Is Metformin Bad For Your Kidneys? Does Metformin Cause Kidney Damage? This Is What Actually Happens

Metformin is an oral anti-diabetic medication, approved by the U.S Food and Drug Administration in the treatment of type 2 diabetes.
Other indications of metformin include treatment of gestational diabetes, polycystic ovarian syndrome, and to prevent diabetes in individuals with pre-diabetes.
Metformin exerts its effects through several mechanisms.
Its major action is to reduce gluconeogenesis, or new glucose production in the liver.
In addition, it increases the uptake of glucose from peripheral tissues, especially the adipose tissue and muscle.
It also increases the fatty acid oxidation, decreases glycogen, protein, fatty acid, and cholesterol synthesis, decreases intestinal absorption of glucose, and reduces LDL cholesterol while increasing HDL cholesterol in blood, which reduces the cardiovascular risk in patients with type 2 diabetes.
Over the years, metformin has been studied thoroughly in relation to its potential benefits and risks.
Many studies have determined that it has a very low side effect profile and many additional benefits other than lowering blood glucose levels in individuals with type 2 diabetes.
However, most people think that long-term intake of metformin leads to kidney damage.
Let’s break this down.
Although metformin has a low side effect profile, in toxic levels, it can cause a serious condition called lactic acidosis.
This occurs primarily due to the inhibition of glucose production by the liver.
Patients with lactic acidosis will have symptoms such as vomiting, rapid heart rate, rapid breathing, confusion, muscle cramps, and weakness.
This condition occurs when metformin accumulates in larger amounts in blood, such as in kidney failure.
Like many other drugs, metformin is excreted unchanged via the kidneys.
However, in renal disease, the excretory ability of the kidneys declines, resulting in accumulation of metformin in blood.
Therefore, metformin is contraindicated in individuals with end stage renal disease, especially when the glomerular filtration rate drops below 30.
This is the actual relationship between metformin and kidney disease.
Metformin is not a causative factor for kidney disease, but rather it can cause life-threatening lactic acidosis in individuals with impaired kidney function.
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[@refffundle8779]

This is important

[@user-hn9bo4qf5j]

Good video ❤