Kidney Function Declines During Aging-Can It Be Reversed?
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- čas přidán 7. 07. 2024
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Paper links:
Predicting Age by Mining Electronic Medical Records with Deep Learning Characterizes Differences between Chronological and Physiological Age:
www.ncbi.nlm.nih.gov/pmc/arti...
Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis:
pubmed.ncbi.nlm.nih.gov/23360...
Consumption of long-chain n-3 PUFA, a-linolenic acid and fish is associated
with the prevalence of chronic kidney disease:
pubmed.ncbi.nlm.nih.gov/21255...
Quantitative reduction of short-chain fatty acids, especially butyrate,
2 contributes to the progression of chronic kidney disease:
pubmed.ncbi.nlm.nih.gov/31467... - Věda a technologie
I was diagnosed with stage III kidney disease about 5 years ago and I went to a low fat whole food plant based diet. My eGFR is >90 and no sign of kidney issues. No animal products including dairy, no processed refined fats (no oils) and no processed refined carbs other than a little high fiber bread or crackers from time to time. I also turned around my erectile disfunction, cardio vascular disease, neuropathy, and diabetic retinopathy....yes I was almost blind in my right eye and now I see with only a little bit of noise in my vision and it is still clearing, finally my insulin use is down to 15 units/day using only a basil insulin, way down from over 50 units a day. At 60 years old I have turned my health completely around and I feel like a kid again!!!! Low fat whole food plant based diet is the key! BTW....Great video! I love your work!
Good job Lucky Hanger 13, and thanks!
Hey do you have an email address or facebook page? i would like to learn more about that diet.
@@philipshropshire5985 BTW good luck!
I was vegan for 8 years. I believe low fat is super important, with no oils, except coconut. but whole food, plant based I feel is irrelevant. I think fruit is very important, but I don't think eating vegetables is particularly helpful.
Why is olive oil bad, even the first pressed unfiltered organic type?
Awesome video! I’be been tracking everything I eat for a week and am getting my first blood test tomorrow morning. A journey of a thousand miles begins with a single step. Thanks!
Sounds good, Neil, keep me posted!
My mother missed being 95 by three weeks, killed by bedsore due to nursing home neglect. Texas governor Abbott banned family members from visiting; absent that she might still be alive; I had her on carnosine. She never had any known kidney issue.
I’m 62. My eGFR is 105. My diet is low fat unprocessed vegetables and fruit only
High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study
"Conclusions
A high-protein diet increases the risk of RHF and a rapid renal function decline in the general population. These findings suggest that a high-protein diet has a deleterious effect on renal function in the general population."
I've watched a bunch of your videos and I think they're great! Thank you so much for putting this info out there.💪😁👍
Thanks Steve!
Thanks Michael. You have taken lot of work to do this.
Wow . . . a profound implication from this video presentation. Will have to study this one further--and soon. Thanks a bunch!
Very useful information and very well presented. Many thanks.
Thank you for these videos. Well presented and very pertinent.
My eGFR varied widely from high 30’s to about 75. Doc sent me to kidney specialist who performed a few more tests and lots of questions. He said eGFR is not the be all and end all of determining kidney function. Some people have apparently low eGFR but normal kidney function. Apparently low function is normal in my family but most live into their 90’s. Red wine can increase eGFR.
To account for that, measuring Cystatin C is on my to-do list.
Exactly. Why isn’t a cystatin C test done all the time? I’ve had blood work done numerous times and every time my creatinine was slightly above normal. I work out intensely about 4 days a week and have a muscular build. After feeling stressed that I had first stage kidney disease, I went to a nephrologist and sure enough, my Cystatin C test showed I had normal kidneys. These tests (eGRF/creatinine) can give false positives and leave the patient feeling unnecessarily worried.
@@Beans-great not only unnecessary worry. I was denied life insurance for a period because of the ridiculous notation on my file of CKD. Made by a doctor without further investigation and complete disregard for the dramas he caused in my life.
