Can Psilocybin Treat Depression?
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- čas přidán 14. 05. 2024
- Research suggests psilocybin may have effects therapeutic for depression. In this episode, we discuss some of the neurological origins of the hallmark hallucinatory effects, how the research is conducted and what a clinical session looks like, and some of the qualities of the psychedelic experience that most lend psilocybin to be potentially therapeutically beneficial for depression.
There is a difference between recreational use and the clinical protocols used by researchers and clinicians. Learn more by watching the original interview with Dr. Roland Griffiths here: • Roland Griffiths, Ph.D...
Episode show notes can be found at:
www.foundmyfitness.com/episod...
CHAPTERS:
00:00:00 - Scientific milestones
00:01:00 - Why we hallucinate
00:01:31 - Treatment of mood disorders
00:01:55 - The Clinical Protocol
00:05:57 - Psilocybin vs. Antidepressant (SSRI)
00:06:39 - Changes in brain anatomy
00:08:46 - Immunomodulatory activity
This episode was fiscally sponsored through The Film Collaborative and a grant from a generous anonymous donor. www.thefilmcollaborative.org
This interview is not meant to act as a substitute for clinical diagnose or treatment of depression. - Věda a technologie
Hi, everyone! Thanks for watching the video. If you'd like to hear more from Dr. Roland Griffiths, you can listen in on the larger interview with him (now a bit dated, but still good) here:
czcams.com/video/rkBq33KWFmY/video.html
You should do a video on Human Persistent Perception Disorder. Mines more like visual snow. It can be caused from consuming things from this class of substances. Especially if using them in an irresponsible manner and not under a practitioners care. To be honest it's been complete hell since I've gotten it. Threw me for a loop. I have to live with the fact my vision will be permanently altered forever due to trying certain things. HPPD should be talked about more within the community. That way people know there is a risk out there. One way I can put it is the world looks a bit unreal especially at night. Pixilated in a sense. Enjoyed the video and I still have faith in these substances to treat mental disorders. Just highly advise people to use responsibly in a controlled environment. As well as under a practitioners care. Alot of us wish there was a cure. Whoever figures one out will be helping out alot of us .
😄
After i quit drinking 8 years ago, after 10 years of daily blackout drinking, I was suffering from the worst depression of my life and remained that way for 2 years. At the end of those 2 years i had a plan to kill myself. As a last ditch effort i decided to grow mushrooms and give them a chance at my depression as i had nothing to lose anyway.. The first time i did them i cried for hours. So much sadness poured out of me. For 3 months after that first time, i didn't want to die anymore, and i was starting to feel like myself for the first time in years. I kept taking them every few months for a while until i didn't need them anymore. I'm still alcohol free all these years later and I am living life to it's fullest and haven't felt suicidal in years now.
One trip and micro dosing weaned me off my years long use of antidepressants - huge saving of money for me for not making pharma rich by continuing buying antidepressants- so proud of you for touching this subject!!
Paul Stamet's story on how it cured his stutter is fascinating.
Yup, his Rogan episode was fascinating.
@@ralphlaguna6168 Stop projecting insecurity and fear in the comments. Sounds like you're exactly who needs this medicine to do some soul searching. Have a blissful day!
@@ralphlaguna6168 Meow.
@@ralphlaguna6168 went to jail for selling mushrooms? Tragic.
Ok. People can. Go to jail for this. Halt the science! DEA knows best. They’re not even doctors but,, stop!!! 🛑 ✋
Yes - it can!!! I micro-dosed for three months. Every 3-4 days I took a tiny amount. I’m a changed person. My depression is gone and even my family is like “You’re so happy all the time!” It was life changing. Try it!
Can you imagine the progress with this type of treatment had they not stopped the testing back in the 50s and 60s. Better late than never.
Its almost was like the drug was discovered, right at the time where we would need it as a society. As you said glad they are researching it now.
I think this video is missing one key point about mushrooms and that is: what the actual experience of healing is like on shrooms. So I will describe my experience that is pretty similar to others I have talked to. I recently tried 2 microdoses of mushrooms and it greatly helped with my anxiety and depression, quite a bit for the depression.
