How mRNA Vaccines Work - Simply Explained
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- čas přidán 6. 06. 2024
- mRNA vaccines have to potential to end the COVID19 pandemic. How do they work? Are they safe? And how could they've been developed so quickly?
The main idea of mRNA vaccines is to trick our bodies to produce part of a virus. This kickstarts our immune response, without getting us sick. All that's needed is a part of the virus's DNA or RNA, packaged into mRNA. Cool!
(mRNA is the technology behind the vaccines from Pfizer/BioNTech, Moderna & CureVac)
💡 Follow-up video
• mRNA Vaccines: Questio...
I answer 10 of your mostly asked questions (and address some misconceptions).
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#mrna #vaccine #covid19 #simplyexplained - Věda a technologie
I really appreciate how you didn't have any background music or sound effects in this video. I'm so tired of all the noise/racket in the background of videos.
True💯💯
too true.
Nothing worse than a two minute intro of dubstep at level ten.
Oh my gosh yes!
I cannot agree more. I find background 'music' so irritating and intrusive that I am unable to watch the video. This video was brilliant, thank you very much!
The problem is that spikes circulate in the blood and the complex of spike and antibody may deposit itself on the cells of blood vessels causing an inflammatory reaction that damages the cells lining the blood vessels.
Been there, done that. triggered vasculitis.
At 3:05 it says you don’t get sick but many people have gotten sick with the injection , how come ?
You don't get sick as in you don't get sick with covid
@@goodvibes1525 but people with the vaccine have been getting sick with Covid and the different variants.
The symptoms right after receiving the vaccine are common responses when your body wants to build immunity. Getting the vaccine doesn't make you invulnerable, just like wearing seatbelts doesn't mean you're not getting hurt if you crash
It's symptoms, but not full blown sickness (most times). Your body is producing active virus DNA, so when your cells replicate it, you might experience symptoms of the virus before your body can shut it down. And by the next day, you're usually a-okay again.
Great vid! Straight to the point, easy to digest, and quick. Literally everything i needed to know!
I think it is misleading that the video didn't make clear that the vaxxx is meant to kill us all.
@@conniemcmurray5146 go back to school
@@conniemcmurray5146 so where are all the millions of dead people?
so basically you don't need the whole enemy to train your soldiers only show them how the enemy's weapon look like.
Haha yeah! Cool analogy!
If your immune system will not react the spike you now produced more coronavirus. Can you have a presentation using DNA.
Absolultely!
We need to keep things in perspective. About 54 million covid vaccine doses have been given worldwide. We would all hope that no one experiences any side effects from the vaccine. I suggest the incidence of serious side effects is rare! It is very easy to highlight cases and blow things totally out of proportion. Which is greater: Getting a severe side effect or getting covid (which has known long-term side effects) and passing it on to others? What is your solution to getting out of the pandemic?
More like showing a photo of their enemy rather than just their weapons, and rather than letting them figure out by themselves.
Why do we need second dose if our immune systems already know that thing
B cells doesn't last forever, and if it is a reocurring experience your immune system will increase the amount of b cells in total in your body.
Many vaccines have a second dose
*10th dose
I swear the thought process that went into these vaccines was clever as hell. Like, who thinks of using our own body to make the key markers of a virus which it will use to identify said virus? That's the most ingenious piece of biomedical engineering idea I've ever heard of.
It is clever as hell. Some have likened it to the invention of the transistor.
But with so many variations one will need booster after booster.
Clever as HEAVEN. Hell isn't that clever.
I believe the originator of the mRNA idea struggled to get funding or anyone interested, until of course until COVID came along…
@@reveal102 Nobel Prize stuff for services to medicine and humanity in my opinion.
Good simple explanation but missing important parts like how does the body stop this loop of continuing to make the spike proteins. And what are the long term affects.
Long term effects? It's still in Experimental stages
I gave thumbs up for the last part of your Video. Dont just trust me, deep dive into the sources. Nice .
Sources: Forbes, Wiki, Business Insider, Twitter?
I'm concerned about the profit motive of pharmaceutical companies that produces vaccines. I don't want to support an industry that prioritizes profits over people's lives.
Travel Restrictions were much, pandemic caused travel restrictions and disruptions to the tourism industry, affecting both travelers and the tourism sector.
