David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast

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  • čas přidán 10. 06. 2024
  • David Sinclair is a geneticist at Harvard and author of Lifespan. Please support this podcast by checking out our sponsors:
    - Onnit: lexfridman.com/onnit to get up to 10% off
    - Clear: clearme.com/lexpod and use code LexPod to get 2 months free
    - National Instruments (NI): www.ni.com/perspectives
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    - Linode: linode.com/lex to get $100 free credit
    EPISODE LINKS:
    David's Twitter: / davidasinclair
    David's Website: lifespanbook.com
    PODCAST INFO:
    Podcast website: lexfridman.com/podcast
    Apple Podcasts: apple.co/2lwqZIr
    Spotify: spoti.fi/2nEwCF8
    RSS: lexfridman.com/feed/podcast/
    Full episodes playlist: • Lex Fridman Podcast
    Clips playlist: • Lex Fridman Podcast Clips
    OUTLINE:
    0:00 - Introduction
    1:34 - Staying young at heart
    5:30 - Bringing people back to life
    11:05 - Wearables and tracking health data
    20:18 - How to solve aging
    30:22 - Why do we age?
    35:50 - Genetic reset switch that reverses aging
    38:20 - AI in biology
    40:52 - Health data
    48:58 - Fasting
    56:29 - Diet
    1:04:40 - Exercise
    1:10:01 - Sleep
    1:18:29 - Data
    1:24:00 - Extending lifespan
    1:26:42 - Immortality
    1:32:28 - Denial of death
    1:35:45 - Meaning of life without death
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  • Věda a technologie

Komentáře • 1,9K

  • @lexfridman
    @lexfridman  Před 3 lety +276

    Here are the timestamps. Please check out our sponsors to support this podcast.
    0:00 - Introduction & sponsor mentions:
    - Onnit: lexfridman.com/onnit to get up to 10% off
    - Clear: clearme.com/lexpod and use code LexPod to get 2 months free
    - National Instruments (NI): www.ni.com/perspectives
    - SimpliSafe: simplisafe.com/lex and use code LEX to get a free security camera
    - Linode: linode.com/lex to get $100 free credit
    1:34 - Staying young at heart
    5:30 - Bringing people back to life
    11:05 - Wearables and tracking health data
    20:18 - How to solve aging
    30:22 - Why do we age?
    35:50 - Genetic reset switch that reverses aging
    38:20 - AI in biology
    40:52 - Health data
    48:58 - Fasting
    56:29 - Diet
    1:04:40 - Exercise
    1:10:01 - Sleep
    1:18:29 - Data
    1:24:00 - Extending lifespan
    1:26:42 - Immortality
    1:32:28 - Denial of death
    1:35:45 - Meaning of life without death

    • @patedward2955
      @patedward2955 Před 3 lety +4

      Howdy Lex! Great work on you definitely being a true solider of Love!! Good job man. Love is stronger, am hoping more folks understand this, join the consciousnesses. One of the best podcast series ever..yours. imo T h a n k Y o u

    • @howardhavardramberg7160
      @howardhavardramberg7160 Před 3 lety +4

      Finally! Thank you for this guest Lex! You the man!

    • @siavashkayal6841
      @siavashkayal6841 Před 3 lety +2

      Please invite Dr. Alireza Haghighi

    • @simon824
      @simon824 Před 3 lety

      What about epitalon?

    • @hypnos2367
      @hypnos2367 Před 3 lety +4

      "I think doctors sometimes have a bit of an ego". You bet, it shuts down their curiosity and limits their knowledge. All from cannabis, psychedelics, NDE's, the ignorance of viewing the mind and body as one thing and not separate things, diet, etc, etc. It basically makes them incompetent. And it leads to great suffering for a lot of people.

  • @troywalt4834
    @troywalt4834 Před 3 lety +1062

    David Sinclair, a hero of mine, instead of sport players these are the guys we should support and care about, the ones that will improve our lives.

    • @hunchodav3484
      @hunchodav3484 Před 3 lety +18

      Exactly!!!

    • @faroke1710
      @faroke1710 Před 3 lety +8

      Well said

    • @cliftonnobles5600
      @cliftonnobles5600 Před 3 lety +39

      How about both???

    • @kasra5096
      @kasra5096 Před 3 lety +27

      @@WacKEDmaN ez don't make kids, overpopulation is no more.

    • @SHIVANJAY619
      @SHIVANJAY619 Před 3 lety +13

      @@WacKEDmaN you dont even know what he is doing , he has said we will die , only that the suffering and pain will be less because he will keep our body as healthy as possible , and living for 1000s of years wont be happening anytime soon , till then we would have found all the extra resources we are gonna need , also not necessary that everyone is going to choose to live for 1000s of years , most of us will get bored about a 100 and decide for euthanasia .

  • @rolandconnor575
    @rolandconnor575 Před 2 lety +112

    I am 67, I lost my brother, the last immediate family member, last year. Suddenly, I have a keen desire to live well into my 90s if not longer. For the first time in my life, I am almost afraid of dying, that, if this is it, I want to experience as much as I can for as long as I can. Thank you Lex and David for a little light in the darkness.

