Metformin, the Big New "Anti-Aging" Drug, Explained
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- čas přidán 22. 05. 2024
- So, uh... does it work?
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Metformin is an old, cheap drug used to help control blood sugar in people with diabetes. Now, it’s back in the news because some people - particularly wealthy people - are using it for possible anti-aging effects. That’s right. One of the most popular ways rich people are trying to live longer isn’t some million dollar cryo-something experiment, but a pill that costs pennies that's already on the market. So, the big question is: Does it work? To find out, I interviewed the lead researcher on the biggest study of metformin for anti-aging, Dr. Nir Barzilai. The answer he gives me? Well, it’s complicated.
Note: I do not take metformin, nor am I advocating anyone else should. Please don't get medical advice from a youtube video! The purpose of this video is to explain the research that exists, explore what it tells us about aging in general, and discuss the effort Dr. Barzilai is leading to learn more.
00:00 What is metformin?
00:53 What is aging?
01:46 Can we slow aging?
02:27 Does metformin work for anti aging?
03:40 How does metformin work?
04:37 What is the TAME Trial?
05:46 Should I take metformin?
07:31 Why slow aging?
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Cleo Abram is an Emmy-nominated video producer and journalist. Cleo produces detailed explainer stories about technology and economics. She wrote the Coding and Diamonds episodes of Vox’s Netflix show, Explained, was the host and a senior producer of Vox’s first ever daily show, Answered, as well as a host and producer of Vox’s CZcams Originals show, Glad You Asked. She now makes her own independent show, Huge If True. Each episode takes on one big technology innovation or idea, explains what it is, and helps people imagine the ways it could improve the world we live in by answering one simple question: If this works, what could go right?
Sources and additional reading:
- TAME Trial FAQ www.afar.org/tame-trial
- Dr. Nir Barzilai, Institute for Aging Research at the Albert Einstein College of Medicine, Faculty Profile einsteinmed.edu/faculty/484/n...
- “A beginner's guide to longevity research,” Laura Deming www.ldeming.com/longevityfaq
- “Aging and the border between health and disease,” European Respiratory Journal erj.ersjournals.com/content/4...
- “Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic control,” Diabetes, Obesity, and Metabolism dom-pubs.onlinelibrary.wiley....
- “A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan,” Frontiers in Endocrinology www.frontiersin.org/articles/...
- “Metformin, a historical overview,” European Association for the Study of Diabetes link.springer.com/article/10....
- “Metformin improves healthspan and lifespan in mice,” Nature Communications www.nature.com/articles/ncomm...
- “Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism,” Cell www.cell.com/cell/fulltext/S0...
- “Cancer,” Our World In Data ourworldindata.org/cancer
- “Forget the Blood of Teens. This Pill Promises to Extend Life for a Nickel a Pop.” Wired www.wired.com/story/this-pill...
- “Silicon Valley’s Quest to Live Forever,” The New Yorker www.newyorker.com/magazine/20...
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An alternative explanation for the diabetes study is that people with mild diabetes (non insulin dependent) often only take metformin but have regular doctor appointments, while the general population does not have the same level of medical care.
What this study can mean is that regular doctors visits increase health and longevity, which sounds like a a very reasonable conclusion.
I hope (and expect) that this will be a factor in the next round of studies.
She said people who take other medicine for diabetes are still dying early. So may be u r wrong too. But regular doctor visits and checkups are good for everyone though
This is a reasonable possibility. However, we also know that Metformin affects cell metabolism. If metformin slows cell metabolism it’s quite possible it legitimately does just cause cells to accumulate damage at a slower rate.
We know that fasting also seems to dramatically increase longevity. Mice forced to fast live a decent percentage longer than their peers consistently.
But then how would that explain the worse outcomes for diabetics on other drugs than the baseline
That doesn't explain the results. People who are type 2 diabetics and metformin have reached a point of weight gain and other issues that would indicate them dying years earlier than a standard group of people without type 2.
Great job explaining a complex topic fairly and succinctly. Btw one of the experts in your clips there, Andrew Steele, is a friend of mine. I’ll let him know he makes a cameo!
please consider doing a video with Andrew Steele on aging biology research!
shes not going to let you smash bro.
When ever I like a video there is a comment from you, there is a very strong correlation.