The experience: Basically your negative emotions come up quite strongly but now they are tagged with their origin story and the logical resolution to them. Everytime I had massive anxiety on mushrooms along with that feeling would come the reason it is there and that there is no longer a reason to carry it around. You also get something very similar from years of therapy. Mushrooms basically know all of your bullshit, puts it front and center for you to see and then gives you permission to let it go. Shrooms condense therapy down into a single intense therapy session. I went through 1.5 years of therapy and got a lot out of it but depression and anxiety creeped in. I also think allowing your brain to rewire itself during these trips is what makes it so lasting. Therapy can take months or years to rewire your brain and there are so many opportunities to fall off of the wagon so to speak.
I take mushrooms about every 4-5 months when I feel depression coming on. I have found that especially during the winter months they help a lot when it comes to seasonal depression. I also supplement heavily with vitamin D.
Imagine a society where they want to cure people instead of drugging them with severely addictive and harmful pharma medicine.
That's how the world SHOULD be
@@jcbanbury Agree 100%
I felt relaxed on mushrooms. I felt so relaxed I tried to give myself a panic attack, which I'd normally feel throughout the course of my average day, and I couldn't trigger any unease. I never felt so comfortable existing. I yawned, and went comfortably to sleep.
In 2008 I used magic mushrooms every weekend for about six weeks to quit smoking and get over a really deep depression from the dissolution of a long term relationship at the time. I was alone every weekend, which I think helped, for me. I'm more of an introvert and it was some of the best time I've ever spent by myself.
This is awful advice. You should probably only do a dose of mushrooms once every three months at the minimum. Whoever reads this, do not follow this. Less is more with psychedelics
@@blackout2430 it was shared experience not advice, get back I your box with your advice maybe.
@@MrSpudguncat fair enough I misinterpreted
@@blackout2430 no worries, I've a fair bit of experience with Entheogens and have pretty much always traveled alone. Nobody is gonna overdose and plenty research beforehand then each to their own! It can be beautiful and scary in equal measures especially when your ego gets all deaded 😁 to come round alone after that is quite the experience!! I'd you feel you need someone there it's cool n probably for the best but once the doses are big enough we're on our own anyway. Travel safe and enjoy, we are one...
The research coming out on this and its potential for mental health support is amazing.
Dr Patrick, I am sincerely excited to hear you talk about psilocybin and depression!
After going through a bout of major depression for over a year where I basically starved myself, I took psilocybin and it cured me!
Forreal? Can you elaborate some details, ie, how your depression felt, how the experience of the psychedelic was, how you felt afterwards etc
@@ralphlaguna6168 my primary symptom, suicidal ideation, was stopped completely after I finished tripping. Like it didn’t happen at all. I attest, it cured me!
Fasting is quite amazing if done intentionally xD
@@ralphlaguna6168 such wisdom you have.
fasting can also treat depression
Thanks. I am glad you found a way to cover a topic without a 1-2 hour interview. I learn from videos, but smaller time blocks are greatly appreciated.
Just legalized in Canada for medical use.
Such an interesting conversation! The idea of psychedelics used in mental health gives me hope at a time where our world needs healing now more than ever. Thank you for sharing this!
Worked for me. Helped restore cognitive function after suffering a TBI.
I think it’s helped me immensely after my second stroke. I think it help carve new brain pathways to help restore some of my lost function.
It’s seemed particularly helpful in the first six months.
I was taking .5 grams approximately every other day. Some days I would take a full gram if I was pushing myself to take a long walk.
I think it’s benefits a well beyond just helping depression. Neurology needs to start experimenting with mushrooms and TBI
Awesome - thanks for sharing! 💪🍄
@@adrianflo6481 it’s my experience. AND I SAID NOTHING ABOUT A STUDY ON LAB-RATS.
And yes I am accounting for my own hard work.
I’ve now recovered from two strokes (no reason was ever found). That were about 11 months apart. First one was on the left hemisphere of the parietal lobe, and it took every bit of 11 months to recover about 90% functionality, before I had my second stroke, which was on the right hemisphere of the parietal lobe.
