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- čas přidán 28. 06. 2024
- In this “Ask Me Anything” (AMA) episode, Peter and Bob dive deep into nicotine, a complicated and interesting molecule that has effects on both the brain and the body. They analyze the results of the studies that describe nicotine’s cognitive benefits and potential for inducing weight loss. They talk about a smoking cessation technique called nicotine replacement therapy and give a full breakdown of the various routes of administration, dosing, and safety. Finally, they explore the fascinating and counterintuitive observation that cigarette smokers are less likely to get a severe case of COVID-19.
In this sneak peek, we discuss:
00:00:00 - Intro
00:00:10 - How Peter first became interested in the potential benefits of nicotine
00:06:00 - Untangling nicotine from tobacco
00:09:50 - Nicotine replacement therapy (NRT) for quitting smoking: products, protocols, and a review of the literature
00:16:40 - The cognitive benefits of nicotine: Overview of the literature
This is a special sneak peek of AMA #23. To view the full video, you'll want to become a podcast subscriber. You can subscribe to the podcast and learn more about all the subscriber benefits: peterattiamd.com/subscribe.
In the full episode, we also discuss:
-Where nicotine has the most positive impact on cognition
-Possible mechanisms conferring the benefits of nicotine
-How modafinil and other nootropics compare to nicotine
-How nicotine may induce weight loss
-Relationship between smoking and COVID-19: Analyzing the observation that smoking appears protective against COVID-19
-Breakdown of the various nicotine replacement therapies: route of administration, dosing, and safety
-Concluding thoughts on nicotine: use cases, addictive properties, and more
Show notes page: peterattiamd.com/ama23
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
Learn more: peterattiamd.com
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Started using nicotine pouches after seeing this and Huberman speak about the benefits. However, after a few months my hemo a1c was way up and my testosterone was way down. My diet, exercise, routine didn't change. Looked it up and both are negatively affected by nicotine use.
Great podcast, I’m so glad I’m a premium listener! I have one complaint, I can’t just pause and come back, it get hung up and I have to refresh the app on my iPhone and fast forward every time.
I experimented with caffeine for the first time in my life last month, chewed a 2mg and felt great, instant boost and got a great workout in after work. I then tried a 4mg piece of gum a week later and holy crap I thought I was going to die, I vomited and killed any chance of working out.
I’m also prescribed Modafinil and take it very sparingly. I am the opposite of you, I get a euphoric feeling and am so focused too, it’s so powerful to me that I stopped taking it for a while out of fear that nothing this powerful good be good for me. As I mentioned I now take 100mg a few a times a month when sleep deprived
Great podcast!
Did a 2mg dose today a few hours apart. I definitely feel different. I did have to “park” it on the side of my drinking glass when I started feeling that nausea. I’ll retest tomorrow. THANK YOU.
How have you not interviewed Andrew Huberman yet?
Huberman has interviewed Pete on his podcast
I could just listen to you two knuckleheads goof around all day. I love it.
In my experience as a serial vaper, the reason NRT did not work is because the nicotine levels are too low for some people to reduce or eliminate cravings. I tried to quit vaping dozens of times with NRT with no success. However, when I decided to increase the NRT dosage to a level that eliminated cravings, I was able to taper down over the course of two months and quit entirely. For me, that included two of the highest potency patches available in conjunction with nicotine gum or lozenges. I first cut down on the strength in the patches until I was able to eliminate them, after which I cut down on the strength of the gum and the frequency in which I chewed it. At that point I moved on to regular chewing gum to conquer the oral fixation. Even that was a small challenge to quit, but I was able to do so after a few weeks. The level of nicotine I was getting from NRT might seem dangerous to some, but it still paled in comparison to what I got while vaping the highest potency juice around the clock.
I really liked this podcast. Conversational and easy listen
I’ve been chewing nicotine gum and lozenges for 6 years. Lol I love it. Vaping before that. I want to quit but only because of the cost.