    • @chukim8012
      @chukim8012 Před rokem +7

      You are a very fortunate man to have lived to 67. I am 37 and facing a health problem Ive never faced before. Im wishing I could live for 10 more years, let alone 30 more. Have you not accepted Death, even at your age?

    • @rolandconnor575
      @rolandconnor575 Před rokem +9

      @@chukim8012 83% of Americans take at least one prescription medication a day. I do not take any, I just reshingled my roof alone. I work at a job I love and will continue to do so into my mid 70s. I have understand Death so in that respect I accept it, but fear the thought of premature death based on how I feel today. I have decided to live as if there is a God even though I have no evidence of that existence. That final thought prepares me for the acceptance you ask about.

    • @kawataufik5098
      @kawataufik5098 Před rokem

      I have a sale men selling watch Spair part one day I go buy some parts and take some times I told him I go have a smoke while you find my order he said do you think how old I am I said 65-70 he say I am 104 years old never drink alcohol and mom and any and smoke you see me I was amazed how never see working and physically very active so we just take care ourselves and this info at help is more an those have health problems number one is often eat less more fasting more destroy all viruses in our body even high blood pressure and stop sugar

    • @jimmydean9602
      @jimmydean9602 Před rokem

      ​@chukim8012 damn bro you a lil salty

    • @su....
      @su.... Před 10 měsíci

      ​@@rolandconnor575 the evidence simply seems that we exist consciously. that life is even life. let alone the ability to personally relate to this magnificent creating 'parent', one on one, heart to heart.

  • @fr0stmourn3
    @fr0stmourn3 Před 3 lety +301

    I love hearing Dr. Sinclair speak because he always brings up something new.

    • @tomu4725
      @tomu4725 Před 3 lety +5

      Aubrey de Grey is pretty cool to listen to if you like the longevity space. He'd probably also have something new to say but he's regularlu being interviewed on smaller podcasts 1-2x a week

    • @Ejejebbdd
      @Ejejebbdd Před 3 lety +1

      @@tomu4725 could you give some examples?

    • @spenser6353
      @spenser6353 Před 3 lety +4

      people will always die. This guy is delusional

    • @macpoopum7124
      @macpoopum7124 Před 3 lety +12

      @@spenser6353 you're delusional. He literally said many times immortality is basically impossible biologically and he also said he knows he's not going to live forever.

    • @spenser6353
      @spenser6353 Před 3 lety

      @@macpoopum7124 He said humans can possibly live 1,000 years. Thats basically immortality.

  • @rigbi889
    @rigbi889 Před 2 lety +18

    Until I heard the this episode I had a definite idea that the contemplation that we are mortals inherently drives meaning to our every moment.
    I took assurance from the Greek mythology where said that gods are abusing humans because they are jealous of our mortality, as they, the Gods, have meaningless existence because they can’t die.
    But now, after hearing this episode I realize that contemplating of living forever is IDENTICAL to the contemplation that we are going to die, and that it gives THE SAME meaning to every moment.
    Because both give time no meaning.
    Think about that: if you live forever what is the meaning of delaying to tomorrow?
    Time has no meaning.
    Tomorrow is identical to today.
    So when time has no meaning, it’s critical to make the maximum of every moment. Not because it will not come back (mortals meaning of life), but because you can’t escape your eternal present (immortals meaning of life).
    Thank you Lex and David for this existential epiphany.

  • @delkroupa
    @delkroupa Před 3 lety +61

    This was difficult and painful to watch, as my wife and I just lost our son, an only child, to sudden heart failure, on May 2, at 44 years old, leaving a 15 year old daughter. We are both 76 years old. Daniel and his daughter enjoyed time together, walking and talking about issues, gaming, cooking, etc. Still, I am glad that I watched it, and I surely would have shared the link with him, even though we both had Lex on our subscribe list. It pains me to discover that we are on the verge of wearing sensors that would have likely seen the heart failure signs far enough in advance to save him.
    Daniel worked IT at the University of Michigan, Medical Services, helping to keep all of the software and hardware issues fixed. I am crying once again as I write this.

    • @delkroupa
      @delkroupa Před 3 lety +1

      @@StrongerThanBigfoot Thank you. It's been 5 weeks, and I still cry daily about it.

    • @delkroupa
      @delkroupa Před 3 lety

      @@WacKEDmaN As was explained, the user would choose who the data would be shared with.

    • @chewyjello1
      @chewyjello1 Před 2 lety +7

      I know it's been a while since you wrote this, but I'm so sorry for your loss. Your son sounds like an amazing person. I have an only child who is about to leave for college and I can't imagine what I would do if I lost her. I'm glad a part of your son lives on in your granddaughter and hope that brings you comfort. ❤️

    • @delkroupa
      @delkroupa Před 2 lety +4

      @@chewyjello1 Thanks for your thoughts. It has now been over a year now since Daniel died. It is still very painful to think about.

