SARS-CoV-2 Interactions with the Host Innate Immune Response and the Ubiquitin System

Presented By: Ricardo Rajsbaum, PhD.
Speaker Biography: Ricardo Rajsbaum, PhD is an Associate Professor in the Department of Medicine and the Director of the Center for Virus-Host-Innate Immunity (CVHII), at Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Webinar: SARS-CoV-2 Interactions with the Host Innate Immune Response and the Ubiquitin System
Webinar Abstract: The host antiviral innate immune response protects the host against infection. Like with other viruses, the host recognizes SARS-CoV-2 infection and triggers a series of signaling cascades that culminate in the production of cytokines and type-I Interferons (IFN-I) that reduce virus spread. To avoid detrimental inflammation, the IFN system is regulated by different molecular processes, including the host ubiquitin system. However, like other viruses, SARS-CoV-2 has developed mechanisms to antagonize both IFN induction and signaling. In this talk we will discuss mechanisms used by SARS-CoV-2 to escape the innate antiviral response, with a focus on interactions with the host ubiquitin system.
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