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Vitamin B12 (Cobalamin) Deficiency - Causes, Symptoms, Diagnosis & Management - Hematology Series
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- Äas pĆidĂĄn 10. 11. 2017
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âșđšâđ«đAntibiotics Lectures: www.medicosisp... ... Check out my brand new "Electrolytes" course at www.medicosisp... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. In cases of vitamin B12 deficiency, both Homocysteine and Methylmalonate are elevated.
RDW is elevated in Vitamin B12 deficiency as well as in folate deficiency.
Strict vegans are at risk of developing vitamin B12 deficiency.
To make red blood cells during hematopoiesis, DNA replications require the presence of vitamin B12 and folate.
Folate is stored in your liver for months.
Vitamin B12 is stored in your liver for years.
Vitamin B12 (cobalamin) deficiency = Megaloblastic anemia+ Neurological Symptoms.
Folate deficiency = megaloblastic anemia [withOUT neurological symptoms]
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Hello sir i want to know something sir i am herion addict and my vitamin b12 is very low can i use vitamin b12 injections in addiction of herion please help me sir tell me i am a addict by mistake and from india my english is not good but i try you understand my problem and help me sir please reply
Hi dear,
How are you?
I strongly recommend that you talk to your doctor!
@@MedicosisPerfectionalis hello sir i am fine and now in recovery and using cyanocobalamin for increase vitamin b12
Stay safe
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Your channel is a million times more informative than my lectures, thank you so much for everything!
My pleasure đ
This is much more helpful than a whole lecture at college. Thanks a lot!
Thank you so much đ
So i've watched 26 videos of this playlist within 3 or 4 days, and i'm speechless!!! I really like how your videos are not that long and by the same time are full or usefull information, plus the way you explain is so clear and you even make me laugh at some words of yours which is quite interesting and positive! I really ENJOY watching your videos. Thanks again and wish you all the best in your life!.
Thank you so much! I appreciate you!
I cant belive that youÂŽve just made a reference to Oasis, this channel is incredible! Thanks for your videos and effort, cheers from Argentina.
Thank you so much!
I appreciate you!
Would you please help me by sharing?
Vitamin B12 stored in the liver for YEAAAARS
Is it really so?
that was great! waaaay more than I anticipated from CZcams but I learned a lot. thank you.
My pleasure đ
So b12 deficiency produce iron defiency too?
I watch all ad on your vedio,,
i didn't watch it because I am busy but feel that content is perfect,,
Thank you so much đ
Just saying, I am a committed vegan and obtain B12 from cereals. Keeping well after circa 10 years. Animal products also have their drawbacks, especially red, processed meats and dairy, best avoided. Good video, thanks and best wishes. đïžđ§Ąâš
No man, we can't thank you enough !
This touches my heart! Thanks for your encouragement!
Your voice in my head...What a amazing teaching skills ...You are the great....
thank you for the explanation. you forgot to add tests for pernicious anemia including anti-intrinsic factor Ab and anti-parietal cells Ab.
You're right.
"they will get divorce" XD
+Sheena Marie Tubiano :)
Sheena you are medical student
You're Indonesian?
What are the neurological side effects ?
Peripheral neuropathy is the most common.
Also subacute combined degeneration of the spinal cord, as well as dementia.
"That's the story Morning Glory! "
đđ
American Academy of Neurology:
People with inflammatory bowel disease may also be at risk for
developing nerve damage and other neurological problems, according to
research that will be presented at the American Academy of Neurologyâs
59th Annual Meeting in Boston, April 28 - May 5, 2007.
Inflammatory bowel disease includes digestive disorders such as
ulcerative colitis and Crohnâs disease that cause swelling and/or
bleeding in the intestines. For the study, researchers compared 103
people with Crohnâs disease and ulcerative colitis to 51 people with
other digestive disorders, such as irritable bowel syndrome, gastritis
and chronic heartburn.
The researchers found that those with inflammatory bowel disease were
about four times more likely to develop neuromuscular conditions,
including carpal tunnel syndrome and small fiber neuropathy, which
causes pain and lack of feeling in the feet. Those with bowel disease
were also more than six times more likely to also have a disorder called
sensorimotor polyneuropathy, a nerve disease that can cause weakness,
pain, and numbness. These diseases were more common in women with bowel
disease than men.
