Aging, and the Life of Fat with Dr. Ben Bikman
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- čas přidán 12. 03. 2024
- In this episode of The Metabolic Classroom, Professor Ben Bikman, a biomedical scientist specializing in diabetes, metabolism, and fat tissue, delves deeper into the topic of fat tissue, focusing specifically on its storage locations and the factors influencing them.
Dr. Bikman emphasizes the complexity and nuance of fat tissue beyond its commonly recognized role in energy storage, insulation, and cushioning, highlighting its function as an endocrine organ that produces various hormones and signals.
Ben begins by discussing the enzyme lipoprotein lipase (LPL), which plays a crucial role in fat storage by pulling fats off circulating triglyceride-rich lipoproteins in the bloodstream. He explains how the expression and activity of LPL are influenced by factors such as insulin, exercise, and sex hormones, particularly testosterone and estrogen.
The lecture explores how sex differences play a significant role in fat storage patterns, with males tending to store fat centrally around the abdomen due to increased LPL expression induced by testosterone, while females typically store more fat in subcutaneous depots such as the breasts, buttocks, and hips, influenced by estrogen. Ben also discusses the impact of menopause on fat storage, noting shifts towards central fat deposition in women as estrogen levels decline.
Additionally, Dr. Bikman touches on the effects of aging on fat storage, explaining how fat cell number tends to plateau in adulthood and decrease in older age, leading to hypertrophy (enlargement) of existing fat cells and potentially ectopic fat deposition in organs like the liver and pancreas.
The lecture concludes with Ben addressing the difference between hyperplasia (increased fat cell number) and hypertrophy (increased fat cell size) in subcutaneous and visceral fat depots, emphasizing the metabolic implications of storing fat in different locations. He also briefly mentions the influence of non-caloric signals, such as chemicals leached from plastics, on fat cell growth.
Overall, the lecture provides a comprehensive overview of the multifaceted nature of fat tissue storage, highlighting the interplay of hormonal, physiological, and environmental factors in shaping fat distribution and its metabolic consequences.
00:01 - Introduction to Fat Tissue and Lipoprotein Lipase (LPL)
01:14 - Overview of Fat Storage and Influencing Factors
02:12 - Review of Subcutaneous and Visceral Fat Deposition
04:07 - Role of Lipoprotein Lipase (LPL) in Fat Storage
05:16 - Influence of Insulin and Exercise on LPL Activity
06:30 - Effect of Sex Hormones on Fat Distribution
07:43 - Puberty and Fat Storage Differences Between Genders
08:50 - Impact of Androgens and Estrogens on LPL Expression
10:00 - Hormonal Changes During Menopause and Fat Storage Shifts
11:52 - Estrogen's Influence on Female Fat Distribution
13:10 - Estrogen's Effect on Fat Storage and Metabolism
14:21 - Menopause and Changes in Fat Distribution
15:18 - Shifts in Fat Storage Patterns with Aging
16:21 - Reduction in Fat Cell Number During Elderly Age
17:49 - Overview of Fat Storage During Infancy and Childhood
18:50 - Transition from Hyperplasia to Hypertrophy in Adulthood
20:02 - Hypertrophy and Its Consequences for Fat Cells
21:30 - Visceral Fat Hypertrophy and Pro-inflammatory Effects
23:35 - Difference Between Hyperplasia and Hypertrophy in Fat Storage
24:25 - Subcutaneous Fat Hyperplasia and Female Fat Distribution
25:33 - Metabolic Implications of Subcutaneous and Visceral Fat Storage
26:42 - Visceral Fat's Increased Sensitivity to Fat-Burning Signals
28:02 - Influence of Non-Caloric Signals on Fat Cell Growth
29:02 - Impact of Plastics on Fat Storage
30:09 - Conclusion and Summary of Key Points
#insulinresistance #metabolicsyndrome #metabolichealth #type2diabetes #type1diabetes #weightloss #intermittentfasting #intermittantfasting #fasting #lowcarb
Learn more at: www.insuliniq.com - Věda a technologie
Much bigger fan of Ben Bikman in this "solo" setting. He can then methodically cover the topic without constant interruptions.
Absolutely concur. No mediator needed .
Alsolutely,
This is much better
Really!👍
Dr. Bikman, you make science fun and understandable. Your graduate students are very lucky and blessed. This is my second month of 100% carnivore. I am doing bike sprints to address visceral fat. 73 yo woman, getting younger by the day. G*d bless you.
Thanks for your kind comment, Virginia.
