VLDL Increases During Aging, And Is Associated With Adverse Cardiovascular Outcomes
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- čas přidán 16. 07. 2024
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Papers referenced in the video:
Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk:
www.jacc.org/doi/10.1016/j.ja...
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling:
www.sciencedirect.com/science...
Joint distribution of lipoprotein cholesterol classes. The Framingham study:
pubmed.ncbi.nlm.nih.gov/6573877/
Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS):
pubmed.ncbi.nlm.nih.gov/20223...
Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease:
pubmed.ncbi.nlm.nih.gov/33272...
Remnant cholesterol and coronary atherosclerotic plaque burden assessed by computed tomography coronary angiography:
pubmed.ncbi.nlm.nih.gov/30870...
Premature myocardial infarction is strongly associated with increased levels of remnant cholesterol:
pubmed.ncbi.nlm.nih.gov/26687... - Věda a technologie
My VLDL is 7, triglycerides 44, HDL 71 on keto-lowcarb diet.
Are you female?
I'll never have the patience to measure my caloric intake, but I'm on a consistent low carb, moderate protein (1.2g/kg/day), moderate fat (no dairy) diet. For me, cardio/HIIT/RT exercise as an isolated factor is what drives down my remnant cholesterol. Now in my early 60s, it's at 11.5 in a fasted state. But when I stopped exercising for 6 months during the lockdown, it ballooned to 24.
Meanwhile, my LDL has dropped from roughly 300 on a pure keto diet (with only light to moderate exercise) to 176. HDL up to 67. TG at 25. BP is 110/70. I like to think I'm healthy while being entirely meds-free. Of course, physicians focus on TC or LDL, and have been recommending a statin during this journey to controlling my own health.
Don't take it. My maternal great grandfather and grandfather lived to 106. They never took statins!
This is the best longevity chanel on CZcams, you need more subscribers!
Great video, this topic needs all the exposure it can get.
You’ve helped me a lot, thank you!!
Thanks a lot for the video it’s very very valuable info 👍
Have you tried Dave Feldmans LDL "hack"? - the week before your test, lighten up on caloric intake for 4 days. then over eat for 3 days leading up to the un-fasted test. Your LDL will drop significantly but your remnants will rise. Remnants correlate strongly with triglycerides. Then do the reverse - over eat for three days and cut calories for the 4 days leading up to the fasted test. You'll see the results flip.
Great video, thanks.
However, you have overcomplicated this equation😉. VLDL is basically trigs divided by 5. Since LDL = TC-HDL -(TG:5) and your presented calculation was VLDL=TC-HDL-LDL therefore VLDL=TG:5✌
I am surprised that your VLDL didn't correlate with sugar as this is the nutrient that has ability to rise TG (at least postprandial). It has to be your activity levels and fast metabolism which allows you to burn those trigs during the day. Which also could explain your total caloric intake correlation with VLDL (Trigs).
Thanks Krzysztof H. The TC - LDL - HDL isn't my equation, that's what's used in the literature. Nonetheless, I agree, the TG/5 method also works, for calculating VLDL.
@@conqueragingordietrying1797 In my case VLDL is approximately triglycerides divided by 4. Measured (or calculated?) by "The Doctors Laboratory" in the UK on two separate occasions.
@@bottlenecks I'm not sure if it's calculated or measured, but yep, there is a strong correlation for VLDL with TGs in my data, too.
I have only had two blood tests done recently, very few, but I had one prior to starting drinking matcha and one after being on matcha for about a month(2 cups one with breakfast one with dinner, half teaspoon each cup.). Total cholesterol decreased, LDL decreased, and VLDL was cut in half. Will need more data to see how it goes, but preliminary seems positive.
Another great video … I wonder what the vldlc would ha=been if you directly measured ldl- c instead of the FW equation from tg’s?
Carb/sugar intake is vastly more harmful than calories alone.
Thanks. You did not mention anything about exercise in relation to calories. Of course if I increase exercise like 6 days per week, my calories will be high.