âInflammatory bowel disease patients commonly suffer from several other
medical conditions, like B12 deficiency and glucose intolerance. These
nerve conditions we have reported are often not diagnosed by their
primary care physicians,â said lead study author Francisco De Assis
Gondim, MD, MSc, PhD, Professor of the Federal University of CearĂĄ in
CearĂĄ, Brazil, and a member of the American Academy of Neurology.
âPeople with inflammatory bowel disease who develop new symptoms, such
as pain or numbness in the feet, should see a doctor.â
Most informative so thank you for taking the time of explaining this in great detail. My Hematologist has written a report to my doctor noting that I have developed mild Pancytopenia and have already started on B12 injections last month. My B12 is within normal range however the HoloTC (Holotranscobalamin)level was abnormal so is still being looked into as to why. I have been having severe Hemiplegic Migraine with other Neurological conditions over the past 3 years.
Best of luck to you!
Excellent explanation of pathogenesis and diagnosis of Vitamin B12
Thank you đ
I think I am getting addicted to your videos đ€Łđ€Ł
I really hope I can get into medical school and be a good doctor
I feel I understand almost all the concepts you discuss.
Probably the challenging part is to memorise it. I hope I eventually get there.
Wow so you are watching these videos even though you are not a medical student?? Then there is so much hope you will become a doctor...an amazing one!
By the time you will read all this in medschool, you will memorise it and better than your classmates because you will be studying it for the second time again!
@@starrysky1588 I really hope so. But the problem is that I cannot study medicine in my country as they mainly offer it for Highschool graduates. I got admitted in NewZealand as an international student but I donât have money to study. My university will start in three months and I donât know how to pay my fees yet lol đ
If no miracles happen, I may kiss my offer goodbye đ
@@ahmadaljazeeri9287 Oh I see! Don't worry God will create some solution for you. Why don't you try in a more affordable country like Pakistan? We have a lot of international students here. And don't worry people in countries like new Zealand or Australia work part time and can pay their fee. Looking at your passion, I wish so much that you become a doctor someday!
@@starrysky1588 thank you Zahra sister :) I will do my best and try hard to one day become a doctor. I appreciate your encouragement so much!
If alcohol prevents folate absorption and folate deficiency is a cause of macrocytic anemia then alcoholism can cause both megaloblastic (folate def) and non-megaloblastic (chronic alcoholism)?
2 years ago i used metformin for weight loss, i lose wieght but got ice pick headach which i never experienced in the past, after that i got grey hair in th area of ice pick headache. Than i stop using metformin and from past 1 and half years im using vitamin B12 sublingual, Now i get less pain and some of grey hair turn blach. But now due to my stress and depression nothing works, my hair turns grey faster. Im 32. Now what can i do. Also premature grey hair is not in my family genetics .
Try to take B12 injections. Very big difference. Your r protein could be not created by body and b12 not absorbed. Move to another city out of depressive environment.
I came to this video in the hopes that it would help me understand my B12 deficiency after seeing a neurologist for my symptoms. It was very helpful in understanding the processes; however, I just wish the doctors could tell me the REASON for my deficiency. Iâve been receiving injections but Iâd still like to know why.
Sometimes, itâs difficult to identify the cause.
If your symptoms are getting better with the treatment plan, then youâre on the right track. If not, see another doctor.
I wish you the best!
Do you have stomach or digestion issues? Mine is from celiac disease which ruined my stomach lining so I couldnât take in vitamins and got really malnourished
@@oxyroid I do have GI issues. I go to the bathroom numerous times a day. I normally canât plan long outings from home because Iâm afraid Iâll need to use the bathroom. Itâs pretty terrible. Iâve mentioned this to my doctor many times but she has not had an interest in testing me for anything.
@@meggbaker9380 look into SIBO if you haven't already.