I started smoking at 10 years old. I was a Division I athlete with full scholarship. I smoked cigarettes from 1963 to July 5, 2000.
It took me six years to quit. I would quit and start and quit and start.
I was monitoring my cardio regularly at a health club. I smoked 10 to 20 cigarettes in a binge after being off for months. My cardio was off 50% from that one day return.
I was the type of smoker who people who also smoked would say, “Jesus, you inhale to your Fuck’n toes, man.
Nicotine therapy to quit is bullshit. Like taking opiates to quit opiates. You have to keep failing to quit until it finally sticks.
Regardless, it's MUCH safer and healthier than cigarettes - so even if you stop smoking and move to gums, sprays.etc. - you're already doing yourself a monumental favour!
@@kaibe5241just do it until quit, there is no spray I need to quit.
Man, I wish I could afford to subscribe! I love your content.
Nicotine would have great therapeutic benefit if it wasn't horribly addictive, as one of you said. I say this and agree with your general understanding out of respect for your expertise and as a longtime nicotine addict.
There are studies showing nicotine helps w ADD. I’m an x smoker. Had to go to a hypnotist to quit. Quit naturally before following a serious surgery- my body just did not want a cigarette for weeks. I couldn’t even force myself to smoke. Both times I noticed that I had developed a debilitating level of ADD which led to anxiety so I started using the patch ( I hated the oral NRTs). I still use the patch almost daily- years later- to control my ADD.
Do you think your addiction to smoking was actually helping your ADD. also do you think it was the nicotine, the act of smoking, or both you were addicted too? i think I’m the both.. I haven’t smoked in one month now.. I’ve quit cigarettes for almost 2 years now. But I would smoke a cheap cigar about 2 days out of the week until last month where I completely cut it out but now that I’m on the month I want to smoke so bad. Nicotine should be out of my system now so idk if I’m just addicted to the act of smoking itself that helps me relax as well.
You can purchase very inexpensive liquid nicotine in a bottle that comes with a dropper. It's just nicotine in Glycerine / Propylene Glycol. No other added toxic crap that Nicorette and similar brands add. (like poloxamer 407). It's called Easy Mix Nicotine. Can take it under the tongue but that might sting, can just add a drop to a glass of water or something. The danger is you can easily overdose so need to be very careful.
Progesterone is also a supplement that may reduce addiction if you're sick of nicotine.
The NRT results are lower than expected because nicotine isn’t as addictive as claimed.
Nicotine is a social ritual enforcing agent, it’s the psychologist of smoking itself that’s the issue.
As a state certified hypnotherapist, I’ve helped hundreds quit, with a high success rate, about as high as psychedelics therapy.
what about arterial stiffness?
Any thoughts on nicotine's impact on blood glucose levels and insulin resistance?
What about the harm to our gums and teeth from nicotine pouches? And isn’t nicotine bad for vascular health?
Studies have actually showed that there is possible risk for pancreatic cancer. But there is 70% more risk to get type 2-diabetes if you are a high consumer of nicotine than who does not. Also its makes your arteris stiff and high blood presure. But sure it makes you feel good and a bit sharper for the moment.
By the way Petter should put the patch under the upper lip
@@tengrisherpa4517 where did you find that 70% figure?
@Albert Escamilla it's conjured out of thin air, as its nonsense.
Crazy dreams with the patch!
lol, yes this true.
Hmm. Years ago I used to use the gum. It destroyed at least 2 of my teeth. I was probably using it for 2 years. My dentist told me it was a common occurrence. I’d say if you were only using it a bit you would be okay. Also giving up smoking is a lot to do with the people you associate with and how much exercise you do.
What's the mechanism by which nicotine gum destroyed your teeth?
@@hanslick3375 I need to put this in context first. It was about 18 years ago when this happened. 1/ I was over using the product. I would chew them when I was playing Call of duty for about 3 hours most days. I felt it gave me a competitive edge and after doing limited research I felt nicotine could be a beneficial. In fact my game results showed it did.
I’m 1/2 Irish so would also go drinking most weekends. I could eat a full box of 20 in one night.