@@ashmac4732 dang
@@ashmac4732 LMFAOO
At first, I was scared of the way this video would talk about taking a drug without prescription. I found you did it very responsibly. Thanks you.
This drug is OTC in many countries
@@AznDudeIsOn Unfortunately in Europe its only with prescription.
With 5 extra years, I'd be able to watch even more CZcams videos.
Cleo is awesomely responsible. Trust her.
I wouldn't be able to take that if it increased my heart rate. I already take meds fhat increase my heart rste
The problem is if researchers confirm that this drug is "anti-aging" it would immediately be much more expensive, and at the same time less available for the people with diabetes, who desperately need it... Let's not forget about that!
But I desperately need to live longer
@@benoitavril4806 Do you? Think about what you're saying.
In the US, sure. But not elsewhere, since the patents are expired.
@@Daniel-Davies-Gonstead-Student I don't see the problem, yes I do
@@benoitavril4806go hoard some then like buy 10kg supply and resell later
I'm so looking forward to see this channel become HUGE one day. Fine job Cleo. Keep up the good work👍
Huge, if true
@@kevinkwon3608shit u beat me to it...a yr ago too dammit
I like this format. One topic, not too deep, not too shallow, just enough to educate us enough for more research if interested. Great going Cleo! Good luck and keep growing!
Cleo, I'm a diabetes researcher building an artificial pancreas for controlling people's blood sugar in intensive care units. Blood sugar is actually _enormously_ important for mortality in critically ill patients, and people with diabetes who are just under general hospital care. You can reduce mortality by 30% _across the board_ by controlling blood sugar well (and 300% in COVID patients), making well controlled blood sugar in hospitals one of the most widely applicable technologies since the invention of penicillin, or the polio vaccine!
Let me know if you want to talk about the wide world of glucose control some time, would be happy to share!
What does it mean to reduce mortality by 300%?
Hey I was watching this thing about a group of Vegans who have a massive caloric deficit (like 1200 calories a day), and one thing they were talking about was blood sugar control and its impact on lifetime (also limiting cell damage overall). Could just being a vegan with a caloric deficit help you as much as this pill?
@@jakebruce11 1/3rd as much ? i dont know
@@jakebruce11 But i do not think you can decrease something by more than 100% or else you get into negatives or something, so they probably worded it wrong
Hi! Appreciate the comment :) This is a colloquialism to mean it's 3x smaller, so if you want a stricter more mathematically correct term, you might say:
COVID patients with good glucose control have a mortality rate that is 1/3 of the mortality rate of patients with poor glucose control.
In other words, if you have COVID and don't have good glucose control, you're 3 times more likely to die. It's pretty serious stuff!
My Dads been taking Metformin for the past 30+ years for Diabetes. Fought serious Covid, Heart attack, Broken Hip and still goes to work at the age of 70! Maybe on to something here...
I take 2,1000 daily,rather than insulan,10 years,am 67,still alive
Metformin fought covid?…
This is a masterclass for anyone that wants an example of brilliantly presented, informative, and responsible journalism. Beautifully edited, and just plainly honest and heartfelt. 12/10
As someone who works in the field of research, we have already been using Metformin as one of the trial arms for prostate cancer due to observed anti cancer effects. This trial is still ongoing and results will probably be published in 5years.
4 years left, fingers crossed
Remind us in 4 years!
I dont have time on my hand so I would take the plunge considering metformin pretty safe throughout its 60 year use in treating patients.
I was diagnosed with stage 1 endometrial cancer this past August. I almost lost my mind all the doctors kept trying to push a hysterectomy on me but I haven't had children yet. I started fertility sparing hormone therapy. I stayed up for 2 months trying to learn as much as possible about my condition. I came across a couple of studies where merformin was used in conjunction with the hormone therapy and had excellent results. I had my doctor prescribe it. 3 months after starting my therapy my first biopsy came back absolutely completely normal.
Oh my GODDD!! Your journalism - ugh it’s so good!! Such a responsible take on a potentially life-changing technology. No hype, no clickbait, no jumping to conclusions - just strong reminders of how complex this world is and how difficult it is to acquire information and weigh the risks. This was a LOVELY breath of fresh air journalism. Oh my gosh thank you so much. 😊
Hi Cleo! I don’t know about aging but I’m a not diabetic woman taking metformin because a side effect of it is controlling polycystic ovaries (PCOS) syndrome. It blew my mind when, several years ago, my gyno prescripted to me because of that side effect scientists found about.
