George Church, PhD: Rewriting Genomes to Eradicate Disease and Aging
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- čas přidán 28. 07. 2024
- George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.
EPISODE LINKS:
Show notes and transcript: www.foundmyfitness.com/episod...
Dr. George Church on Twitter: / geochurch
Dr. George Church on Instagram: / george.church
Church lab: arep.med.harvard.edu/
Regenesis Book: www.amazon.com/Regenesis-Synt...
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CHAPTERS:
00:00:00 Intro
00:02:52 History of the Human Genome Project
00:09:48 Manufacturing cell phones (with biology)
00:13:21 Genome Project-Write
00:15:51 Writing a human Y chromosome (from scratch)
00:16:36 What if you could eliminate viral disease?
00:18:38 De-extinction and reinstating lost traits and genes
00:22:53 The Vertebrate Genomes Project
00:25:35 AlphaFold and other AI tools
00:37:14 CRISPR vs. Base Editing (emerging tools of genetic engineering)
00:45:27 Why multiplex editing will change the world
00:48:05 Molecular flight recorder
00:49:18 Preventing viral spillover and enhancing livestock
00:53:27 PCSK9 gene therapy for cholesterol
00:56:17 Is aging an evolved program?
01:01:08 Treating aging with a combination gene treatment
01:04:51 Does animal research help us understand human aging?
01:07:28 Organoids as a model and therapeutic
01:09:21 Could engineered transplant organs become better than the originals?
01:12:05 Embryo editing controversy
01:24:28 Gene editing for space travel
01:26:28 Can synthetic biology alleviate poverty?
01:29:55 Is in vitro fertilization and embryo selection practically similar to editing?
01:35:00 The occasional cost of brilliance and neurodivergence
01:41:33 Eradicating disease with Gene Drive
01:44:43 Technologies to solve Lyme disease
01:47:45 Personal experience with narcolepsy and creativity
01:56:29 Why George encoded his book in DNA
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Thank you for watching!
#crispr #syntheticbiology #genetics - Věda a technologie
Chapters below! We don't have sponsors, but we do have people that get perks for funding the show. www.foundmyfitness.com/crowdsponsor
00:00:00 Intro
00:02:52 History of the Human Genome Project
00:09:48 Manufacturing cell phones (with biology)
00:13:21 Genome Project-Write
00:15:51 Writing a human Y chromosome (from scratch)
00:16:36 What if you could eliminate viral disease?
00:18:38 De-extinction and reinstating lost traits and genes
00:22:53 The Vertebrate Genomes Project
00:25:35 AlphaFold and other AI tools
00:37:14 CRISPR vs. Base Editing (emerging tools of genetic engineering)
00:45:27 Why multiplex editing will change the world
00:48:05 Molecular flight recorder
00:49:18 Preventing viral spillover and enhancing livestock
00:53:27 PCSK9 gene therapy for cholesterol
00:56:17 Is aging an evolved program?
01:01:08 Treating aging with a combination gene treatment
01:04:51 Does animal research help us understand human aging?
01:07:28 Organoids as a model and therapeutic
01:09:21 Could engineered transplant organs become better than the originals?
01:12:05 Embryo editing controversy
01:24:28 Gene editing for space travel
01:26:28 Can synthetic biology alleviate poverty?
01:29:55 Is in vitro fertilization and embryo selection practically similar to editing?
01:35:00 The occasional cost of brilliance and neurodivergence
01:41:33 Eradicating disease with Gene Drive
01:44:43 Technologies to solve Lyme disease
01:47:45 Personal experience with narcolepsy and creativity
01:56:29 Why George encoded his book in DNA
One of the most critically important areas of research and one of the best interviews EVER! Thank you Dr. Church and thank you, Rhonda
Amazing. A podcast with a transcript, visible glossary and direct citations that are referenced live. Your production quality is extraordinary.
Wow, thank you for the praise!
This interview is unbelievable. Thank you Dr Patrick for putting this together. Definitely one of your best interviews.
Thank you!
This video has lots of important points on how to solve the human aging problem ASAP! Thanks George & Rhonda!
🙏❤️ A great interview on one of the most important research areas/developments of our time. George Church is a true visionary ...🖖
imo this technology/area of research is going to be the most important thing in the 21st century
I just finished reading Woolly (Ben Mezrich) and I see this interview?!?! That’s awesome!!! The book is about Dr. Church’s work in reviving Woolly Mammoths. Really really good book. It got me very excited for the wild breakthroughs in Genetics I’ll see in my lifetime.