Also if you supplement creatine with a high protein diet, it's gonna be all over the place.
@@Beans-great same for me. If you take creatine as a suppl + favor resistance training the effect is very strong. I always go with cystatin c. and it is important to understand that a single measurement is only indicative for the trivially bad values. for managing health it is the tendency that must be observed.
Great explanation. Thank you.
Dr, that one eGFR rating you got that was in the 60’s… really low. Technically stage 3 CKD. Do you remember what you were eating around that time to have driven your score so low? Great job raising your numbers and saving your health!
Hi K J, it was a bodybuilder-type diet, including too much protein, not enough veg, and thanks!
@@conqueragingordietrying1797 i wonder if it comes down to whats being filtered out as load of vs recirculated as % proportion that is a major affector on eGFR
@@jarrodhockley yes. eGFR is just a guestimate based on creatinine in blood. If you eat more protein and/or creatine (for body building) creatinine in blood will go up and eGFR score will lower.
@@conqueragingordietrying1797 wow! and i guess not in the form of salmon or sardines...
Amazing content 😊
Thanks very well done. Much useful information.
Thanks Elliott Rubenstein!
Thank you for your video, thank you for sharing thank you for taking the time to track everything so you could share it. Very informative really appreciate it.
Thanks jan mosley!
Great work! 8)
Thank you so much! You are the best ❤️❤️❤️
Thanks facade!
Thanks!
GFR vs age graph: both axis should start at zero, graph displays relationships visually, that is a distortion. 15 GFR (kidney failure) or 0 GFR would make more sense.
An extremenly interesting data analysis! I a curious, does your eGFR somehow corellate with an updated eGFR formula that you (or your lab) perhaps started to use from 2015 onwards? Or perhaps the lab switched to a standardized way of calculating the serum Creatinine? Did you use the same CKD-EPI formula and based your calculations on the Creatinine levels alone?
regarding the relation of fish and eGFR. You refer to Sardines which may have several effects (+Ca, +D3, +O3) such as increases HDL and thus decreasing CRP. When searching for O3 and eGFR there are several studies, eg "Blood Omega-3 Fatty Acids Are Inversely Associated With Albumin-Creatinine Ratio in Young and Healthy Adults (The Omega-Kid Study)" or "Omega-3 fatty acid supplementation as an adjunctive therapy in the treatment of chronic kidney disease: a meta-analysis" , which found a positive effect, but in DM II there was no effect.
O3 is critical for all high performance exchange membranes, such as in synapses and kidneys, hence the positive effects.
i have to take Calcitriol 0.25 three times a week. Doctor says my kidneys are weak. last test my GFR WAS 55 I'M 77 YEARS OLD THE REST OF THE BLOOD TEST WAS NORMAL . pth read 93 what next. will kidneys get worse.
Choline is a semi essential nutrient. A number the foods you mention are high in Choline. While the body can manufacture some choline it doesn't manufacture enough. The rest of the choline needs of our body has to come from our food and and supplementation. The last review by the Institute of medicine of choline intake was done in 2018 and largely confirmed The Institute of medicine's food and nutrition recommendations from the late 1990s. According to these recommendations we are clearly not getting enough choline into our body. While there was clear evidence choline was necessary for the functioning of the liver, there has also been mention in the literature that choline is essential for kidney and many other functions in the human body. I urge you and your followers to research choline as it may be one of the overlooked supplements that reverses aging in the human body. People can't just rush out and buy a choline supplement because it has been associated with the increase in TMAO. TMAO is associated with Cardiovascular Disease. This increase in TMAO is related to the microbiome break down of choline by-products in the gut though it is clearly not fully understood. If you take antibiotics with choline TMAO is not produced and the choline is then distributed throughout the body including into the brain (which needs it to produce acetylcholine). The proper amount of choline does wonderful things to the body. For example the proper amount of choline reverses non alcoholic fatty liver disease which was thought to just be a symptom of Aging in older people. Choline deficiency may be related to sarcopenia and Frailty in that proper amounts of choline are necessary for the body to manufacture muscle cell membranes. I have not been able to document whether the body scavengers muscle cell membrane when it needs to produce choline and does not have enough available from our diet. It could be that as our muscle cells age and die the body cannot produce new ones because it doesn't have enough choline to manufacturer cell membranes for the new muscle tissue. Choline is necessary for the manufacture of cell membranes of virtually all of the cells of our body. There is a special set of statements issued by the Institute of medicine about choline and there are several review articles about choline. I believe that if you can consume choline and stop the side effect of the production of tmao you will see significant anti-aging effects throughout the body. You're increased function of your kidneys may be related to increased choline absorption from your diet.