I'm 72 and feel 30 again being carnivore now 526 days. I have been so incredibly happy with how lean this eating style has made me while losing 100 pounds. I did vegan and it made me fat, increased my arthritis and felt like I was dying quickly. Carnivore turned this around so fast and Dr. Bickman's valuable lectures got this medical providers attention and has been instrumental in my recovery. ❤
Wow!! Get it, girl!! 😁😁
Maybe that’s what I need to do. I’m keto/low carb right now but I’m not as lean as I want to be.
He is one of the smartest people in the low-carb space.
There are two things you need to keep in mind about Dr. Bickman. He is a research scientist and therefore knowledgeable as opposed to smart. He also doesn’t really have a lot invested in being an influencer which makes him very influential. Ben is simply following what he is learning.
More importantly, he's able to make me understand the information. I'm a huge (learning to get smaller, ha!) fan.
Literally can't get enough of listening to this man's talks. Thank you Ben, this information is invaluable 😊
Thanks for your kink comment.
Ben, you are the best!
I have bought your book "Why we get sick" and listen to your lessons with great attention. Thank you for such important information 😊❤
Thanks for commenting, and for your kind thoughts.
"More knowledge better health." Too true. Thank you Dr. Ben Bickman. Bought, read and implemented strategies from your book. thank you. You are a hero
Thanks for your kind comment.
When I lost 90# on carnivore diet, my reliance on my CPAP became less
🎉❤Dr. Bikman you opened my eyes on metabolic health, fasting insulin etc. Thank you for what you do!🎉❤
Thank you for these talks, Sir. I look forward to your next chapter on the post menopausal woman.
Ben, just found this podcast. I've always been a fan and have seen you on interviews on other podcasts. I recommend that you make a "deal" whenever you appear on another podcast for them to list a link to this podcast. I've watched you many times being interviewed and I was never aware that you had your own. I look forward to learning more from your channel.
Just had my fasting insulin retook. 8 months ago it was 6.2 , yesterday it registered at >1
Thank you Dr. Bikman
Wonderful presentation and the plastics part is quite sobering.
Yeah. I've got some yogurt to throw out now.
67 year old that about a year ago I had an adrenal removed. It was the last of my three organs removed. Had some muscle invasive bladder cancer. My proper human diet was instrumental in keeping my Cushing’s symptoms to a minimum. I’m pretty sure the scan coming up soon will show a huge decrease in visceral fat. It never moved until the adrenal induced metabolic dyscrasia was corrected.
I wish you good health
Outstanding presentation - thanks so much
Much appreciated information given in a very understandable way. Your book, How NOT to get Sick, is on order👍🏻
For me the most impactful statement came at the end. The study that looked at plastics effect on fat storage...plastic yogurt cups, ie., food containers, excrete chemicals that stimulate and cause their chemicals to increase fat storage, was profound. I knew microplastics were damaging but this aspect of their action really caught my attention. I have made a concerted effort to stop purchasing anything in plastic but dairy products like cottage cheese, sour cream, yogurt do not come in glass with a few exceptions. I will return to making my own such products because I can get the raw ingredients in glass containers. Thank you for discussing this valuable research paper.
even if I cook myself and buy meat at butchers it is going to wrap ti in plastic, no escaping
My butcher wraps my meats in plain, non coated butcher paper. If I go to a new butcher, I take my own butcher paper just in case. So, yes I can escape plastic.
Спасибо, профессор.
Great to be with you for this
I m so thankful with this gentleman for all this such paramount value information for all women explained in a way that we all can reach to understand ❤❤❤
Take some notes is right!! Thank you Professor!!
Dr. Bikman always helps me connect multiple concepts into one congruent thought process. The "ah-ha" moment!
Best I have taken part of for a long time, Amazing. It all adds up, I can clearly relate to me and my friends.
Wow . Thank you . 5 full pages of notes and now my brain needs a break . Very interesting and informative.
Thanks for watching, and for taking your valuable time to comment. I appreciate it.
I just love your educational content . I am always looking forward to the weekly classroom discussion. My health has improved so much by incorporating a low carb / organic lifestyle .
Thanks for commenting. Glad to hear it.
You are a great teacher
Thank you for sharing!
You are far too kind. Thank you. Certainly not expected in any way, but appreciated. Please let us know if there is anything we can do to help you on your metabolic journey toward better health: www.insuliniq.com
EXCELLENT video Ben!! It really helped me understand! Thank you!
Thank you Dr.Bikman. You are awesome!
Thank you!
Wow! This was extremely educational. Thanks sooooo much.
