B12 Shots Not Working? Here's Why
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- čas přidán 11. 05. 2018
- Looking for reasons your b12 shots not working? Here I discuss common reasons that your b12 shots don't give you the desired effects. I discuss type of b12 for best results, the amount needed, and more. Find out why your b12 shots not working.
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Check out my book that goes into details vitamin B12 levels, deficiency, labs and more:
"Don't B12 Deficient" amzn.to/35TQBWt
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Thank you for this very informative video. I was prescribed Hydroxocobalamin injections. Is this type ok?
Yes this one will work good especially if you have more inflammation. Mainly just want to avoid cyano-B12
I appreciate that you listrd the anemia as a later symptom. I'm dealing with neuopathy and cognition problems but perfect red blood cells. Adequate folate seems to compensate for lacking cobalamin.
To some degree it might but your body needs both. My other videos on methylation might be useful
Does calf pain(RLS) one of the reasons for the lack of b12? Mine is very low.
Ive read many comments even though this is an old.post i wanted to say that i have severe palpitations, fatigue, nausea and more when i take B12 (methylcobalamin) its due to B12 depleting potassium which many dont realize can happen. Also, my B1 was getting low which causes potassium wasting already. Vitamin D also depletes potassium. I had my thyroid removed last Sept so im learning things i never knew before. Scary to realize that many doctors dont have this info either. Theyll just say "thats weird, i have nonidea." Lol Good luck everyone.
Video starts at 3:21
What can be added for the added benefit of weightloss?
I have had b12 deficiency for the last year the first 2 times they put me on ferrous sulphate and that seemed to work but this time they decided on the injections my level was 104 I have had 6 shots. The first 2 I felt great could see a difference then after that I feel exhausted again. Its really effecting my mood and my lifestyle I feel so down because I feel I don't have much of a life with the exhaustion and horrible low mood and feeling irritable. The injections are just not working. Im so exhausted. I'm going to request a full blood count to see what my thyroid and vitamin d levels are like because I have had issues with my vitamin d in the past and also have been borderline thyroid last year aswell which sorted its self out but maybe its full blown now.😩 sorry for the big paragraph.
ferrous sulfate is iron. There are different kinds of b12 so check out my videos n that.
Hello, how are you doing now ? Did you recover ? Cuz I have the same issue, first shot worked and then nothing
Maybe you just need higher doses.
Tell them to check your testosterone level I could be the problem
Try strong b complex may be u r deficient in b2 and b9 some cases of b12 depletion accompanied by b2 and b9 due to over active mtr gene or may be better to get a multivitamin with alot of be complex
Thank you for this video. I’ve had two vitamin B12 injections recently and ended up feeling extremely fatigued for almost 24 hours afterwards, had a headache, very mild nausea, and mild dizziness. My doctor used the methycobalamin B12 and gave me 2.5mL each time. My blood work shows my B12 is mid range. I have two heterozygous MTHFR mutations and I’m wondering if this could be the cause of the side effects. I know they headaches, dizziness, and nausea are listed as side effects but I can’t find anything stating that fatigue is a side effect of B12 injections. I had a B12 injection about 4 years ago and had the same side effects then.
Hi Debra, yeah I have had patients feel fatigued from methylB12 as well. I think that is from inflammation (this is a theory) and that you may do better from adenosylB12 or maybe much small doses of the Methylb12.
I have fatigue also from the 12 especially injections
This guy doesn’t know what the root of the problem is. I’m just a truck driver that loves someone enough to research and solve this ugly problem.
My daughter is prescribed hydroxy b12 shots since her genetic tests says she can’t tolerate methyl b12 or methyl folate . So we do hydroxy b12 with folinic acid . I learn from ur video that neurological symptoms take time and I am willing to give it that time. The prob is she is having lot of mood swings / meltdowns that makes it difficult to stick to it . Can u pls suggest anything to combat that ?