    • @lizeggar2421
      @lizeggar2421 Před 2 lety +2

      I am so sorry for your loss. The pain you both have to bear is unimaginable, and I pray that your grandaughter, as a part of him, brings you some solace, as she matures into a woman.
      I am your age and widowed, with an only son aged 51. To lose him would be to lose a part of myself.

  • @RWHsuzuki44
    @RWHsuzuki44 Před 3 lety +461

    Dang lex has been really killin' the guest lineup lately

    • @FromFame
      @FromFame Před 3 lety +5

      I’ve always read this comment on every video lmfao

    • @phobowl
      @phobowl Před 3 lety +4

      No kidding. Each podcast makes u smarter

    • @cerebralmethod9112
      @cerebralmethod9112 Před 3 lety +5

      That phraseology, and its irony, under a podcast about life extension. 😂

    • @geirmagnusjenssen1136
      @geirmagnusjenssen1136 Před 2 lety

      @@cerebralmethod9112 and he is still: Great Scott, free

  • @jeffamg
    @jeffamg Před rokem +13

    I so agree with Lex when he talks about doctors being pretty much negligent about collecting datas, and often doing diagnostics based on %.
    I'm 38 now, training a lot, and running (did half marathons and marathon). I've been on antidepressants for 10 years, I stopped this year. It's a struggle, been I'm trying to be living naturally. I've been given meds but never have they check for my testosterone levels and other potential key elements that contributes to anxiety and depression. This video inspire me To work on staying healthy and trying to be stress free.

  • @enovasia
    @enovasia Před 2 lety +11

    Extraordinary. Beautiful. Riveting conversation. Memorable. Stimulating. Smiled with intellectual pleasure throughout. David Sinclair is a superstar, yet modest and personable with it.

  • @mrloveandgratitude
    @mrloveandgratitude Před 3 lety +489

    Big love to Grandmothers who raised their grandchildren.

  • @user-md4wb4nb1g
    @user-md4wb4nb1g Před 3 lety +826

    Lex is Joe Rogan without the Bro Jogan

    • @Aryan-qv8hz
      @Aryan-qv8hz Před 3 lety +36

      Roe jogan PhD MBA DMT LSD is not as calm as this guy.

    • @pendragyn777
      @pendragyn777 Před 3 lety +13

      Frex Lidman is Lex's biological doppelganger.

    • @UserName-ii1ce
      @UserName-ii1ce Před 3 lety +58

      Lex = Joe Rogan - Joe Diaz

    • @snowman1722
      @snowman1722 Před 3 lety +20

      Joe Rogan without the Bro Jargon **

    • @Haikan.
      @Haikan. Před 3 lety +4

      @@UserName-ii1ce Lol Good one!

  • @ThomasEricWendt
    @ThomasEricWendt Před 3 lety +18

    This type of conversation helps me to examine my choices day by day. Thank you!

  • @denniskatinas
    @denniskatinas Před 3 lety +1

    Lex, David, you both operate on the level where I’d like to be. This conversation embodies so much of my goals and practices. I can do it for hours, sometimes a few days, but I have a long way to go making it a constant stream. Yet, being right here doing these things, it feels like being at the forefront with you guys. It feels like support. Thank you both.

  • @goheartgo861
    @goheartgo861 Před 3 lety +471

    Lex is killing it with this guest!
    A pop tosis!
    Cheers

  • @taylorroberts8690
    @taylorroberts8690 Před 3 lety +98

    David's Book Lifespan is a great read...a must read imo. Looking forward to listening to this, luv both you guys!

    • @chavdar.dobrev
      @chavdar.dobrev Před 3 lety

      it’s really hard to understand for the normal person. I consider myself an intelligent guy but still I was lost many times while reading it.

  • @paradoxart2323
    @paradoxart2323 Před 3 lety +5

    LEX ! I was waiting for this one... Thanks a lot for all the great work you put into these podcasts. Greatings from Belgium.

  • @luisrodrigueziii7316
    @luisrodrigueziii7316 Před 3 lety +7

    Couldn't have come at a better time! I've been waiting for David to be back on JRE, but having him appear here is arguably an even better treat. Thanks Lex!

  • @timealchemist7508
    @timealchemist7508 Před 3 lety +222

    May we live as long as we wish.

    • @geoff7894
      @geoff7894 Před 3 lety +4

      Sounds like a horrible idea. Unless we can convince people to die we will have massive overpopulation

    • @CossyTheOne
      @CossyTheOne Před 3 lety

      If the vaccine dont prevent that 😂

    • @TimoNoko
      @TimoNoko Před 3 lety

      @@kevyt3095 That is the main issue. Nowadays most people seem to be living little bit longer than they wish. But there is no easy exit, if you cannot travel to Switzerland.

    • @wlada5
      @wlada5 Před 3 lety

      @@StrongerThanBigfoot boooooriiiing

    • @danielleach3532
      @danielleach3532 Před 3 lety

      2017 eclipse in Pic?

