Michael Addition Reaction Mechanism
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- čas přidán 9. 05. 2018
- This organic chemistry video tutorial provides a basic introduction into the michael addition reaction mechanism which consist of a michael donor / nucleophile and a michael acceptor / electrophile. The michael donor is resonance stabilized enolate ion and the michael acceptor is usually an alpha beta unsaturated aldehyde or ketone.
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Overacting 100/100
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What’s crazy is that everything you’ve been posting lately I was looking for 3 months ago when I was struggling in orgo 2 😩
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Thanku soo much sir very nice explained
I had no idea (or totally forgot) about the difference in attack between weak and strong bases. Thanks for another very high-quality demonstration!
hey! why did the weak base attack at the beta carbon and not at the carbon hving the oxygen?
@@lilbanana6159 I think that's a great question! I just googled it and found a page on LibreTexts that had this to say:
If the nucleophile is a weak base, such as alcohols or amines, then the 1,2 addition is usually reversible. This means the competition between 1,2 and 1,4 addition is under thermodynamic control. In this case 1,4-addition dominates because the stable carbonyl group is retained.
I have a question. Why is not the nucleophile adding in alpha position? Why doesn't the alpha Carbon become positive since the keto group is an electron withdrawing group?
@@shreemoyde7031I think it has to do with how the electrons flow. If the nucleophile attacked and donated electrons to the alpha carbon, then the electrons from the carbon-carbon double bond would have to move onto the beta carbon, forming a carbanion. On the other hand, if the nucleophile attacked at the beta carbon, then the electrons can move up onto the oxygen, which is more electronegative.
has nothing to do with that otherwise why would a strong base work?@@PunmasterSTP
This was very informing, could you at some point do the thia-michael addition
I have a question
suppose there is a leaving grp like a OME on the acceptor will 1,4 addition still be there or can the grp(OME) leave?
Thank you so much sir
Thank you Soo much sir 😢
Superb sir
my carbonyl lecture i love you
In the last ques won't the water also hydrolyse the cyanide to an acid I just got that part wrong...???
Very nice example of steric effects, which prevent the attack on carbonyl and favor michael addition’s product formation. Well done 👍🏻
I also just made a video about Michael addition and would be happy to hear honest opinions :)
Please make a video about synthesis of vitamin A by darzen condensation and reformatsky condensation
Thanks sir
Thanks
Can acrylamide and acrylic acid undergoes micheal addition
Massive legend
Thanks Ganzalo
in the last step at 6:40 can I protonate the O- and then forms an enol and then the enol tautomerized into aldehyde ? (sr for bad english)
Enolates are resonance stabilized..so that step happen faster to stabilize it.
More over keto form is more stable than enol,c=o is more stable bond than c=c.
Hope it helped.
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A simplified chemistry channel.
@@aiswaryanath9844 thank you very much
Can you add mannich reaction plz
Sir how to calculate pka value?
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Innocent Ntuli his voice reminds me of Mark Wahlberg... I think it’s Mark Wahlberg.
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Whats the first prodcuts name o: ? Please and thank you
I think it is called 3-(1-oxoethyl)hexane-2,6-dione but I am not 100% sure if the =O at the last carbon atome is named as a ketone or an aldehyde
Awesome
I believe you are missing a + on the nitrogen of nitroethane at 13:16
I was thinking the same thing! I was like do i know nothing about nitro group charges?
Isnt there a Internal tautomerization going on instead of just adding a hydrogen? czcams.com/video/dEdsR-6dKWE/video.html
If you're named michael you should apply to the michael acceptor school.
sup michael; patreeeeek
wants to explain the michael reaction... 1st we need a Michael donor
*DOESNT EXPLAIN WHAT A MICHAEL DONOR IS*
And people wonder why chemistry is hard... it's not hard but the teachers suck
Is this considered part of the Enolate/Enol/Keytone/Aldehyde reaction group? Have an exam in 5 days and looking for videos that help.
Keytone?