A couple clarifying question, do her genetic tests show she cannot tolerate methylb12? I am not aware of any SNP's (genetic alterations) that would show this (or methylfolate intolerance). Do the injections seem to be causing the mood swings or are you using this injections to help the mood? Sounds like the former but just want to be sure.
It will definitely be the folinic acid causing the mood swings. I have mthfr gene mutations and I do not methylate any type of folate supplement, including methylated types. Just take the b12 by itself because it helps the body absorb b9 from food sources as b12 and b9 work together.
Ive been looking for information on the synergistic b12 folate connection. Wondering if the high levels in fortified foods could cause that lowering of B12 over time
High folic acid in food would cause low b12? Don’t see how
I’ve had 6 shots hydoxycobalamin in feb after 6th shot felt poorly as I have fibromyalgia my fatigue now is worse and I have burning tingling and numbness in hands and feet palpitations and shakes. Everything is worse’s and my now clear skin has acne. This happened two years ago on the fifth injection they gave me and stopped the last injection then they gave me just one injection last year in this time they have never rechecked my levels and never told me what my levels are. I’ve been back to the doctors and they just said you should feel well and no explanation just that I will feel better on the next injection in May. It just seems to me that most doctors think that one size fits all. I asked if I could have the adenocobalamin shots instead but was just told that’s not on our list should I insist that they check my levels before I agree to the next shot.
Did you take folic acid with it? It's a cofactor to enable it to work.
Buy 800mcg folinic acid. Avoid folic acid (just my advice). Methylfolate can give some people anxiety. Also with injections you’ll need electrolytes, plenty of potassium, and a reasonable b complex minus the b12 and b9.
Do you know the best place to get meth type b12 , I found some that comes England comes powder in a small bottle and youadx 10ml of sterile saline and I'm not sure how much to inject and they say do a shot every day for 3 month because they say you'll have all new loaded b12 red blood cells and after that test to see jow often you need a shot.
Compounding pharmacy make it.
@@swintegrative thanks for your reply , I'll check them out .
I had borderline low B12 levels and was doing weekly B12 injections and they were helping a lot but I developed numbness in my hands. I went through expensive carpal tunnel testing and my medical team was shocked that I did not have carpal tunnel. I discontinued the shots based on some googling of symptoms and the numbness went away. My doctor and neurologist "never heard of that" and said they didn't know what to tell me. I am bummed out because it did work and now I am back to feeling crummy.
Which form of B12 was you injecting?
@@mgwalker77 doctor never told me. I didn't know there were different kinds at the time.
@@spiderling88 Ah OK. Which country you are in is often a factor as to which is most commonly used.
@@spiderling88 I hope you can try a different form of B12 and you have some luck with that. I have heard that methylcobalamin and hydroxocobalamin are the best forms.
Maybe take smaller doses more regularly?
I have had serious fatigue while taking Wegovy- my endo gave me an RX for b12 (CY) injectable (1000 every other week). From what I have read, I should have noticed some improvement within 72 hours. I’m at 72 hours today and there is no improvement at all. Is the 72 hours an unrealistic expectation on my part? I work in mental health and this fatigue is making it extremely hard to get through my patient load (even with long naps)
Not many people experience fatigue from B12, but it can happen.
When you do, yes 72 hrs is reasonable. You may respond better to a different kind of B12.
I get so sleepy in the afternoon too. I have been taking Sleep3. Which contains Melatonin... it makes me sleepy in the afternoon too -- I think.
Is there any reason why the energy and mood improvements of b12 injections seem to only last 1-3 weeks and then go away despite continuing injections? If I stop daily injections for like 2 years and try again then I get the same initial energy and mood improvements temporarily but of course vanish after 1-3 weeks. It’s like building up a tolerance. I’ve tried even really high doses like 50000mcg per day (methylcobalamin subcutaneous injections).
I think that just means you are no longer deficient. You get the boost in energy and mood bc the levels are low and things are, suddenly, working better in the presence of more B12. When it’s already normal there is nothing for the b12 to improve.