  • @rishukumarsingh9428
    @rishukumarsingh9428 Před 3 lety +50

    Wow. Was just hoping that he would call David and boom it's in my recommendation. Thanks LEXU

  • @kennyfortuin8865
    @kennyfortuin8865 Před 2 lety +8

    This interview was worth every minute. Great in depth and meaningful conversation Lex.

  • @crabofchaos7881
    @crabofchaos7881 Před 3 lety +288

    "How nice it is to collect data about a person, to CAPTURE that person" - Lex Fridman, Russian supervillain, 2021

    • @aaronleeper8664
      @aaronleeper8664 Před 3 lety +2

      🤔 Ha, ha!🤣😂

    • @krisamagus1
      @krisamagus1 Před 3 lety +1

      not funny-like hunting....pathetic

    • @crabofchaos7881
      @crabofchaos7881 Před 3 lety +10

      @@krisamagus1 well, funny is an aesthetic category, it's individual, so you do you. For me shitposting is a part of fun, it's what I do to amuse myself during a long work day. AND on my weekends. It's my hobby. I'm a bit bored AND very textually fixated, so sometimes I am guilty of leaving more than one comment on a video, this one is quite engaging after all. You could try testing your hypothesis before jumping to conclusions. I could say that you made that comment because you are 12, or because your wife doesn't give head. I could, but I won't because it conflicts with my main theory- you've got a huge brain tumor that's going to kill you in a matter of days, so you cling onto life and try to make up for all those years you wasted playing roblox by writing to a random guy and saying that you don't like his comment. It doesn't make sense, but less and less things do as the tumor grows. Black and white shapes sёём то маке seиse ьut тнеу gеt less and гёss familiar as you яeadd them. Шнат аяе тнеу? Геттерс? Геttёясс? Шнат does it all mean? You panic, because suddenly it goes back to normaг, iт sёёмs somewhaт иоямаг... Уоця degяадатион iз инэвитбл. Your рiиеаг gгаиd sёсяетs dёaтн ноямоиеssчлвщooOHмmMY GOD AM I DYINGовзыхыгаовш I DOИТ ШАИИА DIЕыоГвовоОвиыгТщылттттщщшшщХщХгШнрыпун 8===========э💦💦💦💦💦 this is a dick

    • @crabofchaos7881
      @crabofchaos7881 Před 3 lety

      @@shitjustgotreal4550 thank you

    • @apacheslim
      @apacheslim Před 3 lety +5

      Lex is currently downloading everything on Putin in order to replicate him for an interview and private mentoring

  • @MrTagus97
    @MrTagus97 Před 3 lety +15

    Fantastic guest choice! Love seeing scientists I’ve discovered on separate occasions coming together for an enjoyable and insightful conversation.

  • @suzannahwhite4292
    @suzannahwhite4292 Před 2 lety +5

    Lex - I'm addicted to your podcasts! Working my way through them all and learning a lot. Thank you for helping me remain curious.

    • @Love-vi1ki
      @Love-vi1ki Před 2 lety +1

      He has definitely made more interested in learning more about staying health

  • @BrentNally
    @BrentNally Před 3 lety +42

    Huge thanks to Lex for having David on the podcast! It was EPIC! I interview healthy life extension enthusiasts, host Lifespan News and I'm the CEO/co-founder of Longevity Plan. I'm super focused on solving the human aging problem ASAP!

  • @trylliumt5441
    @trylliumt5441 Před 3 lety +4

    Great conversation! Always good to hear David's insights and knowledge as well as Lex's philosophy! Thanks!!!

  • @Mikemikemike13579
    @Mikemikemike13579 Před 3 lety +200

    “Death smiles at us all; all we can do is smile back.”
    ― Marcus Aurelius

    • @jetsonvibes
      @jetsonvibes Před 3 lety +2

      I love this

    • @King-O-Hell
      @King-O-Hell Před 3 lety +1

      I thought that quote might have been Gandalf, but I stand corrected.

    • @HFeyn
      @HFeyn Před 3 lety +25

      "Hahaha, sucker"
      __ transhumans in the year 2200 CE

    • @technomad4942
      @technomad4942 Před 3 lety +5

      "Nah we can knock that sucker's teeth out bro." -a very wise man

    • @technomad4942
      @technomad4942 Před 3 lety

      "Nah we can knock that sucker's teeth out bro." -a very wise man

  • @douglasauruss
    @douglasauruss Před 3 lety +95

    David got me interested in longevity. Aubrey de Grey showed me that we know what to do to reverse the hallmarks of aging. I hope you invite Aubrey onto the podcasts as well!

    • @Libertas_P77
      @Libertas_P77 Před 3 lety +7

      Aubrey de Grey is the legend of the longevity field - his role is drastically underappreciated by most outside the industry, because he doesn't interview as widely.

    • @Stupid23590
      @Stupid23590 Před 3 lety +2

      Just went to the comments to say this

    • @chriscaro6832
      @chriscaro6832 Před 2 lety +2

      He doesn't know how to do that.

