This episode is also on the FoundMyFitness podcast on Apple and Spotify. Show notes: www.foundmyfitness.com/episodes/axel-montagne 00:03:23 - What dementias have in common 00:04:22 - The importance of preserving small blood vessels (in the brain) 00:05:17 - Changes in the blood-brain barrier in aging that cause "leaking" 00:06:50 - Predicting cognitive decline early with biomarkers - an opportunity for intervention? 00:08:11 - Why targeting amyloid isn’t enough 00:10:34 - The impact of the APOE4 genotype on brain vasculature 00:15:58 - The cause of white matter damage in the brain 00:25:26 - Why the loss of omega-3 transport affects pericytes 00:27:04 - The role of exercise in prevention of blood-brain barrier dysfunction 00:27:25 - Why high heart rates during exercise preserve brain function 00:28:28 - The role of exercise in preserving vision health 00:31:56 - Why leaky vessels damage myelin and the brain 00:37:10 - Can you have more than one type of dementia? 00:39:34 - Does the breakdown of the blood-brain barrier cause “type 3 diabetes"? 00:45:43 - Why omega-3 may prevent detachment of pericytes 01:06:14 - Why a hepatitis drug restored cognition in APOE4 mice 01:11:19 - Why blood-brain barrier disruption results in the accumulation of amyloid-beta 01:16:54 - Why lifetime hypertension increases dementia risk 01:28:53 - Effects of obesity on blood-brain barrier leakage
It seems to me by the studies that the root cause of AD and most diseases are caused by mitochondrial dysfunction. Which can be reversed by a ketogenic diet, fasting, cold therapy and resistance training. Also by minimizing toxin/ endocrine disrupter exposure and consumption. There are also some great mitochondrial support supplements like Omega 3, Niacin, COQ10, L- carnitine and others.
There is something wrong on Apple podcast. I tried listening there and what I get is a different podcast show by some guy talking about goals. Checked several times, not me. Really weird.
His English is leagues above my French, and I could not conduct this level of scientific inquiry in any language so I am grateful for this video and the work from this incredible young man and our beloved Dr. Rhonda.
Dr. Rhonda and Dr. Axel, this interview was one of the best I have ever heard about brain health. Dr. Rhonda, your team adding all the references, images etc is so appreciated and so helpful to better understand. Thank you both!
Excellent discussion and content. Dr Montagne is fascinating and knowledgeable, Dr. Patrick is the best interviewer in the CZcams space - she is knowledgeable about the science, respectful of guests, and let's her guests speak and finish their points. The graphics and integrated definitions are excellent. Thank you!
This was a fantastic episode, Rhonda, thank you. Was hoping to hear more discussion about Covid 19, which is largely recognized now as a vascular disease, and the role of the spike protein, and its impact on the blood brain barrier, endothelial cells, etc.
Excellent podcast. Thank you very much to Rhonda and Axel for presenting the science so well. Every bit of hope for future treatments is desperately important for people like myself, full time caring for parents with dementia in our 50s and knowing we have some of the risk factors that our healthy lifestyles cannot remove.
LOVE your channel! I've watched/skimmed 1000s of heath videos/ channels. Congrats! Yours is one of very best for your HONEST and INTELLIGENT interviews/ subject matter covered
Great bloody podcast! I can't believe ive watched every single one of your JRE podcast but never even knew you had one of your own. Every time JRE podcast ended I was left wanting more, so excited to binge all these episodes, thanks for your content Rhonda! You and Andrew are the best!
Good for you, but Get Out! If your HIIT session is up to snuff - how is it that you can fully 'listen' and take this content in while in a HIIT session ?... without your brain and all your attention and energy being focused on where your next breath might be coming from?!🤯😅 Hope you were kidding! If not...then I suggest you revisit what a REAL HIIT session is all about 😆
Thank you for posting your experience. I’ve been researching Dr. Bredesen’s protocol for my father as well, and he has both APOE per 23andme. I was thinking about signing him up for RECODE, and wasn’t sure. Now I’m going to sign him up. I’ve been following Dr. Patrick for years also, so was excited to see this interview.
@@Jessica-kk1cz That is great to hear! The protocol is effective, but it is not easy. For many people, the diet and exercise are the hardest parts. Commitment and consistency are key. Your father is lucky to have such a caring daughter. Good luck and God bless you both.
Could you look into the topic around Bacillus Subtilis? It is theorized that it may improve cell and barrier protection in gut and maybe even in the brain by some sort of biofilm and may protect against neuro degeneration.
@@niviensaleh9688I learned to tolerate the ‘acquired taste’ of Natto for its possible benefit to CVD, and most things that are good to the heart and blood vessels are generally also good for the brain. I’d recommend consuming Natto instead of just taking Nattokinase as a supplement. The whole food form provides the same benefits as consuming soy, with the added benefits of many postbiotics not just the single form in Nattokinase.
Před 10 měsíci
Super interesting ! Thanks for putting this first hand info out to the public, as we can take immediate action !
Very interesting info about fibrinogen, APOE4 carriers, maintaining vasculature and other amazing tidbits on the "bleeding edge" of research. Thank you, Rhonda and Axel! Now if I could just find out how to get some of these biomarkers tested.
I hope we'll see sPDGFRβ in the wider world, soon. That's the one that signals that pericyte damage is occurring and it's good news that it's already being trialed in hundreds of people (soon thousands, according to Axel). Thank you for watching, Debra!
Excellent presentation! I have read mostly sic lit for the toxicologic mechanisms of the co-morbidity of the metal lead Pb. I am increasingly concerned that it is not commonly incorporated into research related to brain micro-vasculature mechanisms. Understandably, research is necessarily oversimplification in order to try to make sense of the mechanisms, their additive and synergistic complications of pathogenicity. I would love to hear you two discuss any aspects of Pb toxic mechanisms in BBB involvement related to the complexity you have so well clarified here. Lead is said to cause per oxidation of lipids on contact, which seems important to consider for endothelial integrity in BBB. And, given our lead body burden accumulations (typically 100 to 1000 x's that in prehistoric bone), and mobilization of Pb when the body comes under stress of old age, illness, pregnancy) where the body seeks additional calcium (lead follows calcium through many physiologic pathways). Significant research has been done about brain lead adverse effects on many functions( eg. glutathione reductions of up to 60%, GABA reductions, per oxidation of membranes, astrocyte damage, etc.) seemingly very important to inclusion into more depth of discussion of existing research of brain lead as co-morbidity in BBB effects and more. Then, there is the spike protein damage brain vasculature effects initiating BBB perforation, and the nitric oxide importance in small vessel dilation of smooth muscle function for blood flow, and how so called 'ED of the brain' might have a wild possibility of some kind of alleviation of constrictive mechanisms via sildenafil use(?) on and on complexity... so grateful for your work!