@@swintegrative Sorry, what I meant was the improvements in energy, etc are temporary and then revert back to what they were prior to b12 injections, it feels as if I never had b12 injections. Every physician (internists and psychiatrists) I’ve brought this up to had no explanation for it. They all just try to push me to psych meds for fatigue and attention problems (ADHD meds didn’t work, nor did antidepressants). What kind of doctors generally know about this sort of stuff like methylation, b12, methyl folate, food, amino acids and how all this stuff works together and may impact symptoms?
@@martinlutherkingjr.5582 Maybe you could see a functional doctor.
In November I was diagnosed with low B12 (blood level 115) and was given three injections of 1000mcg for three weeks and then two injections of 5000mcg every two weeks for the past 4 weeks of methylcobalamin...haven't noticed any difference in anything, but especially not fatigue - is this common? I appreciate your realistic approach to the process.
Hi Jane, not noticing any improvement in energy is a bit unusual . If everything was perfectly fine and you only had b12 deficiency then it would be but we don't know this. The fact that you do not have more energy suggests there is another problem. There are many possibilities but I would be curious about iron and digestion. Do you ever get energy form the b12 sot even for like 1-2 days? Also the serum b12 test is not the best and you have to be off all b vitamins when you test for a few days at least, methyl malonic acid is better test.
@@swintegrative Iron levels were good. No noticeable improvement in any symptoms, no energy increase. The only thing noted after the 5th shot was that I slept for 6hrs straight one night, instead of 2 hour intervals. I was actually thinking low stomach acid and/or low intrinsic factor. (I'm a Holistic Nutritionist). I wonder if I can seek out that methyl melonic test. Thank you for the ideas.
Sounds like your levels were low for a while so I would continue with the b12 injections and blood testing. The Methylmalonic acid is a blood test that your doctor can run.
I know this is an older thred, but was your Ferritin level checked, or just a CBC? You could be iron deficient, but not anemic. Just throwing that out there. Folate goes along with b-12, so if it wasn’t checked I would do so.
@@nancynelson242 Iron levels were checked and great - not iron anemia, its B12 anemia (different shape to the red blood cells). Folate was not checked but will be in follow up next month.
The nurse I have said that you need to have high levels of vit D in your system and to take magnesium as well to help absorption especially while on the loading course of shots.
Hi, do u have more info about this? Maybe a study or something?
@@missz339 I don't have one. As I said it's what my nurse said.
I took 4 shots of vitamin b 12 but not working.. my hair shedding and wrinkling on my face 😢.... when i can see improvement
I don’t know if I have a low b12 but I started taking the shots I do 1000mcg of cyanocobalamin 2 times a week and it’s been 3 weeks and I don’t notice a difference at all.
Check out my he b12 playlist there is are video that talks about timelines and b12 deficiency
What can we do if the B12 helps many symptoms but causes impossible insomnia??
Take magnesium
My b12 was 180, I took supplements but didn’t see big improvement so I switched to injections. The questions is how often should I take them ? Thank you
That’s a very contextual question so you will need to ask your doctor. My book does go into some strategies given certain circumstances. Typically it is weekly moving to monthly or as needed.
How are u now ?
Hi doctor. I was diagnosed with GERD 2 months ago. And from last month I was feeling extreme fatigue, and got my B12 levels checked. It was 158. I was then recommended to take 1 dose each week for 4 weeks. The first two shots worked, but again I started to feel the same symptoms.(fatigue, lightheaded). What should I do now? Please help doc
Find a strong b complex some times b12 is accompanied by b9 and b2 deficiency
Hi I would really like to know your recommendation if I need to insist on getting B12 shots more frequently. I get two injections of 1000mcg each every week for 1 month. I had 300 of vitamin B12 in the blood. I was vegetarian for 10 years. First I lost 70% of my hair in 6 momths(thats was the first symptom). The dermatologist thought it was stress related(Telogen effluvium)🤦🏻♂️. Then came joint paints,back pains,muscle pains,really bad insomnia,weird smooth white coating on the tongue,memory problems, vision problems stabs pains in hand, cold hands and feet,weight loss and my nails turned very pale and white. Then came fatigue. I did lab test on october and I wasn’t anemic. I started this week with 2 shots and felt improvement but neurological symptoms still didn’t improve and I’m afraid I’ll have irreversible damage(I’m 26 years old🙁). Do I need to insist to get b12 three times a week or more? or keep with two times per week? I have also mild iron deficiency but I was taking iron pills 2 times a day for the past two months. Thank you!!