Michael, thanks for the precisely researched, analysed presentation. No doubt your work will benefit many people for the years to come. Does your yogurt intake have anything to do with the improvement of kidney function? What about beans? Do you have any data on these?
Thanks Ariel! Yogurt likely doesn't impact my kidney function, as it's the major contributor to my dairy intake (also whey protein, cheese), which wasn't significantly correlated with eGFR. I wish I could incorporate more beans, but I have a food sensitivity to many of them, which results in GI distress, so I minimize their intake.
Thanks, Micheal.
@@conqueragingordietrying1797 Have you tried sprouting them before eating? The process of germination neutralizes most of the antinutrients in them. That being said, the process can be quite work-intensive unless you sprout them in bulk.
@@mujtabaalam5907 I haven't, and maybe I'll try that in the future!
@@contentviewer7 Regardless of the mechanism, it makes more sense to avoid them completely, at least for me.
Looking back at the lab test from my dr. last October, it does list eGFR, but it only states that it is greater than 60 and that it is in the standard range. I don’t know why they don’t give the actual value, but I am doing a test through Life Extension now and will get the actual estimated number soon. However, I do eat around 1660g/day of vegetables and 49g/day of salmon, so it looks like those things will be in my favor. After watching your video, I am excited that I really do have room for improvement. I have eaten even more vegetables at times, but haven’t had the tools to measure and drive my biomarkers towards their optimal value. Now I do! There is a huge wealth of information in your videos. Thanks!
Thanks Neil! Note that I eat like that because it seems to optimize my blood biomarkers. While eating like me may replicate the same pattern, it also may not, but with enough trial and error, you'll find the dietary approach that best optimizes your biomarkers.
If your results include creatinine, you can calculate eGFR using this link:
www.kidney.org/professionals/kdoqi/gfr_calculator
@@conqueragingordietrying1797 Oh, believe me, I totally get it. The idea is not to replicate your eating pattern, but to replicate your process of seeking out correlations between your diet, exercise routine, etc. and your blood markers and then to use those correlations to wiggle your way up to optimum health. To tell you the truth, I discovered your channel at the perfect time. I have been unsatisfied for a little while and have been increasingly measuring things. Last Christmas, I got an Apple Watch and a scale that measures my body fat % and I follow an exercise program that measures my progress and allows me to determine whether I am making progress in an objective way. I was already planning on doing some experiments with the measurements that I had and understood. But, I still hadn’t figured out how to do the same with food. So, that is the gap that your channel filled for me. It’s possible I might have arrived here with time, but in addition to speeding the process up a lot, you also have a wealth of information here about each of the biomarkers and what the literature says about them, not to mention your expertise in the area of gut microbiome.
My report does have creatinine but not Cystatin C, but thanks for that terrific link!
Thanks again!
I have my eGFR now. It is 94, so looking like its in a good place but still room for improvement. Now I know that trying more veggies is definitely worth trying as well as reducing beef. Is beef your only non-fish meat? Do you eat chicken or turkey? Just wondering since you didn’t mention them in the video.
@@neilchristensen538 94 is good, now the key is to keeping it that high (or higher) for the next 50+ years.
