Coagulation Cascade Animation

The second of three videos on the topic of clotting (haemostasis).
In this video we discuss the coagulation cascade with the help of animations.
There are different ways of looking at coagulation, and this often causes confusion. We look at the traditional model including the intrinsic and extrinsic pathways, but also look at the more modern descriptions of coagulation including the 'thrombin burst'.
LEARNBLOOD aims to make difficult concepts in haematology easy to understand though short, easy to digest videos. We combine dynamic animation with spoken tutorials.

[@projectvideos01]

you are amazing, this is the first time this has made sense for me

[@vanillylmandelic4870]

Brilliantly explained. it's the ever first time that i got the concept of it.
Thankyou so much.

[@ToycarLKS]

Thank you !
I am doing a presentation on Heparin tomorrow, this playlist really helps me a lot :)
Looking forward to other videos :)

[@_immaculata]

The best!! God bless you

[@ahorsfield94]

Really, really helpful even for a veterinary medicine student :D thank you!!

[@tharwathabib2613]

OMG, your explanation is really amazing I like it so much Thanks alot 😍 💖

[@Vitorsilva-zw1wk]

Very helpful. I finnaly got it

[@katealden7824]

Awesome! Thanks!

[@ameenabuhamdan8412]

Thanks, very useful

[@Dazzletoad]

Let me ask a questionh here that I have already asked so much before but haven't been given a single answer, never mind a satisfactory one. I am an aspiring medical student with very little scientific background, and these concepts can be monumentally frustrating.
But first, let me make a point or two.
The extrinsic pathway is remarkably simple, but your video is contradicted by other CZcams content.
You described the extrinsic pathway as that activated by 'substances without the blood, subendothelial tissue factor, but doesn't that also include extravascular substances, such as collagen?
I ask this because the collagen in another video was marked as an initiating substance, however that was for the intrinsic factor. The video wen't on to even contradict itself by having the collagen outside the vessel, which is definitely extrinsically located, not intrinsic.
You say thrombin activates factor 11, which will go on to activate downstream, but you didn't mention factor 12 to 12a, neither did you mention the activation of factor 8.
Finally to my question, regarding the abovementioned, is there any way that the intrinsic pathway can be activated without the extrinsic pathway, and if so, what event or insult makes this happen?
A simpler way to ask is the following, I suppose. Does all intravascular haemostasis begin with the extrinsic pathway?
It might seem like a backward way to put it, but since there are two distinct pathways it would be nice to have a little more clarification on factor 12 and the goings on of the intrinsic pathway. And I know you dismissed the HMWK, and kallikrein, but since they are of even small importance, you really should have covered them. Could you perhaps elaborate a little?
Great video by the way, and I hope you can shed some light on my questions.
Huge thanks :)

[@Ky-fb5fv]

Explained well. If only I saw this last year 😒.

[@naveenkumar-sz1cg]

vry helpful thnq

[@vaishikads7852]

When does extrinsic pathway occur and when does intrinsic pathway occur

[@hooos518]

Is this the new model or the previous one? My lecturer suggest me to learn the new one & the difference between the new one and the previous one

[@veronicademelo6933]

made me not hate it anymore haha thanks

[@bhaveshchaudhari9912]

better explanation

[@sherifelfeel1495]

❤❤❤❤❤❤❤❤

[@abdallahelbhairy636]

OMG