Thankyou for thiis very interesting video!😊❤
Amazing information, thanks a lot !
Amazing, as always. Thanks a lot 🙏
Glad I came acrosss ur lectures ; thank youu
Damn Ben
I always learn something from you every time! Please keep making videos because your gift of knowledge is so extraordinary. I am as excited as you are with your discoveries in your field. I have been following you for years and all I can say is God bless you and your family. There are very few good guys in the world now a days and you are one of the best!
Gods speed to you Ben!
best regards,
Brant
Thanks for your kind comment, Brant.
Excellent thank you
I just ordered Why We Get Sick. I cannot wait to get into it. The sample pages I read convinced me this book deserves my undivided attention.
Amazing!
Very interesting
I'm so glad that insulin IQ is back on youtube
Awesome!
❤❤❤ Dr. Ben!!
He's fabulous no matter what he's doing or who he's talking to.
Professor is THE MAN!!👈🙏
An absolutely fascinating and very illuminating explanation of the different types of fat and their role in our bodies. I wish I had known all of this years ago as it makes one understand so much more why we need to manage insulin through low carb/carnivore way of eating.
Thanks!
That’s very kind of you, Arthur. Certainly not expected but appreciated. Please let my team and me know if there’s ever a question we can help you with. www.insuliniq.com
Dr B is so freakin’ good. 🙏
Thank you so much for your videos! I took notes on this one. As a woman n my 70’s, I’m very interested in the effects of aging on insulin resistance. Could a future video focus on this topic?
Thanks, Barbara, for you comment. We will look into that.
Hello from Pennsylvania
Thank you, Dr. Bikman! I readily enjoy you as a guest on others' channels. Insulin IQ gives us the opportunity to see your knowledge/lectures in a format where you set the course material. I subbed right away! I always learn something new from your presentations and discussions. Today, it was that visceral fat is more readily burned as fuel over subcutaneous fat. My cheap, inaccurate 😉, electrostatic scale has even calculated the difference in rate change (come to think of it), on my health/fat-loss journey. This lecture also helped solidify my understanding of the differences between hyperplasic and hypertrophic adiposity that you've discussed several times in various videos. Now, onto the next Insulin IQ video on fat burning. Thank you very much!
Thanks for watching and for taking your valuable time to comment, Christopher. I appreciate it.
So much incredible information! I had to listen 2 to 3 times to certain sections to really retain the details. So anxious for upcoming episodes. I’m 64 and post menopausal and starting to take hrt cuz I also have osteopenia …. Not sure what the side effects will be on my fat cells. I’ve been keto for 3 years. So interested!!!
Thanks, Eileen, for your comment. Many people benefit from becoming part of my Insulin IQ Community. Perhaps you would find value there, through group coaching and like-minded people working on their metabolic health: www.insuliniq.com/insulin-iq-community-membership-signup
Thank you for sharing your scholarship . I am getting healthier and improving the health of my husband also .
Nice to be able to put the pieces together: 1) visceral fat, hypetrophy, pathophysiology that follows from over-stuffing, 2) cold therapy, caffeine, exercise (in a low insulin/plastic setting) can help reduce visceral fat.
Thanks
Wow. Thank you. Certainly not expected, but appreciated. Thanks. Let me (and/or my team) know if there is anything we can do to help you. www.insuliniq.com
@@insuliniq
Thank you for the knowledge you share Dr Bikman. I have read your book and looking forward to the second one.
TY
post the Q&A. we can learn a lot from other people's questions.
Well I've been struggling with holding this type of fat for years and now that I'm pre menopausal at 48, very nervous, my body is not shifting 100 lb overweight for years, keep going up and down fluctuating between 10- 20 lb gaining and losing gaining and losing, so I pray I can get a handle on this, going to go get my hormones checked soon..🙏🏽💜
Thank you. How fat is created, how it is burned, the sex differences, are really useful for our fat loss journey.
More good news. 🙏
BTW AGE 68.
I went from a 235 lbs blob to a 210 paleo low carb gym 🐀.
Three years and rocking it. HOW I FEEL IN THE BATHROOM, THE BEDROOM...
Fat in my diet or on my body, no problem. Thanx Dr. 💪🙏
Looking forward to the new recipe book but will you be releasing another book like Why We Get Sick (not the recipe book) ?
I have so missed being in a classroom. Love your talks which are inspiring. Found an online class in intro biochemistry that I want to take and got the book "Biochemistry for Dummies." :) I am trying to like every video I can find that you are in. Trying to figure out other ways that I can help get your message to other people.