So if the pharmaceutical companies don't make a profit who will pay for the development of new vaccines and new drugs to treat illnesses? People see the big profits but no one asks how much money it takes to develop and test a new medicine.
Yes, and 2 vaccines and 100 boosters later!!
Listing sources gets a huge thumbs up.
You get a gold star if u get ur 2 injections :)
This is the best and clearest explanation of mRNA vaccines I have heard so far. Excellent !
seriously !
Very good indeed!
Better than my coworkers over a Skype call this morning. "mRNA will fuse to your genes and kill you." I'm still speechless. These people get paid around $25-40 an hour and they think Bill Gates is trying to microchip us. I only realized this morning how nutty a couple people on my team really are.
@@funkyfreak97 Isn't 25-40$/hour quite a bit even for well developed countries? 25-40$/hour is a lot in my country where minimum net salary is 317 US dollars like imagine getting paid around1,5$/hour like not getting paid in a day of work as much as you get paid in one hour.
I agree 100%!
One of the best explanation videos ever!!
Spike proteins themselves can still cause lung damage and blood thickening.
💩
@@talltree3941 like, oh 💩 !!!?
@@awayfarer6813 no, like this guy “David” is trying to push some bullshit story to try to scare people from getting the vaccine. So the emoji is meant to mean “bullshit”. But maybe I coud Try: 🐂💩
@@talltree3941 Haha, well, I just hope people are doing their due diligence and homework about the vaccine before making a decision, and not stopping at this simple video. I respect whatever personal decision people make...and what I mean by personal is thinking for oneself, and not giving in to coercion or societal pressure either way you go.
@@awayfarer6813 I got fully vaccinated in March. No issues. I live in a large city. Millions have gotten fully vaccinated. I haven’t heard of anyone experiencing any serious side effects.
wow, not mentioned any risks, only the benefits. Bravo
Thank you so much.. saved me from failing in my Final school year Bio Examinations
... Hoping to get at least 90... 7 questions from the subject came and I answered it will thanks to you
You will not get 90 if you take vaccines frequently.
@@MacLuckyPTP what?
@@stellarch9524 you will not live to be 90
@@SHREDTILLDEAD I like how you didn’t even correctly explain it, this guy is talking about grades not the age so your clearly just as stupid as the guy I replied to
Well that shattered one or two illusions I had! Thanks for that video.
just like that huh? did you bother to research further? probably not...
@@taraakins8273 Whaaaat? Wow, just....wow 🤦
Thank you for taking the time to simply explain. First video that I have found that actually makes it clear and precise.
Wonderful! Thanks for the straightforward explanation. Brilliant!
Thank you brother!
I love your ability to Simply Explain complex topics. Subscribed.
But why we also hear people still experiencing symptoms and other illness after getting mRNA vaccines..??
Great explanation and graphics!
Thanks for sharing! Finally some clarity : )
Thanks for the explanation. Easy to understand and relatively quick/to the point.
Glad you liked it!
Great. The only problem is as it turned out that the spike proteins on their own also make you sick. So I think that part of the explanation is simply not true. Anyone with some info on that?
Really good explanation and super understandable, thank you!
Except he didn't mention the following:
1. The purpose of the research Dr. Fauci funded was to engineer the spike protein to be EXTREMELY toxic. So the spike protein our bodies manufacture are just as toxic as the spike protein on the virus, and they are causing major problems.
2. It's the spike protein that is mutating to create the new variants, which is why these vaxes don't provide lasting immunity ---- after the spike protein mutates, our immune system no longer recognizes the spike virus. Which is why dead antigen vaccines are so superior --- because we develop immune recognition to all 32 viral proteins, so when the spike protein mutates we can still recognize the rest of the virus.
I've been trying to find a clear and simple video to show friends and family, this is perfect - thank you!
Awesome, couldn't find any info on the actual breakdown of the produced spikes by the body's immune system after vaccination has taken place. This was clear and concise for laymen like me. :-)
Me too
*mARN is UNSAFE UNSAFE UNSAFE UNSAFE UNSAFE UNSAFE UNSAFE*
Incredible video explaining some incredible technology! I'm amazed by the scientists that managed to come up with this technique and put it into effective use! Incredible stuff!
I wouldnt get to excited. Lets see how it works a year down the line.