This B12 is a promiscuous vitamin. First it binds to R protein, then to intrisic factor and in the end to the transcobalamin
Greetings of the day Sir, you are doing a great job. Your lectures are very impressive, precise, understandable & providing great concepts. Sir I want to ask you does Gastric sleeve surgery can cause Vitamin B12 deficiency. Thanks
Yes, it can, but to a lesser degree than Roux-en-Y gastric bypass. Here is a link to an abstract of a systematic review on the subject. pubmed.ncbi.nlm.nih.gov/24091055/
Yayyy our genius has a video about my presentation title đ
Thank you đ
Thank you! SO complex. PS: some chronic parasitic infections eat our RBCs and B-12. Over several years time they cause Malabsorption, chronic fatigue, B-12 anemia. Hookworm, Babesia, and Fish Tapeworm. Case numbers exploding. Doctors do not know about this!!! And the lab tests for them are often false-negative. đđ€Ź Thanks for helping us.
Good to know. Indeed
Exactly, to bad they donât test here in the states until theyâve caused lots of damage and making tons of $ off of people and insurances. Itâs a cheap test and cheap treatment. Unfortunately they recommend we treat our animals for them at least twice a year but not humans even when we are around them on a daily basis. Not including all the other places we can be exposed to them such as restaurants, unwashed fruit ect.. it just doesnât make sense to me. Thankful we are able to get the treatment for them from a local place that was willing to get us some. One time treatment. One pill then one more 6 weeks later to treat eggs that may have not been rid of. They recommend doing this at least two times a year to be safe.
@@MariaReyes-jp4lb my sister is dying because she can no longer absorb B12. Do you know if it's possible for her to buy these pills before it's too late? Thank you.
@@ccassidy2006 many people have even taken the animal parasite med as it has the same exact ingredients and tested to be safe. She should detox once done with the treatment. Simple.
@@ccassidy2006 I am so sorry i just now saw your question. I hope she healed and still alive and better. Iâd try anything. Take ivermectin or fenbendazol (not sure of the spelling but they are anti parasitical and also detoxes heavy metals ect,) hugs â„ïžđ.
Thank you! these videos are great. very easy to understand. keep them coming please.
Sure!
Thank you so much for watching!
Okayyy. this is myy fvrt youtube channel
Thank you đ
how about other b vitamin (B1,B6,B9,B5) gets absorbed in body similar to B12 ? If someone has B12 deficiency will there be problems with other B vitamins as well ?
All the b vitamins work together, if you are b12 deficient then you need to take a b complex too.
I m new at your channel it's wonderful thanks for sharing your precious knowledge with us..
May Allah bless uh â€ïžâ€ïžâ€ïž
Thank you đ
You too!
Youâre so cool đđ«¶đ» thanks for doing these videos. You are very good at explaining and itâs fantastic what Iâm learning from your channel â€
Thank you so much!
08:17 I sense an Oasis fan... geez Dr Medicosis Perfictionalist is just Perfection!!
Who's "Oasis"?
You can work on a course to teach Professors how to really teach , Thank you Million times.
I appreciate you!
I have kidney disease 3 stage but the doctor telling me I canât eat things that have potassium I been eat spinach because I heard is good for the iron but not for my kidneys check that out now I feel weak I had to go to a health store and bring up the iron so tell me what is good that I can eat that wonât affect my kidneys đ©
Thank you for all the videos. They're extremely helpful.
Youâre very welcome đ
@@MedicosisPerfectionalis does this causes sevier back pain in waist
God bless you soo much,I appreciate all your videos and efforts,you're so brilliant and innovative in educating us....I love you. thank you.. I appreciate you â„ïžâ„ïžâ„ïžâ„ïžkeep up the good work
Thank you so much đ
I surely can't Thank you enough...
Donât mention it! Thanks for your comment!
@@MedicosisPerfectionalis I have got University exams in two weeks. With your Help and GODs Grace ill surely pass my exams.. đ
I certainly hope so...Best of luck to you! Keep in touch!
chat.whatsapp.com/FVtPrBmTgTF9KhmnwXa3fF join this for b12 deficiency
Liked and previously Subscribed.
Thank you đ
I have some questions - To which protein is cobalamin bound in the liver? Is it still transcobalamin? Is it correct that amylase cleaves cobalamin and âanimal proteinâ as it actually serves as an enyzme for carbonhydrate metabolism? Thanks a lot!