People need to maximise the genetic potential they already possess. The majority of their problems are self inflicted from their lifestyles. How are you going to genetically reverse or prevent the effects of 30 plus years of smoking, drinking, poor diet and sloth? I'm 70 and , by not doing those things, am healthier than almost all of my 50 and 60 year old patients.
I wish every podcast had references included like this one. Spectacular job interviewing George!
Amazing podcast. Hope this gets the mass attention it deserves. Very, very well done.
What a wonderful interview. As usual I learn so much from your podcasts. Thank you for your work.
Thank you, Sue!
Thank you so much for your channel!
I only looked a few videos so far, but I really enjoy the fascinating content and your art in leading the interviews. I especially like that you put the literature references and comments directly into the videos.
No question - immediate subscription :)
Excited about this one Doc;)
Brilliant episode!
I'm trying to find answers on our vitamin D ranges as I'm confused on so many different ranges / levels ! Please help me on this !! What are the optimal rages to aim for ,and what ranges to be symptom free ? Thank you
Thank you so much!!
Thank you so much for watching!
I’m sorry my question is a little off topic. If you will indulge me, please, I’d like to know what the differences are between autophagy induced by fasting and the clearing of senescent cells through senolytics. Thank you.
Online interviews are very difficult to follow especially on these topics.
Miss Rhonda could you make a video on colloidal silver please!!!!
Its Amazing that this Legend is available on CZcams for and yet people rather watch trash.
omg that book encoding part 🤯
Is this a theoretical talk or about concepts that relate to what a person can apply themselves right now to improve their life?
This talk will not tell you how to diet. However, I'd stop short of calling it theoretical, because the entire video is oriented around describing the technological leaps that have happened in a few short years (actual milestones) and, only after establishing that point, tries to impress upon the listener what that might mean in the very near future.
Dr would it ever be possible to get Dr Michael Levin in the pod? It's not a reach to say he may be the most interesting person you can interview.
Dr. Ronda you need to have a podcast studio with good furniture to keep people watching and interested . This black background is so uncomfortable to set through…. The podcast is not breaking through because of these simple things. Thank you again for all the hard work you are wonderful 🌺
I like the black
Endlessly fascinating!
Meditation can be another source of creativity or walking or showering!
Is there a concern that directed evolution will eventually reduce biological diversity and we won’t know the long term consequences for a while?
Where has this visionary been hiding? SO thankful you discovered and brought this long series of stellar achievements into a wider public view and dialogue. Masterful work Dr Rhonda Patrick and Dr George Church.
Thank you! My pleasure. A real privilege to get to speak with Dr. Church so at length.
Adding to the genome would work. All mammals have around 25K genes. Humans are only able to be much more evolved by capturing a microbiome to do the basic work ...and allow for advanced genes to code the uniquely human. This is likely a downside. I see the microbiome as the source for aging related decline. Mechnikoff predicted aging as caused by "rogue bacteria." My work shows a relationship along the lines of internal parasitism caused aging.
Explosive growth of rogue bacteria could certainly eat up all available amino acids. In this case even prefect RNA cannot code protein/hormones/peptides without having all necessary amino acids. We'll see how my pending patents advance. The USPTO doesn't seem to like granting patents in this area. I know! I've been submitting them since 2012...🙃
What do you use for facial skin care?
Dr Church's definition of comparing chemistry to the chemistry of biology misses a key point which I find is a shortcut which is flawed. Quantum physics and the unified fields which store and communicate memory are a key component of biology.
Dr Bruce Lipton
Cuckoo.
This is not gonna end well. Humans are too smart for their own good. Just bc we CAN do it doesn’t mean we SHOULD. Not fully understanding pleitropy- how a single gene controls multiple functions- should be enough to approach this with extreme caution.
A disease is a legal title that grants treatment to licensed medical practitioners, since disease is only an academic invention and most illnesses are related to nutritional deficiency and environmental toxicity, what will this do to prevent gene expression?
If I were president of the world , I would make George my chief science officer
He looks and sounds so much younger than he is
Bring back the passenger pigeons!
Fascinating interview
Isn’t this what MRNA was originally developed for
Interesting to learn Dr. Church has narcolepsy.
🥳