Amazing discussion, thank you. Axel made the same point I was shouting at my device about! The devil is in the detail and we have to think of alcohol in its specific context. Nobody drinks ‘alcohol’ ...they drink ‘alcoholic drinks’ and could that not explain the sex difference in data between men & women and the effects of ‘alcohol’? There’s no denying that on average women are less likely to drink pints of beer, and more likely to drink wine, or spirits & mixer, even if we keep the alcohol quantities comparable. Axel saved the day by reminding us that the French, par exemple, drink moderate amounts of red wine often, which contains (?) protective compounds. However, Rhonda, you quickly countered that daily drinking should be discouraged. But what about the Sardinian centenarians who drink a couple of small glasses of their local organic wine DAILY, and never seem to develop any chronic, vascular or degenerative illnesses whatsoever (at least until they’re over 100!). Although personally I choose to drink alcohol only at special celebrations, if I lived near a source of organic Cannonau red wine from locally grown grapes, things would be different! I really do feel enough distinction has not been made between the drinks nature themselves. As a 61 yr old meditating, non-smoking, regular exercising (cardio/resistance/boxing/yoga), sauna goer, intermittent faster (earlyTRE pattern) on a plant based diet with regular oily fish and a little meat now and then (40-50 plants per week), zero added sugar, constant brain stimulation from work & play, no increased genetic disease risks that I know of, a wonderful family, low stress and a safe home, I feel grateful and blessed, but for goodness sake, leave that moderate intake of organic red wine alone! Oh and I eat a square of 70% dark chocolate daily - please may I reserve my telegram from the King when I’m 100? Many thanks to both, you clever, clever scientists 🙏 🙏
And plenty of brain ‘exercise’, time with friends, family, community and a sense of purpose...oh and I find early Time Restricted Eating to be incredibly vitalising and energising
Great discussion, thanks for bringing Axel on. I wonder what he or Rhonda would suggest as a diet/exercise/supplement/drug regimen in suspected CTE cases?
I would think it would be along the lines of eating whole natural foods that are anti-inflammatory, lifting weights, three times a week and getting your 150 minutes of cardiovascular exercise in a week
@@buckw65 part of a scientist's job is to educate people so I hope she looks at it that way and also Rogan loves her at the very least it's a good place to be to disagree
Plus Rhonda gave him a run for his money and set him straight over the nonsense he was parroting re vaccines, so no...she’s not afraid to challenge anyone. Go Warrior Rhonda!
My brain has been bashed more times than I can count, both accidentally and clinically. ER trips for dream reenactment behavior accidents and brain biopsy for CNS vasculitis. I can honestly say survived all this and have even experienced some reversal of so called incurable conditions. I'm saving this video for future reference. My brain is very precious to me.
Amazing presentation! Thank you and would love a follow up that covers some preventative interventions and also would be very interested your views on the recent study showing an adverse interaction between Rapamycin and plaque development in mouse models.
I wonder how similar blood brain barrier health is to skin health? Perhaps all of the supplements that help skin like collagen would also have a beneficial effect on the blood brain barrier membrane.
My grandfather and all his siblings died of Alzheimers and it was not hereditary (autopsy was done). However, they were all exposed to high levels of DDT in the 40's and 50's and DDT is a known risk factor. Unfortunately, that stuff is still in our food supply as it's still used in some parts of the world. Lots of different causes.
My father and most of his siblings are going through this. My dad is still alive but is end stage. 2 of his sisters have already passed wIth it. 2 others have and are not as far along in the process. One doesn't have it - I'm sure he's waiting his turn. Needless to say, the next generation of our family is worried.
@@JMSsssssss sorry to he hear about what your family is going through, it is really hard. Dreadful disease. My dad and all his siblings have been worried about getting it too. But they are all in their 70's and so far fine...So many were exposed to DDT years ago and are now elderly, I wonder how much of the Alzheimers today was possibly caused by that.
The bigger poison that your relatives were exposed to and that you yourself were exposed to its called sugar the resulting insulin rise and blood sugar rise causing you heard them say small vessel disease what's cluckin the small vessels.. plaque caused by excess of sugar we are our own worst enemy we poison ourselves
fyi..the body repairs itself and also does away with many toxins regardless of the exposure and time of it. Proper nutrition is what prevents it. it's important to take note that 200-300 years ago the European #Nordic #foodDeserts #reindeerherdsman we're still roaming the #articTundra and had no diseases. In #Mongolia and #Siberia the reindeer herdsman are still very active but have new wrapped manufactured foods such as sweet breads where now they get diabetes and high blood pressure and even cancer. So it is very important to take note that salt consumption has gone substantially down and that everyone is afraid of saturated animal fats and now stay away from organ meats. please understand that if you take a #statin, if you take an #anticoagulant any of these are devastating your #collagen stores in your body and your body is unable to rebuild it. #DrDaleBrenesen #DrDonaldLayman #metabolicMind #charlieFoundation what heals your brain heals your body but you must heal your body first. #carnivoreCure
Ronda, Fabulous interview. Thank you. I have Alzheimer's on both sides of my family so I'm working it hard. My current thoughts on my Alzheimer's and Dementia prevention protocol... ... High dose of Omega 3 daily to get my Omega3 index as close to a dolphin as possible (I'm at 18% now) ... High intensity cardio several times a week (sprint spin classes) Zone 5 training driving Vo2Max up. ... Dry Sauna sessions frequently ... Lift weights and eat loads of protein to build muscle mass. ... Get great sleep targeting at least two hours of deep sleep each night. Anything else?
