The Hair Loss Industry Is Broken | Evidence Quality Masterclass
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- čas přidán 9. 06. 2024
- In the hair loss industry, the phrase “science-backed” no longer means anything.
Marketers have uncovered a repeatable formula to manipulate clinical trials - all by taking advantage of the broad legal definition of "hair loss" and "hair growth".
First, they design their studies in such a way to all but guarantees good results - and for any pill, supplement, topical, device, or shampoo they want to sell. They do this by:
-Starting a study in September to produce false-positive hair regrowth due to hair cycle seasonality
-Jam-packing people who just quit minoxidil into a placebo group, so they shed lots of hair
-Picking study participants with temporary forms of hair loss that will self-resolve without a pill
-Advertising a "clinically studied" product, then bait-and-switching to sell an unstudied product
-Grouping vellus and terminal hairs together to force statistically significant hair count results
...and more.
The end-result: consumers buy these products, their "real-world" results almost never match the study's "clinical results", and then they blame themselves. In actuality, the blame should be shifted to the companies who knowingly engage in these practices - at the expense of consumers and to the benefit of their bottom line.
In this video, we’ll expose these practices.
We’ll feature dozens of examples from big brands - companies with study designs so deceptive that their "clinical findings" should not - in our opinion - be trusted.
Then, we’ll reveal a step-by-step framework you can employ to protect you from deceptive marketing practices: a framework for evaluating evidence quality.
With this framework, you'll be able to evaluate the real evidence on any hair growth product before you even buy it.
We hope this video helps you make better treatment choices, avoid bad product purchases, and save you years of wasted time, money, and hair.
If you want access to any of the studies or references in this video, here's our full write-up on the video: perfecthairhealth.com/evidenc...
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About Rob English:
-Editorial board member of Dermatology and Therapy
-Consumer advocate, medical editor specializing in hair loss disorders
-Peer-reviewed publications: perfecthairhealth.com/publica...
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00:00:00 -Intro: "Clinical Studied" = Meaningless
00:06:34 - Study Types: Nonclinical, Observational, Interventional
00:06:47 - 1. NONCLINICAL STUDIES (i.e., "MECHANISTIC")
00:07:10 - Example: Safety Testing A New Drug
00:07:59 - Problems: Poor Translatability To Humans
00:08:26 - Ex #1: Selenium + Vitamin E Supplements
00:09:10 - Ex #2: 18% Of Human Studies Contradict Mouse Studies
00:09:44 - Ex#3: Reishi Mushroom For Hair Growth (Reddit)
00:10:39 - Ex #4: Carbon 60 + Copper Peptides (Auxano Grow)
00:11:29 - 2. OBSERVATIONAL STUDIES (HUMAN)
00:12:18 - Ex: Genetic Mutations On Type II 5-Alpha Reductase
00:13:30 - Problems: Cannot Infer Causality
00:13:42 - Ex #1: Shark Attacks & Ice Cream Sales
00:14:16 - Ex #2: "Dairy Causes Hair Loss" (Pantene)
00:16:34 - 3. INTERVENTIONAL STUDIES (HUMAN)
00:17:30 - Hierarchy Of Evidence: A Tool To Predict Treatment Success
00:18:36 - Ex #1: MDhair
00:19:05 - 4. RANDOMIZED, BLINDED, CONTROLLED CLINICAL STUDIES
00:20:10 - RANDOMIZED
00:20:37 - Problems If Absent
00:20:49 - Example #1: L-Carnitine For Hair Growth (Oxford Biolabs)
00:23:34 - BLINDED
00:23:46 - Problems If Absent
00:23:47 - Ex #1 (Participants): Placebo Effect
00:24:11 - Ex #2 (Researchers): Biased Analysis (Multiple Sclerosis)
00:25:20 - CONTROLLED
00:26:04 - Ex: Setipiprant Study (PGD2)
00:26:19 - Problems If Absent
00:26:20 - Problem #1: Placebo Effect
00:27:12 - Ex: Scalp Massage Study
00:28:43 - Problem #2: Hair Cycle Seasonality
00:30:32 - Ex: Brotzu Lotion Study (Trinov)
00:31:26 - Summary (So Far)
00:31:38 - RANDOMIZED, BLINDED, CONTROLLED: PROBLEMS
