Making Medicine - How Tablets are Made - Naked Engineering
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- čas přidán 3. 07. 2024
- We visit the tablet manufactuing site of Glaxosmithkline to see how millions of tablets are made each year with accurate precision for the global drug market...
- Věda a technologie
Kind of crazy that it doesn't show the actual process!
From the comments below there seems to be a lot of interest about how tablets can be made. First of all it is likely useful to understand that a vitamin tablet, say, that can be gotten from your local pharmacy is in fact a small “cookie” (for the lack of a better word. If I recall adequately from way back when, it is a two step process: typically the non-medicinal ingredients include wheat or corn flower with any dyes, quite a bit of sodium stearate (for the lubrication for the processing machinery, (there are a number of well, recipes are approved by the FDA and the CDC, and so on), sodium chloride (table salt), some distilled water --- mix well until the consistency is about like molding clay then bake for about 30 minutes (as I noted above that are a number of approved recipes, grind up the cooked and then cooled materials. Often such activities can take several hours with the grinders often appear like concrete mixers (stainless steel with covers). The now more or less uniform powder is sifted so that there is a certain approved physical consistency in this powder. The powder is chemically check for water content, and so on. All officially approved. This powder, once the approved steps are checked, is very carefully weighed out along with the vitamin powder. More hours of mixing with those covered stainless steel concrete mixers. More careful, officially approved chemical tests. Finally, the pill press is readied, according to official procedures. (The plant might look like a ho-hum average building, but everything inside is incredibly clean and there are small armies of cleaning experts, officially approved, going through the various stations cleaning this and that.) The press machines, after being readied, with the proper shoe (the carrier of the now medicated powder is loaded in to this shoe) on the presses stainless steel table... and the press is turned on there are several motors that drive cams (in the more common examples) that slide the powder ladened shoe goes back and forth across the machine's table to drop a specific volume of powder into the hole that contains the bottom steel die, the shoe pulls back and a rod with the upper die advances to compress the charged hole, with approved pressures (otherwise there is capping, in which the tablet is too fragile and falls apart as the tablet can't be handled). The upper die pulls up and the bottom die pushes up the completed tablet --- which is gathered up with the shoe that is now advancing to deliver another charge. It's a cycle that lasts about one second or less. So that the machine, if operated continuously, can make a bit over 3,000 tables per hour. So practically speaking, have to have permissions to do this and that. Plus the costs of the building, the costs of highly educated folks, a pretty good chemistry lab, and on and on. For many firms the costs in the US are prohibitive, so they do the tablet making part overseas. Then when the tablets are shipped into the US, the shipment is checked out like outfits like the USP, or USP approved labs. Then the pills are sold to drug distributors. One can be easily reminded of an anthill, because of the business of the the process.
Very interesting! You seemed to give a more thorough explanation of the process then the video did lol.
This thread proves that reading is still the number one form of information, 😊👍
The one question I have isn't answered; how EXACTLY are the ingredients combined to ensure they are distributed evenly amongst the individual tablets
Witchcraft
They weigh the ingredients and fillers and pass it through a mixing apparatus that mixes the ingredients evenly.
They go into a rotating blender in exact weights/ratios. The one in my job looks kinda like an ice-cream cone with an upside down ice-cream cone on top and it spins until they're a uniform mix. The blend is sampled every 15 minutes or so when the very first batches are made so there's a record of when the perfect blend is achieved, or if it will de-blend if spun too long. When the blend time is done, then you can be certain that every sample taken will be identical proportions of the ingredients.
study four years of pharmacy LOL
There is a machine that has a V- shaped cylinder in which the ingredients are placed. The cylinder is rotated for a certain amount of time to allow the different ingredients to thoroughly mix. Here's a longer explanation and picture: www.bionicsscientific.com/pharmaceutical-blenders/v-cone-blender.html
I wanted to see the actual processes involved not just a tableting machine from afar. I wanted to see what the punch and look like and how the ingredients are measured and transported to the punch and die.
The Punches and dies are how they get the thickness, hardness and weight. That's important because the amount of dose, how the tablet is digested, also how the tablets fits in the bottle.
Informative
I wish I had that machine in my house and it made me percocet
Mad Mike what does it mean
Opana
🤣🤣🤣🤣🤣
Aye you good?😂
@Cody Simpson wow
But, how EXACTLY do you acquire this?