If vascular disease is the culprit then wouldn't a plant based diet, reduction in stress, in addition to exercise be a preventative measure from alzheimer’s/dementia?
I think that's reasonable. I've noticed a couple of the health channels I like seem to avoid tackling the plant-based vs. other diet options too directly in relation to health topics, such as this one about brain diseases. Possibly for fear that proponents of other non-plant based diets will take offense. So they've determined that it's just not worth the grief and loss of platform revenue to commit too strongly on that front. Instead they concentrate upon the exercise, sleep, stress minimization aspects, with only a lesser degree of exploration into the dietary components. Just my hunch anyway.
@The Monopoly Experiment Well, it's more a case of not really knowing...as in, scientific fact. And, no I'm not talking about epidemiological 'studies'. It's all hypothetical - the pb diet health benefits.
Thank you for this interview. Fascinating information. Question please: Do you think warm climates , especially exercise during warm days, enhance cardiovascular benefits, similar to the effects of using a sauna?
So from the first part it sounds as though maintaining the integrity of the pericyte is key and one method is through stem cell therapy. I saw something recently that sai having 2 cups of hot cocao or cocoa a day will at least double your natural stem cell production. I love hot cocoa, worth a try .
At about 20 minutes in I noticed that Axel seems to have a Star Trek style jumper (jumper: is English for pullover) on, then suddenly darker bands appeared lower down; Ye old Bumble Bee jumper. Well, apart from that, ramping up to be quite a good discussion (as usual). Thanks you two. Bye.
Air pollution in Mexico City has high levels of fine particulate of lead, and given that lead atoms are well known to turn lipids rancid on contact, this seems likely to be a mechanism of olfactory bulb membrane damage and entry into the CNS?
I am curious how specialized pro-resolving mediators can play a role in reducing the loss or protection of pericytes. SPM function can decrease with age and poor nutrition so I am curious if this is seen in correlation with pericyte loss.
Exercise- do you need to achieve any particular level of heart rate and if so for how long? Repetitive throughout the exercise period or for longer periods, or?
Usually the intensity of exercise that it’s proven to help with cardiovascular disease is 30 min daily of brisk walk; the “ gauge” would be to walk fast enough to have difficulty talking fluently.
My Mom died of Vascular Dementia in the "80s. The term vascular was used back then so I am not too sure how new (or old) the identification of this type of dementia is.
Axel calls out high heart rate, specifically. There's some evidence that the shearing forces of higher heart rates themselves promote BDNF in the brain. Furthermore, you're likely to see more lactate production from a HIIT style... I'm a fan! That being said, being active in whatever capacity is always going to be better than not being active and put you worlds ahead of being sedentary.
What about Vitamin D3 supplementation ( prior vitamin D level check)? I know it’s important in PD, MS and other movement disorders( as well as depression, sleep quality).
I wonder if because the blood brain barrier doesn't let fructose pass in and out of it, but artificial sweeteners can pass through and are converted into fructose (e.g., sorbitol), fructose gets trapped in the brain and causes problems related to AD?
Wha??? Oh my that is scary! Do you remember the source of that info? I’ve been using artificial sweeteners for quite a while and I’m just now starting to hear some bad things about them, so I’m curious to learn more.
@@RosieJ7223 hey! I don't on hand, but if you look at the enzymatic process for sucralose, you'll see it is converted directly into fructose. Also, respective searches for "does fructose cross bbb" and "does sucralose cross bbb" should have answer in top result.
See: Robert Lustig, on sweetness on receptors on the tongue signaling for storing everything as fat, even to the point of reducing metabolism levels to keep from burning fats.@@RosieJ7223
What about Specialized Pro Resolving Mediators for a “stronger” means of having the affect of Omega 3? Especially in cases of noted disease pathology, could Specialized Pro Resolving Mediators be a wise idea? This was an in incredible interview!
Cheng H, Yang B, Ke T, Li S, Yang X, Aschner M, Chen P. Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders. Toxics. 2021 Jun 17;9(6):142. doi: 10.3390/toxics9060142. PMID: 34204190; PMCID: PMC8235163.
You always make exceptional YT’s .. thank you. So, until advanced therapies available …. Aerobic exercise, keep ldl cholesterol (and apoB) glucose, BP as low as possible, at least for small/micro vessel / vascular dementia?
Gluten is known to to cause cerebellar ataxia (loss of balance) when it crosses the BBB in the elderly. There was mentioned on the biomarkers screen tight junction proteins. In the intestines zonulin is the tight junction protein that gluten breaks. Is this, please, the same protein and process that happens at the blood brain barrier ?
Thanks, recap , exercises food, sleep,stress, most disease are vascular diseases and blood flow like watering plants, sunshine,nutrients and oxygen.Brain is just one organ in the ecosystem of the body which is part of all ecosystem. All connected. ,
If BBB is frequently imaged as starting to become more 'leaky' at the hippocampus, and lots of research shows that the hippocampus is a site of brain tissue having elevated toxic metal lead, is it the per oxidative action of lead on bi-lipid layers on contact with the lead, that might be initiating much of the leakiness? Bone body burden of lead is in most of us, and can be mobilized as calcium is sought from bone to deal with physiologic stresses of old age, illness, or pregnancy, when we are most vulnerable?
It's got to be mostly cellular degeneration and probably caused by diet. It's very likely similar to cellular level unhealthiness that causes leaky gut problems.
Did they give any protocol? Dr. Andy Galpin told Andrew Huberman to give MAX effort to MAX heart rate once/wk at least "just touch it" but preferably 4x/wk. He also gave a separate protocol of a weekly HARD effort that can only be sustained from 4-8 minutes once/wk, preferably 4x/wk. Did Dr. Patrick/Montagne give a protocol recommendation of their own?
@ MR8RAVES - That's totally out of context. (Of this subject) Huberman and Galpin are discussing overall health benefits in the context of exercise for strength and hypertrophy. Different context than the subject of exercise & BBB, alzheimers, and benefitting blood vessels in the brain, as discussed here. You'd get closer to this subject about how to apply exercise for cardiovascular health & brain health, by tuning in to Huberman's most recent interview of Dr. Peter Attias. (This past week, I believe ;)) That is not to say that Andy Galpin's exercise expertise is any lesser, imo, than Peter Attias health/exercise expertise - but the two Huberman interviews with 2 different health experts, focuses on two entirely different aspects of applied exercise & health.