Desastroes Desolat specifyđđ€Šââïžyou keep on contradicting yourself instead of asking a question
"Thats the end of the story... morning glory" wtf dude đđ
Savage mode
So, if I am hearing you correctly; basically, I can be a vegan for eight years at a time followed by a meat fueled cheat year?
Also, Love your videos!
Fish tape worm!!!!! Yikes, and I love sushi. However, I'm still having a blast learning stuff I may never need to know. I try not to mention any of this in social settings as it tends to annoy some people. And I don't as a rule mention parasites.
Youâre right.
Any cure for pernicious anemia?
Fun fact: it's actually quite rare for a vegan to be B12 deficient these days. Plant-based milks and vegan products are now fortified with both B12 and folate
But worldwide, that's a small percentage.
â@@MedicosisPerfectionalis You are incorrect. The best source is not from animal products. b12 is made from bacteria....however the world is more sterile now. We used to get our b12 from pond water (water is now treated) and we triple wash our produce (soil )...so it's affect the general population (meat eaters and vegans). Animals are supplemented with b12 so why not get it directly and cut the middleman? go plant based
Do you have evidence that B12 deficiency didnât exist before we sterilized the water?
D Ou is never heard that oneđ sounds made up
MedicalS
Synthetic supplementsđ·đ
Medicosis when is the best time to take B12 and can it be taken with B1 and B6 and Magnesium together?
Multivitamin tablets can contain all three...So, no problem.
Does taking cobalamin under the tongue by pass the whole process with intrinsic factor? Can it be absorbed by those who have trouble absorbing due to their intrinsic factor?
Pleas biochemestry lecturs like the hematology lecturs that is very helpful thhanks budy
Sure! Stay tuned!
We know ,what lovely doctor...
We want u to do CVS videos...what do u think
Will do all topics one day...Thatâs my dream!
What is the cause of low transcobalin? How would you treat this?
you are the best!!
Thank you so much đ
Thanks so much for this incredible explanation with drawings! I really enjoyed it.
My pleasure...Welcome to the channel :)
Allways You are the best. đđđđđđđđđđđđđđđ thank You very much for this great thing.. go a headđčđč
Thank you đ
The thanks is for you đ
Youâre very welcome đ
this only discusses very drastic symptoms. what about subtle symptoms like high triglycerides, higher homocysteine and slow memory loss, in cases where b12 remains low in spite of oral supplements.....
thanks alot doctor you always make it clearđâđ
Youâre always welcome...Thanks for taking time to leave this nice comment!
YOU SHOULD BE INFORMING PEOPLE THIS CAN BE CAUSED BY FLUOROQUINOLONE TOXICITY.
What is âthisâ referring to?
@@MedicosisPerfectionalis Thousands of people including myself are being crippled by cipro and levaquin/levafloxin antibiotics -the most prescribed antibiotic on the market And I guarantee you there are hundreds of thousands of people out there that donât even know why theyâre so ill and so many that have been missed diagnosed because of this poison. One of the things that it does is completely destroys your gut flora and youâre unable to absorb any nutrients -The B vitamins are just one of the many vitamins in which the body becomes deficient. Many people do not have symptoms from taking these antibiotics but itâs a cumulative affect.
What if someone has a MTHFR mutation and can't utilize the standard form of B12? Is it true that only methyl b12 is effective?
Itâs my understanding that people with the MTHFR mutation shouldnât take folic acid supplements
Great question! Yes. I have been recently injecting methycobalamin and feel so much better. My GP kept saying that my b12 levels were too high in my blood work and to stop taking it but I was barely taking any supplemental form at all so it clearly didnât make any sense. Then I learned that high b12 levels in the blood can actually indicate a deficiency. I was having severe heart palpitations and horrific anxiety amongst other odd symptoms. I am homozygous for two MTHFR mutations and decided to do my own research. Since doing my intramuscular injections I feel like a different person so itâs clear that I was in fact deficient and my GP was very wrong. Also Viatmin K2 and a very low dose of Lithium Orotate will help the absorption of B12 a lot. Hope this helps a little đ
Peaka01 Absolutely correct! Methylfolate is the correct form for us mutants đ
It can cause anxiety however.. so in my experience it is best to start very slowly and work up to a comfortable level. đ
Panda1122 A I've read several medical journals regarding high b12 levels and the conclusion was that it was not getting metabolized due to the mutation.