    • @lukeneill1568
      @lukeneill1568 Před 2 lety

      @@chriscaro6832 just promoting his products. Smart guy

  • @andresteiner4325
    @andresteiner4325 Před 2 lety +4

    I truly appreciated the podcast and all your (both) philosophical points of view about life… it has been truly an honor… thanks and give us more

  • @Compassionate38
    @Compassionate38 Před 3 lety +5

    One of the most beautiful/optimistic podcasts you’ve done. Amazing to hear why no stressing out makes practical sense from a biology standpoint.

  • @bobdavidson4163
    @bobdavidson4163 Před rokem +3

    Thanks for introducing me to David Sinclair. Just downloaded his book on Audible. Cheers Lex!

  • @chewyjello1
    @chewyjello1 Před 2 lety +5

    2:58 I love that Lex read this poem! I have vivid memories or reading that poem when I was 6 years old proudly to my mother...and then reading it silently to myself and feeling quite proud of how I had grown. 6 really is the BEST age. The age full of wonder, when you first start to peice the world together and search for your place in it.

  • @jefftmcdonald1
    @jefftmcdonald1 Před 3 lety +7

    Lex has become my favorite podcaster. Thank you Lex for contributing to make the world a better place.

    • @funtimes8296
      @funtimes8296 Před 3 lety +1

      @@cardanowithpaui7889 You are not the real Lexi Fridman, quit playin

  • @beth3011
    @beth3011 Před 3 lety +4

    Beautiful, insightful, emotional conversation. A BIG fan of David Sinclair’s life’s work. So enjoy your conversations with the 🌍 /universe’s thought leaders.

  • @Mllet3d
    @Mllet3d Před 3 lety +10

    This was time well spent, great interview.

  • @WaketheFupwithJeffro
    @WaketheFupwithJeffro Před 2 lety +1

    Very helpful stuff, thank you guys both so much for the awesome content!
    And Lex, thanks for the brown noise tidbit. I tried it, and it was helpful in zoning in +/tuning out -. I use white noise with some success, but it’s always nice to have another tool in the focus shed! 🤙🏼🌞

  • @rodmanlu88
    @rodmanlu88 Před 3 lety +3

    Wow awesome interview Lex. Seen many interviews with Dr. Sinclair but you really killed it with this and got him to open up about much more, with your great questions and extensive research.

  • @TAYLORHWALL
    @TAYLORHWALL Před 3 lety +5

    It's always a fascinating listen with Mr.Sinclair! Excellent episode, as per usual!

  • @9999classy
    @9999classy Před 2 lety +4

    One of the most enjoyable discussions both sides had a lot to give Dr David Sinclair is always a pleasure to listen to your facts

  • @galileo3431
    @galileo3431 Před 3 lety +1

    I think it's really worth mentioning Lex' improvement as an interviewer. I LOVED his philosophical rants while giving his guest a break in speaking and thinking. Really professional! 🙏🏼💯

  • @vbabbitt948
    @vbabbitt948 Před 3 lety +2

    This is perfect timing, very excited to watch. Thank you Lex!!

  • @TheRealStructurer
    @TheRealStructurer Před 2 lety +5

    Another inspiring interview. Interesting to hear what is going on in the labs and what we hopefully soon can use for a reasonable amount.

  • @chrishenderson420
    @chrishenderson420 Před 3 lety +44

    I can see Lex becoming the top podcaster in the world in a few years. Great guest.

    • @elon2159
      @elon2159 Před 3 lety +3

      Nah he'll never be bigger than the greatest podcaster ever Bro Jogan.

    • @Kaylbee
      @Kaylbee Před 3 lety +1

      If he tightens up some of his interviewing technique, maybe. He definitely gets good guests though.

    • @chrishenderson420
      @chrishenderson420 Před 3 lety

      @@asdfasdfasdf12 There's a reason why the world envy's America. It's the freedom they have for one.

    • @chrishenderson420
      @chrishenderson420 Před 3 lety

      @@matyas_laczko Yes the freedom to do and say what you please. America is the most free country in the world, much more so then Canada where I am from.

  • @danplove97
    @danplove97 Před rokem +1

    This is probably my favourite ever podcast. Could listen to these two all day. I can’t remember the last time I questioned my perspective so many times in a short amount of time 😂

  • @johnfelix503
    @johnfelix503 Před 3 lety +2

    Amazing interview Lex! Learned a lot with it.

  • @BogdanLiviu7
    @BogdanLiviu7 Před rokem +5

    50:23 to 50:32 - what a sweet moment. Lex and David Sinclair are two wonderful people!