Watching this made me start researching the supplements of lysine, L-Citrulline, L-Arginine and the soy milk I drink, but I lack the background to figure it out but I can't help but think that an increase in nitric oxide might be helpful. Luckily I get tons of exercise, so much so I worry about stroke, that is how I started taking supplements that increase it. And thanks to Rhonda, I get lots of cold water fatty fish dishes.
N-Acetyl Glucosamine + Red Light + HDL cholesterol + Omega-3 + micro doses Aspirin and GLA compliment the Red Beet Extracts / time restricted eating and 24-72 hour Fasting to decrease Insulin Resistance - these are the Avenues
R-Lipoic and A-Lipoic acid reset the biochemical circadian rhythm, that is Synchronicity, in combination with Red Light Therapy and HDL cholesterol restore the endothelial cells fluid.
Alzheimers, surely partly a result of reducing cholesterol when really calcium just needed k2to stop it clogging arteries? Cholesterol would have more room...? My husband was a man who regularly cycled and he got dementia and died young but he had been fit We need an overhaul infarming to put k2 back indiets
Which of the symptoms. Such as damaged vessels, microbleeds whitematter, lacunes, spaces, and brain atrophy, etc. can be repaired, once already present, via exercise and or supplementation?
I did the following cardio process to reduce endothelim surface plaque, inflammation at age 66. Regardlsess of age, the inflamation of endothelium can be reduced by a diet that brings about the natural NO endothelium production process. Cruciferous vegatables eaten with acedic acid in vinegars or, if allergic to Cruciferous vegs, other green leafy vegs, again w acedic acid. In each day, 6x times per day, a small handful of green leafy vegs, (with each meal = 3x, 2 hrs after each meal). This causes the endothelium to cleans inside of vessels. The inflammation, some call plaque, can be reduced in size. To decrease the size of arterial plaque, the inflamation do 3 more things: 1. Eat spicey vegs having capsaicin. Doesn’t have to be super hot, but spicey. Raw, cook is a personal preference. Cook longer reduces the hotness but capsaicin is still anti-infalammatory. 2. Stop eating foods that cause inflamtion. You will need to determine very common foods in Western diets that cause the inflamation of blood vessels on the endothelium, and it is NOT ONLY CHOLESTEROL! 3. Elliminate inflamatory foods. No oils from a bottle, no processed deli meats, no GMO wheat, grains. This application of green leafy vegs, anti-inflammatory foods and ellimination of infammatory foods. is potent and it works. Must get exercise once a day to some sweating, doesn't have to be excessive sweat. Joints stop aching, reduces the roo. Inflammation plaque while i creasing diameter of blood flow area in vessels. Ref: Dr. Caldwell Essestyn MD, Cardiologist, Cleveland Clinic This dr recovers cardio patients who are inoperative, cannot have surgery. The extreme form of this diet removes all animal meats and is coupled with a vegan diet that used plant- based proteins.
This episode is also on the FoundMyFitness podcast on Apple and Spotify. Show notes: www.foundmyfitness.com/episodes/axel-montagne
00:03:23 - What dementias have in common
00:04:22 - The importance of preserving small blood vessels (in the brain)
00:05:17 - Changes in the blood-brain barrier in aging that cause "leaking"
00:06:50 - Predicting cognitive decline early with biomarkers - an opportunity for intervention?
00:08:11 - Why targeting amyloid isn’t enough
00:10:34 - The impact of the APOE4 genotype on brain vasculature
00:15:58 - The cause of white matter damage in the brain
00:25:26 - Why the loss of omega-3 transport affects pericytes
00:27:04 - The role of exercise in prevention of blood-brain barrier dysfunction
00:27:25 - Why high heart rates during exercise preserve brain function
00:28:28 - The role of exercise in preserving vision health
00:31:56 - Why leaky vessels damage myelin and the brain
00:37:10 - Can you have more than one type of dementia?
00:39:34 - Does the breakdown of the blood-brain barrier cause “type 3 diabetes"?
00:45:43 - Why omega-3 may prevent detachment of pericytes
01:06:14 - Why a hepatitis drug restored cognition in APOE4 mice
01:11:19 - Why blood-brain barrier disruption results in the accumulation of amyloid-beta
01:16:54 - Why lifetime hypertension increases dementia risk
01:28:53 - Effects of obesity on blood-brain barrier leakage
Definitely worth listening to it twice too! So much information to absorb
Ppp00
It seems to me by the studies that the root cause of AD and most diseases are caused by mitochondrial dysfunction. Which can be reversed by a ketogenic diet, fasting, cold therapy and resistance training. Also by minimizing toxin/ endocrine disrupter exposure and consumption. There are also some great mitochondrial support supplements like Omega 3, Niacin, COQ10, L- carnitine and others.
There is something wrong on Apple podcast. I tried listening there and what I get is a different podcast show by some guy talking about goals. Checked several times, not me. Really weird.
I’m u
Just back from the gym and a nice reminder, especially as I approach my senior years, that it is worth it.
His English is leagues above my French, and I could not conduct this level of scientific inquiry in any language so I am grateful for this video and the work from this incredible young man and our beloved Dr. Rhonda.
Yes his vocabulary and grammar are perfect. His accent make it hard to understand some parts and have to repat some sections though
i used subtitles
Dr. Rhonda and Dr. Axel, this interview was one of the best I have ever heard about brain health. Dr. Rhonda, your team adding all the references, images etc is so appreciated and so helpful to better understand. Thank you both!
Such a privilege to get to talk to Axel. And I am SO appreciative for your comment. Makes the work of these releases worthwhile!
@@FoundMyFitness hi Rhonda, Will you be getting the flu shot or bypass it?
Excellent discussion and content. Dr Montagne is fascinating and knowledgeable, Dr. Patrick is the best interviewer in the CZcams space - she is knowledgeable about the science, respectful of guests, and let's her guests speak and finish their points. The graphics and integrated definitions are excellent. Thank you!