Hi Cheryl. Thanks for your comment. One good way to start would be to create a free Basic Membership on our website which gives you access to my introductory course, “Raising Your Insulin IQ for Improved Metabolic Health”. This may really help you spread the word: www.insuliniq.com
Design! Intelligent design!
Thank you for another easy to understand presentation. You spoke about a fascinating study done on plastics around 29:00 minute time frame. Is Miralax on such plastic? Would you share the research paper your referenced please.
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
Dr.B , any notion on "how" if we can (at all) limit glutamine? The ingredient in green tea? I forget the Ingredient
Please ask professor bickman to make a video on insulin and Ed and it's remedy for men above 40 age, thanks
6:00 … very interesting … it then translates that consuming fat AND carbs in excess at same time MAY give rise to more efficient and quicker weight gain (fat storage being enhanced) … and the more adipose tissue available gives opportunity for even more weight gain … (?) … if I understand that correctly …
Could u slightly elaborate on the physiologic pathway n outcome of mono n poly unsaturated fats as regards cholesterol n LDLs n HDLs
How does one get help gaining weight?
Fun fact: a healthy woman will often have more testosterone than estradiol in her blood, in terms of mass per volume. Testosterone takes much more material to affect the body than estradiol, and it turns out that a strong estrogen signal achieved with estradiol needs about as much hormone material as a weak androgen signal achieved with testosterone.
When we order a lipase lab, why do we only get the total instead of the breakdown of the 3 types that are produced in the oral, pancreas/liver and adipose tissues? What am I missing?
I'm wondering if the difference in how the fat cells "grow" is related to why some people get lipidema and some don't. My understanding is they have created a new phenotype for people with lipidema as a disease. Do you have any research and/or opinion how this new phenotype? I am enjoying this channel very much. Thank you for all of this wonderful information. ~Mrs. C
Hey Ben,greetings from ireland. Q:Does estrogen dominance in men affect fat distribution & function & testosterone dominance in women through PCOS effect fat distribution & function in women?
I spy your new book in the back next to your first book 😍🥳
I’m surprised! Must find the “new” book: How Not to Get Sick! Thank you for sharing/noticing!
@@denniswilliamson6899 My pleasure! It’s on preorder on Amazon
This was amazing thank you so much for your work. I also love that you say evolutionary or by design:)
Thank you I am going to start watching all your videos... 55 inches tall, 45 inch waist.... age 79, I have to do something! I have been yo-yo dieting for decades... five years trying to eat Carnivore... failure... failure... failure...
Thanks for sharing. Sorry that you are struggling. You may want to consider joining our community to get a little more support and some ideas from our coaching team and from other like-minded people working on their metabolic health. You can do a 10-day trial at no cost: www.insuliniq.com/insulin-iq-community-membership-signup
Dr Bickman, can you please address Lipodema ?
Hi Alison. We are going to do a classroom episode sometime in late April on Lipedema.
@@insuliniq great. Thank you for all the work you do
Thank you for participating.
Dr, Bikman, you always say don't be afraid of fat. Should men with prostate cancer avoid fat?
Watch the bone density on your research animals. I have been ketogenic 8 years more longer Carnivore 81 years broken femoral stem osteoporosis. I really need to know if I am affecting my bone density?
Do alpha and beta cells slowly stop making more over time and age or because you use them all up from too much insulin?
Great lectures. I would like to join your courses in the university. How do I go about it?
It's in the notes....
Why is it that general physicians, labs, and the internet all get it wrong about what is normal fasting insulin level? Labs will show a normal range going up to 20. In you type in "what is normal fasting insulin," a google search returns "answers" about glucose as if glucose IS insulin. What's up?
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
Question. How would a type 1 diabetic deal with being insulin resistant ? Would a low carb diet be good ?
Hi Karen. We have actually created a log of content about this topic. You may want to go to our website and ask my team: www.insuliniq.com
its really hard to get away from plastic, almost impossible
Thank you so much for all of the information you share with the public! I have a question. Why is it that some of us women- even before we go through menopause store our fat like our male counterparts usually go? Mid section.
Hi Tassie. Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
Thanks Prof. Bikman for these amazing lectures. I have a question : in your book you mentioned that too much insulin inhibits aromatase in the ovaries leading to decreased conversion of androgens to oestrogens. At the same time the fat tissue produces Aromatase in both sexes and increases oestrgen level in the circulation ! If inhibited aromatase leads to increase andrgens in females , does it icrease andrgens in the tests? If a woman has more oestrgen in the circulation due to besity , why should she have PCOS and infertility ? Would you please talk about this topic . Thank you.