  • @RANDYFRANCISMMA
    @RANDYFRANCISMMA Před 3 lety +282

    I swear this dude gets younger looking every podcast lol

    • @kenster1682
      @kenster1682 Před 3 lety +10

      I think you are just doing carnivore and aging faster😂😂

    • @RANDYFRANCISMMA
      @RANDYFRANCISMMA Před 3 lety +9

      @@kenster1682 nah I'm actually almost 30 and everytime I go out people think I'm 21 cause I workout so much and have always fasted naturally for martial arts (weight cutting)

    • @RANDYFRANCISMMA
      @RANDYFRANCISMMA Před 3 lety +3

      @Brett M I only fasted the day before a weight cut for 24hrs. Fasting for high performing athletes isn't great cause your muscles will self cannibalize if you don't get enough calories. I follow a lot Dr Mark Hymans advice for what I choose to eat and try to eat a lot of good fatty food with high protein content. For example one meal I eat chicken thighs, broccoli, and Japanese sweet potatoes with almonds, a banana, a Greek yogurt, blue berries and a avocado mixed with 1 cup hemp/chia/flax seeds (1:1:1 ratio for the seeds)

    • @RANDYFRANCISMMA
      @RANDYFRANCISMMA Před 3 lety +1

      @Brett M weight cutting is mostly just water loading and cutting sodium the week of the weight cut

    • @tunnelsloth5948
      @tunnelsloth5948 Před 3 lety +2

      I wonder if it's the intermittent fasting or if the metformin and/or resveratrol really is keeping him younger.

  • @MrCananball
    @MrCananball Před 3 lety +2

    Thank you for doing these interviews Lex! You guys are amazing humans!

  • @18883434262
    @18883434262 Před 3 lety +1

    Thank you for putting timestamps on your videos 🙏

  • @chribjslaha
    @chribjslaha Před 3 lety +3

    I've been waiting on this one. Mad respect to Lex and David

  • @Connaissances3
    @Connaissances3 Před 3 lety +6

    What a beautiful interview
    Thank you gentlemen

  • @mikl2345
    @mikl2345 Před 2 lety +2

    This conversation was a work of art. I was going to say some of the podcasts have got a bit long recently, and that this one was nice for being a more digestible size, but I think my view on this is uninteresting, the three hour talk with your dad was amazing lex, thank you and much love.

  • @FUTUREWA
    @FUTUREWA Před 3 lety +1

    Lex is at the top of his game. Excellent interview style.

  • @sarcazamk
    @sarcazamk Před 3 lety +9

    Can we just appreciate how well he explains those concepts with analogies. One of my favorite podcasts already.

    • @sarcazamk
      @sarcazamk Před 3 lety +2

      Reported that scammer guy.

  • @wendypolatajko2485
    @wendypolatajko2485 Před 2 lety +6

    One of the best podcasts I have ever listened to. I have just learned of David Sinclair this week and yourself Lex today. Amazing discussion. Thank you so much! Part 2, 3, 4, 5, 6...? :-)

  • @00specmiataracer
    @00specmiataracer Před 3 lety +2

    Absolutely amazing , Lex every time I listen to you I get inspired, great guest !! Thank you both so much ❤️🤙🏻🤘🏻👍🏻⚡️⚡️⚡️⚡️

  • @samuelec
    @samuelec Před 3 lety +2

    Beautiful interview, thank you both

  • @chrisbecker5472
    @chrisbecker5472 Před 3 lety +3

    Another mind blowing interview.

  • @switzerland
    @switzerland Před 2 lety +5

    In my view, your most important or impactful interview yet. Especially since it affects everyone and at the same time is out of scope for nearly all of us.

  • @ssiddarth
    @ssiddarth Před 3 lety +2

    Was eagerly waiting for this & boy was it worth it 😬 Thanks Lex ❤️

  • @jackdunning3403
    @jackdunning3403 Před 3 lety +2

    Lex, the work you do is wonderful. Like David, you are making the world a better place. Thank you

  • @double051
    @double051 Před 3 lety +10

    His book is great too, and he reads for the audio book version. I highly recommend it

  • @brutal_mike5783
    @brutal_mike5783 Před 3 lety +202

    casually says " my friend in LA just cloned his dog three times " how nice is that :D at 26.48 mn

    • @oliverbeck3505
      @oliverbeck3505 Před 3 lety +16

      I would of questioned that. How did they just skip over it as if it was normal

    • @Uubermensch
      @Uubermensch Před 3 lety +20

      @@oliverbeck3505 cloning is a regular thing. It’s not very special anymore

    • @godlikemachine645
      @godlikemachine645 Před 3 lety +10

      @@oliverbeck3505 most of the factory farmed animals are actually clones nowadays. It's pretty crazy stuff, when you really look into it lol

    • @FreshhGraffz
      @FreshhGraffz Před 3 lety +7

      @@oliverbeck3505 you would HAVE questioned that.

    • @kanalarchis
      @kanalarchis Před 3 lety +2

      Is there anyone who can help me clone certain people I love?

  • @michaeltrapp1952
    @michaeltrapp1952 Před 3 lety

    Brilliant conversation. Will remember this for a long time. Thanks!

  • @Sbgniagararobertcook
    @Sbgniagararobertcook Před 3 lety +2

    Great talk, I didn't want this one to end.

  • @SDFordOfficial
    @SDFordOfficial Před 3 lety +4

    Great talk, so intriguing on multiple paradigms. Might be a big ask but Lex, do you think you’ll ever be able to get Ray Kurzweil on the podcast?