Thanks to the FMF staff for putting together the slides and footnotes. We really appreciate your work.
This was a fantastic episode, Rhonda, thank you. Was hoping to hear more discussion about Covid 19, which is largely recognized now as a vascular disease, and the role of the spike protein, and its impact on the blood brain barrier, endothelial cells, etc.
Awesome episode. The integration of visuals, definitions and citations makes this learning experience so cool. Thank you, Dr. Patrick.❤
Best brain health video I've seen this year.
Excellent podcast. Thank you very much to Rhonda and Axel for presenting the science so well. Every bit of hope for future treatments is desperately important for people like myself, full time caring for parents with dementia in our 50s and knowing we have some of the risk factors that our healthy lifestyles cannot remove.
LOVE your channel! I've watched/skimmed 1000s of heath videos/ channels. Congrats! Yours is one of very best for your HONEST and INTELLIGENT interviews/ subject matter covered
Great bloody podcast! I can't believe ive watched every single one of your JRE podcast but never even knew you had one of your own. Every time JRE podcast ended I was left wanting more, so excited to binge all these episodes, thanks for your content Rhonda! You and Andrew are the best!
Fascinating discussion from two gifted expositors. Thanks Doc.
Great episode Dr. Rhonda. And thanks to Dr. Axel Montagne for sharing the insights.
I am an Apoe4/4 who recovered from MCI using the Bredesen Protocol. I’m listening to this while doing my HIIT training😅
Good for you, but Get Out!
If your HIIT session is up to snuff - how is it that you can fully 'listen' and take this content in while in a HIIT session ?...
without your brain and all your attention and energy being focused on where your next breath might be coming
from?!🤯😅
Hope you were kidding! If not...then I suggest you revisit what a REAL HIIT session is all about 😆
Thank you for posting your experience. I’ve been researching Dr. Bredesen’s protocol for my father as well, and he has both APOE per 23andme. I was thinking about signing him up for RECODE, and wasn’t sure. Now I’m going to sign him up. I’ve been following Dr. Patrick for years also, so was excited to see this interview.
@@Jessica-kk1cz That is great to hear! The protocol is effective, but it is not easy. For many people, the diet and exercise are the hardest parts. Commitment and consistency are key. Your father is lucky to have such a caring daughter. Good luck and God bless you both.
Thank you very much for this video! I learned a lot. It is important that this knowledge is shared.
Could you look into the topic around Bacillus Subtilis? It is theorized that it may improve cell and barrier protection in gut and maybe even in the brain by some sort of biofilm and may protect against neuro degeneration.
Yes, please discuss research on nattokinase (substance produced by bacillus subtilis) and, e.g., its reduction of fibrinogen!
@@niviensaleh9688I learned to tolerate the ‘acquired taste’ of Natto for its possible benefit to CVD, and most things that are good to the heart and blood vessels are generally also good for the brain. I’d recommend consuming Natto instead of just taking Nattokinase as a supplement. The whole food form provides the same benefits as consuming soy, with the added benefits of many postbiotics not just the single form in Nattokinase.
Super interesting ! Thanks for putting this first hand info out to the public, as we can take immediate action !
love having the accompanying slides
Very enjoyable to listen to your discussion and your questions.
THANK YOU BOTH..
Very interesting info about fibrinogen, APOE4 carriers, maintaining vasculature and other amazing tidbits on the "bleeding edge" of research. Thank you, Rhonda and Axel! Now if I could just find out how to get some of these biomarkers tested.
I hope we'll see sPDGFRβ in the wider world, soon. That's the one that signals that pericyte damage is occurring and it's good news that it's already being trialed in hundreds of people (soon thousands, according to Axel).
Thank you for watching, Debra!
Excellent presentation! I have read mostly sic lit for the toxicologic mechanisms of the co-morbidity of the metal lead Pb. I am increasingly concerned that it is not commonly incorporated into research related to brain micro-vasculature mechanisms. Understandably, research is necessarily oversimplification in order to try to make sense of the mechanisms, their additive and synergistic complications of pathogenicity. I would love to hear you two discuss any aspects of Pb toxic mechanisms in BBB involvement related to the complexity you have so well clarified here. Lead is said to cause per oxidation of lipids on contact, which seems important to consider for endothelial integrity in BBB. And, given our lead body burden accumulations (typically 100 to 1000 x's that in prehistoric bone), and mobilization of Pb when the body comes under stress of old age, illness, pregnancy) where the body seeks additional calcium (lead follows calcium through many physiologic pathways). Significant research has been done about brain lead adverse effects on many functions( eg. glutathione reductions of up to 60%, GABA reductions, per oxidation of membranes, astrocyte damage, etc.) seemingly very important to inclusion into more depth of discussion of existing research of brain lead as co-morbidity in BBB effects and more. Then, there is the spike protein damage brain vasculature effects initiating BBB perforation, and the nitric oxide importance in small vessel dilation of smooth muscle function for blood flow, and how so called 'ED of the brain' might have a wild possibility of some kind of alleviation of constrictive mechanisms via sildenafil use(?) on and on complexity... so grateful for your work!
Amazing discussion, thank you. Axel made the same point I was shouting at my device about! The devil is in the detail and we have to think of alcohol in its specific context. Nobody drinks ‘alcohol’ ...they drink ‘alcoholic drinks’ and could that not explain the sex difference in data between men & women and the effects of ‘alcohol’? There’s no denying that on average women are less likely to drink pints of beer, and more likely to drink wine, or spirits & mixer, even if we keep the alcohol quantities comparable. Axel saved the day by reminding us that the French, par exemple, drink moderate amounts of red wine often, which contains (?) protective compounds. However, Rhonda, you quickly countered that daily drinking should be discouraged. But what about the Sardinian centenarians who drink a couple of small glasses of their local organic wine DAILY, and never seem to develop any chronic, vascular or degenerative illnesses whatsoever (at least until they’re over 100!). Although personally I choose to drink alcohol only at special celebrations, if I lived near a source of organic Cannonau red wine from locally grown grapes, things would be different! I really do feel enough distinction has not been made between the drinks nature themselves.