Love your videos! Huge fan from Argentina 💘🇦🇷
This sounds weird. But I am so jealous you’re on metformin. I have PCOS and my doctors say “just lose weight. It will cure it” (I physically can’t lose weight because of PCOS.) EVERY woman tells me to get on metformin. So I ask my PCP, and they ALL refuse to give me metformin because I’m not diabetic. It’s so frustrating
@@deo3367that is so frustrating! I also have pcos and could not lose weight because my energy levels were so low and my insulin was high. If you cannot get ahold of metformin I highly suggest you try inositol. I found some at a vitamin store like gmc no prescription needed.
PCOS and insulin resistance go hand in hand which is why Metformin works
@@Roswell33 the way a friend explained it explained it well for me. “ you can’t lose weight because you’re always tired and hungry, and you’re always tired and hungry because the food you do eat isn’t being converted into enough energy because of insulin resistance “ this mindset was a game changer and ultimately the kick I needed to go to a specialist. It also took some of the shame and guilt out of my weight gain. My energy and even vision are back!! I no longer go home and just nap. I now go home have energy to feed myself properly with a more thought out meal and have the energy to exercise or do stuff around the house! I’m so much better off! The weight is gradually going down and I don’t have to starve myself. If you’re suffering from pcos do yourself a favor and get professional help, it’s not your fault but it is your responsibility to to what is best for you.
Never have i heard about someone taking a drug because of the side effect thts interesting to me
This is slowly becoming my favourite channel on CZcams, it's well researched, and really has an optimistic and personal side to it that i feel is really lacking in general these days. Looking forward to seeing more of this for sure!
I happened to read about Metformin being used as an anti-aging drug some time ago and I've always wanted to learn more. This is a great video 👍
I was on metformin, but was taken off of it because (I believe) it was hard on one of my major organs. I think it was either the liver or kidneys. People should check out side effects before self medication
Bad drug. Kills kidneys. It’s the poison they give pour diabetics. 😢
When I took it, it was hard on my butt hole. 😢
So if Metformin is hypothesized to counter ageing by reducing the amount of blood sugar flowing in our cardiovascular system, would switching to restrictive sugar diet achieve similar effect?
Yes that is indeed a viable strategy, check out episode 2 of this series: czcams.com/channels/wD5YYkbYmN2iFHON9FyDXg.html
Yes. Cutting sugar has many benefits, and one is decreased all cause mortality. There may be some causation/correlation issues though. People who are willing to cut sugar for health (or take a pill that makes you shit funny) are probably doing other health related things that the general population isn't doing as much.
Yep, keto and low carb has quite a bit of good studies when it comes to diabetes and PCOS
Yes thast why doctors talk about fasting causing you to age less
Basicly yes. The thing is that high sufar levels in our Blood cause a ton of problems. But fats too. We better get rid of them by locking them somewhere else.
One of the strengths of this channel so far appears to be general video production value and finding interesting topics. One of the clear weaknesses is the lack of due-diligence with research.
The arguments in favor of the videos' attention grabbing premises are backed by expert interviews (from people very close to the industry), while any objections are from Cleo's voice instead of a contrary expert interview. That framing elevates experts with vested interests in their particular niche, and devalues the more sober views of other experts filtered or omitted through Cleo. So far it's just two videos, but I'm suspecting it'll be a pattern in future videos. "Is fracking actually ok?"=talk to expert engineer in fracking, "Drug makes you live longer?"=talk to professor promoting and likely looking for continued funding on his own work with the drug.
What would have taken this video up to the next level would be finding an expert in the field who objected to the conclusions offered by the experts. Have someone on to talk about the likely causes of the reduction in all-cause mortality that aren't related to metformin. Perhaps, people with diagnosed diabetes are generally more aware of their day-to-day health and make more frequent doctors visits, and would have better outcomes in regards to preventative health practices. Or perhaps Metformin may have specific knock-on benefits in reducing heart disease. While it would have been a damper on the more positive interpretation of the premise (which I understand is the channel's mission) I think it would have added a lot of depth.
Great video series so far though, and I look forward to more videos!
I liked the video but I agree that this is a valid criticsm, constructively delivered!