We are both 65yrs old and my wife is 10.6 and I am 9.0 VLDL -March 2021 and we have both increased calories because of increased exercise. I think the equation should be a relation between VLDL and excess calories to be more precise.
would like to see vldl vs body fat ratio corr!
Just got my SED rate tested: 8. Lab reference normal for my demo is 0-15. Have an autoimmune condition. General thoughts?
Sorry if it's already asked, what about TG? I have very low (talking about recommended values) LDL, high HDL (they have almost the same value) normal total Cholesterol but closer to high TG... my diet is 100% fruit and vegetable almost all whole food and high in antioxydants, what's that? Thanks in advance.
edit: I saw the comment below and I made a calculation of VLDL based on my TG 3 years ago, it's 28 mg/dL slightly below the max I think. Not the best. But I think the results were better in the last test, I was overweight 4/5 years ago and then I lost a lot, now my BMI is stable since then at 22, male 47y. I should exercise more I think.
Wow, I did not know that VLDL is associated with fatty liver disease. About a year ago my VLDL was at 15 and my HDL was at 55. Previously my HDL had been at 65, definitely going in the wrong direction and I got to do something about that. I recently got a GGT test done because I thought this biomarker was associated with fatty liver. Is this true? My GGT test result was 23 which is considered normal. I appreciate any tips and suggestions that you have to offer.
on my third view of this amazing video.
at 8:40, there is no classic Reaven ratio of TG:HDL, do anyone know why this is?
Thanks IblisTheMage. For whatever reason, the authors of that study didn't include TG/HDL. But, when considering that a rough estimate of TG/HDL can be obtained via TGs=VLDL *5, and, knowing that remnant cholesterol is mostly VLDL, the TG/HDL ratio is likely buried in the remnant/HDL ratio, ~1.7-fold higher risk for a premature heart attack with higher values for that.
Do you know why a raise in calories cause greater remnant cholesterol in the blood? What is the mechanism by which this works I wonder?
Increased calorie intake over maintenance = more fat delivered to the liver, which is packaged as triglycerides in VLDL is the most likely scenario.
What foods do you recommend?...Thanks.
That's likely variable, it can differ from person to person. What I recommend it regular blood testing and diet tracking, to find out what works for you, or not.
High VLDL indicates there's a lot of fat hanging around in the bloodstream rather than being taken up by the cells. The cells have decided they don't want any more fat...Solution: reduce caloric intake so the cells get more interested in grabbing fat out of the bloodstream.
Great video as always Michael! My VLDL is 8mg/dL, so that makes me happy. :) My calorie intake is regularly on the high end of your plot, but so is my daily calorie burn. I actually wonder whether it is the absolute calorie intake that is most important or whether we would find greater correlation if we used the daily calorie surplus/deficit. So, if you burned 2800 Cal but ate 2900 Cal, that would be a surplus of 100 Cal, and so on. Have you looked at this? I think it would be useful and interesting. And, actually related to this, it might be body-fat percentage that is driving this, or some other similar thing you can measure, more than the absolute daily calories. Anyway, something to consider. Thanks!
Thanks Neil, and your VLDL at 8 is great! It's tough to compare the daily surplus/deficit vs VLDL, as I'd need to overeat, and then measure VLDL the next day. Conversely, purposefully under-eat, then measure VLDL. If I had a blood test analyzer in my house, I could do that! Ha, maybe someday...
@@conqueragingordietrying1797 , sorry, what I meant to say is the average daily surplus/deficit. You have shown how some things correlate with your weight in some videos and that you love fruit :), so I assume you have periods with average surpluses and other periods with average deficits. In any case, I wonder if it is the absolute calorie intake that matters or if it depends on the amount relative to what you are burning each day, so a surplus/deficit analysis might be interesting.