2/ because I never really smoked much I took the lowest dose of it I could find which meant I used more then if I got a higher dose.
3/ l ended up having a preference for one type which was very hard.
My dentist told me that it was like I had done bodybuilding on my jaw. I broke 2 teeth. They showed no sign of decay.
I then changed to using tables things. Then things got better. I continued using them for a few years.
I ended up getting a lot of dental work and my teeth are really good now.
The end
@@RobertNaik I see, thank you for answering my question! Basically you developed some sort of masseter muscle hypertrophy. Which may have contributed to the braking of your teeth. I'm glad to hear it isn't a direct result of the nicotine, but rather the chewing itself. I use (maybe overuse) nicotine gum myself. About 5 x 4 mg gums per day. I love them I must admit. Definitely help with mental acuity and alertness. - Greetings!
Ha! I just bought some! Never done it
I'd love to know what pouches Peter uses.Anyone know what is a good safe lozenge/pouch brand of nicotine? I'm in the UK. Thanks in advance 🙏
Loudness level varies throughout the show and between shows. It would be good to make sure the level is consistent. You can use different methods to do that, one inexpensive way is to use the audio Normalising of the free shutter encoder.
It’s called compression. Learn audio engineering nomenclature before posting on the internet with “advice” to experts.
@@vanizell7937
en.m.wikipedia.org/wiki/EBU_R_128
Compression is independent of loudness.
I didn't say I'm an expert but I work as a video editor for more than 20 years.
en.m.wikipedia.org/wiki/EBU_R_128
Compression and loudness are two different concepts. Clearly you understand neither. But feel free to continue lecturing professionals.
I'm pretty grateful that I can use smokeless tobacco and not feel the need to smoke. Really want to try the puuches now though to cut the tobacco leaves out next. I used to avoid the pouches thinking they had more chemicals or they I wasn't able to control my dosage, but it seem like the pros of pouch products out weigh the cons of chewing tobacco products
Try a spray if you want that "instant kick" whilst not smoking - it's a super clean buzz, and VASTLY superior health-wise.
Smoking kills you with a heart attack rather from lung cancer. So the actual culprit here is nicotine.
What about the premature skin aging. Any way to prevent that?
Just FYI as a T2 if you use nicotine gum I'd suggest checking your blood sugar. I used it for quite a while before I tested and saw I was at 200. The effect lasted for a few days. I tested on and off cycles several times and the increase was consistent. I loved the cognitive enhancement, but the cost was way too high.
Was this with flavoured Nicotine gum (mint) or regular / original flavor?
@@matthewrichmond4139 I don't recall, but I'm sure it wasn't from the gum's calorie count if that's what you mean. I've noticed some other nootropics I have tried also radically raise my blood glucose levels.
Dentists are claiming that nicotine pouches and lozenges contribute to gum disease. They seem pretty worried about it. Any input?
Any thoughts on nicotine-patches? Are there any benefits/downsides to getting the nicotine trans-dermally.
Yes, it is a ton of nicotine for a non-smoker, even if someone is a light smoker. Makes you sick very quickly if you are not careful.
@@jaredn.3484 The dosage>>>effect variability is not unique to any one ROA: nicotine is quite strong to the unhabituated. Transdermal patches do have a longer time till onset and also a longer duration ; so I could see this being problematic though. They typically come in 7;14 and 21 milligrams dosages, and despite what warning labels may say, can be cut into smaller pieces.
I would suggest trying a different ROA if I had no habit though. Each ROA has it's advantages and disadvantages.
I smoke a pipe now (without inhaling).
nausea, constipation, strange dreams, to name a few of the possible side effects. also even if in lower concentration than cigarettes there are a plenty of nasy chemicals in the patches. i found acupuncture plus those pouches the best thing. but acupuncture not cheap and they banned the pouches . i started smoking again.
Check out the pixotine nicotine toothpick
Former 10 year chain smoker: nicotine pouches high dose are 100% replacement for cigarettes. You physically won’t be able to smoke once that’s in your mouth, and cravings die.
