2-Minute Neuroscience: Sympathetic Nervous System

The sympathetic nervous system is the subdivision of the autonomic nervous system that is typically associated with expending energy and the “fight-or-flight” response. In this video, I discuss the general anatomy and functions of the sympathetic nervous system.
TRANSCRIPT:
The sympathetic nervous system is a subdivision of the autonomic nervous system, which is the subdivision of the peripheral nervous system that controls automatic processes in the body like digestion, heart rate, and respiration. The sympathetic nervous system is typically associated with expending energy and the “fight-or-flight” response, which is a general response to alarming or threatening situations that involves increasing the ability of the body to act. The idea that the sympathetic nervous system is only active during “fight-or-flight” responses is an oversimplification, however, as it is also active in non-emergency responses and during times of rest.
The nerves that make up the sympathetic nervous system originate in the thoracic and lumbar spinal cord. Like other neurons of the autonomic nervous system, they do not typically travel directly from the spinal cord to their targets but Instead extend from the spinal cord to clusters of neurons in the peripheral nervous system known as sympathetic ganglia. The sympathetic neurons that travel to the adrenal medulla are one exception to this rule as they extend from the spinal cord directly to the adrenal medulla. Some of the ganglia of the sympathetic nervous system form a network of interconnected ganglia called the sympathetic chain ganglia. The sympathetic chain ganglia are found close to the spinal cord, while other ganglia known as prevertebral ganglia are closer to the organs they supply. The neurons that travel from the spinal cord to the ganglia are called preganglionic neurons, and they typically synapse with neurons in ganglia called postganglionic neurons. The postganglionic neurons then extend to the targets of the sympathetic nervous system, which are diverse and found throughout the body. The preganglionic neurons of the sympathetic nervous system primarily release the neurotransmitter acetylcholine, while the postganglionic cells primarily release norepinephrine---although there are some postganglionic neurons that use acetylcholine as their primary neurotransmitter.
References:
Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, Mooney RD, Platt ML, White LE, eds. Neuroscience. 6th ed. New York. Sinauer Associates; 2018.
Wehrwein EA, Orer HS, Barman SM. Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System. Compr Physiol. 2016 Jun 13;6(3):1239-78. doi: 10.1002/cphy.c150037.
Thanks to Nicole Lookfong for help with fact-checking the script for this video.

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Your videos are amazing!
I love how you break down the topics into easily digestible shorts. The easy to read print and illustrations are a bonus. You make this complex topic accessible and simple to comprehend. Thank you!

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I learned something today! Muchos gracias!

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Great video for someone like me who is just starting out with learning this stuff.

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Hey, nice video! Although I had to research on a lot of these terms since they weren't thoroughly explained, I think you did a good job of overviewing such a complicated system in the span of 2 minutes. This was a big help with organizing my ideas.

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Absolutely impeccable timing! About to cover the CNS with my class, im hoping a parasympathetic nervous system vid is coming (please!) :)

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I'm working on it right now :) It should be done sometime next week.

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Thank you...💐💐

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THANK YOU

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Information about sensory/ motor fibers and their origin to carry would be nice

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thank you

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Thank you!! I didnt understand my lecturer at all with this part

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In an awe !!!!
That lengthy a topic got divided into comprehensive chunks!
Really helpful

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Can the part of the SNS or PSNS that are damaged by Covid/EBV reactivation be detected by MRI?

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Great! As all your videos 👍

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Thanks!

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Good stuff

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This has to do with hiperhidrosis, right?
I'm suffering that.
What are your thinkings on this?
Thank you.

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Sympathetic hyperactivity is one proposed mechanism, yes, but in general I think hyperhidrosis is poorly understood.

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Probably all of the above. "Psychedelic drugs" is a broad category, so first it depends on what drug we're talking about. But drug effects (especially with psychedelics) also depend to a large degree on the individual taking them and their characteristics (e.g. biological, psychological). So I think some psychedelic drugs may offer benefits to some people, and some drugs might have negative side effects on certain people that outweigh any therapeutic benefit. I think more research is needed to be sure about benefits, risks, details like most beneficial doses, and so on.

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Brain

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