Thanks for your question. You may want to go to our website and ask my team: www.insuliniq.com
I am 3 weeks into low-carb, (again) plus some carnivore meals to help my hyperinsulinemia calm down. I lost 105 lbs 2 years ago but rebounded. I tried OMAD, but it weakened me, gave me A-Fib. I did not like how I felt. * I am determined to make this happen, and work smarter to be my permanent lifestyle with no more rebounds. I had surgical menopause at age 38 after 7 live births. Iam disabled now with an agressive osteoporosis. Everywhere but my ankles basically. So my focus is predominantly on diet. I have your book. 😊 Any suggestions for me?
Thanks for your comment, Nancy. Many people benefit from becoming part of our Insulin IQ Community. Perhaps you would find value there, through meetups, group coaching and like-minded people working on their metabolic health: www.insuliniq.com/insulin-iq-community-membership-signup
Try berberine. It will increase insulin sensitivity , promote ampk and modulate the gut bacteria as well. It also increases glp 1. High dose B1 will aid in atp and methylated b vit complex. Chromium and multi minerals pften help as well. Take berberine with food or extra fiber to mop up bacterial die off.
I don’t have any fat, I’ve eaten it all😂
There’s one type of fat storage you don’t seem to study, and consequently you have no information to share. Why? Subcutaneous and visceral fat is a painless luxury compared to the fat tissue of ugly PAINFUL lipedema? How does this talk to the rest of the body? What purpose does it serve? What colour is it? What signals does it send to the rest of the body? How does one turn it off? I work 3 days per week, exercise 3 days per week, I’ve been keto since 2019 and my CGM shows a consistent 4-5-5.5 mmol/l. Thoughts?
Perhaps there is a scientist out there whose work focuses on your desired topic.
Dr. Ken Berry recently had a video about lipedema - look it up on CZcams - about one month ago. Very interesting video.
Very good question. I am very interested in listening to Dr Bikman on lipedema.
@@user-yw2wb6rf3h Yes, I’ve have seen it (Berry) but not enough research has been done to take the information to the depths that Dr Bikman can go. I’d like to know more science. Two Australian researchers found the gene in 2020.
This is the topic ì was hoping to learn about as well.@@venkateswararaosunkara6571
Wow, never thought fat would be this interesting!
Jimmy Somerville
I'm type 2. If I cut carbs and increase meat/fats. Will this not push my ldl colesterol. Blood fats etc up. And contribute to heart disease???
Thanks 4:32
nope, it does the exact opposite bcuz carbs/sugars CAUSE high triglycerides and push cholesterol UP. Mine were high until I started carnivore diet. The both came down to normal in only 60 days.
😊❤
👏👏
Ben said "even a lean human has hundreds of thousands of calories stored on their body ready to be used .. "
At 3,500 calories per pound of fat, this can't be true?
Right?
I have been ketogenic for a year, but struggle to lose weight. I eat less than 10-20gms of carbs a day, do intermittent fasting, and fast 3 days every month. I do drink 2 cups of coffee with Kitu creamer 0 carbs - it’s cream with stevia, vanilla, and MCT oil. I was diagnosed pre diabetic with an A1C 6.2 a year ago and have dropped it down to 5.8, but my sugars still run high and I can’t get into ketosis except on fasting days and then only 1.2. My cells won’t let the insulin in to get the glucose out! How can I make my cells less resistant? Is there a detox or supplement I can take or maybe a protocol to improve my sensitivity. I don’t qualify for a CGM, and I am testing 3-4 times a day with a glucometer, and my fingers are bruised! Any suggestions will be appreciated!!
Eat only beef, beef fat, water and salt. Cut out all Carbs. Eat one meal per day. This is my diet and it is good.
I eat less than 10-20 gms of carbs, but I do believe I am responding to the carbs I am eating. Thank you for responding!
For your supplementations question, I highly recommend the CZcams channel: POTTENGER’S HUMAN
@@MrTrdaI will look it over, thanks for the info!
Sounds like high cortisol.
Why don't you number the videos so viewers know which videos should be seen first to better understand the topics ?
Thanks for your suggestion.
You lost me on the effect of plastic on the growth of fat cells. Does plastic increase the number of subconscious fat cells or the size of the visceral cells or both?
During Menopause, when women start to store fat more centrally, is that far still more subcutaneous or is it deeper (below the muscle)? Women get the muffin tops while men seem to have more solid fat.
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