I rarely eat chicken or turkey, but in terms of animal protein, I eat ~80g of sardines, 250g of low-fat yogurt, and ~15g of whey protein daily, and eggs ~5x/week (for now, to see its effect on my cholesterol levels).
@@conqueragingordietrying1797 do you get sardines from a can or fresh?
This make me realize how low carb almost killed me, at 20 my eGFR was 97. Last year with a lot of plants it came back to 115, I wonder how much it has improved since, I’ll do a test in June to see
Is there correlation between probiotics - AKKERMANSIA and Kidney function? And What about Urollithin A?
What could be the potential side effect of this much vegetables? Too much oxalates? Too much potassium? etc... I eat about 1250g of vegetables, plus 40g cocoa powder, my oxalate is already significantly higher than the recommendation, I am not too confident in increasing the vegetables even more. The choice of vegetables might be important when raising the vegetables so much, not sure. Perhaps adding lemon juice could be a thing to consider to bind to the oxalates.
I'm a big proponent of blood testing, especially if you're worried about oxalates. Based on that, my biological age is significantly lower eating that many vegetables and its corresponding 100g of fiber/day. For ex.,
czcams.com/video/mc7jMFoyJW8/video.html
in contrast, if oxalate intake was detrimental to my health, we'd expect to see worse blood biomarkers.
Another excellent. Yet. 3yrs ago I took advantage of COVID to transition to a whole food,plant based diet … i also noticed a significant increase in eGFR. When looking at the eGFR formula … I noticed that I was being screwed by the algorithm as it includes “age”.
Thanks J P. One way to get around the eGFR equation including age is to track creatinine, or even better, Cystatin C, BUN, and uric acid, and their age-related changes. To goal is for each to not increase during aging.
Woah, this video just made me a vegetarian and bought primo cod liver oil. New to this channel, would love to know thoughts on supplements like vitamin d and milk thistle. Hope this helps filtering protein too
Milk thistle (silymarin) has let me down. I still take 1 per day, I'm much more interested in jiaogulan, fucoidan, glycine, cordyceps, lactoferrin, sulforaphane and hibiscus tea.
Also for best results the ancient principle "speak to the mountain."
thanks 👍👍👍
You mention that high eGFR should be the pursued since it's found in youth but at 1:45 for people with eGFR >=120 there is more than a 200% all cause mortality increase, what is going on?
Hey @nuovoaccount998, muscle mass declines towards the end of life, and when considering that creatinine is proportional to muscle mass (eGFR was derived via creatinine levels in the video), eGFR is very high in that case, which is associated with an increased mortality risk.
thank you, i'm reading some books to understand better all of this @@conqueragingordietrying1797
I was diagnosed with CKD about 10 years ago. I'm 67. My mother who is 95 was diagnosed with CKD many years ago. My son was also diagnosed with CKD about 5 years ago. His company sent him to a kidney specialist who performed a number of tests and lots of questions. The specialist told him that his kidneys are functioning normally and that the eGFR is not always the best test as some people lead long healthy lives with low eGFR but have no signs of kidney disease. The problem here being that many people are refused insurance in the mistaken belief that the eGFR is always perfectly correct when it quite obviously is not.
Along those lines, measurement of Cystatin C can help with a diagnosis of CKD. For the majority of the population, though, eGFR using creatinine has been validated in multiple studies.
@@conqueragingordietrying1797 Sure. I was just making the point that not everyone diagnosed with CKD by the eGFR method, actually has CKD. Therefore some people are condemned as having a disease that they do not have. This fact should be made clear in any discussion of eGFR and CKD.
@@conqueragingordietrying1797 I am wondering: my eGFRcre is 67, while my eGFRcys(cystatin C) in the same day same blood sample is 102. I would like to know your educated opinion whether I should be worried?
Hi Michael, what is your average fiber intake per day please? Tx, jt
Hi John, most recent data is in this video:
czcams.com/video/CdEEaf72rjE/video.html
For Test #3 in 2023, that diet composition will be in a video on Wednesday or Sunday of this week!
