More Stereochemical Relationships: Crash Course Organic Chemistry #9
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- čas přidán 30. 07. 2024
- Enantiomers have almost all the same chemical and physical properties, so it can be tough to separate them. But it’s still super important that we know how to tell them apart! In this episode of Crash Course Organic Chemistry, we’ll recap all the types of isomers we’ve learned about so far, and also learn about polarimetry as a way to separate enantiomers and how to predict the number of stereoisomers a molecule will have.
Episode Sources:
“THINK BIG! Must the molecules of life always be Left-Handed or Right-Handed?” Smithsonian Magazine.
Spinoff 2004 - “A NATURAL WAY TO STAY SWEET”, NASA.
Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.
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On the flow chart at 8:18 we made a typo! The word diastereomers shouldn’t have that extra s. Thanks to the viewer who caught this!
Hey, the crash course app isn't working. Help
this is probably my favorite crash course series. congrats!
Word
Thank you for bringing the idea of enantiomers to light.
I see what you did there
In the graphic @ 8:47 'diastereomers' is mis-spelled 'disastereomers' - a DISASTER-ous typo.
At first I thought I was missing some nuance of the pronunciation, then I saw it was spelled correctly elsewhere on the chart. Glad I wasn't the only one who did a double take.
disastereomers are what happens, when you get unexpected racemization in you reaction
I really appreciate the effort that went into this. I can't imagine how many takes were needed to get through all of those tongue-twisters correctly. 👏
Where was this when I was struggling through organic chemistry in the late 90s. What a great video!
Ok boomer
Thank you all for providing so much entertainment to me during my high school years. All of the music, how to, life videos, just talking about problems, etc. It has all been a great help to keep my mind off the horrible things that are happening on the outside. Can’t imagine what I would have done without you all there distracting. I wish I could repay you all but I am just a sad jobless teenager. But now, I’m going to college to hopefully train, get a real job, and then hopefully pay it all back; somehow. For now the best that I can do is just say thank you for now and know that I hope you never stop making awesome content. I hope that youtube doesn’t screw you over too much this day and age. Look forward to bringing your content along with me to college as well. And thank you once again for keeping my mind off all the horrible things that are happening these days. Really has kept me sane all these years. Thank you all soo much!
This is an incredibly informative and very fun series, so I definitely wanted to make that point first, but I love your style this episode too!!
Thanks a lot
I am so glad you always tell us the information contained in big books in a small and good way
Thank you!!, I'm not good at organic chemistry, however, I like it and I love this series
first time i have watched great video now ill catch the rest im more physics myself but great content and well put over great job
Yes!!!! I've waited for the next update
Thank youuu
Always found your videos very informative and knowledgeable
I love your channel and videos😍
Just what I needed!! #lovechem
Good stuff! 👍🏻👍🏻
Keep going CrashCourse!
11:19 Can't you also deduce 2R,3S and 2S,3R are the same from the fact that you can number the carbons from whichever end and get the same carbon numbers for the chiral centers?
Content is awesome 👊
i am waiting for the next series, please put it up faster
yeeeeeeeeeeeet!
I love this channel
It gets more viewer if you add english subtitle to oncoming vedios
Thanks alot..
Very informative lectuers
Well this series is better late than never!
What is the reason that S and R enantiomers _cannot_ be non-experimentally mapped to L and D? Not even with fancy atomic-level EM-wave simulation-tools? This would mean that we (the scientific community) don't fundamentally understand what cause of the rotation is within molecules.
Nice!
Why did you relate D configuration to dextrorotatory and L configuration to laevorotatory... That's supposed to be d- and l-. D and L have different meaning. Like there is D-(+)-Glucose and there is D-(-) -Fructose.
Awesome video!! Thanks!
Flaming Basketball Club right now, I do Biology and Anatomy/Physiology lectures. They are lecture based, so more like being in a class. I have breakout videos where I am focusing on some harder topics. I will eventually include some microbiology and histology when I finish with the other two.
Just to sound better than you guys, well in this way, I know enough about naming org molecules I got the diagram correct.
Of course I often spell molecule 'molocule' so I'm not perfect.
The rest is somewhat new stuff.
Is polarimetry still even used? We only use chiral chromatography to determine enantiomeric excess. In my 20 yrs I've never used a polarimeter.
Up until now I was following this series rather well, but this video turned my brain to mush. What?
My brain is melting, so you must be doing something right :D
Thank you mam
tasting and smelling chemicals to figure out what they are sound like it could get me high, so count me in
Didn’t expect a bit of physics at the start of the video.
Yeah!