Hi El 10, I think it is important to not assume all of these symptoms are from B12 deficiency. While they could be from this, there are plenty of people that are vegan for longer and don't have such severe health problems/symptoms. Since you are early on in the treatment you won't know until you continue w treatment for several more weeks or months. To your question, I think it would not do any harm for the first couple weeks but after this I don't think it will add much benefit either. If you do this you would want to ensure they are spread out evenly so as to get the most benefit.
Southwest Integrative Medicine Thank you for the quick reply :). I did so many tests besides the complete blood test-for STIs, H. pylori, zinc, vitamin D, stool tests for parasites, tongue cultures for candida- everything came back normal/negative except low iron and low B12. So its reasonable that everything is related to this. what seems odd to me is that I’ve been taking methylcobalamine sublingually for a month and it didn’t improve anything. My Dr told me I need higher dosage and that only about 1-2% of the pill is getting absorbed. Ok, I’ll make sure that the shots are spread out evenly. I really hope symptoms will clear out soon but anyway I’ll stick to the therapy.
Ok sounds good.
@@E10l hi even I suffering with b12 deficiency and the same symptoms you mentioned.. How are you doing now is your nerve problem cured and are you still taking b12 shots plz reply so that I can be confident about this b12 problem.
@EL10 hi even I suffering with b12 deficiency and the same symptoms you mentioned.. How are you doing now is your nerve problem cured and are you still taking b12 shots plz reply so that I can be confident about this b12 problem.
Thanks a lot for this informative video! I am pescetarian and I got my levels tested in September and had a level of 150. Then I got 3-4 weekly injections and then monthly injections for the next 3 months. My mood improved a lot which was great. I stopped injections in January and ate more fish and eggs and stuff. I did feel more irritable again and got another test this week and tested 136, so even lower before the treatment started. I tested for pernicious anemia and all my blood values were find. What could explain that further drop in my B12 levels?
Not 100 but likely the higher b12 (during the injections) stimulated increased cell division which uses B12. You obviously need a lot more B12.
Your body is unable to produce the intrinsic factor enzyme. Anywhere below 500 should be considered deficient. In Japan doctors like the levels around 1200. When they added the minerals to “enriched “ flour. It was mandated because it will stop the intrinsic factor enzyme. It’s all part of their plan. Medical problems create income for them.
Stick to a daily injection for 7 days. Then 2 per week for a month. Then once a week for life.
@@rogerthat6221 are daily injections of 1000microg fine ?
B12 @ 150 is life threatening low
My doctor can only give cyano is it still going to work .. my b12 was only 58 two months ago
Yes this will still work just fine for most people.
People take B12 for weightloss? Far out. My worsening & undertreated deficiency has caused 16kgs weightloss in a year (I was a normal weight to start with, now I'm a bordering on emaciated). My expectation was that adequate treatment would make me gain.
Can high levels of b12 ( not getting into the cell) cause dizziness?
Hi Jrod There are many different causes of dizziness. B-12 deficiency can cause this too.
Sir, do you take Unicare health insurance?? I need a good doctor! Willing to relocate for!
No mostly private pay
@@swintegrative soon that may be a possibility. Will definitely keep you in mind.
I got b12 shot and i noticed pink urine .....adenoclobin 2mg.....is that mean that am not absorbing??
Typically "absorb" refers to intestinal absorption but I take this question to mean absorption into the cell. The answer is no, pink urine does not mean this. The only way to verify this is through blood tests but smaller doses probably would not have the same effect.
Do B shots contain mercury &/or other heavy metals?? I've looked online. Can not find.