A number of studies relating (oily) fish (omega-3) consumption to kidney function published after the date of this video
e.g. "Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts" Ong, et al, 2023, BMJ
Nice, thanks for sharing @ptinvite7942!
Something interesting I found out is that the eGFR calculation (any I'm aware of) automatically includes a decrease with age independent of the creatinine value. That's why the plot of eGFR decreases so dramatically with age and makes one think our kidneys are in really bad shape. For the CKD-EPI method the calculation is: eGFR = 141 x (Creatinine)^(-0.329) x (0.993)^age. So, for example if one was able to keep a constant creatinine level over time starting at age 30 one's eGFR is 140 by age 50 it would be about 100 and by age 70 about 50. Seems strange but that's how it work. So, if you can keep eGFR constant with age or increasing like you have done that is an excellent accomplishment because you are fighting the calculation method, but at some point you will likely succumb to the calculation.
yes those calculators are ridiculous. They are based on stupid epidemiological studies, based on a non-understanding of statistics. You can find that nonsense in many studies.
Be advised: the first graph in this video is NOT for healthy people, it is people with kidney disease.
A healthy 60-70 year old should have eGFR around 90
Egfr fluctuates...though trending downwards you can't place value on discrete measurements. My egfr fluctuates between 65 and 81 and I eat the same diet. Perhaps simply consuming less nitrogen affects the gfr positively...also..fasting increases gfr more than anything...so...nitrogen has such an inverse relationship to gfr that decreasing intake of nitrogen alone could produce the resulting elevated egfr....while during fasting you consume no fiber...so butyrate, acetate, and proprietary would be lower in the gut...yet gfr is elevated. I think this is all pretty fascinating. I plot my test results also but I don't know as much as you do about analysis that's for sure. Glad I found you
omega 3 from natural sources is the key fr the functioning of high-performance membranes. --> sardines and makerels
How does one account for the many successful adherents of a zero carb diet, in particular those with health conditions who find relief, not just bucks that can get away with anything at a tender age?
Weight loss.
In my opinion weight loss affects almost every bio and laboratory marker positively {period} this can be done with all sorts of diets {period}
Not many people have much knowledge about low-carb and zero-carb diets. So, you aren't likely to get many informed responses here. See my long comment above about ketones and ketosis. Without ketones, humans would die after a short period of time. So, it would be strange that a diet that promotes ketones would be harmful, especially when also an animal-based diet that provides more essential nutrients than found in plant foods.
WOW....THANK you 🙏 I have a question you might know the answer that I can’t find anywhere. Are kidney stones a precursor sign of future kidney problems or disease? Is there any research on this I’m just not finding? Would appreciate even your hypothesis based on your expansive knowledge. Thank you again 💞
I'm not an expert on kidney stones, as my focus is on prevention, health, and longevity. That said, if kidney stones are forming, that's a sign of suboptimal kidney function.
@@conqueragingordietrying1797 thank you! Just taking stock of all the signals my husband had throughout life. Lower back pain, kidney stones, benign prostrate problems, ED, and figured they all are probably connected. Thank you again...I TRULY value your opinion 💞
@@conqueragingordietrying1797 Calcium among other things can build bone structure.But if the calcium is not sufficiently absorbed and stays in the blood, it can build up in other structures such as osteoarthritis, heart valve stenosis and kidney stones. To prevent this from happening one can maybe supply with magnesium, D vitamin, K2 vitamin and zinc in combination. Zinc however as an isolated entity for preventing kidney stones is a double-edge sword.
@@kari25nov Getting these nutrients from food is the lowest risk approach for what you mentioned.
You may want to do research on Boron. Also the already mentioned vitamins D3 and K2 are extremely helpful. When taking D3, also supplement Magnesium in a well absorbed form, like bisglycinate.