First of all, I'm a huge fan of the series and of crash course in general. I'm looking this one to refresh some stuff I've learned in my biochemistry degree and it's been so informative! You are so grate at doing this
I’ve never fully understood how a vial if organic molecules could “rotate” polarized light. How do they do this, even though they’re in random orientations within the solution itself?
There's a great explanation by a science communicator by the name of Steve Mould, it might even be his latest video. He uses the analogy of spiral pasta, and it makes so much sense x)
Random orientations dont matter the only thing that matters is that there isnt a compound in the solution with the other handedness
Again! Like the other guy who just replied you should watch Steve Moulds vid, thats where i learnt all of these anyway!
if you turn a screw upside down, the edges still go from top-right to bottom-left. again, steve mould is your guy
I thought you would start Asian history
We want Asian History
Love your channel
but how does this relate to what I smell when I urinate after eating asparagus?
one of my favorite topics.
remember Walter White's meth was so good because it was enantiomerically correct :) :)
Of course it was never explained how that could possibly be.
The science advisor for breaking bad was an organic chemist from University of Oklahoma. He office was directly above my mass spec lab and when the show was in the final season, she had to have the campus cops escort her in and out of the building because of the media coverage
But I wanted nose spray
Dope
do cells sleep?
I wish the show took better care with their language and focusses more on applications and less on naming conventions and definitions. The sentence "stereoisomers that have non-superimposable mirror images like s-carvone... (5-7 difficult terms in one sentence, why???, and why show butan-ol on screen then). Who has remembered non-superimposable from last lesson, and can understand it within 0.2s before the next term kicks in. Just say "isomers that have a mirror image are either enantiomer or are meso-compounds".
There are also so many sentences that can lead to misunderstandings here. Plane polarized light is not vibrating in only one plane. The E or M fields do however oscillate in one plane. A slitted disc or lens will mostly just block light and is a very poor polarizer. The enantiomeric excess does tell the molecular fraction but in a non-obvious was: ee=fraction1-fraction2. The mirror image of the s/r tartaric acid is wrongly drawn if using the mirror technique as used 5s before with ss tartaric. For the specific rotation, the equation is only right when using water to dissolve. the chemical in for the concentration as you assume 1cm3 is 1ml. The image where meso compound is placed inside a box near the stereo isomers suggest that it is not an member of the set of stereo isomers but it is. This is related to the sentence: "one molecule can have many isomers", which by definition it can't have. You need at least two molecules to compare to each other to see if the are isomers from each other and which category they may fall in.
where are Russian subtitles, I would very much like
Hi
Wonderful post thanks
see you next
Leverodatory and Dextrarodatory. Couldn't just call it Left rotating and right rotating. Because the terminology isn't complicated enough. 🤣🤣🤣
Someone should repost this, but playing backwards and mirrored. Lol
steve mould talked about this
Yep!!!
disaster-eomers
How you know how atoms connected. I mean nobody actually saw atom..
tl:dw sorcery. Sorcery and witchcraft. Got it.
Joke: what’s an organic chems favorite kind of game? A game that has some pair of disastereomers.
Joke: what is an organic chems favourite kind of disaster? A natural Disastereomer
Hello
Can you do math💕💕
"You are not your mind. You are not your intellect. Who you are is not your thoughts. You are not your beliefs. You are not your memories. You are not your conflicts. You are not those things that you identify with.
The mystery of who you are exists beyond the reach and the realm of the intellect and beyond the reality of the body. But you are inhabiting this body now. And the intellect is there to help you to navigate this world and to participate here. It is a marvelous vehicle of communication. It is exquisite, profound and capable of doing marvelous things if it is cultivated correctly. But for all students of Knowledge in all traditions, it is necessary to realize the difference between your real nature, your deeper nature, and the makeup of your mind and your system of beliefs, however organized or disorganized they might be.
That you live at the surface of the mind and do not know of its depths, its mystery and its true power and abilities-this must be a recognition, or you will think that spirituality is a belief or a system of beliefs. You will think that spiritual practice is about reinforcing ideas, reinforcing beliefs, and, of course, this is tremendously manipulated by government and religious institutions-the manipulation of belief because most people are not yet aware that who they are is not their minds, and so they think that what they think is what they are, and it represents their reality.
Once you are able to break this assumption and this fixation, a whole door begins to open to your inner life, where you will soon experience that you have a greater nature, a deeper nature beyond your thoughts and ideas. Sit still for twenty or thirty minutes, and this will become very apparent to you."
A quote from a teaching titled Who You Are is Not Your Mind, from the *Power of Knowledge* book. One of the great books of the New Message from God, which you can read or listen for free at *NewMessage org*
Hey you stop scrolling through the comments and study
Binod
Please pause between statements. You talk too fast!
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