Platelets and Von Willebrand Factor animation

The first video in a series of three on the topic of clotting (haemostasis).
In this video we discuss how platelets work. We also look at the drugs used in medicine to inhibit the action of platelets.
LEARNBLOOD aims to make difficult concepts in haematology easy to understand through short, easy to digest videos. We combine dynamic animation with spoken tutorials.

[@alexleatherdale711]

I realize this is meant to be an introductory video, but I think it would be worth noting that VWF is present in multiple components of the blood and the vessel wall in multiple forms. It is present in both the Weibel-Palade bodies of endothelial cells as well as platelet granules. On top of that, large VWF multimers flow freely within the plasma. Immunostaining has also shown VWF is stored in the subendothelium (presumably bound to collagens), which further primes the exposed vessel wall to be pro-adhesive. Lastly, fibrin tends to accumulate closest to the vessel wall and decreases toward the lumen, effectively preventing total vessel occlusion by the hemostatic plug.

[@adamjones1780]

Alex, thank you for your comments. You are right, it is difficult to get all the science across and still create a good narrative of the processes for the student who is new to the subject. I think clotting is particularly challenging in this regard!

[@iloveu975]

Those who are confused:
Adhesion = vWF - Gp Ib
Aggregation = vWF - GpIIIa/IIb

[@fatm4403]

This is genius! Thanks❤

[@romeolhk1008]

Clear as distilled water!!! Thank you!!

[@sclair10]

Thank you for the excellent explanation.

[@bio366geethasankar7]

🙏

[@noone8583]

I think its "Gp 1b ix-v" receptor on the platelets which binds von willebrand factor and "gp IIb/IIIa" receptor which binds fibrinogen! Any correction will be appreciated!

[@hakanozduran7534]

von wilibrand tip 2b

[@swatipatel8948]

It is both actually.
Vwf binds Gp 1b ix v and helps in cell adhesion to vessel wall. Gp 2b 3a, is in resting state, when Vwf binds to it, it gets activated and vwf forms a bridge between two gp2b3a receptors on two platelets. This helps in aggregation ( along with fibrinogen)

[@danicaamano9778]

Is it not the glycoprotein Ib that binds to vWF and IIb-IIIa that binds to fibrinogen?

[@kapulachifunda2011]

noticed too

[@Abbasbaby-girl]

Daniel Caamaño no. He is right.

[@Andr295]

No, he is not right. Gp IIb/IIIa is a receptor for fibrinogen. Gp Ib is a receptor for vWF.

[@lybomanolov5054]

GP Ib => VWF
GP IIb/IIIa => fibrinogen

[@boredtodeath741]

yeah you're right. i was freaking out cuz i thought i memorized it wrong.

[@burakozvit7480]

What a nice explaination Sir ❤

[@markoilickovic4884]

Great video! Thanks!

[@wenw2140]

this video is veyr clear and informative, very easy to understand. thank you so much

[@vaishnaviramakrishna265]

it was very useful!! thank you sir! 😊👏

[@user-qf8qp7ej7s]

great👍👍👍👍

[@gjzztrrettmmggrrertzhgyena4950]

Incredible 🌹🌹🌺🌺🌺🌺🌺🌺

[@nehapatel6006]

Awesome 👍👍👍👍👍👍

[@jed5356]

nice video, thanks a lot

[@monirayusuf30]

thanks

[@sherifelfeel1495]

❤

[@pinkray7052]

Thanksss💕💕💕

[@abdullahhussain9589]

Thanks mate

[@imenboukhefardji3540]

merciii

[@koolilaura]

The background music was distracting.

[@kapulachifunda2011]

very distracting!!!

[@prachishah2304]

Great video and a great addition to my notes, but please get rid of the music in the background!!

[@debabratamanna1863]

Does paracetamol also inhibit cox pathway...I think it doesn't...it is centrally acting drug

[@jullian95m]

mint

[@lindanorris2455]

HOW COME VWF IS NEVER BROUGHT UP WITH ENDOMETRIOSIS PATIENTS?

[@TheFujiwuji]

This is a great video, but the music is too loud and distracting, making it harder to follow.

[@VonJay]

Why don’t you have a billion followers? The world is mad

[@juliusgrecu8887]

nice

[@SuperJohnnyuk]

this guy is HOT

[@americanbee]

I couldn't understand the accent because of loud music

[@bomhayhay]

thanks