Boron plays an important role in controlling the calcium/magnesium balance AND boron reduces the peed-out amount of calcium.
I prepare my own boron supplement from... Borax that I ordered on internet. The household quality is fine. I dissolve 10 grams of borax in 500 ml water. 1 ml solution contains 2 mg of elemental boron. I use 5ml of solution per day in a glass of water, this gives me 10 mg of elemental boron.
Official guidelines can be found online, these state that 20 mg Boron per day is safe.
Could some of this improvement in Kidney function be achieved with, just for example, things like supplemental potassium , Sodium butyrate, and glycine to counter excessive methionine?
Sodium butyrate is interesting, especially when considering the correlation for butyrate with eGFR. But in the presence of fiber, the butyrate that is produced in the colon travels to the blood, where it positively impacts the kidney. With sodium butyrate, is would be absorbed into the blood from the small intestine without reaching the colon-would some of the effect be lost because the butyrate is first produced in the colon when fiber is present? There are no RCTs that have examined this (yet), and hopefully I can stay in science long enough to test it.
@@conqueragingordietrying1797 I guess there's a whole series of biological processes to consider in understanding the effect of supplements vs whole foods.
@@Lucasukx Yes, that's true. Unfortunately, there is an abundance of supplement-based studies, whereas whole food-based studies are much, much fewer.
Lucas Red ginseng will strengthen kidneys cycle it 3 months on 1 month off best of health
Interesting. I reduced my meat intake and eat more sardine and fast long hours and I improved my eGfr. For those who cannot skip meat, you will need to fast 16 hours or more to improve kidney function. Dry fasting is the best for kidney function.
Is fasting still good with CKD?
How long did it take n by how much please
Super interesting. Thanks! I changed to a mostly vegan (+b12) diet a couple of months ago but it seems that fish plays a vital part of the good functioning of the body. Im still doubting about eggs and molluscs, do you have any thoughts on those?
That may be true for me-I can't guarantee the same results for others, but the approach of tracking your own data, and identifying which foods, whether its eggs or mollusks, are best is the way!
I am vegan and supplement with algae capsules
@@garydinmore1598 Do either increase your eGFR?
@@conqueragingordietrying1797 I will track my own data in the future for sure!! In the meantime my previous question was more like: "Have you find in your personal data any negative correlation with longevity of eggs and moluscs?" I've seen some of your videos and protein is the only think I can think of.
@@viracocha2021 Eggs are correlated with higher blood cholesterol, but whether that's good or bad is debatable, and I rarely eat mollusks, so it's unclear about their effects.
What are the best supplements for kidney function? I'm diabetic so this interests me.
The focus of the video isn't on supplements, but on the impact of whole foods on kidney function.
If you're a weightlifter and take creatin could be relevant to estimate gfr with cystatin c too. I had some (very) different results and I found out that the worst was based on creatinine only.
@@f.r.8828 Yes, true. Most people in large epidemiological studies are not taking creatine, though.
My EGGR is just reported as greater than 60. I guess I need to ask for a more precise estimate. Thoughts on effects of coffee?
If you measured creatinine, you can calculate eGFR. In terms of coffee, or any food, I support blood testing to determine if it's net beneficial or not for your biomarkers...
@@conqueragingordietrying1797 creatinine was .94 at most recent test. Multiply times age? Use 1 for Caucasian and 1 for male?
@@Avital4414 You can use this link to calculate eGFR:
www.kidney.org/professionals/kdoqi/gfr_calculator
@@conqueragingordietrying1797 Aren't creatinine and eGFR dubious biomarkers? I'd posit that, perhaps, creatinine levels are meaningless (see below) and only cystatin based eGFR matter. Natural bodybuilders always have high Creatinine due to muscle mass and protein intake = CKD Stage 3/4 eGFRs, even in those not taking creatine = false positive. Data suggests high protein doesn't actually damage kidneys. When they test Cystatin they get good eGFR #s (ie: Creatinine derived eGFR of 50, Cystatin derived eGFR 90). Seems much of the emphasis on creatinine is due to measuring it in obese people (our societal norm now) who have damaged their kidneys with diabetes/pre-diabetes/high BP. Thoughts? btw, GREAT content- best in your category on youtube.