00:32:35 - Problem #1: Participants Of Study ≠ Consumers Of Product
00:32:52 - Androgenic Alopecia (AGA) Vs. Telogen Effluvium (TE)
00:34:42 - Ex #1 & #2: Nutrafol & Viviscal
00:36:56 - Ex #3: Vitamin E
00:38:37 - Problem #2: Study Timeframes
00:38:42 - Hair Regrowth Takes Time Due To Hair Cycling
00:40:09 - Ex #1: ProCelinyl White Paper (Revela)
00:41:38 - Problem #3: Measurement Endpoints
00:41:56 - Hair Assessment Tools
00:43:32 - Issue #1: Subjective Endpoints Aren't Paired With Objective Endpoints
00:44:19 - Issue #2: Reporting Total Vs. Terminal Hair Count Changes
00:45:13 - Ex #1: Copper Peptides Study (ALAVAX)
00:46:00 - Problem #4: Product-Study Fit
00:46:18 - Issue #1: Product Studied ≠ Product Sold
00:46:21 - Ex #1: Laser Caps (Capillus)
00:47:07 - Issue #2: Ingredients On Label ≠ Ingredients Inside Product
00:47:17 - Ex #2: 80% Of OTC Products Fail Labeling Claims
00:47:55 - Issue #3: Product Delivery Vehicle ≠ Study Delivery Vehicle
00:48:11 - Ex #3: Caffeine Shampoo (Alpecin)
00:49:18 - Final Thoughts
Want study references or prefer reading over watching? See our article on evidence quality:
perfecthairhealth.com/evidence-quality-hair-loss-industry/
many thanks, as you wrote, research and technology gets better over time, it's good to review the most updated research and products?
Watch scott primal and aajonus vonderplanitz hair loss cause by detox through hair follices and shampoo wash hair with egg and eat raw primal diet is best soliution ever i growed back hairs im 18 only my father bald but i changed is opposite my hair is thick now
Currently I am 24 and balding , most probably at norwood 2, consulted with a dermatologist, he said I have MPB ,most likely will prescribe minoxidil, but I am hesitant to use it, need suggestions from your side how to regow and maintain hair naturally
Is it possible to get your hair massage instructions somehow? I signed up through a link under one of your older videos, but didn’t get any email. Thanks!
@@arckocsog253 Here you go! perfecthairhealth.com/scalp-massage-free-guide/
this is a borderline masterclass on layman's understanding of scientific fudgery for manipulating data on everything; not just hair loss. well done and bravo.
Knowledge the could be applied elsewhere, such as when the FDA wants you to vaccinate your 6 month old against covid...
If you want a good example of "scientific fudgery", look no further than the official scientific report on how Building 7 collapsed. Also read the hacked 'Climate-Gate' emails.
haha I was just thinking this
@@bob15479Absolutely
False advertisement must be illegal and be charged. Thanks for sharing and surfacing the truth. 👏👍
That's big pharma in a nutshell, raking in billions at the costs of many lives without consequences, hair loss is just one area.
Outstanding. Giving MDs, influencers, and shady companies a good old fashioned spanking. Thank you - we need voices like this in all corners of medicine
As a graduate school student who is majoring in pharmacoepidemiology, this is the most comprehensive video I watched in anti-hairloss studies. Superb work!
Not only useful to better understand papers relating to AGA but also to better appreciate how complex it is to critically examine research in general. Thank you, Rob!
This guy is the most honest and gives factual knowledge for hairloss. Good to see you again brother ❤
Yeah but he claims he has MPB when in reality he doesn't
I get the skepticism. I retained my hairline but lost density in the presentation of female pattern hair loss - which is more globalized diffuse thinning. That makes it look different from standard cases of AGA.
@@PerfectHairHealth 3 years back I followed your advice and it worked !!! And seeing your videos I can relate all the things you say about hairloss from my own experience so thanks brother !
@@The_Voice_of_Reason748 Male pattern baldness not only affects temple areas but sometimes can only target the crown area or diffused thinning ! I have experienced all three of them .