Except in this particular video we are still waiting for any conclusions. So to argue another side would be inconclusive at this point. Hopefully she follows up down the road on some topics. Because your right a journalist should present both sides of a debate.
Holy cow, what a great intro to your channel. I was worried for you going out on your own at first but you made me excited, happy, sad and reflective all within a very short time span. Subscribing and sticking around!
You are doing awesome work. Really appreciate the time you put in and the palatability of your approach to complex topics.
First time your channel pops up in my recommendations and I am impressed by your presentation, honesty, knowledge, frankness, and the warmth that you brought with the generations of your family. You have a sub, and I hope that you gain a great viewership… you deserve it.
Love your research and the delivery girl!! Keep going!! I love the offbeat topics you pick. Would love to see more tech debunks from you.
1. I really love reporting like this. Taking existing conclusions accepted by the public and saying “wait, let’s really look at this”. Allowing the search for truth to cut though. Awesome.
2. The Doc reminds me of Paul Simon. Just saying.
3. If it turns out that Metformin actually works in some appreciable way, you can bet the drug companies will find a way to produce it (or a more ‘stylish’ version) for far more $$$$ per pill than it goes for now.
4. By stock in Metformin.
Yup
I mean, does the price have to go up to make it insanely profitable? If every single person in the world has to pay $5/mo for the pills, that’s literally close to half a trillion dollars a year.
@@chrismarinohardin9929 yeah, but ya know what’s better than half a trillion?…..a trillion. Profit leads the greedy by the nose. My daughters all have Cystic Fibrosis. Among other meds, they all have to take enzymes (Creon 20) in order to digest food. Years ago I was between jobs (so no insurance) and needed to pick up a 100 count bottle of Creon pills. That’s enough for about 20 meals. The cost without insurance? $800. Trust me, if there’s a way for greedy humans to make money on a common drug, they will find a way.
This is my favorite series on CZcams right now. Candid coverage of important topics.
I loved this! I mainly enjoyed seeing you weigh the pros and cons of the drug and illuminate the nuance in a topic such as this. This was wonderfully explained and pulled on my heart strings!
its soo exicting to watch such informative videos with unique topics. u are doing great job, thanks Cleo! we love u:)
I was prescribed Metformin and I was taking it for about a year. I have PCOS which means I have some insulin resistance, but I am not diabetic. I lost weight and had trouble putting on muscle. For someone that was already underweight, this became a big issue for me. I was excited to read about possible longevity effects of Metformin and made me more inclined to continue taking it, but I quit a lot of medications in order to try conceiving. I don't believe I will take Metformin again unless my Endocrinologist thinks I should go on it again. I felt fine taking it, I feel better off of it. Excited to see what these studies find, always wanted to learn more.
Thank you for showing how good journalism can be. I deeply respect and appreciate people who do this.
I'm in love with this channel. I eagerly wait literally for every single video and can't wait to see what you have planned next.
Thanks for this story. Love your work and the way you storytell - you’re awesome. Metformin has been studied by the stem cell community for a while and while it’s promising, it also seems to have some potential effects on stem cells (our collaborators saw this in the brain in mice and it’s in trials too). So I’d add that uncertainty to the potential risk (and benefit!) calculation. I also worry how the affordability and availability might change if there’s more demand (particularly among wealthy Americans) and hope it remains accessible for those with diabetes.
It's not accessible for those with diabetes. Ireland my da can't get it anymore because of worldwide shortages. The drug they put him on to substitute caused an allergic reaction and he had to be jabbed with an epi pen by paramedics.
All I can think of is the lyrics to red hot chilli peppers californication. Sicker than the rest there is no test to break the spell of aging. The song alludes to people with money can just pay to get whatever they want
JOey Rogan talked about it must be legit. lol. Love the video keep up the good work.
The kind of work you are putting out their is commendable.
More power to you!!
I love you. Period. Nothing else to say. Your content is amazing, refreshing, clear, calm .. THANK YOU FOR YOUR WORK
I take Metformin as a pre diabetic (PCOS) . I also changed my diet to low carb and no processed sugar. I get my Metformin, like you said, CHEAP! I would be terrified to hear that people use it as an anti-aging drug and my medication price ranks up.
Don't you think production would also increase?
@@tkc1129 I think it will be taken advantage of to make massive profits despite any increase in production.
