed this.

  • @skinlesswalnut6259
    @skinlesswalnut6259 Před 2 lety

    Just got home from the gym, first time I've been in at least 5 years, couldn't lift my arms after, just went pee and it was pretty much black, also got a little fever, I've also been drinking cranberry and raspberry juice all day but I don't think that causes change in pee colour, should I go to hospital? It's 3 in the morning so not a lot I can do right now, Im also on the tail end of an addiction to crack heroin and alcohol and thought my kidneys were damaged anyway for many reasons, can someone let me know please who's been through it thanks

  • @janaenae1338
    @janaenae1338 Před 2 lety

    I'm so sad and so alone please help me understand how to fix this. Is it positive potassium ions or ???

    • @cherylm2C6671
      @cherylm2C6671 Před měsícem

      Bananas, potatoes, do nothing excessively.

    • @janaenae1338
      @janaenae1338 Před měsícem

      @@cherylm2C6671 ? is this real advice or is this sarcasm I'm literally unsure

  • @janaenae1338
    @janaenae1338 Před 2 lety

    I have hypokalemia or my mom does.....and I have an addiction to methamphetamines and my body is suffering from severe body odors of any and every kind....no one likes me and I feel so terrible and awful when I use...but the addiction is strong enough I have been having a hard time quitting ...why do I develope overpowering body odor to these extremes

  • @freshtoast3879
    @freshtoast3879 Před 2 lety

    I recently had this and my creatine kinase level was 50'000!!

    • @JohnnyJayVisuals
      @JohnnyJayVisuals Před 2 lety

      Mines was 125,000

    • @tiradom.7918
      @tiradom.7918 Před 2 lety

      Mine is 30,000

    • @freshtoast3879
      @freshtoast3879 Před 2 lety

      @@JohnnyJayVisuals did you lose the limb?

    • @justincruz5057
      @justincruz5057 Před 2 lety

      Im feeling soreness in my knees and thighs what did you do to pass this phase . I’ve been out the hospital for a month or so now but still struggle to walk or go up and down stair

  • @silvio4pierce
    @silvio4pierce Před 2 lety

    Awesome project about the different medicine, as well as the signs, symptoms and diagnosis. I love the way you explain the mechanism of action. It's rare to come upon such fine and easy to comprehend videos. Where can we send inquiries about desired themas (email)?

  • @Dr.ShruthiKotaprolu
    @Dr.ShruthiKotaprolu Před 2 lety

    Very informative. Thank you so much sir.

  • @shuaizhengxing3995
    @shuaizhengxing3995 Před 2 lety

    LEARNING HAS OCCURED!!!!!!

  • @TheDesertkat
    @TheDesertkat Před 2 lety

    Are there contraindications with drugs like Anoro Elipta?

  • @namitabepari1337
    @namitabepari1337 Před 2 lety

    Thank you so much sir ...may god bless you. ..please make more vedio

  • @oxfd611
    @oxfd611 Před 2 lety

    As a paramedic in the event I have a patient that I have sizes symptoms and suspect rhabdomyolysis should I consider the possibility of transporting such a patient to a elevated trauma center as opposed to a general local emergency department? Of course follow my protocols or consulting with my local medical control to make such a request?

  • @xXPhYc0t1cXx14
    @xXPhYc0t1cXx14 Před 2 lety

    Hey guys. I had rhabdo back in 2019. I had obtained this job that had a fitness test as part of the onboarding. On my first day of training I had to jog up and down built in cement bleachers at a football stadium. I barely made it to the quarter mark until my legs finally gave out. I had proceeded with the other training for the next 2-3 days . On the 3rd day I was in such agony pain. I gave it my all for this job with only 3 days of intense training. At this point I couldn't hide the fact I was in a lot of pain. My manager that was training me the whole time said something about it. Right after I completed my training . With the intent to finish my physical on boarding at a later time. He tells me, “congrats man , you completed your training with us!” “ although, I do see you are in some pain stull from the other day. Im really concerned about your health. So you have to have this cleared by your doctor before you can come work with us”. At first, I was actually really proud of myself for completing the straining. But then I realized what was really going on. I knew I wasn’t going to get cleared to work by the doctor. Very discouraged. Later on that day , I remember I was driving with my buddy in the passenger. My legs hurt so bad to the point where I could not use my right leg to drive. I knew at that point I had to go to the hospital. When I had got admitted they find out I have rhabdomyelosis. Extremely puffy thighs , beyond the definition of sore. Although it wasn't until after I got to the hospital my urine turned tea color. Mind you I also have type 1 diabetes. The doctor told me if I had not come in a day later, I could have died.. Took me about a whole week to recover at the hospital. My advice is please be strategic on how you work out and please consider the amount of time you have gone without exercising. I never knew that this could potentially put your life at risk for not taking proper precautions before getting back in shape. Thanks for reading, I hope I helped someone out with my story.