Aimee Murphy Thanks Aimee. Yes exactly. Itâs scary that so many Drs are still unaware of this. Thanks đ
Great work sirđ thank you so much :)
Most welcome đ
my god.... Every commercial is from headspace... and its making me lose my mind...
can explain why fetal neural tube defect occur in vitamin b12 deficiency?
Thank you stomach
Yes
you are just good
Thank you đ
What b12 dose do you recomend for maintnece as a vegan?injectable..
Regards
So i watched more than 25 lectures of this playlist only todayđątomorrow is my exam
I wish you success!
I enjoyed this I have a B12 deficiency, ..will check out the , macrocytic
I wish you the best of luck
Help me to get rid of neurological problem and eye blurness if yours is fixed ?
I am a vegan who is making sure I get enough B12; but my meat-eating grandfather supposedly died of pernicious anemia. Is it possible to die *from* pernicious anemia? Or is it really death from *complications* of pernicious anemia?
meat contains heme iron which is bad..
Pernicious anaemia itself means that a person can't absorb b12 from food and supplement, they survive only on b12 injections.
according to some studies, b12 stores deplete after 6 months.
Hi iam facing more problems due to b12 deficiency dizziness pins numbness etc I am taking pills of b12 since last 8month but I am not feeling well what to do
Perfect*__*
Thank you very much đž
My pleasure đ
Sir I m getting ur all points i wants to remember these all like a story in mind but I don't know how to make it possible
Thanks Dr Mcdreamy!
Haha đ
Very Interesting, thank you,
My pleasure đ
brilliant as usual
Thanks đ
Why folate should not be given in b12 defciency kindly explain
Bcoz it interferes with neurological symptoms improvement, which is due to b12 deficiency. After loading doses of b12, then folic acid should be given, meaning first b12 levels should be raised . After loading we have to take folate as well, because both work together to make red blood cells along with iron. Also folate helps in processing b12.
Nice explanation ,Thanks
My pleasure đ
I got some lad work itâs showing my b12 is 377 and in the ranges says ppl with 400 less experienced symptoms. I been loosing hair my hand and feet get numb and cold , I have Poor circulation what should I do
are you vegan?
You should start supplementing according to your symptoms. If you are vegan, then you have to either change diet or take supplement, if you are taking non veg frequently, still symptoms, then you have difficulties in absorbing b12 from food , in that case you need injections. Serum b12 tests are not reliable. We should always look for symptoms and try to treat them. It's true some people feel symptoms even in 400 level and some don't even in 200 range. The only way is supplementing and seeing whether you feel better, this is what I did. I am on b12 injections. Along with this you also need to take folate in order to process b12, they both work together.
I love your videos! Just too funny! :)
Thanks a million! đđ
You are doing such a great job. Your videos made it so easy for me to understand everything. Thankyou :)
Awesome đ
Please share!
Just found your video, great! 3 years ago I had bleeding due to ulcers, due to H pylori, from there they told me I had pernicious anemia, I suppose to get B12 shots every month for life, however my anemia improved, the Dr. said I donât need shots, now my B12 is borderline and I do not have anemia, why does this happen?
Some people can not digest b12 from our foods.
Doctor b12 also helps in lumbar canal stenosis??
Thanks for your brief videos. What is the solution. Please I need reply if uiu have time or is it in your previous video.
Solution of what?
I mean food or medicine for this vitamin in your body thanks.
I had no idea what you said but I tried to agree with itđđđđđđ
I think giving only folate in case of B12 can actually cause some permanent neurological damage
elaborate?
Vitamin b12 deficiency with mthfr mutation in severe villi atrophy due to a refractory celiac disease ? Is b12 absorbed in the distal ileum ?
you're the best thanks a lot
My pleasure đ
Hello đ thank you very very much for your efforts đ·đ·
But i have two questions one is amylase for carbs digestion ? But u said it help to dissociate B12 from protein ? Is this mean amylase has two functions ???