Do you tolerate it? I’m prediabetic and I had bad tummy problems
The side effects can be horrible. As someone that was put on metformin when I was younger as it was suggested for PCOS sufferers, it's not something I would recommend unless you need it as in have pre existing conditions. But everyone's different. Great video though, really interesting topic
was prescribed it to counteract increased appetite from antidepressants and yep, it was worse than it sounds
Same here. Not just a little diarrhea and not just the first week. Do not recommend.
It definitely hits different people differently. I have periodic diarrhea, but the appetite control is 100% worth it to me, especially after I quit birth control. I've seen a lot of other folks with PCOS find the side effects too much vs. the benefits, though.
I a have been taking metformin for type 2 diabetes for over 25 years, 1X2mgs daily. No side effects no liver or kidney damage and no low B12 level. Works great for me. Also,, I'm 78 now and hoping that longevity thing proves to be true.........
@@robertstancliffsr9575 That's awesome. Sadly not everyone has the same response. As with any medication it people can have varying reactions. It also doesn't help that up until recently clinical trials were primarily done on Men and not women. Our bodies are different and can respond in different ways
I love how you’ve provided an argument that wasn’t one-sided!! Excellent job! (I was a bit worried about the video at first, but it’s excellent!)
This is such an incredible balance between comprehensive journalism and personal reflection/emotion. Thank you for this!
Your journalistic ethic is a rare and honorable thing to witness. Sharing your personal, and vulnerable perspective really brings the information home and places our responsibilities on ourselves. Brava!!!
My grandmother lived to 95, but Dimentia took her mind at the age of 72. Besides her ability to run around the nursing home, she was incapable of speech or recognizing anything. I'm not sure I'd want to live longer than that what age your mind goes.
Depends. If I am no longer self-aware or no longer have an identity, I'm probably not going to care. Also, I would be interested in the process of losing my sanity and memory. While it will be horrific, at seems highly interesting. I need to complete a memory map before it happens so I can trace what goes first and how it affects identity.
@GnosticAtheist you say you wouldn't care but my granddad has been suffering with alzheimers for years. He is very distraught and confused most of the time. He's quick to sadness and anger and has acted out violently towards nursing home staff. He used to be the most gentle man. He may not remember the net suffering but most days are really hard on him. The one silver lining is that he doesn't remember that my Grammy died, so he's not heart broken by that
@@msjkramey Why let him suffer?
This is going to seem crude, but if you care about him, follow this.
Most people don't let a pet suffer. Why let him suffer?
I'm not looking for an answer, I'm just hope you think about it.
@@Daniel-Davies-Gonstead-Student what are you suggesting? That we murder him?
@@msjkramey Wow, it's very interesting what people are willing to write to strangers online. As a fellow human, I'll apologize to you for that guy. I wish you luck through a very tough time.
Absolutely love your new series! I followed you here from TikTok. Keep up the great work!
Cleo, you’re so great!!! Very informative and beautifully presented. Thanks for your work.
Hey Cleo! Great job :)
The video is well done and nicely presented.
I am personally always skeptical about things that seem overstated. Especially when it is the ultimate easy way out - a pill.
Plenty of existing studies clearly show a correlation between exercise, healthy plant based diet, occasionally being uncomfortably cold or hot, etc. and a longer healthier lifespan. Seems like we can all benefit from such a lifestyle improvement rather than taking a pill that we hope works.
I’m hearing you but every study on plant based diets I’ve ever read failed to account for the fact that the average vegan is simply more conscious of diet choices than the average non-vegan. A Wholefoods vegan will in general be healthier than someone eating 5 BigMacs a day, but factor in similar deit profiles but one person includes milk while the other has potatoes friend in Omega-6 loaded vegetable oil, and the milk drinker will likely be better off.
@@chamuuemura5314plant based doesn't mean vegan
Your videos so far have definitely got me hyped for more of your content. I can't wait!
As with all of the other videos you make, this one is very informative and well-organized. But what I especially loved about this video is the part of connecting longevity with spending more time with the people we love. Wonderful content!
I really do hope you do good and are successful you deserve it
The book Lifespan by David Sinclair is a really good read that talks about metformin and other drugs and non-drug activities that are at least correlated with being healthy for longer and some of which they have isolated the cellular effects that are actually causing the improvements.