@@NoBSGameZone can you please explain in a concise way exactly what did you do to fight hairloss? I'll highly appreciate
This video is criminally underwatched. Extremely impressed and thankful for it!
haven't watched the whole thing yet but I'm always impressed with the effort and research you put into this, thanks, you're helping a lot of people
Thanks! We worked hard on this one and I hope it helps you out.
@@PerfectHairHealthHey rob pls pls give answer
Im a 18 year old boy and i have been facing hairloss like for a year now my pattern is like thinning on top and side and back area like lines in which there is less hair i have lost density and it happened when i was previous year in huge stress and then pain happened in my scalp and then doctor told me thhat its androgenic but i dont think althougj i have family heritage but im so young and can you pls gibe your opinion on it my pstgern is like as i remeber first lines were forming in my top scalp and then hair started to losse density and now my density is low can it be reversed? I am taking finanstride for 2 moths 0.5mg and ive seen that my hair have become thick and hairloss stopped like in first week taking pill kindly give your suggestion 🙏 what can be the cause of it ive been facing it for one year and also can your recomend some treatments as im taking only 0.5mg ffin and multivitamin and not minoxifdil will ill get my hair back
Just finished the video. Really appreciate the hard work!
The internet can be a scary place sometimes. Even media types like forums advertise expensive anti-hair-loss products. People suffering from hair-loss are very receptive to 'new' types of solutions, because of desperation. Important not to get mislead.
Welcome back! Excellent video that shows very well what we should be aware of when analyzing the information provided to us about a given product. In fact, and as you said in the video, things as they are seem like the wild west. Thank you for your work in enlightening us.😃
crazy how i just found you and you upload again for the first time in a year
HAIR GOAT IS BACK AFTER 11 MONTHS 🎉
Still with a perfect head of hair
YES IVE BEEN WAITING
@@ColtonLoberglooks like a perfect head of wig 🤔 though I love watching these
How
@@ColtonLoberg
Thats cause he doesn’t have hair loss
Thank you for this information, really, it is an eye opener. I have wasted so much money buying products and my hair is still falling
Thanks, it's so nice to see you back!
I appreciate the effort you put into making these videos, and the overall effort into treating and slowing the AGA THANK you !
Thanks for warning people. Awesome video with great details. Far too much false advertisement and misinformation out there. Why malicious businesses are not punished.
Thank you! Great video as always. Dr Google is a nightmare to navigate when searching for health advice relating to specific foods. Switching my information base from these generic articles to posted studies and taking these studies with a grain of salt but keeping an open mind helps.
What a great video i really appreciate the work and time you put in this video. Great information and well explained. Thank you man 🙏 i subscribed
Amazing work and analysis Rob!
Great video, thanks. This is useful info for other cosmetic products as well.
Thanks for this well researched & thoughtful content Rob. Any recommendations on how long to wait after dermarolling before using lllt to not short circuit the beneficial inflammation?
Can I make two video requests please? The first is a video on diffuse unpatterned alopecia (DUPA), there is a lot of confusion in the community regarding what causes this type of hair loss and how to treat it. Further many more men than originally thought have this type of hairloss than originally thought. With an important point being that until men with dupa stabilise their hairloss they can’t get a hair transplant. The second request is a video covering your thoughts on CosmeRNA. Glad to have you back!
Hi. Thank you for the very helpful advice. I'm looking forward to your next video. 🎉❤
I was waiting for your upload, Always like watching your content.
Hey Rob! thanks for this video, as usual very helpful :). Recently I've been looking into Laser helmets but it is not easy to find their clinical studies nor their results. So besides the most expensive capillus model (my got is expensive!), have you looked into other brands and found some products with good clinical studies results?
Greetings from Italy. I’m a Med student and I hope one day I will be just as competent and professional as you are!
Legend is back ❤ Respect Bro 🙏
Thanks for the information, and the video was very well built...
You're a kind man!! many thanks!
I love this channel a lot. Rob, I have a question. The scalp massage session treatment you've talked about in earlier videos, those 20-25 minute sessions, what harm is done if I skip those once in a while. Because sometimes, I'm just in a great haste and I simple can't find 20 minutes on some mornings and nights. Will it not work at all?