Nor does my doc ever have the insert available.
No mercury. cyanocobalamin has cyanide
😳🙄
Thank you for your replies. Much appreciated.🙏🔥😘
Get methylcobalamin no cyanide…
I get it with no preservatives and it is made from a sterile compounding pharmacy. I had to call around ( 4) I’m in CT and my source is here. I said I was identifying as someone with Autism. I want nothing in the shot but the methylcobalamin. Hope this helps you. I just started on this journey, good luck to you.
What is the B12 absorption issues video titled?
i don't think I have any on b12 absorption issues. Did you mean high B12? If you go to the playlists on B12 you might find what you are looking for czcams.com/video/o1Hmkl9Bf-U/video.html
Hi, is methylfolate better than folic acid?? I am taking weekly injections of methylcobalamin along with folic acid supplement.
Before starting treatment for b12, my hb was 12.4 , after 2 months when I checked, it is now 11.but my symptoms are better after weekly injections. Still fatigue is there.
For some people methylfolate is better. Check out videos on methylation and methylfolate.
Folate is B6. No it masks the symptoms and it effects your ability to absorb due to stopping the intrinsic factor enzyme which is needed to protect the B12 through your stomach acids. Enriched flour did the world in on this. And it was all part of the plan.
Yes, methylfolate is readily absorbed by the body. Folic acid is not natural. If you have mthfr start off on folate in very small amounts. I had to break tablets in pieces and gradually move it up each week. A telltale sign youre overmethylating is the overwhelming feeling of irritation and sometimes rage. Back off, listen to your body and try again in a couple weeks with a much lower dose.
My 6th shot it doesn't help only my eyesight is much better now still feeling tired my feet still hurt and my tongue too and Iam vegetarian 15 years now
Can sleep be improved with the b12 shots?
Yes sometimes
Is subcoutaneous as effective as IM?
Yes
Hey ,im 17 & healthy boy
Mine VITAMIN B12 is 193 pg/ml , from 2 months im having issue of memory loss & difficulty in thinking , concentrating & processing information,Brain fog, depression before that i was super sharp .. Some thing that i did was for 4 months i didnt get sunlight + Social isolation(not completely but some) + i had some depression in last year...
What can be the reason ? Pls reply , im going through very bad now🙏
Reasons for low b12 are likely from.. not enough in diet or poor absorption.
@@swintegrative Ohk Thanka
Saying a prayer that you'll feel better soon❤
@@SamaQu I am almost recovered.
Thanks a lot for this
It takes up to 4-6 months to fix a deficiency of b12
What about hydroxocolbalamin?
What about it? See other video on best b12 for you. Hydroxy is fine though
For energy
I'm low B12 and deficient in folate. Would B12 Injections help me or do I just continue with folic acid tablets?
I have a host of symptoms, dizziness has calmed down with the tablets but I'm just so fatigued all day even with a healthy diet and daily walks.
EDIT - also I did have a methylcobamin injection once in the arm a long time ago but the burning when the fluid went in I thought my arm was going to drop off and the pain didn't go away for a hour.
I can't give you medical advice but when a blood level of b12 is low most people will feel better when that level increases.
I don’t like it , I got 6 out of 12 , only the first 2 ! I felt great , b12 lipo tropic injections, I now notice my inner lower leg has a tender area now ,, weird ,, never had it before,,
No weight loss
Energy only went up 48hrs after 2 shots after that nothing
I was not deficient prior , had blood work 3 weeks prior
Injection 1 time a week
They can give the other 6 away , I’m done
Hi The SensualGuru, sorry to hear that.
b12 shot gave me more fatigue anxiety headaches and fatigue.
That's interesting. Do you know if it was cyanocobalamin or methylcobalamin?
@@swintegrative I'm not too sure which one it was but this is the second time taking a b12 shot and had the same response.