My take on the pleasure of actual smoking a cigarrette is that besides the nicotine rush you get to do nothing for 3 to 5 minutes. That is when smoking by yourself. It is an introspective break from it all, a quasi meditative state of mind that relaxes you, a hole through which one is able to blow off some of the steam of daily routine. It becomes a bit of a ritual, just like the first coffee or streching after a weight session.
To sum up: smoking is an introspective break from life. It is difficult to replace the nature of that experience.
PS: I was only a low key smoker. Never bought a pack in 6 years only single units, one to six cigarrettes a week. I don't smoke anymore though (1 year now), my woman does not like it. I have sex instead. It is a fair trade off.
What about nicotine liquid & DMSO on the skin?
What pouch product does Attia use?
Pretty sure its Velo
Peter, or anyone reading this: I use nicotine for focus with my ADHD. It seems to be raising my blood pressure though, and I was cutting it close to pre-hypertensive numbers as it was before... I have read that nicotine does raise blood pressure, and I am curious how you, Peter, mitigate that cardiovascular risk factor as a nicotine user? I want to cut my dosage in half and watch my numbers. If that doesn't help, do you or anyone in the comments have any further advice on ADHD, focus and blood pressure?
The lozenges gave me terrible heart burn. Never tried the pouch
Same
Maybe there is something that is in tobacco leaf, or has been added to cigarettes, that is far more addictive than nicotine?
MAO-inhibitors are in tobacco. I think the majority of addiction comes from the social setting and habit of consumption, which you don't get when using lozenges or patches while studying.
How about the Harvard 2016 study that showed that nicotine wasn't addictive but the Perrines that was added to cigarettes
I hear nicotine constricts blood vessels. Any notes on this?
What do you people think of IQOS and other "heat-not-burning" nicotine/tobacco based cigarettes??
Love me some Nicotine!
Among famous long lived people Bertrand Russell made it to 97 as a pipe smoker
How bad is an occasional cigar?
I attribute my hair loss to either nicotine or a bad variation of keto
I recall a journal article that says smokers have significantly higher levels of testosterone.
Are the show notes really as good as they say??
Yes, they’re amazing
They are studies that show the nicotine is not addictive.
Why is NRT not successful? Because nicotine isn't additive, its the chemicals they add to cigerettes that is addictive, the companies add these addictive substances to make it addictive. Many doctors have done podcasts on this fact. I haven't read the studies, but I use a nicotine patch for varying reasons and have never had issues with addiction, so I tend to believe them.
It's funny how you talk about nicotine pouches as a new thing, when we have been using them for over 200 years in Sweden already xD
Next time do heroin, Mr. Attia!
Well, seems like I'm starting nicotine first thing tomorrow
Oh god you’re in for world of pain and suffering, you don’t need iy
Don't. It's not worth the addiction and effects on blood sugar.
Are there any good all natural nicotine products available that are not chalk full of other garbage like artificial sweetners? Or, at least minimal....
Swedish match snus
I’ve been long saying that cigarettes aren’t unhealthy when it’s used in low doze. Now the science is coming to that conclusion.
Is the science actually saying that,nicotine is the subject not cigarettes.
69 chemicals.... NICE ;)
Pay. 😂😂😂
$20 a month for information that can be found for free online GTFO
NRT did nothing for me because it doesn't help you stop the craving. I'll put this out there because it's a potentially cheap solution that many people find effective. Allen Carr's Easy Way To Quit Smoking. I can't tell you how a $7 book made me quit but it did. I've never thought about smoking a cigarette since.
I want to know if nicotine alone hardens arteries?
Yeah really wish the cardiovascular risks were discussed in this preview. Also the risks of the dreaded ED!
yes it does, nicotine in general affects the tiny blood vessels all over your body due to constant constriction and increase in stiffness... sure it can be ok if u use one pouch a day, but that's bullshit, everyone ends up using it most of the day.