Great video, very informative 👏
English isnt even my first language, and watch it till the end even realizing it was already ending the vid, so cool, so clear
I hope to find a way to improve my hair condition and i hope all of you too
Welcome back!
That video was amazing. I learned a lot with this
The king is back! 👑
Thanks Rob, really well presented video. Good job.
Thank you!
so glad you're back mate, you give me hope.
God bless you 🙏 man . Thank you for doing this for us 💜
Good to see you upload again after so long. I've downloaded your hair massage video and I'm practising the techniques now.
Bludflo
appreciate your efforts!!
Thank you
Informative and very clearly communicated without loosing on the crucial data and terms. Cheers
You must be the no.1 youtuber in Hairloss topic!!!
Here in india we gets a great fake market of Hairloss industry,
I wish Your video may available in hindi(or other local language of India) So that indians don't watch those indian hairloss youtuber's unethical practices and worsen there condition(which i had done).
(You know! People here usually don't go meet doctor for cosmetic realated issue, they just google there symptoms and gets unethical product and start using that which makes the situation worsen)
Love from INDIA!!!!!
❤♥❤❤
I thought we are never gonna get any videos again….thanks for uploading ❤…..also what can be done for teenage (currently 14) hair loss and can it be dht based?
Thanks Rob, it was very insightful. Let's unmask shady business!
Its been like 7 years since you posted! We need frequency, glad to see you back!
made it through the whole video. great job !
Thank you!
This channel is the conscience of hair loss information
Rob, can you make a video on how gut health and scalp environment play a role in hair loss?
Excellent explanation of the subject. 👏
great stuff per usual Rob thanks for this
Thank you!
A good scientist at work! Very informativ Video!
We've missed you!!! 😭😭
Happy to see you back ! (Gerard).
Hope you are doing well man!!
@@PerfectHairHealth yes, thank you ! My hair is going well too :).
Nothing amazing but my hair are still getting thicker, after 16 years of balding. I am a little Nw2 with thick hair. Should be completely bald.
I will probably give some news on the forum soon .
Hope you are going well too !
Thanks Rob. The hair guru
Wow , after being summoned by Haircafe's last video you ressurected!
very informative video. Thank you video creator
Could you please make a detailed video on hair growth serums and hair oils ? Greetings.
I started balding and you came back. Let's hope you have the answers I seek because there is so much misinformation....
I love you. dude. Thanks to you I started using microneedling, Minoxidil and Finasteride. I am going to send you the pics in 2 months. Great gains. You would've thrown in the towel long time ago with my case.
Amazing!! I'm really happy you're seeing regrowth. Looking forward to the photos!
@@PerfectHairHealthHey rob pls pls give answer
Im a 18 year old boy and i have been facing hairloss like for a year now my pattern is like thinning on top and side and back area like lines in which there is less hair i have lost density and it happened when i was previous year in huge stress and then pain happened in my scalp and then doctor told me thhat its androgenic but i dont think althougj i have family heritage but im so young and can you pls gibe your opinion on it my pstgern is like as i remeber first lines were forming in my top scalp and then hair started to losse density and now my density is low can it be reversed? I am taking finanstride for 2 moths 0.5mg and ive seen that my hair have become thick and hairloss stopped like in first week taking pill kindly give your suggestion 🙏 what can be the cause of it ive been facing it for one year and also can your recomend some treatments as im taking only 0.5mg ffin and multivitamin and not minoxifdil will ill get my hair back
Great informatic video, I have a question though, did you reach any data concerning the continues use of minoxidil for more than a year? as I've seen most of the studies are made for a year and some months , nothing more , which makes it in my opinion a not reliable option, as from my knowledge about reading and watching videos like yours, minoxidil doesn't focus on the problem which is DHT rapid production in scalp ( as a blocker), but it accelerate hair follicle to produce hair and remove terminal hair(or weak hair that will fall anyway) , which introduce shedding every certain period until minoxidil doesn't work at all because the follicle is over used and its health % is lowered due to this drug, hence why the date is mostly 1 year and not supported over a year ,... Too much words but is this claim accurate or am i going the wrong way here, because I started minoxidil 2019 and then got progressive hair loss after 3 months then stopped it then after 9 months i did 5 sessions PRP which helped a lot ( no idea if its from minoxidil or the 5 months PRP sessions )then after those 5 months my hair went to fall phase again , so i tried Rogaine again after 2 years but only 1 months due to doctors recommendation that I have Androgenic alopecia , so currently stuck with other solutions like flotene and vici and such , which are not doing much and considering using Rogaine but a bit afraid and losing hair very fast.