And, yeah, being able to measure our blood in real time would be amazing. Apparently there are rumors that the next Apple Watch will measure glucose, which is pretty dang cool! We are definitely headed in that direction but, of course, the teapot never seems to steam when you are constantly watching it. :)
@@neilchristensen538 Yes, gotcha Neil. My average body weight maintenance calorie intake is ~2500/d, but I'm more active on some days than others. So if my calories burned on an active day is 2800, but I eat 2500 calories, am I in a 300 calorie deficit? I'd have to know how many calories that I burn every day. I do have average HR data for the past ~2 years, which can be used to estimate calorie expenditure.
@@conqueragingordietrying1797 I understand. I am still new here so I don't know what other people are seeing versus what I am seeing. I have an Apple Watch that talks to my iPhone. I also have a scale that estimates my body fat and BMR and talks to my iPhone. Cronometer uses all this data to estimate the amount of calories that I burn each day. (I assume the same can also be done with other manufacturers.) I had my doubts about the accuracy of all this, but so far, my average weight has increased when Cronometer tells me I am in surplus consistently for several days and my weight decreases when it tells me I am in deficit consistently for several days. I measure my weight nearly every day, so I see the fluctuations, but the long-term trend does agree with Cronometer's estimate. The scale only cost me around $30 and has turned out to be really interesting. It might be interesting to add this to your data stream since it isn't very expensive and appears to me to be really useful.
@@conqueragingordietrying1797 It actually looks like my phone/watch combo estimates my calories burned. It estimates resting energy and active energy. Cronometer just reads that in.
What is the research showing for cause of increased vldl levels in young, healthy weight, individuals already on calorie restricted diet.
It would seam that with the primary drivers of aging, obesity, and high calorie diet eliminated only reasonable causes would be fatty liver, sedentary life style, or high levels of alcohol consumption as the likely contributing factor to the vldl level.
In which case how would you identify root cause among the three to treat it.
Is there any existing research on root cause in those kinds of individuals.
Is there something in your expert opinion which would make my assumptions about the probable three as driving causes in the scenario unlikely?
"What is the research showing for cause of increased vldl levels in young, healthy weight, individuals already on calorie restricted diet"
-I don't think that data exists....
@@conqueragingordietrying1797
Damn. It is always the information that would be personally relevant that lacks sufficient research.
@@brian-818 Which is why I promote that we identify that diet, exercise approach, supplements, etc. that best optimizes our health based on objectively measured systemic biomarkers.
I have 0.01mmol/L or 0.18mg/dL. Maybe because I'm not eating enough. Is there risk associated with too little of vldl?
0.01 mmol = 0.3867 mg/dL, not 0.18. Can you please double check your data, as yours is the lowest I've ever seen! VLDL as low as that is rare, and I didn't see anything in the literature about increased risk with values that low.
@@conqueragingordietrying1797 Yeah, sorry about wrong conversion. I had 5.41md/dL in 2014, 37.89mg/dL in 2018, 2.71mg/dL in 2020 and now 0.38mg/dL. Maybe it's somehow correlated with low triglycerides which is also very low 0.48mmol/L(18.56mg/dL). Maybe I should go to the other test lab. Anyway thanks for answer and content you are producing!
@@OneManStartup VLDL is basically total triglycerides divided by 5!
LDL is calculated as TC-HDL-(TG:5), where TG:5 is basically remnant cholesterol. Check your lipid test and you will see.
My level was low. I can’t find anything on that.
Lower VLDL should be better for health, when considering age-related changes and associations with CVD risk.
TC 93mg /DL - HDL 38mg/DL - 53 mg /dl = 2 VLDL should i be worried about my general low levels of everything ? TG are 55mg/dl, non HDL 55 mg /dl
Hey Kev, are you on a statin?
@@conqueragingordietrying1797 No i am only on 100mg Testosteron Enanthate e3d with 12,5mg Aromasin. No Statins. I Eat very healthy 3g Omega 3 Every Day, Olive oil, Good Carbs, good Protein sources. 2000mg NAC, 1000mg Vitamin C, 1000mg Citrus Bergamont. But in general my Lipids are like that over years, HDL varies between 35-48, LDL, TC and TG are always pretty low at my Bloodpanel. Last time i took also oxidized LDL it was 71,9 ng/ml.
