VDJ recombination | antibody class switching
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- čas přidán 22. 09. 2016
- VDJ recombination lecture - This lecture explains about the mechanism of antibody class switching and somatic mutation that leads to the development of antibodies by the plasma cells. Plasma cells undergo genetic VDJ recombination that allows them to shuffle DNA segment between variable region of antibody which helps in the generation of different types of antibody modifications. This process is known as antibody class switching when the antibody class is switched from one type to the other.
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Thank you for watching the VDJ recombination and antibody class switching video lecture in immunology.
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Once again a brilliantly clear lecture making it easier to understand this complex subject, thank you so much!
+Dawn Horan glad it helped. All the very best
I opened kuby book I was confused with how this switching taking place but within a mints I got the concept
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you’re so good at explaining things, thank you for clarifying this, just wondering if you have a video on T cell receptor diversity?
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thank you sir, that was really healpful, i have difficulty to understand that TDT part , and how it cleave the unnecessary part of the gene
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Great sir... Even in kuby it's hard to understand bt sir u made it more interesting.. Goona b very helpful in my coming exams..
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You made it much easier! Thank you
Clearly explained Sir. Thank you very much.
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First comment
I m BS Biotechnology student of 4th semester
Explanation is oxm
I HV no words 💓
Love from Pakistan
this is the best detaied mechanism explanation I could found. thank youu
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thanks shomu after 7 years you are still #1
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Genius ...thnks alot from kashmir
my immunology teacher suggested me to watch thiz video:)...nd its amzaing sir...
Very informative lecture, Thank you very much
Big thanks your sir❣️If i haven't seen this video I will never understand vdj recombination thanks legend of microbiology.
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Respect level up !!! After seeing this video.
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Thanks a lot sir the video solved all my doubts and confusions
This video was soo helpful, Thank you so much Sir.
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Beautifully explained. Thank you!
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I'm watching the vedio in 2020 it's so easy to understand. Thank you
its a really smart learning... watched not almost all but huge no. is there.. nd all r great.. thnk u for this tutorial .. hope u will give notes on your google + or your website..
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this video helped me a lot sir
U helped me a lot... and thank u so much sir... keep uploading ❣️
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Literally you are very hardworking guy..one thing that I can learn from you is Consistency..Hats off to you..
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superb explanation sir...
I found this really helpful :) but I have a question: what makes the D and J regions ( and also the V and D regions) come together?
RAG(recombination activating genes) 1&2 are the protien complexes which are responsible to bring V&D...,D&J to come together..
Variable diversity joining
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Super helpful!!
Why did it get so much more difficult in the last two minutes :(
exactly .. i also could not understand the VDJ part ...
@@sahelidas244 Same here brother .
Keep watching this part again and try to draw the same step by step. It's not that difficult.
@@viveksinghchauhan7496 *Sister*
Because he plagiarized it.
Just before my exam.. It was awesome. Love from Bangladesh
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You are the best. I have learned a lot from you
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clear explanation sir
The best explanation of Antibody diversity
Thank you
As the title says it produces antibodies of different class but can you please clarify would they be of different subclasses as well?
Okay so just I make sure, when the plasma cell makes antibodies they all have same vdj sequence because they all are specific to one antigen right? But the type switching happens on the constant region.
Sir u r the best ❤🙌
Really useful, cheers!
Love all you video. Thanks
+sanwithz thank you.
Sir,really amazing ...well defined !!...
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Unbelievable explanation!!
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Sir you said that hey will always recombine at those fixed positions. If thats the case IgD will never be formed, because between M and D there is no recombination site. Isn't it sir?
Hi, first I really like your videos but I have 2Q: 1.Why does a class switch occure later in the course of an immune response? 2.When does clonal expansion not occur?
wow it's so clear now ,thank you
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Thankx alot you are the solution of my all study related problems again thankx alot alot of prayers for you
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May I ask something, Sir? How B cell creates IgD when Mu and delta segment always cleaved together? Thank you
My answer is probably a bit late and I can only guess but as far as I know when IgD is produced, IgM is also produced, seems like IgD definitely cannot be produced if IgM isn't since they sit in the same region. Also since the frequency of IgD is below 1% i think there must be a specific pathway that somehow overgoes the immunoglobulin becoming an IgM. I know this is not really an answer to your question, just my thoughts.
You didn’t listen carefully then.. there is a small chance of recombination between the blue dots. Then if it’s between M&D, there will be IgD. And if both are cleaved together only IgM will be produced which has the highest concentration by the way
It was very well explained !! Thank u so much
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I don't like immunology ..... but I try to understand it .Your explanation is nice and simple to helpe me alot ,,, Thank you
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A Really good video.. Thanks a lot sir !
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Thank you! Great explanation.
+Sarah Winkler you're welcome
I have a quick question. For the constant region recombination, there seems to be no recombination site between M and D. So how can IgD be expressed if it seemed to be masked by IgM. thanks
u r the best sir👍
Thank you
Great job.
According to the blue dots you made on the board, IgD will never be made as it'll never be joint directly after variable region. Then How is IgD made?
IgD is expressed alongside IgM in immature B cells. So it is already there as a B cell receptor
Thank you sm!! Very clear
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This was very useful! Thank you :)
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Shomu sir aapki..ek..baat..bahut ..achha lgta h..yhi..ki..
That is about it...
Ha ha..
Really i like it...and hatts off u
You are the best
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my teacher -from korea-
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so so so briliant. thanks so much
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superb... thank u sir......
Hai Sir.. I got with one doubt. What if a New Antibody needs to be produced from the Cleaved part of DNA during the previous Antibody production... How will the cleaved DNA part (of variable or Constant region) be used again for a new Antibody synthesis?
It really helped.thank you😊
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ur new surcriber from Pakistan,u did great job☺
thnxx fr making it..
+Benish Shah thank you. Glad you liked my lectures
☺
Thank you!
thank you sir
U r just awesome....😀😀😀
thank you so much for this video
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Plz get understand somatic hyoermutation and somatic recombination( vdj )..bcz I think both process are different but mostly it is mixed in all online videos..
Thank you Sir this was very helpful👌
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This was a great help thankyou
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If the recombination is from blue dots between M&D, G, E, A then how is igD produced ? As there is no blue dot between M and D (please reply).
Simply excellent........
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Thankyou so much sir, you made it so easy for me.
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I thought somatic recombination was orchestrated largely by base substitution, not deletion? There are deletion events where error prone polymerases fill in the gaps
Thank you so much. I hv 2 confusions and will be grateful if addressed.
1. How are IgDs formed? As there is no switch before delta segment.
2. Isn't somatic hypermutation a different thing than somatic recombination ( VDJ recombination)? I thought it's a point mutation by AID in the Germinal centre during affinity maturation of centroblasts. Please clarify.
Poukhami Sen igD is formed by splicing where the mu gene is spliced and delta gene is expressed. Gamma alpha and epsilon gene are expressed via process of class switching.
Great sir..
Thanku so much ❤
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bhai korechen ki? apni tokhon 10k subscription e chhilen..... hats off
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Love youuuuu! ❤
Thank you
My best teacher ❤️❤️
Thank you
Thanks a lot Brother ❤
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Brilliant ❤️
Thank you
Very well explained sir😊
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Great!
Thank you
Please share link of animation vedio where you explained VDJ region of antibody.
dada, there is another topic called " GERM LINE DNA SEGMENT" in antibody diversity mechanism. Can you explain that?
I have a doubt
1) is the both variations occur simultaneously or one at a time
2) is this possible to convert or switch form antibody into another type?