Hi bob...can we know your haircare routine like what are the medications and what are the dosage and their types like oral or topical and how long you have been using them and did you get any side effects (your response will be helpful to somany people like me who are fighting against the genetic hairloss)
I was waiting for a new video thank u
Rob you are "THE" baldness fighter
Dude, you been sleepn! Welcome back
Good one
I missed you so much 🙏🙏🙏
Great Job
Great video!! So what are the current available treatments/active substances that pass the evidence quality standard test?
Thanks! This will be one of our next videos.
What do you think about cold water rinses to stimulate the scalp? I’ve always suffered from hairloss and couple years back my hair grew back thicker and longer than ever. It was unbelievable. I just recently realized that when my hair grew back, I was doing daily cold water rinses. After I stopped doing these cold water rinses I lost all my hair again. Could there be a connection???
What then, can I ask, is your opinion on Azelaic Acid? I've had such bad luck with 5 AR blockers. Ive also considered topical Saw Palmetto.
He is back🤩
Hey rob. What do you think about myotonic dystrophy which causes frontal hair loss without androgen effects? This disease affects muscles. Maybe scalp tension theory can explain this situation Or maybe there is some unsolved mechanism.
Mannn, we’ve missed your uploads so much. It’s a amazing to have you back. What happened to the topical Dutasteride video you were planning? ;)
Thanks! I really appreciate that. I'm sorry we haven't gotten to the video, but it's still in the works! We ended up turning that project into a manuscript about topical / mesotherapy pharmaceutical 5-alpha reductase inhibitors, and if the manuscript passes peer review, we're going to publish it + make a video about the key findings - similar to what we did with our microneedling paper. I know I owe you this video, and I promise we'll get to it!
@@PerfectHairHealth amazing dude, I appreciate you. Thanks for being such a valuable part of the community.
Hey i am 23 suffering from male patterns baldness for 2 3 years i never tried minoxidil or finastride.i use only demaroller and oil but the results are very minor in contrast the hair receds gradually. In your opinion is there any way to prevent hair loss if yes then what should i do.
He is so underrated
Hey Rob, your channel is a true treasure trove
What do you think about keeping minoxidil hair by using a dermaroller? In one of your previous videos, you talked about how using these two together may prolong the effect of the minoxidil. However, what happens if you start out as minox + dermaroller and later on drop minoxidil?
I put the local solution Minoxidil 5% + Finasteride 0.05% daily twice a day every 12 hours and I had no problems! Now that I've added 25mg of DHEA (which raises testosterone) I feel like my hair has started to fall out!
Would it be good to increase the dose of the topical solution to minoxidil 5% + Finasteride 0.1% ??
Hi Rob. I wanted to ask if you started finasteride in low doses as you said you were planning to in another video and if so, what is your impression?
Pls make video related to female hair loss and how inmflamation affects hair loss and can inflamatory hair loss be reversed ??
I use topical finasteride with minoxidil and I have definitely got thicker and new hair growth. I am also testing my testosterone with 3-monthly blood tests and all levels are normal.
@@jsy8 Why would you chicken out if it could change your life? Scared of the tiny prick or?
How much time did it take for you to get the hair thick and new hair growth ? And how much did your hair fall in the first 2/3 weeks ?
Can you explain it a bit..! I mean your dose, your testing timings and what are the different tests you are undergoing..?
Is it possible that if you have long term deficiencies in say B vitamins, vitamin E, zinc, or iron etc. that there is a sort of long term telogen effluvium? Or would it just be a alopecia caused by nutrient deficiencies?
Hey Rob.
Could you go through Revita's (DS lab) studies at one point? Do you think they're legit or have shady practices?
Thanks in advance and it's good to see you back.
Yes please !! Are you using it ? I just purchased some
I used a dht blocker with serenoa repens and some pills for hair regrowth with biotin and zinc. The problem was thah the dht blocker pills have zinc. So i take too mutch zinc of the raccomanded doses. Is safe to stop suddently?