@@markarmani9636 Most studies don't include large amounts of bodybuilders, and for the general population, there are decades of research behind creatinine and eGFR for estimating kidney function. Would cystain C be better when considering the contribution of muscle to the creatinine pool? Sure, but from y experience, creatinine-based eGFR and cystatin C track similarly as kidney function biomarkers. Also, thanks!
Wo to conclude... what GFR should we be aiming for ideally?
> 90, maintaining youthful levels for as long as possible/resisting the age-related decline.
@@conqueragingordietrying1797 thank you. How does that translate to UK readings please? I am GFR calculated abbreviatd MDRD - (JN) -
122 mL/min (female aged 30s)
@@littlevoice_11 It shouldn't matter if you're in the UK. Do you have creatinine data? we can derive eGFR from that.
@@conqueragingordietrying1797 I will email you what I have. I am happy for you to use me as an anno. case study video :)
My eGFR was healthy 80-90 forever, up through this past January 2021, at 69 YO Caucasian male. Then on May 3, 21 eGFR dropped to 35. If anything, my diet improved as I eliminated almost all animal protein sources. My blood pressure also spiked. Theory: Covid 19 Pfizer vaccination in March 2021. Beware.
There's no published data that SARS-CoV-2 vaccination impairs kidney function. Separately, in this study, there was no effect of Hepatitis B vaccination on eGFR:
pubmed.ncbi.nlm.nih.gov/29926711/
George Bush thanks for the medical history!
Please come back and give an update here on current eGFR, which I dearly hope are great like before.
I had excellent eGFR scores in my 50s, like 114, but then my kidneys got messed up from gadolinium from the VA cardiac work up I had when I had pericarditis from a vaccine!
Then my eGFR was 72.
I was really pissed because I was given that contrast dye in a dehydrated condition.
Since developing other signs of nephrotic fibrosis from same episode I am avoiding the VA like the plague it is.
the va? @@kathrynmcmorrow7170
If I increase eGFR will it decrease Alkaline Phosphatase?
I'd bet on the opposite-increasing intestinal levels of alkaline Phosphatase (see: czcams.com/video/NGrYzOKGBXA/video.html) are correlated with lower serum levels of alkaline phosphatase, which collectively would be expected to positively impact kidney function (eGFR).
@@conqueragingordietrying1797 doesn't a lower Alkaline Phosphatase result in a lower (better) age? I was thinking we want higher eGFR and lower Alkaline Phosphatase. That is how the Ptypic Age calculator you created appears to work.
@@jskweres2 Yes, what you said is true, but we want higher levels of AP in the intestine, which can help with lower blood AP and better eGFR.
@@conqueragingordietrying1797 gotcha... this helps thanks for helping me understand.
I noticed you don't eat any oats or rice on your foods list. Care to elaborate why?
I like grains, but they're calorie dense and don't have as much soluble fiber as veggies. One of my strategies for slowing aging is optimizing the gut microbiome with very high soluble fiber amounts, and veggies, not whole grains, help get me there. That said, oats are on my list rarely, but not never. These days, I've included corn into my diet more often, as its less calorie dense than oats, but I need to be careful, because too many carbohydrates increases TGs and lowers HDl in my data.
@@conqueragingordietrying1797 Interesting. Thanks for sharing. I guess genetics is huge. I pound carbs every meal, active, and my trigs are always below 40 (and HDL 60-70). I also eat way more meat than you. Could you make a video about berries? I eat blueberries in my oatmeal but rarely eat other berries. Thanks 👍
@@wanderingdoc5075 Got an idea in mind about berries? I like to make videos about under-reported stories, the link between berries and cognition, for ex., is well known.
