Grignard Reagent Synthesis Reaction Mechanism - Organic Chemistry

This organic chemistry video tutorial discusses the synthesis reaction mechanism of grignard reagents with water - H2O, D2O, aldehyes including formaldehyde, ketones, esters, acid chlorides, epoxides - ethylene oxide, CO2, etc. This video contains examples and practice problems that not only help you to predict the major product of the reaction but also how to choose the right reagents to synthesize a primary, secondary, and tertiary alcohol. In addition, other reactions were included in this video such as oxidation by H2CrO4, PCC, KMnO4 & H3O+, in addition to Na2Cr2O7 with H2SO4. Reduction of an alkyne to a cis alkene using H2 & lindlar's catalyst and to a trans alkene using Na and NH3 were also considered. The conversion of an alcohol into an alkyl halide using SOCl2 and PBr3 were also mentioned. The reagents used in this video include phenyl magnesium bromide, methyl magnesium bromide, ethyl magnesium bromide, acetyl chloride, cyclopentyl magnesium bromide, acetaldehyde, 2-butanone, etc.

[@TheOrganicChemistryTutor]

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[@josemarrufo2745]

5:14 he expelled the leaving group, very good

[@WardenOfTheGreatSaltLake]

Nobody:
People who drive their motorcycles down the street at 3am: 5:14

[@binabiswas5337]

Thanks for posting this video.No one explains reaction mechanism like you do.

[@toohot2trot]

Your videos are absolutely AMAZING! Thank you for taking the time to post these, they are incredibly helpful!

[@D_kiki999]

5:14 omg omg im awake im awake jeeezzzzz doing me a scare😵😵😵

[@iitjee4465]

Being a JEE aspirant, I find this channel extremely helpful for last minute revisions before test.

[@kanchandoifode6438]

IIT JEE

[@techienauty1689]

you have a really great knowledge. keep up the good work.

[@sofiaregalado7063]

You just made my homework a lot easier!

[@shauvik.rana.1970]

best video in youtube of grignard reagents....thnkz....best xplained....with a great pace...nd hats off to the long nd continious lecture......best among the best....videos....

[@shfaakhalis9827]

Can you help me Quickly???!

[@asdfghjklmao]

What does the H3O+ do in the the first alkylation reaction at 27:32 ?

[@monicasiamtei8633]

Fall in love with this voice.....😵

[@MandTism]

Hello and thank you for all that you do! Love the videos. Question, at time 29:17 you can see a cyclopentane attached to an alkyne in the bottom left corner...Shouldnt the carbons attached to the carbons trippled bound be 180 degrees (due to alkynes being sp hybridized)?

[@henryarias256]

Quick questions, on the examples at minute 21, for #2, why is the answer an epoxide? wouldn't we need an Aldehyde to get that product? With an R group (CH3) and a Hydrogen on the other side.

[@neonpothos122]

Thank you for your service

[@jyothi26rab]

thanks for explanation. through granard reagent how can we create secondary or Tertiary alcohol .do we have to add an hydrogen or methyl group to get 2ndry product
thanks

[@houndnobleman876]

Thank you for helping.

[@anirudhtammireddy464]

10:21 Isn't the partial positive charge more stable on the tertiary carbon compared to the carbon as shown there>>?

[@bladivoustok5363]

Really helpful videos = )

[@sarahsalahuddin7361]

Thank you so much!!!

[@shamimanasrin233]

What abt benzyl bromide....can we react that with magnesium to make grignard reagent????

[@muhammeddibbasey3928]

Superb thanks

[@user-gf8qr6hd7n]

Amazing

[@priyankapailu1007]

Thank you sir ... 😊😊

[@angelmarg6238]

thanks a lot

[@saumya209]

how ethane is prepared by grignard reagent explane plzzz

[@MrHawking91]

Great video! Very clear explanation. But isn’t the grignard reagent suggested to form via a radical mechanism? DOI: 10.1021/ja00196a053

[@kendalldoer5466]

There’s both a radical and an ionic mechanism theorized, but no one has been able to conclusively demonstrate one over the other

[@shkurtejahiu6820]

At 7:37 I don't understand why we have 2 CH3, where did the H go from the aldehyde?

[@armitairavani3120]

Why are you not using 1 bar hook? It Ida radical reaction when you're making the Grignard complex?

[@vintagenow]

Because this video is about grignard reagents... (See title).

[@dorothyotogbolu6485]

this made me laugh

[@leannguyen4860]

The reaction in which the grignard reagent reacted with akylhalide is illogical because if so, what would happen when we try to synthesize the grignard reagent is in chaos

[@bleuuu9679]

Am I the only one who finds his voice very soothing? 😅

[@rakhidas3405]

Why carbon of epoxide is attacked?
Why not lone pair of oxygen attack Mg2+

[@vishaldhruva4595]

At 37:06, is the reason you cannot use E2 because we are unaware of the specific stereochemistry so we don't know which Hydrogen could be attacked (would be anti and so we could do E2)? Thanks!

[@maloneroam3699]

why is there audio missing 3rd degree alcohols

[@isabelle183]

thanks

[@Kylitovibes]

when the grinard attacks an epoxide . why did it choose the least substituted position?

[@iitjee4465]

Kyle Langlois Steric hindrance.

[@hushupuppies2599]

Nucleophilic attack in the opening of an epoxide in a basic medium is done in the least substituted carbon (Sorry for my english im colombian)

[@saurabhpatil0101]

10:21 best experience

[@HM-dm3qg]

I love grenade reagent!

[@karlpietrzak4467]

What u making ;)

[@666sniperfire]

Produck

[@leannguyen4860]

Such an old video

[@miaeba]

I used to love your vids for gen chem 1. But I think you are making too many vids now. We should start with a carbonyl. You are rushing your explanations too much. The start is just too rushed. Regardless if you are trying to make a RMGX

[@luisdez3124]

dude his videos are great. I am studying for my ochem 2 test that has gringard reactions and his video is great practice. Leave the GOAT alone