YES! Derek from Veritasium sums up Sinclair's findings: to slow or even temporarily stop aging or the shortening of telomeres (while actual cell renewal studies play out) anyone can integrate 4 lifestyle habits:
1. Eat 10-20% less meat
2. High Intensity Workouts
3. Intermittent fasting
4. Spend periods of time in temperatures that are a little too hot or a little too cold for comfort.
@@handlemonium it's probably not meat, but carbs and vegetable oils(linoleic acid).
@@tesladrew2608 that too. He did say less protein.
@@handlemonium doesn't mean he's right
@@tesladrew2608 It's useless to say whether he's right or wrong without knowing the baseline. If you eat meat once a week you might need more, if you eat it twice or 3 times a day certainly less, there's also a difference between red and white meat as well as your individual body. That's the problem that's never talked about when people bring up studies, nobody is an average,
a fat person is different than a
fat active person is different than a
fat active person who eats well is different from a
fat active person who eats well and is stressed is different from a
fat active person who eats well, is stressed and has unlucky genetics... and so on and so forth, there are countless compounding factors that make it extremely difficult to nail down what you can expect the data to do for you. In terms of meat, some people may need more meat, some people might be better with none at all, completely depends how your body is processing it; if you're overweight, taking some vitamins and fasting until you're a healthy weight would probably be better than anything you could eat... being obese is almost as bad for you as smoking a pack of cigarettes a day... and that's just cancer risk.
This is such a great video. I knew I made the right call to turn on the notification bell for new videos. Please keep track of the studies and make new videos as new findings come out. Thank you!
Absolutely loving your work and this series Cleo! we appreciate you sm
My mom was put on Metformin way back in the day before I was born and dropped some 42 pounds. We both have PCOS, and it's kind of annoying that people are using off-label to try and live longer, and that people are using it - abusing it - for weight loss. While I feel bad for people who struggle with weight loss, it is hurting those who rely on it.
Is it hurting people who need it, though? Meaning: do you go into the pharmacy and discover that they can't fill your prescription this month because they ran out? For Metformin, I doubt it.
And if someone else is using the drug to lose weight, arguing that you think that isn't medically necessary or as important as your case is a bit like them coming into your life and arguing that their use is more important than yours. Both arguments fail because neither of you knows what's actually going on with the other one. You can construct some perfect "abuser" to argue against but that's just moving the goalposts so you can win against your strawman.
It’s not in short supply, your comment is redundant
I'm 23(about to turn 24 soon), I've been taking metformin for maybe over 5 years. I don't have diabetes, I was prescribed it because I was overweight, didn't have period and have insulin resistance. I am very familiar with how metformin affects my body. I'm willing to become a subject of the study but I live in Eastern Europe.
I'm very interested in this cuz I'm trying to get off the pill cuz I heard it leads to cancer, and i also lost a lot of weight and have regular period now.
This shit is horrible. It robs b vitamins. Switch to alkaline diet. Problems solved.
The pill (in particular nowadays) does not lead to cancer... it in fact makes it less kikely to have some cancers in our reproductive organs. I would not get off the pill for such a reason. I absoluteely love it and Im dreading the day I will be too old to take it....
Not sure how you choose the topics you share with us. So thankful that you do. 🙏
Great video. I loved the balanced approach to the topic and how you effectively brought in the emotional part about the decision making process. Great work and keep it up!
Thanks for making these videos, with great experts and graphics. I hope you're not afraid to go into detail with these extremely knowledgeable people, for example - how does metformin reduce blood sugar (what's the interaction on a cellular level)? Another small note about the scaling of the disease-risk graph: it seems to me that to preserve the proper shape of the curve, you should have stretched the x axis, instead of compressing the y axis. Of course, this will also lower the rates of disease for a given age, so for illustrative purposes I don't think it matters much. Just trying to keep you sharp ;)
I guess the conclusion is, wait for a solid research before taking any decision regarding that.
Choice of your topics are brilliant! I am so happy that I found your channel!
I am really happy that you have your own CZcams channel and I love your first two videos. If you don't mind, I just have a suggestion. Sometimes in the video I felt that you were speaking at a fast pace and couple of times I had to rewind by 10 seconds and listen to it again. I guess with the heavy topics you are covering, we have quite a bit of information to process. If you could just slow down by 10-15% it would enhance my experience a lot. Been a fan of your videos from Vox days. Looking forward to everything you have in store for us in the coming months. Thank you.
