Metformin Mechanism of Action

Presentation by: Kritika Pathak
Reviewed by: Ben Kronz
Metformin, a biguanide, is a well-documented drug used as the drug of choice for Type 2
Diabetes Mellitus for over half a century. Metformin’s efficacy in diabetic populations remains indisputable however, the exact mechanism of action is controversial with increasing evidence now indicating the presence of certain AMP-activated protein kinase (AMPK) independent pathways changing the perception that Metformin solely reduces hepatic gluconeogenesis physiologically via an AMPK dependent mechanism at the molecular level. Rapid developments in the last couple of decades have helped discover new targets and pathways that Metformin favorably influences to bring about improvements in not just Diabetes but various age-related diseases as well. It is now widely accepted that Metformin brings about its action by acting on various molecular targets and modulating a variety of different pathways and processes. And though we have been using this drug for almost 60 years, new actions continue to be discovered, broadening the range of conditions where Metformin could be used.
Further Studies:
● Decipher the exact mechanism(s) of action of Metformin
● Explore more on Metformin’s effects in the gut
● Validate its safety in non-diabetic populations if used in other age-related diseases
References:

[@user-pradeep_2207]

Thank u madam..

[@immadisarojini2775]

Nice explanation