Nicotinamide Riboside vs. Nicotinamide Mononucleotide - dosing and effects on NAD+ | David Sinclair
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- čas přidán 17. 11. 2019
- Two NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, have been shown to ameliorate age-associated diseases in animals. They are well-tolerated at high doses and effectively raise NAD+ levels. Evidence suggests that these molecules, often referred to as "NAD+ boosters," may increase levels of NAD+ in humans, too; however, the doses used in some of the studies equate to far less than what was provided in the rodent studies. Currently, only nicotinamide riboside has been shown to raise plasma NAD+ levels and may possibly have beneficial health effects in humans. Future research, focused on "super boosters," may have relevance for treating complex diseases such as diabetes, heart disease, cancer, and Alzheimer's. In this clip, Dr. David Sinclair discusses the current state of research on the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide.
This clip was taken from the FoundMyFitness interview with Dr. David Sinclair found at • Dr. David Sinclair on ...
Original episode published on Nov 6, 2019
⏳ #Aging #Resveratrol #Epigenetics 🧬
About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California. She has done extensive research on aging, cancer, and nutrition.
It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach.
Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com
About David Sinclair: David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor. His work on aging has earned him numerous awards for his research, including the Australian Medical Research Medal, and landed him a spot in Time magazine's Top 100 most influential people on the planet. Learn more about David Sinclair at sinclair.hms.harvard.edu/peop... - Věda a technologie
Watch the full episode:
czcams.com/video/5DtWqzalEnc/video.html
FoundMyFitness episode page:
www.foundmyfitness.com/episodes/david-sinclair
More clips from this guest:
czcams.com/play/PLrGxo-5Uw8gIMoEAG-62qQNA7xfiTcQZu.html
people, only take what you can afford..if you try and go all out with powders and supplemts and end up broke and homeless i can assure you that stress because of your financial problems will cause rapid aging... so just stick WITHIN your means..besides, consistancy is key.. then when you get more money you can buy more suppliments.
Lol
Good advice.
Word🙌
Haha true true
This culture does not meet the needs of the people.
This is really good to hear, because I have been wondering if the present NMN &c mode is the best option,
Could really use more comfortable chairs.
Those awkward chairs put your body in defense mode, activating DNA pathways for cell repairing
Omg I am thinking the same about everyyhing around me these days. Its an effect of following Mr. David sinclair
She's talking all the time!!!
The more perceptive folks are listening to Dr. Patrick no matter how long she speaks.
What about Ovasitol aka inositol in specific ratio (different configurations of inositol molecules)...as effective as Metformin in studies for PCOS. Does it also boost NAD+ if works like Metformin??
NR is more efficient because of its molecular mass and size
Can anyone give a layperson the upshot? Are they saying that there is new evidence that taking Elysium and TruNiagin at the recommended doses is now suspected to be ineffective?
What about sublingual formulations?...
We need more clarity on NR vs NMN and whether the whole slc12a8 allows NMN to be transported into the cell. Update from Sinclair is needed at this time based on new studies which he himself posted soon after this video was shot. Can someone make test kits for NR, Nicotinamide and NMN.
We need to wait few months probably for more research. The fact that David Sinclair says that nicotinamide inhibits sirtuins and new research shows that most NMN and NR breaks down into nicotinamide -- is kind of worrying. I started to take extra Pterostilbene and Resveratrol in hopes that it will prevent inhibition of sirtuins. They need to do studies on sublingual NMN and NR. Also, I think there are no studies on sublingual NAD and nasal NAD because some people say that NAD itself can get directly into bloodstream through these deliveries. Screw nicotinamide if we don't need it in our bloodstream.
@@artificialintelligence5087 hi you tested nmn in your tongue ?
@@dariuszgardocki3748 i tried NMN, can't feel any difference but niacin i do feel a lot difference
Yes, it is true, although there is an alternative, which is niacin B3
So, are we still thinking Elysium is the best choice for boosting NAD? I understand resveratrol may, but it hasn't been IBS friendly to me. Nor broccoli sprouts which is more NR than NMN, correct?
It’s all nuts.
Any update on this?
Yes, according to a University of Missouri study, it causes cancer.
I'm looking for info on why NMN is better to consume than standard Nicotinamide? Any help?
Niacinamide is Vitamin B3 and B-Vitamins is water soluble. meaning it can be easily released from your body via pee and sweat so you‘re not getting most of what you need or it doesn‘t stay much in your body if your not taking it many times a day like other water soluble vitamins like Vitamin C.
@@lonewolf5969 Thanks for that, was wondering the same thing
Are we wasting $ taking 600mg of NR daily?
RobT07 Yeah this is sure a new tune. Ugh!
But I’m taking 300mg and feel like I have more energy. How do you feel on the 600mg?