@@garryallison5679 it works great
@@garryallison5679 I got the vaccine it’s awesome. I feel great
@@nickizcool20 the placebo effect....
why are people dying from the vaccine?
My concern is by sending a message to your cells to replicate the "spike" and then to later attack that spike could be setting our bodies up for autoimmune disease.
Which might not materialize for many months or even years later. I am not taking an experimental medication like this until it is proven safe.
The mRNA that tells our cells to produce the spikes are very unstable. They are degraded very quickly and does not remain in your body long term. It is only temporarily there to teach your cells to recognize the enemy. It's like how you would teach maths to kids , but you're not going to stay with them the rest of their lives to show them how to multiply.
@@kenn3758 all you are doing is describing the theoretical mode of action and the intention of the medication. What happens in real world situations is unclear at this stage, though people have already died after taking this experimental medication. Describing the intention is somewhat meaningless in this context.
@@slooob23 I understand your point of view. Though I must highlight that this 'theoretical' mechanism has been well studied for decades, meanwhile the deaths (if any) from this category of vaccines are extremely rare. That is like saying you won't walk outside during the rain because lightning could hit you. Yes there may be a slight possibility of negative effects, but the expected benefit you and your community get from this vaccine heavily outweigh them.
@@kenn3758 to my knowledge this is the first RNA vaccine ever produced, in that regard how can we have high confidence in it until a suitable period of time and the associated monitoring is complete? We also don't know how long it is effective for, corona viruses being notoriously difficult for lasting immune response. If the vaccine is only effective for a few months the risk profile becomes rather more of an issue.
The easy going explanation so far.
Thank you for making this so easy to understand. It really does help give me peace of mind.
Thank you, most articles act like I am a child when I read them.
Glad you liked it!
That might be because most of the people are behaving like children during this whole pandemic
Thanks! Easy and understandable.
If it is that simple then why are there so many people suffering severe side effects & why are so very many reputable & highly qualified doctors warning us not to take it? I don't get it.
I don't think I like the sound of this. What happens when it mutates in your body? Your infecting yourself with something that might cause autoimmune disorder by the looks of it. I will take my chances with nature
@@theotherorange3586 A lot of doctors have said precisely that.
Now Govts need to market this with a brief explanation of how the vaccines work and endorsements.
Exactly, they’re currently just advertising that you should get it and that everyone’s getting it, instead of actually explaining it so people can see it’s safe without having to take the governments word for it
Nie,nie
Very Well, and clearly explained, Great job👍
In theory it sounds great, in practice its unfortunately not.
Thankful for this video and the (majority) of comments being informed and intelligent for once.
So that's the theory. But what about all the spike proteins travelling around the body and causing mayhem in vital organs?
Short and sweet, wonderful and informative video!
You really make it easy to understand. Thank you so much!
Then why are people getting so sick after the second dose?
Great explanation and easy to understand. Everyone should watch this.
Awesome explanation. Keep up the good work Champ!!
So helpful! Thank you so much for this video.
Yes, I agree with you. cool video! clear and easy to understand!
You can tell if someone is really smart they can explain complex things simply with ease.
asking the body to build lots of spike proteins? teaches us how to fight them off? may make sense to some but not to me.
The really smart people never took the jab in the first place
Thank you so much! This really helps me with my Life Sciences 11 Project!
You got my subscription. Totally clear explanation.
The immune system is amazing. I think you could add to the video the effects someone might experience while the immune system tackles the intruder. But keeping it simple is a good way to teach, generally.
Amazing, super clear explanation. Well done!
This is such a great explanation! Thank you so much!
This is great:) now u too can get this amazing injection from god.
Very good video - simple and clear explanation!
Can you make a video for inactive vaccines (eg: for Covid 19) comparing to mRNA vaccines by versus? Appreciate. Great job.
I wanna to know what kind of body cells will take up those mRNA? Are those cells being specifically selected or randomly absorbed? Once those body cells start marking the viral protein and display on their surface, will the T-cell treat them as foreign and attack those cell also? Just like rejection in transplantation?
Good question and it is about 4 days no answer)
@@azaraliyev2064 Either no one can give the exact answer, or someone know the answer but not wanna disclose it.
I've been wondering about that too. I would assume they're just thrown out of the cell to hang out in the tissues or work their way over to the bloodstream where immune cells can find them. (Cells absorb and release proteins all the time after all.)