  • @rteezy5683
    @rteezy5683 Před 3 lety +3

    amazing episode! I really liked sinclair on rogan aswell, very well spoken and super informative 👌

  • @TheNAGC
    @TheNAGC Před 3 lety +1

    Well, i almost never comment on videos, but the topics and content of this podcast #189 with David Sinclair were amazing. I really enjoy this types of talks regarding human biology integrated tech, and how we can improved our health based on that concept and data.
    Hope to see more talks like this one in the future.
    I thank both for the great work !

  • @tommyr9558
    @tommyr9558 Před 3 lety +1

    This was such a great podcast Lex, I hope we see more regarding this topic!

  • @chrisbrowne912
    @chrisbrowne912 Před 3 lety +4

    Lex, you've dropped some incredible content lately👏. I'd love to see a part 2 with your father when we hit episode #200, please upvote if you agree so he sees!!

  • @adityachk2002
    @adityachk2002 Před 3 lety +83

    Vitalik and then Sinclair wow

    • @mathiasfantoni2458
      @mathiasfantoni2458 Před 3 lety

      @@michaelfried3123 Wow, I wasn’t aware. Also haven’t seen the video yet, maybe I’ll check it out and see what just happened 😂

    • @adityachk2002
      @adityachk2002 Před 3 lety +1

      @@michaelfried3123 not true man!

    • @pragmaticvfx
      @pragmaticvfx Před 3 lety

      @@michaelfried3123 what lie? you mean the hard fork stuff? that was bothersome.

    • @adityachk2002
      @adityachk2002 Před 3 lety +1

      @@michaelfried3123 where is it?

    • @cryptohouse1676
      @cryptohouse1676 Před 3 lety

      We are going to live as long as we want guys!

  • @lnc-to4ku
    @lnc-to4ku Před 3 lety

    What a brilliant man, and such a thoughful- thought provoking conversation between you both!
    Thank you so much for always creating such incredible content in your podcasts!
    You're one-of-a- kind Lex, always stay that way!♡

  • @Rahul-ym9uh
    @Rahul-ym9uh Před 3 lety

    It's as though you read my mind with the guests you have, your podcast is mind-blowingly good

  • @eseofepe3856
    @eseofepe3856 Před 3 lety +3

    Hapoy birthday Dr. Sinclair. Happy to be watching this today.

  • @bwells2710
    @bwells2710 Před 2 lety +9

    Absolutely love this interview... David Sinclair is an amazing man but to watch him in total awe listening to Lex is something else. There's so much information in this video it should be pinned to the top of Google search! 😎🙏

  • @ouishi9447
    @ouishi9447 Před 3 lety +1

    Searched for this exact podcast a couple weeks ago, happy to see Lex got David on the podcast, definetly think the ideas David Sinclair is talking about deserves more media attention. Looking forward to watching this :)

    • @ouishi9447
      @ouishi9447 Před 3 lety

      @@pinnedryanserhant6207 I dont know who Gerrad is, but my life savings are on stand-by in case you got a cool investment idea

  • @manuniverse5418
    @manuniverse5418 Před 3 lety +2

    This is a great conversation. Totally agree with David about enjoying life whenever you are immortalized or not.

  • @SDFordOfficial
    @SDFordOfficial Před 3 lety +11

    I clicked on this the save it to my history to comeback to it… It’s 04:00 AM and I’m an hour in

  • @figitvarodvisnik
    @figitvarodvisnik Před 3 lety +6

    Damn bro, glad I found you from chain-link subreddit. You're inviting the most bomb guests 💯🤩

  • @lucyh8710
    @lucyh8710 Před 2 lety

    Really enjoyed this interview. Thank you

  • @itzzitzz
    @itzzitzz Před rokem

    Two of the grandmasters of life. Loved it. Thank you for wasting your precious time sharing it 😊

  • @emilybarry9410
    @emilybarry9410 Před 3 lety +7

    YES to stressed plants🌱💪🍇! LOVE this topic (and longevity in general). GREAT conversation LEX and David🙏💜🤗

  • @konerinstintin
    @konerinstintin Před 3 lety +58

    ive been waiting for this one

  • @TheLiquidpsy
    @TheLiquidpsy Před 3 lety +2

    nice! one of my favourite guests from JRE. nice to see him on your podcast :)

  • @michaellara6199
    @michaellara6199 Před 3 lety

    I've been waiting over 100 years for this podcast.

  • @thomasdovell3003
    @thomasdovell3003 Před 3 lety +165

    You should definitely have Aubrey De Grey next!
    Arguably the most important individual in the field of biology - the OG of longevity research.
    On top of that he fits your podcast perfectly as he was AI researcher before he switched to gerontology.
    He will also very quickly change your mind on this "death is blessing in disguise" nonsense!

    • @Ridiculizer
      @Ridiculizer Před 3 lety +2

      How would anyone know that it wasn’t?

    • @MaynesDaryl
      @MaynesDaryl Před 3 lety +17

      Aubrey De Grey gets all of his Reservatrol through natural means … by consuming gallons of wine a week.