Yep. No shit. Matching strokes. The second one was more severe. I had only 85% functionality and was put on disability. During my most recent recovery,after much reading and self research, I decided that I had nothing to lose and added mushrooms to my regimen.
And today after about 17 months of working hard (with very little help from doctors because they bankrupt me from the first stroke) I consider myself probably 90% healed overall. I have a few deficits that probably will never fully resolve. And I’m hoping to get back to work at some point. Still trying to figure out what I can handle.
This is my experience. I’m not telling anyone to try this their self.
People sometimes self administer, because doctors want to charge you for merely gazing in their general direction, and after they financially drain you and provide very little help or answers.
@@adrianflo6481 you should probably go take 3-4 grams and re-evaluate your comment.
Wow thank you so much for sharing your experience and journey. Have you by chance seen the Ted Talk, My Stroke of Insight? It was literally the first ted talk I had ever seen. reminds me of your story for some reason. Its presented by Jill Bolte Taylor.
@@Yourfriendinendtimes I have not seen that TED but will look it up. Thank you.
Despite being excited/optimistic about my 'trip' (taken in an attempt to interupt my treatment resistent depression), despite a beautiful setting and trusted clinician with a dozen years using the MAPS protocol, mine was a torturous episode. 5 hours of feeling as if I was a rag dog, tossed about in hyperstimulation, pissing myself, vomiting, finding no sense of connectedness/oneness/unity, nor encountering an identifiable boogie man. Not one moment of peacefulness. I only knew that I had to 'ride out' the heroic dose. I was devastated, confused, and out a few thousand dollars for the privilege.This 'bad trip' left me feeling even more hopeless... It's been four months. I feel more despairing than ever. I have no ill feelings toward the clinician. I still believe there is great research/promise in mental health benefits from psychedelic use. I want to brave another attempt, but even the doctor said my response was atypical and looked tormenting. We're both, in a sense, haunted by this experience.
"It's not that science mowed this field and moved on. It's that science has never really been here. We do not yet understand how there is this tremendous, affectionate intelligence that wants to help us. For its sake as much as our own." -Terence McKenna
Love that you covered this segment
Thank you for sharing this and working to help this idea become more mainstream!
Thank you for shedding light on this amazing subject!!! 🍄
Nice work! Very accessible. Great graphics. Appreciate the historical details, too. The more mystical, the more benefit.
Excellent video Rhonda !!!! Enjoy all your great videos. You are a wonderful communicator of ideas !!!!
Amazing videos Rhonda! Thanks for your contribution to bettering everyone's life
Have not used psilocybin while depressed, but have used it many times recreationally and there really is something about it. The moment where everything makes sense can be very uplifting. I have recently come out of a major depression that perhaps could have been blunted if not removed far quicker if psilocybin was more readily available, problem is that Martin Shkreli and the other unscrupulous capitalists have figured out a way to profit from the misery of others...
Very positive post. Thank you, Dr. Patrick.
Love this format!
Bravo Dr Patrick for this video!
Honest overview of the state of research, this was amazing!
Thank you so much for sharing this post. I believe this could be a great help for many people who suffer with various mental states. Less interference from government would be great.
We need more research on natural products like this. There are just way too much resistance from special interest groups which don’t profit from natural products, and they fight hard to keep these natural substances illegal. Hope this will change with cultural shift, like we did with cannabis.
Thank you for this and all you do!
Ketamine infusions are the weirdest thing I’ve ever experienced. It’s hard to even describe. Felt like being in another dimension. Sometimes it even got scary, like I was going to be trapped in this weirdness and not come out of it. The blood pressure cuff inflating every so often was the only reminder that I was still in the “real” world.
great content! Psilocybin has had an incredible LASTING effect on my life. first dose changed my life immensely! after 50+ doses and 2 bad trips (both were avoidable, rookie mistakes) i am a huge fan and proponent of medicinal mushrooms. cultivating my own mushrooms really changed my life.
how do you avoid bad trips?
@@jacksteel1539 setting and frame of mind beforehand, also if you can get an experienced person with you or a guide is good too. These things can also be microdosed so you don't trip. A 10th of a trip dose every few days.