Yes, it is true, although there is an alternative, which is niacin B3
why does it have to be nicotinamide riboside or nicotinamide mononucleotide? Wouldn't nicotinamide have similar effects?
There's some evidence that suggests, according to Dr. Sinclair, that nicotinamide suppresses sirtuin activation. Whether that translates clinically is unclear. Especially in light of the NAD+ flux study shown above. (It was still sort of a brand new pub when Rhonda and Dr. Sinclair had this conversation.)
www.semanticscholar.org/paper/Diverse-therapeutic-efficacies-and-more-diverse-of-Song-Park/d7c1fe11b3bd872c9e9d606040f6169028420ffd
thanks a lot for all your answers. So from the literature you guys have posted there's only this one study where NAM could suppress sirtuin activation in vitro, all the rest seems rather favorable.
@@bonfynil3238 I am using normal Niacin that gives flushing. Also 11 years on a plant based diet low in fat not oil and I could lower this way my arterial age to ome of a 19 years old man. Works better then any supplement out there in keeping you young especially inside.
Niacinamide is a NAD booster but it is cheap and therefore not profitable like NR or NMN. Tests with human cells do not show a negative effect on Sirtuin expression.
Expensive and required high dose.
the alternative Vitamin B3 Niacin does the same job
🧐
Too expensive to take these large doses of NR or NMN for the rest of your life .I doubt serious studies will show life extending properties of either one .Supplement companies will take in big money for now until the next big thing comes along .The only fountain of youth is genetics ,diet,exercise,and luck ,
For diet, see Dr Richard K Bernstein. A type one diabetic who was told around 40 that he had about 5 years to live. An engineer at the time, he managed to get his hands on an early blood glucose meter and realized the food pyramid was upside down. He began to control his diabetes via diet (leafy greens, fats and protein) and small doses of insulin. Became an endocrinologist, reversed his diabetic complications and is now in his eighties, working and working out daily. His contention has always been that diabetics are entitled to normal lives. He's more than proved that, and by the way, recently had a calcium scan and got the lowest score possible. I.e. - no calcification.
Don't believe the the vegetable malarkey pushed by vegetarians, it is All about blood sugar.
@@madben9981 Great comment, thanks for sharing. 👍
That's just your opinion
Yes, it is true, although there is an alternative, which is niacin B3
@@hunteralgeria1453is niacin b3 is as effective as nad and how cheap is that compared to the latter?
How smart would their kids be?
Time to steal my grandmas metformin 💀
Hahahahaha!!!
For an Amazing Arterial Function and Endurance eat a plant based diet low in fat not oil. You will see magic happening... At 43 I reversed my arterial age to a 19 years old young man just with a diet extremely low in fats and of course without dietary cholesterol. The test used to check my arterial age was the PWV test (Pulse Wave Velocity test).
I understand the plant based diet, but I'm sure you need fats, for brain function
@@bruttosporcoecattivo fats are everywhere. All veggis, grains, legumes have fats in them in the perfect amount. I simply cut the foods containing high fats. For omega 3s I use 2 tablespoons full of ground flaxseeds amd it is the only high fatty food we consume in our family. Been doing this for 11 years now. My wife also after an angiogram the cardiologist told me it was hos first time to see new born baby arteries in a 45 years old woman. Eat a plant based diet and cut the high fatty foods and oils.
@@pedecia So, not even nuts for you? Plus, do you take supplements?
@@bruttosporcoecattivo only 2-3 walnuts every few days still for omega 3s. Not other nuts. For supplement we use B12 1000mcg 2-3 times/week and that's it. In winter months if we are in a cold dark place we might use some vitamin D3 and K complex bit seldom as we mostly live in the tropical Australia. This is the video of my medical research sent also to the Cleveland Clinic to Dr. Esselstyn with which I made a 2 hours skype conference call. czcams.com/video/zkC0-sXruM8/video.html
Tried "plant based" for a year. Did nothing for me but weakened my immune system and energy levels. Just in one week of a keto, or low carb high fat carnivore diet I got so much energy I felt better than if I was a child!! No more joint pains, and moving light as a feather!
She is talking far to much for my taste. Is that interview or rather monolologue ? David Sinclair is - in my view - not allowed to speak freely.
I bet any intelligent woman talking a lot bothers you.
@@sky4946 ANY inteligent woman doing interview will ask INTELIGENT questions, and NOT convert interview into her... lecture of very low quality
@@bogdanfutera You question her intelligence when you fail to spell it properly? By the way, real men are not intimidated by successful women.
@@sky4946 sorry - you're right
I misspelled intelligence see, English is my second language
(I speak 4 languages). Point is:
intelligent person EASILY distinguish between lecture and
interview. Do you ???
@@sky4946 You nailed it, Sky.
Poo
Pee
@@WillyJunior wee
She talks way too much