    • @bend6799
      @bend6799 Před 3 lety +4

      Aubrey doesn’t exercise. All his claims become dubious after i learned that

    • @FortniteKingClips
      @FortniteKingClips Před 3 lety +11

      @@bend6799 Because exercise doesn't actually do anything lol, especially if you are already 'calorie restricted' with a low bodyweight. Jean Caulment lived to 122 without exercising. Most of the centenarians don't exercise that much.

    • @thomasdovell3003
      @thomasdovell3003 Před 3 lety +9

      ​@@bend6799 It would be wonderful if diet and exercise increased lifespan by a meaningful degree.
      Sadly this is not the case.
      If it was, we wouldn't need geniuses like Aubrey committing their entire lives pursuing strategies for engineered negligible senescence.

  • @jl3187
    @jl3187 Před rokem +23

    I'm always amazed by Lex's stance against immortality since he has so many personal interests and pursuits on top of his AI work. There are perhaps tens of thousands of professions/disciplines/fields of study/hobbies/interests that people in this world spend pretty much a lifetime trying to master and if you ask them at the end of their life if there was more work to be done they would say yes. Spend 30 years mastering leathercraft then move on to 20 years of studying ants then jump to 50 years of math/quantum physics then 30 years of Muay Thai kick boxing then 25 years mastering an instrument, etc. Hell you could take a break and kill 100 years of playing video games and jump right back into it after. There are over 300 countries in this world and you could live in each one for 10 years in order to fully experience each one and it's culture. You could spend 100s of years traveling every corner of the world. I'm not saying you wouldn't end it at some point but I think it would take thousands of years for a well developed full rounded person to get bored. There are definitely many possible incredibly engaging lifetimes for us to live if we're given the chance to do so.

    • @shadowmistress999
      @shadowmistress999 Před rokem

      I think you're too optimistic, look at our world now, compare the right of longevity to wealth... same

    • @ayaka1255
      @ayaka1255 Před 8 měsíci

      I totally agree

  • @Salman-tt7or
    @Salman-tt7or Před 3 lety +1

    This was absolutely incredible!

  • @j.d.bradley7183
    @j.d.bradley7183 Před 3 lety +1

    You rock, Lex. Keep up the good work my friend.

  • @debsmith3576
    @debsmith3576 Před 2 lety +3

    what a role model we have in him. i am trying to encourage my grand to get into science. we need more humans like him.

  • @cryptout
    @cryptout Před 3 lety +3

    This is the most interesting episode i’ve seen so far. Great interaction and so much information I feel I need to learn more of!

  • @julianlmarin
    @julianlmarin Před 2 lety

    Nice podcast as always, dude Sinclair has interesting mission I'm reading his book and recommend it so far.

  • @TheAIEpiphany
    @TheAIEpiphany Před 3 lety

    One of the best podcasts since 2018 - if not the best one. Loved it.

  • @TheSheekeyScienceShow
    @TheSheekeyScienceShow Před 3 lety +11

    Great interview Lex! I'm really excited to be part of this growing field and the ability to enhance healthspan.

  • @vedamaster7253
    @vedamaster7253 Před 3 lety +4

    "I want it public, live-streamed". Made my day xD

  • @woodysprott5790
    @woodysprott5790 Před 3 lety +1

    👍 Great discussion, very informative & interesting!

  • @StuntmanDan03
    @StuntmanDan03 Před 3 lety +3

    I had this tab open for a few days until I had the ability to give it my full undivided attention and boy am I glad.

  • @arleneportsmouth1263
    @arleneportsmouth1263 Před 2 lety +4

    👏YES!!! 48 minutes in and I am convinced that Lex is a genius! 🏆

    • @Love-vi1ki
      @Love-vi1ki Před 2 lety

      Listening to Lex has made me smarter

    • @lucyceller6206
      @lucyceller6206 Před 2 lety

      He is genius and is very humble at the same time. Perfect combination.

  • @uribe9175
    @uribe9175 Před 2 lety

    i was looking for the words that you said in the last minutes for about one year!!!! Thanksssss

  • @frantisekprokopec9284
    @frantisekprokopec9284 Před 2 lety

    A phenomenal conversation.

  • @cryochamberlabel
    @cryochamberlabel Před 3 lety +160

    Brown noise is interesting, but definitely check out Dark Ambient music as well, lots of writers and creatives use it to great effect

    • @Batm189
      @Batm189 Před 3 lety +5

      New-age music is also one of my favourites, it depends on personality type imo.

    • @chamsabressitoure521
      @chamsabressitoure521 Před 3 lety +42

      The first search result for dark ambient music was a video from your channel. Well done!

    • @doktormozg
      @doktormozg Před 3 lety +4

      Boi is that truly Cryo Chamber? Man I am a fan for almost 5 years, keep it up!

    • @petey4018
      @petey4018 Před 3 lety +1

      CZcams Train rides!

    • @cryochamberlabel
      @cryochamberlabel Před 3 lety +5

      ​@@doktormozg Awesome, all board the monorail :D I wasn't expecting anyone here to know what we do actually, what a pleasant surprise!