As a 61 yr old meditating, non-smoking, regular exercising (cardio/resistance/boxing/yoga), sauna goer, intermittent faster (earlyTRE pattern) on a plant based diet with regular oily fish and a little meat now and then (40-50 plants per week), zero added sugar, constant brain stimulation from work & play, no increased genetic disease risks that I know of, a wonderful family, low stress and a safe home, I feel grateful and blessed, but for goodness sake, leave that moderate intake of organic red wine alone! Oh and I eat a square of 70% dark chocolate daily - please may I reserve my telegram from the King when I’m 100?
Many thanks to both, you clever, clever scientists 🙏 🙏
Thank you for putting out shorter clips!
Thanks Dr Patrick - Always great content!
Thank you for this, I have svd early onset and I found this information extremely useful
Thank you both for this great interview, I'll start exercising again
Axel seems to be incredibly knowledgeable on a variety of related subjects, we're lucky that he's doing research on dementia
Excellent guest and discussion! Of note would be the role of blood brain-microbiome health plays in overall blood brain barrier health
Healthy plant based diet, lots of moderate and some intense exercise,controlling stress, good sleep hygiene has got to help
And plenty of brain ‘exercise’, time with friends, family, community and a sense of purpose...oh and I find early Time Restricted Eating to be incredibly vitalising and energising
Great discussion, thanks for bringing Axel on. I wonder what he or Rhonda would suggest as a diet/exercise/supplement/drug regimen in suspected CTE cases?
I would think it would be along the lines of eating whole natural foods that are anti-inflammatory, lifting weights, three times a week and getting your 150 minutes of cardiovascular exercise in a week
The End of Alzheimers book is a good guide.
Lots of exercise. Deep sleep. Low carb Whole Foods diet. Hyperbaric oxygen chamber sessions. Sauna sessions. Omega-3 supplementation.
I love this interview about Alzheimer and Dementia
Love Dr Rhonda!! Hope she goes back on JRE soon!!
I don't think that will happen anytime soon. Rogan an antivaxers. Dr Rhonda is all about the science. Conflicting to the antivaxers
@@buckw65 part of a scientist's job is to educate people so I hope she looks at it that way and also Rogan loves her at the very least it's a good place to be to disagree
@@jusTRYNAgetaPEANUT very valid points. Thanks for that....gives me hope
Plus Rhonda gave him a run for his money and set him straight over the nonsense he was parroting re vaccines, so no...she’s not afraid to challenge anyone. Go Warrior Rhonda!
That was most interesting and enlightening. Thank you.
Excellent information thank you Rhonda
Awesome episode 👏
My brain has been bashed more times than I can count, both accidentally and clinically. ER trips for dream reenactment behavior accidents and brain biopsy for CNS vasculitis. I can honestly say survived all this and have even experienced some reversal of so called incurable conditions. I'm saving this video for future reference. My brain is very precious to me.
Amazing presentation! Thank you and would love a follow up that covers some preventative interventions and also would be very interested your views on the recent study showing an adverse interaction between Rapamycin and plaque development in mouse models.
Thank you !!!
Gratitude! Heroic work
Rhonda, your lighting is sure excellent.
Fantastic, thanks
ty for sharing
I wonder how similar blood brain barrier health is to skin health? Perhaps all of the supplements that help skin like collagen would also have a beneficial effect on the blood brain barrier membrane.
The research is promising.
My grandfather and all his siblings died of Alzheimers and it was not hereditary (autopsy was done). However, they were all exposed to high levels of DDT in the 40's and 50's and DDT is a known risk factor. Unfortunately, that stuff is still in our food supply as it's still used in some parts of the world. Lots of different causes.
My father and most of his siblings are going through this. My dad is still alive but is end stage. 2 of his sisters have already passed wIth it. 2 others have and are not as far along in the process. One doesn't have it - I'm sure he's waiting his turn. Needless to say, the next generation of our family is worried.
@@JMSsssssss sorry to he hear about what your family is going through, it is really hard. Dreadful disease. My dad and all his siblings have been worried about getting it too. But they are all in their 70's and so far fine...So many were exposed to DDT years ago and are now elderly, I wonder how much of the Alzheimers today was possibly caused by that.
The bigger poison that your relatives were exposed to and that you yourself were exposed to its called sugar the resulting insulin rise and blood sugar rise causing you heard them say small vessel disease what's cluckin the small vessels.. plaque caused by excess of sugar we are our own worst enemy we poison ourselves
fyi..the body repairs itself and also does away with many toxins regardless of the exposure and time of it. Proper nutrition is what prevents it. it's important to take note that 200-300 years ago the European #Nordic #foodDeserts
#reindeerherdsman we're still roaming the #articTundra and had no diseases. In #Mongolia and #Siberia the reindeer herdsman are still very active but have new wrapped manufactured foods such as sweet breads where now they get diabetes and high blood pressure and even cancer. So it is very important to take note that salt consumption has gone substantially down and that everyone is afraid of saturated animal fats and now stay away from organ meats. please understand that if you take a #statin, if you take an #anticoagulant any of these are devastating your #collagen stores in your body and your body is unable to rebuild it. #DrDaleBrenesen
#DrDonaldLayman
#metabolicMind
#charlieFoundation
what heals your brain heals your body but you must heal your body first. #carnivoreCure
Excellent and very informative. Thanks
WOW!!! How to fight these diseases!
Ronda, Fabulous interview. Thank you. I have Alzheimer's on both sides of my family so I'm working it hard.
My current thoughts on my Alzheimer's and Dementia prevention protocol...
... High dose of Omega 3 daily to get my Omega3 index as close to a dolphin as possible (I'm at 18% now)
... High intensity cardio several times a week (sprint spin classes) Zone 5 training driving Vo2Max up.
... Dry Sauna sessions frequently
... Lift weights and eat loads of protein to build muscle mass.
... Get great sleep targeting at least two hours of deep sleep each night.
Anything else?
Fantastic pod! I worry as Covid is slowly looking like an endothelium damaging disease what this means for chronic disease like CD.
Would be very curious to see how COVID can play into this given it's issues with clotting and microvasculature issues.