Sam I think this would be the first thing to figure out as well as wether or not there was anything other than B12 in the shot. If you are getting these symptoms from pure methylcobalmin I would suspect issues with detoxification and methylation. Sounds like you may be sensitive to methyl-donors too. I would have to do some labs to get a deeper understanding. I know that is not too specific but this is not a common symptom for B12. It should give some direction to do in at least.
@@swintegrative could it be that i am weaning off of clonazapam and my nervous system is sensitive?
That very well could be and the B12 is just making it worse. However there are some instance where B12 would make this situation better but it really does depend on what all was in the injection. Check out this article I wrote on Benzodiazepine (class of drug for clonazepam). It may help. www.swintegrativemedicine.com/blog/bid/150441/the-dangers-of-xanax-and-other-benzodiazepines.
So you’re saying, B12 deficiency is related to iron deficiency
No it’s usually not directly related. That’s older video so not sure what you are referring to.
@@swintegrative can u link that video please
@@douggrant3431 sorry not sure what you are asking for.. this video is an older one is what I meant so im not sure where you get that b12 deficiency is related to iron deficiency.
Is it common for your tongue to be sore
Hi Mandy, no my tongue is not sore... ha. JK I don't think B12 deficiency causes sore tongue, if that is your question.
@@swintegrative my doctor seems to think it is?
I think of riboflavin as a cause for this more than b12. I don't think there is consensus but b12 may help in some cases.
@@swintegrative thank you
i've read b12 deficiency can lead to smooth tongue where the papillae regress and you lose taste acuity
If you are not vegan and your serum level is below 200 injections are life long to stop permanent nerve damaged due to malabsorption issues or pernicious Anaemia . B12 needs folate Levels to be optimal to heal at cell level . Need optimal ferritin also most low b 12 are low D
What are your sources ?
This is an older video but I believe these were based mostly on clinical experience. Is there one in particular that you are curious about?
@@swintegrative i wanted to know if it is effective if you have a certain amount of B12 shots, would it be effective ? Because i know that if you only take 1 or 2 shots, it will not be effective. You have to take multiple shots to be normally effective but I don’t know how much shots you have to take. In French we say: il faut prendre une cure pour que cela fasse efffet. But I don’t know how to say it in English.
Could you confirm that what I say is correct ?
@@andreasrossier5244 Yes I can confirm that some people require more than one shot to notice it. I tell people they should notice it after the third shot (if they have not yet).
@@swintegrative but one shot is not effective isn’t it ? They should have more ? My wife is a nurse and told me that people who need B12 shots, should have always more then just once. One time shot has 0 effect. It’s like 4 shots normally. In Switzerland it’s minimum 4 shots
@@andreasrossier5244 it really depends on the goal. If your levels are really low, you may need more than 4 shots and you may need to continue doing it for life bc you don't absorb from food. Some maybe just take it bc they feel better but levels look ok in blood. In this case they may do one shot and 3 mo later do another one. It's not black and white. I guess it may be worth doing a separate video on it bc there are all kinds of things that influence the decision on how many shots to do. I think what you are asking is if you are low how many shots you need. In that case, you probably need 4 shots minimum if you are not taking anything by mouth.
There’s always the opposition
You have to be deficient for them to do anything.
Where I live there’s only cyano
That’s too bad maybe your doctor can order and have it shipped to you.
@@swintegrative they said cyano is fine it’s what we can get And only going to get once a week do you think that’s enough to help me when my level was only 58 in july
@@tinyty6570 how are you now ?
Not at all, buddy.😭🤣😘
Sorry. Finding this video hard to track. This guy is all over the map. Lots of ‘uhs’ & ‘ums’. Gods info, poor presentation.
I took 4 shots of vitamin b 12 but not working.. my hair shedding and wrinkling on my face 😢.... when i can see improvement
I took 4 shots of vitamin b 12 but not working.. my hair shedding and wrinkling on my face 😢.... when i can see improvement
Sorry to hear that. Don't think it will help with wrinkles. If you are using it for hair it takes 3-4 mo.
@@swintegrative my vitamin b 12 is 187 .. its because of vitamin b 12 my hair is falling or another reason ? And skin wrinkles