Hi rob ! Can we dilute topical finasteride gel with minoxidil ?
Thank you :)
Please send me the name of treatment that is a very helpful for hair growth.
Somewhat OT but an anecdote: For a few months I've been taking taurine (1,000 mg, 3x/day) and L-arginine and getting a better night's sleep. I do scalp massages kind of sporadically / whenever I think of it.
I s w e a r I have more hair on the top of my head, down the part line. I look in the mirror and ask myself, "Is it my imagination or am I seeing less scalp?? No, it's not my imagination...this is nuts." My hair just appears fuller and is growing longer in the front corners and there's hardly any fall-out.
IDK if it's the taurine, the L-arginine, the scalp massage, or the better sleep -- or all of the above, but I'm 53 and I've had thinner hair on the top of my head since my late 20s and now it's filling in. I'm amazed.
Damn, this guy is top tier!
Yeah..mental health and mental state is important to healing your body
so as far as you rob would would be your top 3 for hairloss as far as researched backed ?
Experienced heart palpitations from topical minoxidil, and I’m on break until further notice. Should I get back on and only apply once a day, or twice a day but half the dosage, or don’t get back on?
I'm not a doctor and cannot offer medical advice. I do know people who managed to eliminate these side effects by titrating the daily dose - like you suggested. There are also other potential factors to consider. For instance, high-strength minoxidil concentrations likely have higher systemic absorption, and thereby a higher risk of side effects. If you're combining topical minoxidil with retinoic acid, microneedling, or any other ingredient/therapy that increases the permeability of the stratum corneum, that will also drive up systemic absorption. So, consider playing around with these variables (with the guidance of a qualified doctor). Finally, we do have a few members who switched from minoxidil to nanoxidil and noticed these side effects dissipate, but it also came at the expense of reduced treatment efficacy.
Actually awesome that you USE science 👏
Serious question tho, with mpb what is the best thing I can do besides fin / rogain that's showed promising results?
Heard saw palmatto has been debunked but not sure
What bout rosemary oil?
Thanks! We'll make a video on this soon.
Is 5mg minoxidil safe for the heart? I have been using oral minox for 17 days... Thank you😊
Why the long break from CZcams? Dude your hairloss videos are the best on CZcams. If you invest the time you could easily be the number 1 hairloss channel on CZcams!
Thanks for the kind words. The short answer: I over-committed myself to a ton of site projects, and I ran out of time. A year later, those projects are mostly done, and I’m excited to share what we built with this channel. If you have any content requests, let me know here!
@@PerfectHairHealthi have a suggestion, can you do a full guide to hair loss video?
Yes! Will do it.
Hi there!
Can u tell us how did you control your hair loss and gain your hair back please??
Hi.. sir..can.. you. Suggest us.. some medications for hair thinning in crown area...and. for..dry scalp..
I’m interested in your opinion about Hair Regrowth With Alex.
you're a pioneer
Very informative, I feel I now have an understanding of what all this study terminology means. That said, I can't help feeling like this leads back to square one - use fin and min and hope you don't get horrifying side effects, because nothing else will work.
Probably gonna shave my head before I go that route.
That's what I thought (shave my head) but as I noticed hair gradually thinning I picked up the courage and jumped on to finasterided, take 1mg 3x a week, mon, wed and fri. Been on it since April this year and have noticed hair thickening and noticeably less hair loss in the shower. Regret not taking it much earlier due to the potential side effects.
@@rcl300018 yeah well. I'm sticking to the shave plan. Maybe if the side effects were genuinely super uncommon. Maybe if the side effects weren't potentially permanent. Not to mention that you first lose a ton of hair anyway just for starting the stuff, and can take like a year or more for improvement to show, if it does.
Just not worth it imo.
hi rob I wonder if high blood pressure causes poor oxygen in blood. blood with poor oxygen percent do not feed it enough.
why do I think so?
i have high blood pressure and also some scalp tension., perhaps lowering blood pressure alone will help regrowing new hair. by the way I see fine hairs on my scalp which gives me some hope. I wonder your thoughts
thanks a lot for research
stay healthy!