Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment

Aplastic Anemia - All you need to know - Definition, Causes, Symptoms, Diagnosis & Treatment. Aplastic anemia is when your bone marrow scores "F" on the final exam. It's failed.
Aplastic anemia is a Pancytopenia (anemia, leukopenia, thrombocytopenia) causing fatigue (tired all the time), infections, bleeding.
There are many causes of aplastic anemia; can be inherited or acquired.
MCV is usually increased in Aplastic Anemia.
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This is a great video my sister has a aplastic anemia and we are getting ready to start the bone marrow transplant treatment for her

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[@omerali2597]

Nice review of aplastic anemia! Just wanted to add that sometimes you can get a hypocellular MDS that looks similar to severe aplastic anemia. Usually cell morphology and cytogenetics will help you differentiate the two (hypocellular MDS you would expect more chromosomal abnormalities, aberrant megakaryocytes + megs will be small in appearance), however clinically they can look very similar. Thanks for the video!

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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Eltrombopag has been added to standard immunosupression for AA.

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Great video as always! I should note that Parvo-B19 very rarely causes Aplastic Anemia and is more often with Pure Red Cell Aplasia

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Phenytoin.... and thanks for ur time Dr.

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what do you mean about pregnency and its associateion with acquired aplastic anemia and PNH and pregnency ...please explain how this causes occur.Thank you

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You’re always welcome!

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Answer is phenytoin

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Thank you doctor. Is there any foods to supply indirect medicine for the pancytopania??

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It depends on the cause. Unless you treat the underlying cause, it’s not going away.

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So it is low WBC and when blood is diagnosed they should show low in number. But again person can show leukemia. In other words, what will the WBC count be in acute myeloid leukemia and pancytopenia?

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Glad you enjoyed it!

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what about using Eltrombopag to stimulate platelet precursors and bone marrow stem cells to grow?

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Fetal anomaly caused by phenytoin is Fetal Hydantoin Syndrome
And Lithium causes Ebstein's anomaly (atrialisation of ventricles)

[@m2ym2y99]

@Medicosis Perfectionalis I had VSAA but was too old for transplant. Am in remission but still lacking stamina after 3 years. Is there a reason my oncologist didn't want me to take a vitamin B supplement after hATG, while taking Cyclosporine (Sandimmune) and Promacta? Every time I asked he would tell me to wait on that.

[@mishalahsan161]

How is your condition now?

[@m2ym2y99]

@@mishalahsan161 numbers are in the good range, but bruising very easily, and still lacking stamina. Grateful to be alive, try to live life as close to "normal " as I can.

[@nairdarumani5450]

Today i have to learn aplastic anemia for my tomorrow hematology class and this video was absolutely amazing and very helpfull.
I got only one question.. I have read that the hypothesis that aplastic anemia is a state before mielodisplasic syndrome is not so strongly approved according to the new findings in the genome. I dont know how true this is but i read some good arguements

[@MedicosisPerfectionalis]

Thanks for your comment! You are absolutely welcome! As for that theory, I am not sure, to be honest!

[@alshbah.e320]

What abour a megaloblastic anemia does has pancytopenia?!

[@zahrataky8511]

What if he is 12 and most symptoms match except for the count of retics is normal,no stains,nothing on nails and no white hair . ?

[@hdey8653]

11 years a go when I was 10,I was diagnosed with aplastic anemia, Now,no sign of it,but it has brought PNH

[@venukasharma1991]

please clear one of my queries not related to this video ....i.e why are neutrophils high in pregnancy state

[@MedicosisPerfectionalis]

Pregnancy is a physiological “stress” state.

[@gamerberry2451]

Good day Sir, so I have a speculation as well as to why MCV is high is aplastic anemia.I’d love to know your thoughts.
If MCV= Hematocrit(ht)/[RBC]
This would mean that a decrease in [RBC] or increase in Ht should give high values of MCV right?
We also know that in aplastic anemia, while Ht might remain the same (since all the other hématopoïetic cells are also affected), [RBC] is definitely low, hence giving high MCV values.
Just a speculation, please correct me if I’m wrong😊.Thank you.

[@gerryadams2212]

MCV is also calculated via forward light scatter in flow cytometry. This gives each cell a direct reading of size

[@mohamedamineyaich6250]

Do any of the pathologies we've seen so far affect lymphoid cells? Thanks for everything :D

[@mohamedamineyaich6250]

@Ragnar Lothbrook thanks :D

[@sujanbhattarai3698]

How about MCHC ? Is this high or low?

[@yamitsh95]

The Answer for the Question at 18:53 is Phenytoin, a Sodium channel blocker.

[@dominicaibanylla200]

How can we differentiate between the clinical presentation of megaloblastic anaemia and aplastic anaemia when both have pancytopenianin common????????

[@MedicosisPerfectionalis]

Clinical presentation will be the same.
If there’s vitamin B12 deficiency, you might find neurological problems.
The difference is on the bone marrow biopsy.

[@dominicaibanylla200]

@@MedicosisPerfectionalis I still watch your epic series since my 2nd yearMBBS 🥺 so grateful to learn from a great doc like you 🤗

[@tj7683]

Answer- Phenytoin

[@analuisamartinez4597]

I was diagnosed with aplastic anemia with low rbc, low hgb, low hct, high MCV, but high reticulocytes, if bone marrow is not producing enough cells, why is reticulocyte count higher than normal? (Bone marrow cellularity is at 5-10%)

[@mustafacabdisalaan7306]

may b u had MDS[myelodysplastic syndrome has all you listed including hypercellular bone marrow]

[@elijahokoronkwo8610]

Could be relative reticulocyte count cuz its a percentage of whole blood. If it decreaces less than hct decreases then it’ll appear to increase. Theres a formula to get the adjusted retiuclocyte count in his earlier videos

[@michellebierman5]

I'm thinking I was diagnosed wrong. They said I had leukemia but it came back. But I was on nefdipine, And ani seizure meds for migraines. I was also diagnosed with thrombocytopenia, Meloydysplastic anemia. When they would give me iron transfusion my platelets would drop so low that I would need a platelets transfusion. Just didn't make sense to me. Please if anyone as an insight to what is happening. Please let me know because I have a appointment with a new oncologist/hemotologist next week.