@Anderson where?
@@adrianflo6481 alcohol and GHB, no thanks! The less drugs the better
Congradulations, your neurons have been rewired.
Very well produced segment!
Thanks, Dr. Patrick!
I’ve been on antidepressants since high school. 41 now. I hope they can’t get this to mainstream quickly!
Thank you for all you do!
Psilocybin has been the best thing for me. It has cleared my mind of negative and depressive thinking. I plan on continuing using them as needed as a reset from time to time.
Great info Rhonda. Thanks so much.
Hey Dr. Patrick, thank you for not being scared to broach this subject with the world. You have real courage and can tell you care about humanity.
As someone dealing with depression, this is very interesting information, thanks Dr. Rhonda!!!
I hope you and your family are all well.
Your hair looks so healthy! Anything in your health regime that's contributing to healthy follicles?? 👋🏻👋🏻
You were on the JRE just a few months into the pandemic and you spoke at length about Vitamin D3 and how it relates to Covid-19. It turned out pretty much everything you said was essentially correct. I would LOVE to see you on the JRE again to discuss these newest research which has been done concerning Vitamin D3/K2 and Zinc in relation to Covid-19.
Awesome, I find it to be beneficial in multiple ways, there’s a lot to learn still, but personally I think it’s promising. For whatever this is worth, one treatment helped depression and anxiety significantly for over 6 months in my experience. I’ve reluctantly tried a lot of different SSRI and SNRIs and have never had any noticeable benefit with those. Also have done aya ceremonies and still find mushrooms to have been the most helpful in my experience.
We are taking small steps back towards nature. Thank you for your work🙏
I'm a recovering Addict with 29 year clean and sober. If Psilocybin ever become available for people with depression I will be first in line to get a dose. I always felt a good trip to bring in the new year would generally be good for my overall mental health and I came up with that idea more than 45 years ago. I won't mess with mushrooms anymore though.
My trips always ended with me feeling an overwhelming need to make amends to those I've wronged.
Idk about others but it helped tone down my alcohol and coke addiction, among other things.
That was excellent thank you!
Im always happy on my trips so im convinced ! :)
Before you experiment with drugs… I really recommend trying to reach yourself emotionally, if you haven’t already tried. Emotional numbness feels like a depression, but it is something that can be transformed with the right path and support
Thank you !!! I love this!
Yes, it can, with the right dose, route of administration, set, and setting.
Mushroom statue in the background! Nice
Yes I have been doing it for 45 years
Nice one Rhonda.🙂
Any information on similar effects of DMT?
Thank you for sharing your work!
Helped me overcome a lot and quit drinking.
Helped me quit smoking. Also helping with the depression.
I’ve had ketamine for severe suicidal level depression. After 1 or 2 treatments the suicidal thoughts vanished. My clinics CEO told me they were looking into psilocybin, ecstasy and others for depression, pain, and ptsd.
As usual very impressive...
Love you Rhonda you are amazing…🦋🕊🌹
I really wish this stuff wasn't illegal so I could try it.
Be careful they can also have very negative affects if you're vulnerable
good work! thank you.
thanks for sharing! ive tried microdosing and found it to be very helpful.
@@Morning_muzic thanks for sharing!
It's baffling that researchers don't have any idea why we're depressed. We live in a spiritual wasteland where you're forced to trade the most sacred things of yourself for material gain after being raised by people who had their souls crushed long ago by doing the same song and dance. we have lost our way and nobody knows what they need other than less pain, but the pursuit of less pain brings more pain. I certainly feel hopeless a lot of the time.
Keep speaking the truth.
Dr. Patrick's dress looks psychedelic to me. I love it. 🤯♥️
Even after months of a high dose i can feel benefits in anxiety and i reduced tobacco use a 30% , . also I have reduced alcohol use to almost nothing , I change the way I eat for better. I respect this medicine very much. Happy new year!!
I started this week 1g daily, how much and how often have you been taking??
Dr Rhonda from my experience and collating what you’re saying I think this spine is formed based on the environment in which you took the mushrooms. They can be good or bad, they can be long lasting. The place and conditions in which you took the stuff has a huge bearing on the paths that are formed. IE they can also be negative
I love you Rhonda!