Considering all the issues with climate change, biodiversity loss and our society reliance on non-renewable resources, I have trouble being enthusiastic about the prospects of humans living longer. It will already be difficult for everyone to live a decent life with 11 billion people by 2100. If we find ways to extend human life by several decades, a new kind of demographic transition will start with a new equilibrium much higher. While it is difficult to argue that at an individual scale it would be awesome, I am very concerned of the consequences of such discoveries at a global scale.
💯
Death is the natural ending, if we eliminate these types deaths what would replace them?
Nice video. May I ask what you use for the animations? Re Metformin, I feel the mechanism is fairly clear. Higher blood glucose is a bio marker that correlates with faster ageing. Reducing this even in those with no diabetes slows the inflammation that higher blood glucose causes. Less inflammation = slower aging. 🤞
Yeah it’s common knowledge that most people who have access to decent healthcare who are in their 60s/70s can choose to take this, regardless of whether they have conditions like diabetes or not. Right?
She edits in Premiere Pro so likely After Effects
Glucose lowering is not the entire story. Metformin inhibits mTOR, which is one of the 3 main aging pathways.
End credit at @8:14 shows Whitney Theis does both the design and animation in this episode (and probably more!)
Great 2nd video! It's great to see old school journalism again with new presentation. Your editing is on point, music choices enhance the story, you are very clear and succinct, and your find and interview the experts. It'll be Huge if True that your channel takes off! ;)
Just browsed some videos on your channel... and way immediately compelled to subscribe. It's bite sized, well researched stuff with pithy commentary and opinion. Good to know stuff and conversation starters. Loved the metformin video and the WTF F1 as a die hard F1 fan. Well done keep em coming. Cheers
Hopefully the demand for its antiaging use won't affect the supply for people who need it for diabetes...
It’s very cheap and easy to manufacture, so I doubt the supply would run out.
I can't help but think of how this drug, if its anti-aging effects were to be confirmed, would impact the balance between global births and deaths and the ensuing impact on global environmental, economic, and social sustainability.
Putting off death for a couple years, if that, wouldn't have and real effect. Everyone still dies.
@@ernststravoblofeld i wouldn’t be so sure, the balance is still very much changed for however many years and could have very large, not so positive consequences
Fantastic show Cleo, I am so glad CZcams algo suggested your channel to me! Please keep up the great work, I love it!
That risk profile was nicely presented 👌
Thanks for putting Metformin on my radar to see future studies.
I think we need to re-examine how we treat aging people for this to be effective. Assuming it’s not just the rich taking this, we need to take care of elderly longer so that they’re not dying of starvation, freezing, heat stroke or any of the things poor elderly often die from. A universal income for life would be a good step. Universal healthcare would be huge.
Very interesting, loved the video! The biggest thought I had through this was simply - if people stop dying because they can live longer but keep reproducing at what point does the world become overpopulated and what issues does that cause?
Great question, and one I’ve thought about a lot! There’s actually a video on my channel about exactly this if you want to find out more-and, spoiler alert, the amount of difference it would make to population is surprisingly small!
I doubt that people would be living "that" much longer. Maybe a few years but not decades. It would be a way to small factor in terms of overpopulation. Education, wealth and political stability are way more impact full
A related thing is with life expectancies having grown significantly in the past 50 years or so. An example that comes to mind is Japan, with a huge elderly population that can not work, which forces the younger people to work more and pay more taxes to pay for social services, etc. It is not exactly related to overpopulation (Japan's is decreasing now), but it still makes you think about the effect of growing long life expectancies
Essentially, I am saying it might cause depopulation instead, which may be an equally problematic issue
Societies where people live longer healthier lives tend to have less children. Look at Japan. Or just think of the difference between Europe and Africa.
I asked about NMN and David Sinclair in the previous episode and now you uploaded this, thank you!
Oh damn! This topic is so unique and something that's so not thought of by the most! Lost for words. You're off to an amazing start Cleo!
For the longest time I've always followed the simple medical advice that if you do not have the illness/disease/etc that a form of medication treats, then you should *NOT* take it or you may suffer horrible side-effects. I'm not convinced taking some cheap meds for diabetics is the key to living longer and I laugh at the rich, bored idiots who think it is. Cool video, Cleo!