You can see what they are making by searching for the imprints on the tablets.
How long do medications sit at the lab before going to the consumer
It gets stranger than that, there ways of making those medicines is amazing! the machines used to make them are told by way of computer technology through human operations what ingredients to combine together, by size weight, measure, ect... and then when its prepared and ready to be made, it's all a tap of a button and the machine makes them.... the technology will blow your minds...
What are the ingredients? That's what I'd like to know.
Google it, do some research on which ones you are interested in, so many ingredients are used in so mamy, some are natural, some man made, think of it as how you would use spices/seasonings ect to get the right amount needed, anyways each medicine works differently on each part of the bodies functions, take care
0:17 They look like soaps from this view.
@MeatLoafEnchilada you can't blame them, they just do the testing to discover side effects of drugs etc, its the fda and other such companies that decide if its safe or not to market etc in most cases the government just ban it for alot of reasons, I think hemp and pot should be made legal because both have a good market value in them.
WHAT ARE THE INGREDIENTS? THAT'S WHY IM HERE
depends on what drug you are making duh
Wow this is a fuckin interesting
My question wasn't answered either. WHAT are the ingredients, specifically?
Depends on the medicine you’re making. Drug companies are very protective too over it (though I’d just look at the bottles for the ingredients list. The process is up to the video to cover. Dunno the proportions though. Probs Missed the joke though but wanted to add anyways!)
My theory is, that they are made of sewage/effluent...
Silica, povidone, hypermellose, cellulose etc are the main ingredients but it depends on the product. All ingredients have weird names that no one would know what exactly it is.
Good
i take a lot of medication every day and i just want to know what it is? like is it a bunch of chemicals or natural substances?
Both
"natural substances" are just chemicals too. only uneducated people think there's a difference
@MaxBloxs Yeah but organic ingredients are also chemical compounds and mixtures.
@@MrSmackle30 its synthetics, so its worse
@@oreocarlton3343 Many synthetic chemicals are identical to natural ones. Those that aren't are superior in drugs. Pure willow bark extract will eat a hole in your stomach before it relieves pain.
Is he saying 'degradant' or 'dividend' @1:04 ?
Degradant I think
dividend
Medicines can or should be prevented against plastic wrapping and used sand or wooden coated materials to retain their strength..it will increase employment and also boost indian youth confidence
Good morning
Please u say somethingabout Corona viruse.please
pharma want earn money and depopulation in same time, so dont hope for any vax is medicine, healthy life ia key to against any virus
To say that this is a poor imitation of Discovery Channel's "How it's Made" series would be overly generous...
This video doesn't explain anything, and it makes the viewers even more confused...
999
metabolic theory of septic shock
do a search for the above
Didn't want to see a talking head.
Send Kai out
I am trying to design a drug that will make this infinite horror of life go away and .are the infinite good of life be manifest in and out in this world of the mind and of the true reality
I think you just described the concepts of Doctor Jekyll and Hyde when he tried to separate the evil and good of mankind. It’s not really possible because human nature will always exist in itself (like matter if that makes sense?). It’s like describing perfection but that doesn’t exist either because you can’t erase something from existence. There is no possibility for that (and I doubt there ever will be). It’s a state of mind whether or not the bad out ways the good though. There will always be bad in the world, yes, but there will always be good too. You can’t really put it into a pill because it’s a state of mind rather than a physical concept. It’s all a matter of perspective and what you choose to do with your life (and existence as you put it) because the point of life is simply to live. It’s up to you how to do it.
@@nerdyintrovert821 or maybe nah though
@@nerdyintrovert821 it is possible though
@@ayeeee9343 It really isn’t. Not in the way you’re thinking though at least. It’s a matter of thinking and there’s no way to make everyone think the same or make all the bad things go away. It’s a matter of action and thinking though like I said before. The more good you put out into the world the less bad and the less horror and such there is so it is possible to do what you want but not to make a drug to do so (it’s not that easy sadly. I wish it was).
@@nerdyintrovert821 never say never ♡
Y’all asking to see the entire process like your entitled too lmao Why would they show you how to make drugs the right way ? So you can go and start mixing your own ? Come on get real and keep it moving