Please cover lithium
I started looking up how L-Citrulline Malate or Arginine might help.
What did you find? Is it good for the micro vasculature?
Bravo🛎️🙏
If vascular disease is the culprit then wouldn't a plant based diet, reduction in stress, in addition to exercise be a preventative measure from alzheimer’s/dementia?
I think that's reasonable. I've noticed a couple of the health channels I like seem to avoid tackling the plant-based vs. other diet options too directly in relation to health topics, such as this one about brain diseases.
Possibly for fear that proponents of other non-plant based diets will take offense. So they've determined that it's just not worth the grief and loss of platform revenue to commit too strongly on that front. Instead they concentrate upon the exercise, sleep, stress minimization aspects, with only a lesser degree of exploration into the dietary components. Just my hunch anyway.
And improved sleep hygiene too. You make a good point.
@The Monopoly Experiment
Well, it's more a case of not really knowing...as in, scientific fact. And, no I'm not talking about epidemiological 'studies'. It's all hypothetical - the pb diet health benefits.
Excellent video thank you! So saunas and aerobic exercise would help because of the vascular benefits?
Thank you for this interview. Fascinating information. Question please: Do you think warm climates , especially exercise during warm days, enhance cardiovascular benefits, similar to the effects of using a sauna?
There is a *the book on heat* which discusses this topic in detail.
@@GreyBeard_Fit and the conclusion?
So from the first part it sounds as though maintaining the integrity of the pericyte is key and one method is through stem cell therapy. I saw something recently that sai having 2 cups of hot cocao or cocoa a day will at least double your natural stem cell production. I love hot cocoa, worth a try .
Larry, you get the # of stem cells you get, at birth. Totally untrue that your body can manufacture additional stemcells.
Do inversions, such as headstands, help with the blood flow and the health of these vessels?
can the blood brain barrier be repaired after pathological damage
Do the studies on Aircraft Technicians who work at the Airport Platforms .. the most effected studies i guess.
What about the TREM2 gene and microglia cells? Thanks Dr. Patrick for having this brilliant man on. Wonderful. Also BACE enzyme?
Excellent. Lots of fun stuff. Thanks. I’m going to go for a walk. To buy some salmon.😊
@ultramegasuper -, 🤣😂😅
At about 20 minutes in I noticed that Axel seems to have a Star Trek style jumper (jumper: is English for pullover) on, then suddenly darker bands appeared lower down; Ye old Bumble Bee jumper. Well, apart from that, ramping up to be quite a good discussion (as usual). Thanks you two. Bye.
Does anyone know if Dr Patrick, in regards to steam saunas or infrared saunas-which one would be best for lymphoma?
Air pollution in Mexico City has high levels of fine particulate of lead, and given that lead atoms are well known to turn lipids rancid on contact, this seems likely to be a mechanism of olfactory bulb membrane damage and entry into the CNS?
I am curious how specialized pro-resolving mediators can play a role in reducing the loss or protection of pericytes. SPM function can decrease with age and poor nutrition so I am curious if this is seen in correlation with pericyte loss.
I am curious about this, as well.
Dr. Patrick, is this applicable at all to MS, and how would you naturally lower fibrinogen safely or via fibrin-targeted immunotherapy?
What about high heart-rate from medications? Such as the many amphetamine-derived ADHD medications?
Exercise- do you need to achieve any particular level of heart rate and if so for how long? Repetitive throughout the exercise period or for longer periods, or?
Usually the intensity of exercise that it’s proven to help with cardiovascular disease is 30 min daily of brisk walk; the “ gauge” would be to walk fast enough to have difficulty talking fluently.
My Mom died of Vascular Dementia in the "80s. The term vascular was used back then so I am not too sure how new (or old) the identification of this type of dementia is.
Rhonda is ❤️
Anyway to get LPC bound epa dha beyond fish row? Are there any supplements available yet?
What type exercise is recommended to keep the small vessels working? Longer bouts of low level cardio versus HIIT versus,... ? Thanks.
Axel calls out high heart rate, specifically. There's some evidence that the shearing forces of higher heart rates themselves promote BDNF in the brain. Furthermore, you're likely to see more lactate production from a HIIT style... I'm a fan!
That being said, being active in whatever capacity is always going to be better than not being active and put you worlds ahead of being sedentary.
@@FoundMyFitness Thank you
Do a segment on pregnenolone.
What about Vitamin D3 supplementation ( prior vitamin D level check)? I know it’s important in PD, MS and other movement disorders( as well as depression, sleep quality).
I wonder if because the blood brain barrier doesn't let fructose pass in and out of it, but artificial sweeteners can pass through and are converted into fructose (e.g., sorbitol), fructose gets trapped in the brain and causes problems related to AD?
Wha??? Oh my that is scary! Do you remember the source of that info? I’ve been using artificial sweeteners for quite a while and I’m just now starting to hear some bad things about them, so I’m curious to learn more.
@@RosieJ7223 hey! I don't on hand, but if you look at the enzymatic process for sucralose, you'll see it is converted directly into fructose. Also, respective searches for "does fructose cross bbb" and "does sucralose cross bbb" should have answer in top result.
See: Robert Lustig, on sweetness on receptors on the tongue signaling for storing everything as fat, even to the point of reducing metabolism levels to keep from burning fats.@@RosieJ7223
I wonder if there could be a way of detecting vessel leakiness in an eye exam?
Great question. I wonder how closely the retinal barrier health correlates to BBB and whether there's some diagnostic opportunity there...
When you go to a retina specialist they can take pictures of the retina, and it will show any leaking.
i find it funny that the guy who researches dementia forgets the question he was asked after 10 seconds
Do highly active people, aerobic instructors , athletes, get dementia?
What about Specialized Pro Resolving Mediators for a “stronger” means of having the affect of Omega 3? Especially in cases of noted disease pathology, could Specialized Pro Resolving Mediators be a wise idea?
This was an in incredible interview!
I wish there was more research on causes and prevention of ALS. It seems like we know much less in comparison to other neurodegenerative diseases.
Cheng H, Yang B, Ke T, Li S, Yang X, Aschner M, Chen P. Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders. Toxics. 2021 Jun 17;9(6):142. doi: 10.3390/toxics9060142. PMID: 34204190; PMCID: PMC8235163.