The other question is normal flora in our intestine also synthesized B12 true ! ? If the person is strict vegan B12 not become zero ?? And donât reach to severe state ??
Can you clarify this to me ??
And again thank you đ
Answer to:
Q1: yes, amylase has more than one function.
Q2: just because itâs in your gut, doesnât necessarily mean that you will absorb it in sufficient amounts (i.e. the concept of bioavailability).
Instead of looking into theories, look into the statistical scientific studies of patients with B12 deficiency, a huge percentage of them are strict vegans.
Hope it helps!
Good luck!
Medicosis Perfectionalis
Ooh thank you I understand now
Iâm not vegan but i know that intestinal flora made it so i think đ€ the body can get B12 from it
Colorfully explained woowwwww ..thank you so muchđ
Thanks, dear :)
Thank you
You're welcome đ
OMG, now I'm even more wondering about B12 def. Thanks for explanation. Been on Nexium for 15 years, had right hemicolectomy/appendectomy 7 years ago (gigantic tumor). Having very bad neuropathy-like symptoms in arms/appendages for months now (much more history than that) which is about unbearable.
4 years ago I was diagnosed with PERNICIOUS ANEMIA and I have tried everything I could to heal myself, but it was all to no avail, until I saw a post on a health forum about an herbalist preparing herbal medicines to cure everything type of diseases. including PERNICIOUS ANEMIA , at first I doubted it was real, but decided to give it a try, when I contacted this herbalist through his email and he prepared me a herbal cure for PERNICIOUS ANEMIA and sent it to me via the delivery service of UPS from the company, when I received this herbal cure. , gave me step by step instructions on how to apply it, when I applied it according to the instructions I was totally cured of this deadly disease within 2 months of use, I am now PERNICIOUS ANEMIA free, all thanks to Dr. Joshua Ighalo. You can also contact this great herbalist for help by email: drjoshua.ighalo@gmail.com or contact Dr. through his whats-app: +2349057958723 They also specialize in the treatment of all kinds of diseases, VIRUS HERPES , HEPATITIS B, CANCER, BRAIN DISEASE, INFERTILITY, DIABETES AND MORE.
Did you find relief. Similar situation. ONE injection of B12 along with supplements of folic acid, vitaminD and magnesium has me feeling so much better!!
@@CMcKay-82 My onc/hemo said sublingual tablets would be good enough. Not sure any of it has helped me much, even higher dosages (she suggested rather low dose). I always wonder if it's better to have a shot than just a tablet.
Thank you sir
I am facing very related symptoms of vitamin b12 deficiency. I am purely vegan even no eggs. How to overcome deficiency in that case?
Iâm no doctor, but I did watch the video. It seems you have to eat animals and eggs
greatt video
what's the underlying path of glossitis and lemon yellow skin?
Good question, tell us if you looked it up :)
B12 comes from soil or dirt which is then transfered to plants which is then transfered to animals.
Animals are just a middleman
Animals are supplemented b12, they don't get it naturally from dirt.
@@eazyrat They do.
Same with the protein.
It's harder nowadays because of the pesticides and everything else that's being used on fruits and vegetables.
Numerous studies showed it to be true.
Explaination is good
Which writer book of medicine do you prefer for making the video's?
Harrisonâs, Davidsonâs, Goldman-Cecil and Goljan.
Thank you
Why does amylase break up the Protein?
Hi thank you for this video. I am not in the medical profession and I am getting in touch because I keep getting elevated vitamin b in my blood results even when I am not taking vitamin tablets. It keeps coming up as abnormal on my blood test results but my healthcare professional does not explain why. I heard you can still have a vitamin b definitely with elevated vit b in blood. Could you help at all? Could the elevated vitamin b in blood mean I am not processing it correctly? Thank you so much.
Best bit is when he said the strict vegan alcoholic ate sushi.
If you are deficient in vitamin b6 and you have gut issues can it lead to b12 deficiency ????
Coming here bc I have a vb12 deficiency, not only that but iron deficiency as wellđ been struggling with the iron deficiency for years tho. And i eat meat from time to time and have no physical illnesses lol