    • @xXPhYc0t1cXx14
      @xXPhYc0t1cXx14 Před 2 lety

      I had pk levels of 400,000 I was hooked up to a special iv fluid for the whole time .Staying hydrated with alkaline water. Stayed away from protein and sodium.

  • @elijahpunter1067
    @elijahpunter1067 Před 2 lety

    Please address the new rhabdo created by covid.

  • @rusolkh.6345
    @rusolkh.6345 Před 2 lety

    Thank you very much for your time and effort

    • @AnimatedMedicine
      @AnimatedMedicine Před 2 lety

      Thank you for your comment, I hope you found the video helpful.

  • @re9473
    @re9473 Před 2 lety

    Well definitely I guess one of the new causes is Covid so I was diagnosed with Covid was really sick at home then when I started to feel better I was shortness of breath dizziness end up being hospitalized and find out that I have Rhabdomyolysis there’s no other reason but Covid on my end

    • @wastenotime27
      @wastenotime27 Před 2 lety

      How long did it take to recover?

    • @re9473
      @re9473 Před 2 lety

      @@wastenotime27 I was in the hospital for three weeks I’m 32 years old healthy so I was so surprised I end up finding out I had Covid on 14 December and I was taking my behind for two weeks and then it was difficult for me to sleep and I was waking up as well from Being out of breath felt like I couldn’t breathe woke up like I was running track went to the hospital end up being there for two weeks still have short of breath literally have an appointment next week for more bloodwork to make sure everything is back to normal my CK level was 4500 Normal level I believe is between 30 and 300

    • @wastenotime27
      @wastenotime27 Před 2 lety

      @@re9473 wow. Thanks for responding 😀 I tested positive for covid-19 too. My legs felt like I been squatting for a few days. I could barely put on my shoes; it was painful evey time i reach for my toes. I came to the hospital and been hooked up to the iv for 3 days now.

    • @re9473
      @re9473 Před 2 lety

      @@wastenotime27 wow well definitely hope you feel better I was on an IV fluid for that period of time in the hospital believe it or not being short of breath still bothers me I don’t have asthma but they prescribe me an inhaler to help just make sure when you get out the hospital get lots of blood work done and make sure everything is working like it supposed to hopefully it is and you recover soon 🙏🙏🙏🙏 But I know three other people that got Covid and it’s been affecting their kidneys did you ask them what is your CK level

  • @deedeedeadtree4215
    @deedeedeadtree4215 Před 2 lety

    I liked going through the intracellular mechanisms in detail, thanks

    • @AnimatedMedicine
      @AnimatedMedicine Před 2 lety

      Thank you for your comment, I am glad you found the video helpful.

  • @doaa99_16
    @doaa99_16 Před 2 lety

    Good 👌🏽💙

  • @earlisonline
    @earlisonline Před 2 lety

    watching this after experiencing back pain from working out (scared and a bit panicking) but yeah, drinking lots of water too

  • @Kearney700
    @Kearney700 Před 2 lety

    When are you going do make a SEPSIS video please ??

  • @janepanti5476
    @janepanti5476 Před 2 lety

    Is it alright that my heart palpitates when i took salbutamol tablet sudden attack of asthma 66 senior

    • @AvtDropper
      @AvtDropper Před 2 lety

      It is a common side effect of the drug maybe you should raise this with your doctor

  • @gregkaye5583
    @gregkaye5583 Před 2 lety

    thankyou

    • @gregkaye5583
      @gregkaye5583 Před 2 lety

      you might get more hits if you included product names like ventolin in your titles

    • @AnimatedMedicine
      @AnimatedMedicine Před 2 lety

      Thank you for your feedback Greg.

  • @wasd1258
    @wasd1258 Před 2 lety

    Please do the things I’m listing

  • @wasd1258
    @wasd1258 Před 2 lety

    Spinal cord injury

  • @wasd1258
    @wasd1258 Před 2 lety

    Head injury - icp - causing triad

  • @wasd1258
    @wasd1258 Před 2 lety

    Pelvis and long bone fractures

  • @wasd1258
    @wasd1258 Před 2 lety

    Fractures

  • @wasd1258
    @wasd1258 Před 2 lety

    Stroke