Have you looked at Nirtic Oxide levels and what happens when you have a small amount or normal amount?
You always make exceptional YT’s .. thank you. So, until advanced therapies available …. Aerobic exercise, keep ldl cholesterol (and apoB) glucose, BP as low as possible, at least for small/micro vessel / vascular dementia?
How about retinopathy?
Gluten is known to to cause cerebellar ataxia (loss of balance) when it crosses the BBB in the elderly.
There was mentioned on the biomarkers screen tight junction proteins. In the intestines zonulin is the tight junction protein that gluten breaks. Is this, please, the same protein and process that happens at the blood brain barrier ?
Hesperidin diosmin troxerutin could help with small vessel disease?
Thanks, recap , exercises food, sleep,stress, most disease are vascular diseases and blood flow like watering plants, sunshine,nutrients and oxygen.Brain is just one organ in the ecosystem of the body which is part of all ecosystem. All connected. ,
Read prescription drugs side effect warnings for memory loss or cognition (statins); or poison control for others (folic acid).
If BBB is frequently imaged as starting to become more 'leaky' at the hippocampus, and lots of research shows that the hippocampus is a site of brain tissue having elevated toxic metal lead, is it the per oxidative action of lead on bi-lipid layers on contact with the lead, that might be initiating much of the leakiness? Bone body burden of lead is in most of us, and can be mobilized as calcium is sought from bone to deal with physiologic stresses of old age, illness, or pregnancy, when we are most vulnerable?
Would anticoagulants contribute to micro-bleeds in small vessel disease?
Realy greatfulll romania
Have you looked at the people who use KETO diets and what happens to the BBB and what happens to Omega 3 get effected when you use KETO diet?
It's got to be mostly cellular degeneration and probably caused by diet. It's very likely similar to cellular level unhealthiness that causes leaky gut problems.
Did they give any protocol? Dr. Andy Galpin told Andrew Huberman to give MAX effort to MAX heart rate once/wk at least "just touch it" but preferably 4x/wk. He also gave a separate protocol of a weekly HARD effort that can only be sustained from 4-8 minutes once/wk, preferably 4x/wk.
Did Dr. Patrick/Montagne give a protocol recommendation of their own?
@ MR8RAVES - That's totally out of context. (Of this subject)
Huberman and Galpin are discussing overall health benefits in the context of exercise for strength and hypertrophy.
Different context than the subject of exercise & BBB, alzheimers, and benefitting blood vessels in the brain, as discussed here.
You'd get closer to this subject about how to apply exercise for cardiovascular health & brain health, by tuning in to Huberman's most recent interview of Dr. Peter Attias. (This past week, I believe ;))
That is not to say that Andy Galpin's exercise expertise is any lesser, imo, than Peter Attias health/exercise expertise - but the two Huberman interviews with 2 different health experts, focuses on two entirely different aspects of applied exercise & health.
@@barbarafairbanks4578 right, will listen to Attia on Hub... no protocol here though
Watching this made me start researching the supplements of lysine, L-Citrulline, L-Arginine and the soy milk I drink, but I lack the background to figure it out but I can't help but think that an increase in nitric oxide might be helpful. Luckily I get tons of exercise, so much so I worry about stroke, that is how I started taking supplements that increase it. And thanks to Rhonda, I get lots of cold water fatty fish dishes.
N-Acetyl Glucosamine + Red Light + HDL cholesterol + Omega-3 + micro doses Aspirin and GLA compliment the Red Beet Extracts / time restricted eating and 24-72 hour Fasting to decrease Insulin Resistance - these are the Avenues
Fumic and Humic acids with Bentonite detox for cellular tight junctions with more effective blood toxin elimination
R-Lipoic and A-Lipoic acid reset the biochemical circadian rhythm, that is Synchronicity, in combination with Red Light Therapy and HDL cholesterol restore the endothelial cells fluid.
Exercise appropriately, and B1 as Bentfotamine to metabolize glucose excess in brain
Nattokinase (MK-7) vitamin K2
Alzheimers, surely partly a result of reducing cholesterol when really calcium just needed k2to stop it clogging arteries? Cholesterol would have more room...?
My husband was a man who regularly cycled and he got dementia and died young but he had been fit
We need an overhaul infarming to put k2 back indiets
Which of the symptoms. Such as damaged vessels, microbleeds whitematter, lacunes, spaces, and brain atrophy, etc. can be repaired, once already present, via exercise and or supplementation?
I did the following cardio process to reduce endothelim surface plaque, inflammation at age 66.
Regardlsess of age, the inflamation of endothelium can be reduced by a diet that brings about the natural NO endothelium production process. Cruciferous vegatables eaten with acedic acid in vinegars or, if allergic to Cruciferous vegs, other green leafy vegs, again w acedic acid. In each day, 6x times per day, a small handful of green leafy vegs, (with each meal = 3x, 2 hrs after each meal). This causes the endothelium to cleans inside of vessels. The inflammation, some call plaque, can be reduced in size. To decrease the size of arterial plaque, the inflamation do 3 more things:
1. Eat spicey vegs having capsaicin. Doesn’t have to be super hot, but spicey. Raw, cook is a personal preference. Cook longer reduces the hotness but capsaicin is still anti-infalammatory.
2. Stop eating foods that cause inflamtion. You will need to determine very common foods in Western diets that cause the inflamation of blood vessels on the endothelium, and it is NOT ONLY CHOLESTEROL!
3. Elliminate inflamatory foods. No oils from a bottle, no processed deli meats, no GMO wheat, grains.
This application of green leafy vegs, anti-inflammatory foods and ellimination of infammatory foods. is potent and it works.
Must get exercise once a day to some sweating, doesn't have to be excessive sweat.
Joints stop aching, reduces the roo. Inflammation plaque while i creasing diameter of blood flow area in vessels.
Ref: Dr. Caldwell Essestyn MD, Cardiologist, Cleveland Clinic
This dr recovers cardio patients who are inoperative, cannot have surgery. The extreme form of this diet removes all animal meats and is coupled with a vegan diet that used plant- based proteins.