My Last Bloodpanel a half year ago i had. TC 88 , HDL 41, Non HDL 47, LDL 42 and TG 53.
@@kev2069 it could be an issue how the lab is measuring LDL-someone posted in the comments that VLDL also = TGs/5, and when I look at my 40 blood tests, that's accurate. So with your TGs = 55, that would be 11 for VLDL, which is youthful based on the published data.
@@conqueragingordietrying1797 Maybe i am Youthful with 33 Years? :). First of all, thanks for Answering my Questions. I take my Bloodpanel at one of the biggest labs here in Berlin, Maybe i can find some old Bloodpanels from the other Major Lab here for comparing. Should i be worried about my General Low Lipids?
what is vldl?
Did you watch the video?
I've watched this video many times now and I find it confusing that you jump between remnant and VLDL cholesterol. If VLDL is to be used to measure remnant cholesterol, then I need IDL, but I don't see a way to test this.
Also, several blogs & podcasts out there say APOB is the gold standard.. however nobody really gives what the scores ought to be for APOB.
IDL is a very minor component of remnant cholesterol, with most of it attributed to VLDL. APOB is the gold standard for CVD, and it's on my to-do list in terms of a video. Also, APOB can be decently estimated with calculation of non-HDL cholesterol.
@@conqueragingordietrying1797 ok sounds like if I want a complete picture... Then at least a few times I need to measure standard lipid panel, and apob. Then I can see how TC - HDL - LDL relates to my apob.
Looking forward to the apob video! I'm the same age as you and cvd is my biggest concern at this point.
Thank you Michael
Fiber was not correlated with vldl? That's disappointing.
I agree. And in hot-off-the-presses data, my soluble fiber intake, which is exclusively fermented by gut bacteria, is significantly correlated with higher VLDL, which is also opposite from what I expected. That's an unadjusted correlation, so I'll have to adjust these data for calorie intake or another metric that accounts for not just soluble fiber but the foods that they came from.
@@conqueragingordietrying1797 Interesting. Well hopefully that just down to extra calories. extra saturated fats? Though I suppose not or you would have noticed that straight away.
In my own, very rough tracking, I've noticed that during periods of when I didn't drink coffee, my VLDL has been significantly lower. Oh no, i love coffee, but I'll give it up for better heart health for sure.
BTW, if I calculate VLDL using your method, my VLDL has been over the danger limit for my last several blood tests. (drinking coffee). However, if I use VLDL = TG / 5 then my numbers are more in the safe range. 24 and 21 remnants are 15.4 and 13.5. Maybe this is because cafestol is doing something unusual outside the scope of normal lipid function?
Does VLDL correlate with BMI, or blood pressure, or heart beat rate? Or are this independent?
Good points, Earwaxfire909. Because of the correlation with calorie intake, as expected, there is a moderate correlation with body weight (r = 0.51, p = 0.004). I have sporadic BP data over the past few years, which isn't enough to examine correlations for VLDL. I have data for resting heart rate (n=15), but it's not significantly correlated with VLDL (r = 0.00).
@@conqueragingordietrying1797 Do specific foods or fasting drop VLDL? Also are there specific foods like bread, or dairy, or high-fructose fruits that drive up VLDL? Does lack of sleep increase VLDL?
@@Earwaxfire909 Great questions. I didn't look at the correlations between individual foods with VLDL for this video, but that may be in my next video for VLDL. I also have a few years of tracked sleep data, I can also look at that.
Looks like every system collapses, lol, Interesting if it possible to replace 3/4 of things with molecules from outside? just like with testosterone?
Replacement can offer improvements for health, but for me, identifying the root cause and treating that will offer the most benefit.
So eat less but eat quality calories
For me and VLDL, that seems to be true for calorie intake, but it may be different for everyone. I'd recommend frequent testing and dietary tracking to see what works for you...