But if we decrease aging, would the current system still work? The population will increase drastically and how will that affect the environment?
I think you do an awesome job explaining things - and you're honest about your own take on any given subject. I think you're a hell of a journalist! Thank you Cleo...
Loving your videos!! So glad you made your own channel
Mrs Charlotte's is legit and her method works like magic I keep on earning every single week with her new strategy
Sometimes I wonder if she's used magic power trade
I've never heard or seen any of her clients complain of Lost....I think she's just too perfect
Hi Cleo, loving the video style, love hearing about new things the way you describe them!
However as a doctor I do want to add a comment that Metformin is usually the first line of treatment for patients with Diabetes Type 2 who are eligible for medical intervention along with Lifestyle Modification. (Unless contraindicated for whatever reason)
When it doesn't work we change the medication if resistant by adding to Metformin or just different medications (ofcourse this is quite simplified)
So we're comparing earlier diagnosed patients with more serious/resistant patients .. which is not really a surprise to see that the latter have higher mortality.
But yes the video is responsibly made and it gives me further incentive to do my own research!
Good job :)
Great video! I absolutely love the general idea around these videos of looking at interesting and dope stuff that could potentially change the world in a reasonable &responsible way. I know I'm echoing a lot of sentiments that other folks have already expressed, but I'm excited to see what'll talk about next.😀
Yet another amazing video, keep up the amazing work Cleo!
Really enjoying this series! Thanks!
I fully expected this video to not be so thoroughly and frankly informative... I'm astounded.
I think it is awesome you were able to make this transition into becoming an independent creator and focus on the things that you find more interesting or that you can have more impact on.
I am sure that the success of your channel is not HUGE *if true but HUGE *when true!
I'd love to see a video about where the Graphene industry stands today, it was such a hot sector that was promised to be as revolutionary as plastic but it seems like it was either over hyped or just very hard to make progress, is it like the cause with "Fusion Power" an us constantly being 50 years away from being able to harness it?
Anyway, good luck with your future work, will be looking forward to seeing how big this channel grows and where you can take it.
I wouldn't take metformin, but I do take nmn and it's been amazing! I've experienced an increase in strength and my skin is looking much better
I love how your videos give me hope about the future.
I m 23 and i was diagnosed with type 2 diabetes 1 year ago. If want this to be true and i hope this study and research really proves to be a game changing for the humanity.
So I just binged all these videos and they have a very entertaining and simultaneously educating Physics Girl vibe. Love it!
Thank you for bringing these kinds of information in forward to us.
Interesting stuff!
Proud to be apart of the pre-100k subscribers Cleo gang!
You told this story beautifully. Thank you.
Great work! The quality of your videos are always on point!💖💖
Thanks for sharing, I’ve having the same question. And I will wait for more studies.
Your last words defined the video. Keep going - your work is great.
An awesome viewpoint on this,i think u have basically warned us by not giving into fear of aging and wait for the appropriate studies to come and show its effects.Totally amazed by the way you have reported something huge with a neutral mindset on such a controversial subject. Would definitely like you make videos on such mind bogling concept with the same drive 🔥🔥
Another excellent video! A vitally important topic approached with nuance. Well done.
I took it for Wright loss and it worked amazingly
Amazingly high quality video, you should have way more subscribers!
Excellent Video Cleo! This definitely falls into the category of "huge if true". Shoutout to Whitney for the excellent design and animation!
Binging all your content and this one made me cry. ❤
I've taken Metformin for decades. My daughter recently pulled pictures of me over the past 10 years and said. Dad you just don't look older. What's going on? I'm 67.
Amazing work Cleo! Continue like this and your channel will take off big time! :D
you’re on your way to 100,000, this is Huge!
Your great at this C, take it to the limit.
Cheers
As a person with diabetes who has been on it for a long time... I appear to be aging at the normal rate. It just makes my glucose levels lower.... This is like saying that people with bacterial pneumonia who get antibiotics and therefore don't die... have discovered a way to live longer, and we should all take daily antibiotics.
Please do not encourage millions to try to use the medication I need for a real disease because they think it will make them "younger." It decreases the supply and causes shortages. My sister already had to switch off of her diabetes medication because of media stories that it makes people weigh less. Her pharmacist could not keep it in stock for the diabetics who needed it because of all the people who wanted it to get skinny.