Nice animation. I rarely looked at this quality video.
Awesome video, straight to the point and very comprehensible.
Perfect amount of information, explained concisely. Thank you!
Talk about the side effects now.
This is super easy to understand.
What happens to the cells which develop spike proteins? Are they neutralised with the antibodies or are they killed by the immunes system afterwards? How many infected cells die? Since adenoviruses od Mrna can travel through the body anywhere, can it get into the nervous system leading to autoimmune disease?
The protein cells that create the spike proteins remain protein cells.
All infected cells die, hopefully.
There have been cases of infected cells "hiding" in the body, research "shingles".
Well, the mRNA only has one purpose, to create spike proteins, when it runs out of RNA instructions, it stops making spike proteins.
All spike proteins are destroyed by the immune system.
The immune response is normal for the human body.
Very unlikely to cause autoimmune disease.
I like your explanation. However, it must be cautioned that this technology does not have a track record. What will happen when this synthetic rna is produced in other parts of the body? In the case of covid, what about the lipid enclosed nano particles? They are basically tricking the cells into making a synthetic compound. What is being used to create this synthetic compound? What happens to the synthetic compound that was used to create this protein? Can the nano particles be remotely manipulated? How is it possible for the vaccine to enter the cells?
@@renitapayno Jerusalem Times had an article about these mRNA vaccines. I am not an antivaxer I know vaccines work, but this is an entirely new type of vaccine, never been approved for use in humans before. I don't know why they would not used the tried and true weakened/dead virus for a vaccine
@@renitapayno , do you mind sharing that article? I have too many questions about the platforms that they are using with this vaccine. I personally find the whole process very troubling. No one is talking about the nanotechnology used in this vaccine.
Tried to warn coworkers against using this new technology that, ultimately, injects itself into your cells and manipulates them to produce spike proteins instead of what it normally produces.
Extremely invasive.
Most importantly, I said it's not worth taking a risk given you are young and healthy and are at no risk.
Of course, they called me anti-vaxxer.
Towards the end, the video man says "don't take my words".
Still doesn't explain what happens to the cells that manufactured the mrna.
What an excellent and informative video! Thanks!
You really made this very easy to understand! Thank you!
Very nice and clear. Now explain what happens in real life. I dare you.
Thanks so much for sharing. 😎👌🏼
Thank you for this! After tons of videos, now I finally get it
Well done! Now you take multiple injections of this to protect the ones you love.
I will keep my vmat 2 thank you very much
1) So why more than 1 injection is needed?
2) Why there are any side effects or people feel sick and so on?
3) Why there's a talk about "long term side effects"? How learning the body to fight against virus can cause long term side effects?
you can find these all with a simple google search
@@coleross1562 but im too lazy
So if you can’t get sick, why are some people getting symptoms after taking it?
Now I'm understood. Great video!
Dude. Thank you. I’ve recently got the new kurzgesagt book on immunology. It’s great but I either haven’t got to the MRNa but yet or it’s not covered. But I keep hearing about it and I keep hearing about “MRNa entering the cells nucleus” which sounded like bullshit. This totally clears up what the MRNa does so thank you 🙏
Great! And also, once I hear someone says: "But don't take my word for it! All sources [...] are listed below", then you got me. Hit the subscribe button :)
What a terrific video,thank you.
Thank you! Make sure u book ur amazing mrna injection to protecr urself and others.
Thanks for this explanation.
a very nice simple explanation - thanks so much!
Very good explanation, thank you.
Many people I know who get vaccinated get sick almost immediately with covid type symptoms. Why is that?
Thankyou for this info 🙂
Thanks for this, Good day
Nice explanation and appreciated. The part about not getting sick is not quite accurate though. Maybe that is supposed to work that way, but typically doesn’t from all that I talked with, at least a few days. One study even indicating that the spike protein may be getting in the blood in a few cases, anything can take place if that happens. Guess will find out over time.
Exactly
As time passed we found out in a very concerning way
Great Explanation!
So how do you know you only extracted the spike DNA? I mean we don't fully understand DNA code jet. There is a possibility the cell produces something else which could possibly be very bad.
Explained really well for the mere mortal such as I
This was great! Thanks for putting together such a logical and simple presentation.
The most beautiful explanation in its simplicity. Great video !!