I am so glad Dr Rhonda Patrick did this education video, she got me hooked on sauna. She's the best! Also - psylocibin saves lives!
Oh! I saw Rhonda and a giant mushroom on the thumbnail. Clicked on this one very quickly :D
I have previously tried a combination of micro-dosing psilocybin + lion's mane + niacin (Paul Stamets method), and I've had some very positive results for treating neuropathic pain. Take that anecdote for what it's worth, but this area of research is highly interesting to me!
This woman is a legend.
Someone prepping for their next JRE interview? Glad you are looking into these things now and hopefully; welcome into the fold.
Been into mushrooms for a while now and i gotta say even the activity of going mushroom picking is really enjoyable, I've deff gone picking more times than i have actually tripped.
The way they carryout the session is interesting, having the "trip sitters" take a minimal back seat role is really great, like shamanic practices with older medicines, the shaman is not there to involve himself but to ensure the patient is able to interact with the medicine in the best way. However i would be interested in varying the music or even getting rid of it all together to see how and if that changes effects
Fish oil high in EPA and DHA are cofactors for growing new neurons for new synapses that would compliment psilocybin
Anecdotally I have found similar effect at lower doses. I microdose from time to time for mental health benefit and find that 0.12g/100kg of a mild variety is enough to have beneficial effect without cognitive or sensory disturbance.
They always made me happy
Hello, can you comment anything on the psilocybin effects on the 5-HT2B receptor? What would that mean for micro dosing and for taking larger doses once in a while?
They can really help your mind of course, unlock it, but I would say from experience, sometimes it's better to work through things purely on your own, when you know your mind is totally 'normal'. Take long breaks between doing drugs, stay grounded.
Yes, Intermitten Fasting has helped me make incremental improvement while depressed/isolating at 75 yrs. during Covid. I remember having good experiences years ago with psilocybin. I think it would help me now too. How I find it.❓Can anyone direct me, please.🌞
thank you!
Where do all these people get psilocybin?
Thank you.
Thanks very interesting
YES! I love this topic its an amazing compound
Agreed 💯🍄❤️
@@chattycatlove5052 I read it turns off certain parts of your brain that make your thoughts race. Alsp hyperconnects the brain. I think I read something about neuroplasticity too. Its like you feel the flouride vibrating off of your pineal gland. Seeing the world like you use to as a child before you were clogged with toxins. Can give you a detox headache the next day thought.
@Anderson i dont use social media
@@markbalogh9655 sad face.
short answer: YES.
Could you explore the link with depression and Niacin, flush type? Dr A Hoffer is a good place to start ✌️🙌🤙
I cured my tmj fibro and anxiety with just 2 doses. Some microdosing before and then 2 mild doses did the trick...Im 90 percent better and still microdosing very seldomly. I feel like it reset my chronic pain pathways and healed my vagus nerve / also feel like starting sleeping on the floor was amazing for my health. ( not completely but a thin japanese shikibuton , it sucks initially but later...I wouldnt go back! )
I recommend trying small dosages at first and titration of dose until you reach a heroic dose. Afterwards, microdosing will be very effective.
I personally will never go above 3 g. I'm scared of having a bad trip, I just want the positive effects from smaller doses (1g works for me)
Helps me with handling my daily stresses and enjoyment of life as well as social interaction in a low dose supplement . Plus it’s all natural. Big fan . see potential
Brilliant. This lady creates a ripple affect that will be felt through the generations.
Thank you
Shrooms have helped with my depression and anxiety. So very grateful for this natural gift.
January 2021 i was sad alot. I live alone & no one is around me most days. I was really down & lonely. I used this stuff in February & January 's depression left. It can & may come back in life, we are human s after all but 🍄 psychedelic & not have loads of beautiful health benefits I love achieve ing & one effect is helping with depression so yeah. Be safe stay healthy & have fun.
How much did you take and how often? 2-3 times a week?
have there been any studies on the treatment of mood disorders with psilocybin (bipolar, etc..)?