@@conqueragingordietrying1797 for example,
1. Why should we diversify our consumption of hormetic compounds (such as different berries or turmeric) if say we are already drinking tea and coffee?
2. I'd love to hear more about that study where you input your blood parameters and it spits out a biological age.
EX:: we have two 40 yr olds. Individual A has a biological age of 30 per the lab inputs, but is slightly obese, BP is 140/90, and rarely exercises. Individual B has a biological age of 35, but a BMI of 22, muscular, lower fasting insulin, 115/75, and exercises 5 days a week. Would you still say individual A is healthier based on your lab inputs? I'm super interested in this.
@@wanderingdoc5075 You assume that the obese subject would have a lower biological age, but this is inaccurate. Glucose is higher both in obesity and when sedentary, as is creatinine, so worse kidney function. The same is true for CRP. Probably 95/100x the obese person will have a worse biological age than someone that has a low fasting insulin, that exercises, low BP, etc.
For the exerciser with a BA of 35, I'd say that there's stuff in their diet that they're not doing, thereby leading to the higher biological age. For ex., see my video on Paul Saladino's blood test data (czcams.com/video/6Rc9xLvD2PU/video.html).
Gut function FTW :-)
What about hydration ?
I didn't address hydration in this video, but I did in this video on RBCs:
czcams.com/video/3JpyDiNxNeE/video.html
@@conqueragingordietrying1797 I believe he was asking if hydration improves kidney function, not asking if your test results are only due to being dehydrated.
drinking a lot helps the kidneys flush out the dangerous stuff. of course you have to care about the minerals. I found that drinking a lot requires supplementation with magnesium and above all with potassium, for which the RDI has been elevated recently.
Such drinking a lot lowers the creatinine and the cystatin, and the kidneys may appear more powerful than they are, regarding the actual capability for filtration. note that it is called ESTIMATED filtration rate. ...I did not find a study that relates fluid intake to the cystatin measures. Research is blind against it.
However, bad hydration is know to cause damage in capillaries, and the principles of renal filtration is based on proper functioning of capillaries.
Are you a caffeine/coffee drinker? ≥2 cups per day has seen a 20% lower risk of chronic kidney disease development than nondrinkers.
I don't, although I added 1g of ground coffee beans to this morning's mix of cashews+dates. Coffee can affect my sleep onset, so rarely eat/drink it. It it works for you in terms of kidney function or other health markers, that's good!
you have great videos.. But man.. all of these data that you collect.. i'm worried about you.. 😅 very detailed.
Thanks MEK, and ha, no reason to be worried! I don't want disease to creep up on me, and this is the best way that I know to reduce that risk.
2,000 grams of veggies is close to 9 cups of vegetables, no?
Nope, 1 cup = about 80g, so that's ~22 cups.
@@conqueragingordietrying1797 Maybe we measure differently. I calculate 2,000 grams is 70 ounces (maybe that's where we're not measuring the same way) which, divided by 8 (8 oz in a cup) is a little more than 8. Terry Wahls MD recommends 9 cups per day. i get between 5-7 if I'm lucky, and I tend to think that is a lot of vegetables! Eating so many veggies is a ton of work! Buying, chopping, washing, drying, storing, cooking, etc.
@@patriciahoke4722 I get your logic, but for whatever reason, although a cup = 8 oz, that's not true for vegetable-cup measurements, which can range from 80g to 150g. I don't like the "veg in a cup measurement", it's too dumbed down, and prefer the actual weight in grams. There, I average ~2000g/day. Also, I agree, it's a lot of work to eat/chop/prepare that many vegetables!
@@ruralcoder Yep!
@@ruralcoder I'm not worried about it-there are many factors related to stone oxalate stone formation, and decreased kidney function is one of them. In contrast, my eGFR is better with more veggies, including spinach as my main source of oxalates. I don't go crazy with spinach though, as I average 150 - 180g/d. I could easily eat more, but don't.