Thank you for the clear explanation
Brilliant explanation.thank you so much ❤
You have done the world a public service by creating this video and I will share this to all corners of my little world and hopefully it'll spread. Thank you also for providing references in the description. Well done!
Thanks for your kind words! Really means a lot. I hope other people will also see the value (and the trolls stay away)
@@simplyexplained You are very welcome. Ignore all the trolls and anybody else that doesn't have a constructive question or comment. I know, easier said than done. In particular, there is one person I will target this video to: she is a fitness/motivational influencer on CZcams and has urged her followers to avoid vaccines at any cost. I will be sending her your video link directly. Her chief complaint is the mRNA component of the vaccine. This is especially why I'm appreciative of the references in the description. Keep up the fantastic work!
Spread...like a virus!? (Sorry, little vaccine joke)
@@martyes9563 we need laughs so no need to be sorry ;-)
Hope this video will calm down the anti-vaccine people.
I had the 2nd dose of Moderna recently and had pretty bad flu symptoms for about 24 hours (headache especially when moving quickly, muscle pains, fever, skin sensitivity, fatigue etc.). This video says there are few side effects because there is no live virus but side effects are pretty common at least for Moderna and Pfizer, so what is the mechanism that causes this? Immune system overreacting to the spike proteins?
MRNA is a retrovirus. When a virus Is replicating it needs certain conditions. A fever means it is doing what it does to replicate. It's not a vaccine by definition it is infact gene therapy using a man-made retrovirus as a delivery system. You really shouldn't do the boosters, you shouldn't have done the covid shot at all. But that is your choice and you made it
To much misinfo thanks for clearing it up
@@Banishedsoulsofficial You are suffering from what's called the Dunning Kruger effect... you think you understand the whole picture but really, you're clueless.
When
someone can't type mRNA properly, it's a dead giveaway of where they are coming from.
@@Chad_Max I recently watched a talk given by a biochemist who worked at Pfizer for 10 years. He said that there no attenuation (that he was aware of) of the vaccine's effect, which is to cause cells (which cells?) to produce the spike protein. Once you're injected, your body will be producing those spike proteins indefinitely. And since they're so small, they are able to penetrate the blood brain barrier. This leads to clotting (strokes) and inflammation elsewhere in the body. Your body will constantly be fighting to eliminate them and it likely won't be able to catch them all. They're going to build up and we're going to see what the long term effects of that are. It's probably not going to be pretty.
Thank you! Clear and short explanation.
That was a very precise explaination. Thank you
missing the explanation of how those spikes got out of the human cells though... One source I read said that the spikes end up attached to the cells exterior not floating around randomly like in the video... If one fact is wrong, what else is wrong...
I really needed this... it has been so hard to comprehend this new type of vaccine and I finally get it. I could even explain it to others if I had to
Make sure to explain that it is the spike protein that kills people and that this is a depopulation shot.
@@conniemcmurray5146 i got it and didnt die. And where did u get that information?
@@conniemcmurray5146 Prof. Bhakdi puts it down, Dr Robert Malone mRNA vax tech inventor thinks all the data is fake. There are are at least ten to many more natural and 2 cheap generic solutions that make jab EUA invalid.
@@hyperbot2328 Retired German prof. Bhakdi argues against, not depop argument. Vax tech inventor Dr. Robert Malone who had vax for travel thinks all the data is fake. Why am I talking to a bot?
@@Nowhereoh why are you crazy talking?
My concern is that this is the first time mRNA has been used on humans in such a wide scale before. The experts say it is safe, but how can we know for sure that there will not be long term side effects?
Because we know exactly how it works. It's isn't just some random procedure. We have known how mrna works for decades and we simply are using that knowledge to teach out cells to fight off a virus.
@@jonny555333 we don’t know the ramifications and the majority of us can fight off the virus with our immune system so we don’t all need it
@@jonny555333 no, this has never been done before on humans and everyone gettin it are guinea pigs to fight a virus that’s 99.998% survivable!
@@Mnpat lol if you don't have a good resson to get vaccinated (like a disease or whatever) and you don't want to be vaccinated you're irresponsible and more or less an idiot
@@maxmorris4562 we know how RNA works, my buddy began working on this more than 20 years ago.
Wow! It was really helpful 🥰
It is clear and easy to understand.